Article
Psychiatry
Stephen Puntis, Dominic Oliver, Paolo Fusar-Poli
Summary: The study demonstrates that a personalized and clinically-based risk calculator shows external validity in a non-urban population. Despite differences between Oxford Health and urban development databases, the model retains accurate prognostic performance in diverse population groups.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Psychiatry
Tianhong Zhang, Lihua Xu, Yanyan Wei, Xiaochen Tang, Yegang Hu, Huiru Cui, Yingying Tang, Zixuan Wang, Haichun Liu, Tao Chen, Chunbo Li, Jijun Wang
Summary: The impact of the duration of untreated prodromal symptoms (DUPrS) on the development of psychosis in individuals at clinical high risk (CHR) varies. A longer DUPrS is associated with younger age, higher baseline global function, lower previous global function, and higher negative symptoms.
PSYCHIATRY RESEARCH
(2023)
Review
Psychiatry
Michelle A. Worthington, Tyrone D. Cannon
Summary: Research within the clinical high-risk for psychosis paradigm focuses on predicting and preventing negative outcomes to improve individual results. While several risk calculator models have been developed, they have not been implemented clinically, and progress in effective interventions has been limited.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Melanie Iorio, Erica Casini, Stefano Damiani, Paolo Fusar-Poli, Renato Borgatti, Martina Maria Mensi
Summary: This study compares family functioning and perceived stress in parents of adolescents with CHR-P, EOP, or other psychiatric disorders. The results suggest that family functioning has a central role in CHR-P adolescents and could be a worthwhile target for intervention.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Tianhong Zhang, Yanyan Wei, Huiru Cui, Xiaochen Tang, Lihua Xu, Yegang Hu, Yingying Tang, Haichun Liu, Tao Chen, Chunbo Li, Jijun Wang
Summary: Neurocognitive deficits in early psychosis differ with age. This study explored age-related differences in neurocognitive performance among a large clinical population. The results showed significant differences in neurocognitive scores among different age groups, with CHR individuals having lower scores than HC and FEP patients having even lower scores. Adolescents performed better than adults in all groups. Age had a stronger correlation with cognitive function in the HC group, and more neurocognitive domains were affected by age compared to the CHR and FEP groups. These findings highlight the importance of monitoring cognitive trajectory in early psychosis.
PSYCHIATRY RESEARCH
(2023)
Review
Psychiatry
Alexandre Andrade Loch, Ana Caroline Lopes-Rocha, Feten Fekih-Romdhane, Martinus Theodorus van de Bilt, Gonzalo Salazar de Pablo, Paolo Fusar-Poli
Summary: This article systematically reviews studies on individuals at clinical high-risk for psychosis (CHR) in low and middle-income countries (LAMIC). The review found limitations in conducting CHR research in LAMIC, such as small sample sizes, cross-sectional designs, and follow-up issues. The results of an online poll indicate that 75% of researchers believe that CHR research should be approached differently in LAMIC due to structural and cultural issues.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Neurosciences
Gonzalo Salazar de Pablo, Scott W. Woods, Georgia Drymonitou, Hector de Diego, Paolo Fusar-Poli
Summary: The prevalence of the CHR-P state is low in the general population and ten times higher in clinical samples. The prevalence of CHR-P may increase with a higher proportion of females in the general population and with a younger population in clinical samples. The CHR-P state may be unrecognized in routine clinical practice. These findings can refine detection and preventive strategies.
Article
Psychology, Clinical
Gary Brucato, Michael B. First, Gabriella A. Dishy, Shana S. Samuel, Qing Xu, Melanie M. Wall, Scott A. Small, Michael D. Masucci, Jeffrey A. Lieberman, Ragy R. Girgis
Summary: The severity and number of attenuated positive symptoms are less predictive of conversion to syndromal psychosis than the timing of their emergence and intensification. The earliest phase of psychotic illness involves a rapid, dynamic process, potentially with significant implications for CHR research and understanding of the neurobiology of psychosis.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Laila Hasmi, Lotta-Katrin Pries, Margreet ten Have, Ron de Graaf, Saskia van Dorsselaer, Maarten Bak, Gunter Kenis, Alexander Richards, Bochao D. Lin, Michael C. O'Donovan, Jurjen J. Luykx, Bart P. F. Rutten, Sinan Guloksuz, Jim van Os
Summary: Research shows that in clinical high-risk states, the co-occurrence of NPD with attenuated psychotic symptoms can influence the risk of developing psychotic disorders, and early psychotic experiences combined with NPD often result in poorer functional outcomes and environmental risks.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2021)
Review
Psychiatry
Ksenija Vucurovic, Stephanie Caillies, Arthur Kaladjian
Summary: Psychotic disorders encompass a range of disorders with multiple etiologies, and individuals at clinical high risk for schizophrenia show differences in neural correlates compared to healthy controls.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Multidisciplinary
Lourdes Nieto, Tecelli Dominguez-Martinez, Mauricio Rosel-Vales, Ricardo Saracco-Alvarez, Cesar Celada-Borja, Maria Luisa Rascon-Gasca
Summary: This study compares the sociodemographic, clinical, and functional characteristics of At-Risk Mental State (ARMS) youth and those with a first- or second-degree relative with psychosis (Familial High-Risk: FHR) in a Mexican sample. The findings indicate that ARMS individuals are younger, have less education, and are more likely to be male than those in the FHR group. The ARMS group also exhibits more severe prodromal symptoms, schizotypal personality traits, and general psychopathology. Additionally, their premorbid adjustment deficit from early adolescence is higher compared to the FHR group. The study emphasizes the need for early detection and intervention programs in Mexico to support this vulnerable group.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Clinical
Igor Nenadic, Tina Meller, Simon Schmitt, Frederike Stein, Katharina Brosch, Johannes Mosebach, Ulrich Ettinger, Phillip Grant, Susanne Meinert, Nils Opel, Hannah Lemke, Stella Fingas, Katharina Foerster, Tim Hahn, Andreas Jansen, Till F. M. Andlauer, Andreas J. Forstner, Stefanie Heilmann-Heimbach, Alisha S. M. Hall, Swapnil Awasthi, Stephan Ripke, Stephanie H. Witt, Marcella Rietschel, Bertram Mueller-Myhsok, Markus M. Noethen, Udo Dannlowski, Axel Krug, Fabian Streit, Tilo Kircher
Summary: This study found that schizotypy may share less genetic risk with schizophrenia and is not significantly associated with the genetic risk of affective disorders.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Michelle A. Worthington, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Matcheri Keshavan, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, William S. Stone, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Tyrone D. Cannon
Summary: The study focuses on individuals in the clinical high-risk period before first episode of psychosis (CHR-P) who do not transition to psychosis, and aims to develop a predictive model for remission outcomes. Using a data-driven machine-learning approach, the researchers identified clinical and demographic predictors of symptomatic remission in CHR-P individuals. The study found that individuals who eventually experienced remission had lower baseline prodromal symptoms. This study highlights the importance of understanding factors contributing to resilience and recovery in CHR-P individuals.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychiatry
Frederike Schirmbeck, Nadine C. van der Burg, Matthijs Blankers, Jentien M. Vermeulen, Philip McGuire, Lucia R. Valmaggia, Matthew J. Kempton, Mark van der Gaag, Anita Riecher-Rossler, Rodrigo A. Bressan, Neus Barrantes-Vidal, Barnaby Nelson, G. Paul Amminger, Patrick McGorry, Christos Pantelis, Marie-Odile Krebs, Stephan Ruhrmann, Gabriele Sachs, Bart P. F. Rutten, Jim van Os, Merete Nordentoft, Birte Glenthoj, Paolo Fusar-Poli, Lieuwe de Haan
Summary: This study found that a past depressive episode in UHR individuals is associated with a higher risk of an unfavorable course of APS, while past or current anxiety disorders may be associated with a lower risk of an unfavorable course. Additionally, past depression is significantly associated with a higher risk of transitioning to psychosis.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychiatry
Ricardo E. Carrion, Andrea M. Auther, Danielle Mclaughlin, Steven Adelsheim, Cynthia Z. Burton, Cameron S. Carter, Tara Niendam, J. Daniel Ragland, Tamara G. Sale, Stephan F. Taylor, Ivy F. Tso, William R. McFarlane, Barbara A. Cornblatt
Summary: The association between cannabis use and psychosis is inconsistent, especially in individuals at clinical high risk for psychosis. However, this study found that continuous cannabis use in CHR youth was associated with improved neurocognition and social functioning over time, as well as decreased medication usage. Surprisingly, clinical symptoms also improved despite the decrease in medication.
PSYCHIATRY RESEARCH
(2023)
Review
Psychology, Clinical
San Lee, Keum Hwa Lee, Kyung Mee Park, Sung Jong Park, Won Jae Kim, Jinhee Lee, Andreas Kronbichler, Lee Smith, Marco Solmi, Brendon Stubbs, Ai Koyanagi, Louis Jacob, Andrew Stickley, Trevor Thompson, Elena Dragioti, Hans Oh, Andre R. Brunoni, Andre F. Carvalho, Joaquim Radua, Suk Kyoon An, Kee Namkoong, Eun Lee, Jae Il Shin, Paolo Fusar-Poli
Summary: Errors in data extraction may account for discrepancies in previous meta-analyses on the association between depression and inflammatory biomarkers.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychology, Developmental
Gonzalo Salazar de Pablo, Carolina Pastor Jorda, Julio Vaquerizo-Serrano, Carmen Moreno, Anna Cabras, Celso Arango, Patricia Hernandez, Jeremy Veenstra-VanderWeele, Emily Simonoff, Paolo Fusar-Poli, Paramala Santosh, Samuele Cortese, Mara Parellada
Summary: This meta-analysis found that antipsychotics and medications used to treat ADHD were significantly better than placebo in improving emotional dysregulation and irritability in individuals with ASD. Specifically, risperidone and aripiprazole showed efficacy in short-term treatment. However, other drug classes did not show evidence of efficacy. Lower efficacy was associated with comorbid epilepsy.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Ana Catalan, Claudia Aymerich, Amaia Bilbao, Borja Pedruzo, Jose Luis Perez, Nerea Aranguren, Gonzalo Salazar de Pablo, Emily Hedges, Patxi Gil, Rafael Segarra, Ana Gonzalez-Pinto, Aranzazu Fernandez-Rivas, Lucia Inchausti, Philip McGuire, Paolo Fusar-Poli, Miguel Angel Gonzalez-Torres
Summary: COVID-19-related mortality and hospitalization rates were higher for patients with pre-existing psychotic disorders, while patients with affective disorders had lower rates.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Marco Solmi, Giovanni Croatto, Giada Piva, Stella Rosson, Paolo Fusar-Poli, Jose M. Rubio, Andre F. Carvalho, Eduard Vieta, Celso Arango, Nicole R. DeTore, Elizabeth S. Eberlin, Kim T. Mueser, Christoph U. Correll
Summary: Psychosocial interventions play an important role in schizophrenia and early psychosis. However, the literature on this topic is heterogeneous and contradictory. This umbrella review summarizes the findings from multiple meta-analyses comparing the effectiveness of different psychosocial interventions with standard treatment or other active interventions. The results suggest that early intervention services and cognitive behavioral therapy have significant effects on symptom reduction and functional improvement in early psychosis. For schizophrenia patients, cognitive behavioral therapy, psychoeducation, and any family interventions show positive effects on symptom reduction, relapse prevention, and functional improvement.
MOLECULAR PSYCHIATRY
(2023)
Editorial Material
Neurosciences
Rashmi Patel, Matthew Wickersham, Rudolf N. Cardinal, Paolo Fusar-Poli, Christoph U. Correll
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Developmental Biology
Livio Tarchi, Stefano Damiani, Paolo La Torraca Vittori, Andreas Frick, Giovanni Castellini, Pierluigi Politi, Paolo Fusar-Poli, Valdo Ricca
Summary: Homotopic connectivity during resting state is considered a risk marker for neurologic and psychiatric conditions. This study examined voxel-mirrored homotopic connectivity (VMHC) in a sample of individuals aged 7-50 years, finding that VMHC decreased with age in minors but not in adults. Four functional networks showed negative correlations between VMHC and age in minors, suggesting that interhemispheric interactions shape late neurodevelopment.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Clinical Neurology
Marco Solmi, Trevor Thompson, Andres Estrade, Agorastos Agorastos, Joaquim Radua, Samuele Cortese, Elena Dragioti, Friedrich Leisch, Davy Vancampfort, Lau Caspar Thygesen, Harald Aschauer, Monika Schloegelhofer, Elena Aschauer, Andres Schneeberger, Christian G. Huber, Gregor Hasler, Philippe Conus, Kim Q. Do Cuenod, Roland von Kaenel, Gonzalo Arrondo, Paolo Fusar-Poli, Philip Gorwood, Pierre-Michel Llorca, Marie-Odile Krebs, Elisabetta Scanferla, Taishiro Kishimoto, Golam Rabbani, Karolina Skonieczna-Zydecka, Paolo Brambilla, Angela Favaro, Akihiro Takamiya, Leonardo Zoccante, Marco Colizzi, Julie Bourgin, Karol Kaminski, Maryam Moghadasin, Soraya Seedat, Evan Matthews, John Wells, Emilia Vassilopoulou, Ary Gadelha, Kuan-Pin Su, Jun Soo Kwon, Minah Kim, Tae Young Lee, Oleg Papsuev, Denisa Mankova, Andrea Boscutti, Cristiano Gerunda, Diego Saccon, Elena Righi, Francesco Monaco, Giovanni Croatto, Guido Cereda, Jacopo Demurtas, Natascia Brondino, Nicola Veronese, Paolo Enrico, Pierluigi Politi, Valentina Ciappolino, Andrea Pfennig, Andreas Bechdolf, Andreas Meyer-Lindenberg, Kai G. Kahl, Katharina Domschke, Michael Bauer, Nikolaos Koutsouleris, Sibylle Winter, Stefan Borgwardt, Istvan Bitter, Judit Balazs, Pal Czobor, Zsolt Unoka, Dimitris Mavridis, Konstantinos Tsamakis, Vasilios P. Bozikas, Chavit Tunvirachaisakul, Michael Maes, Teerayuth Rungnirundorn, Thitiporn Supasitthumrong, Ariful Haque, Andre R. Brunoni, Carlos Gustavo Costardi, Felipe Barreto Schuch, Guilherme Polanczyk, Jhoanne Merlyn Luiz, Lais Fonseca, Luana V. Aparicio, Samira S. Valvassori, Merete Nordentoft, Per Vendsborg, Sofie Have Hoffmann, Jihed Sehli, Norman Sartorius, Sabina Heuss, Daniel Guinart, Jane Hamilton, John Kane, Jose Rubio, Michael Sand, Ai Koyanagi, Aleix Solanes, Alvaro Andreu-Bernabeu, Antonia San Jose Caceres, Celso Arango, Covadonga M. Diaz-Caneja, Diego Hidalgo-Mazzei, Eduard Vieta, Javier Gonzalez-Penas, Lydia Fortea, Mara Parellada, Miquel A. Fullana, Norma Verdolini, Eva Andrlikova, Karolina Janku, Mark John Millan, Mihaela Honciuc, Anna Moniuszko-Malinowska, Igor Loniewski, Jerzy Samochowiec, Lukasz Kiszkiel, Maria Marlicz, Pawel Sowa, Wojciech Marlicz, Georgina Spies, Brendon Stubbs, Joseph Firth, Sarah Sullivan, Asli Enez Darcin, Hatice Aksu, Nesrin Dilbaz, Onur Noyan, Momoko Kitazawa, Shunya Kurokawa, Yuki Tazawa, Alejandro Anselmi, Cecilia Cracco, Ana Ines Machado, Natalia Estrade, Diego De Leo, Jackie Curtis, Michael Berk, Philip Ward, Scott Teasdale, Simon Rosenbaum, Wolfgang Marx, Adrian Vasile Horodnic, Liviu Oprea, Ovidiu Alexinschi, Petru Ifteni, Serban Turliuc, Tudor Ciuhodaru, Alexandra Bolos, Valentin Matei, Dorien H. Nieman, Iris Sommer, Jim van Os, Therese van Amelsvoort, Ching-Fang Sun, Ta-wei Guu, Can Jiao, Jieting Zhang, Jialin Fan, Liye Zou, Xin Yu, Xinli Chi, Philippe de Timary, Ruud van Winkel, Bernardo Ng, Edilberto Pena, Ramon Arellano, Raquel Roman, Thelma Sanchez, Larisa Movina, Pedro Morgado, Sofia Brissos, Oleg Aizberg, Anna Mosina, Damir Krinitski, James Mugisha, Dena Sadeghi-Bahmani, Farshad Sheybani, Masoud Sadeghi, Samira Hadi, Serge Brand, Antonia Errazuriz, Nicolas Crossley, Dragana Ignjatovic Ristic, Carlos Lopez-Jaramillo, Dimitris Efthymiou, Praveenlal Kuttichira, Roy Abraham Kallivayalil, Afzal Javed, Muhammad Iqbal Afridi, Bawo James, Omonefe Joy Seb-Akahomen, Jess Fiedorowicz, Andre F. Carvalho, Jeff Daskalakis, Lakshmi N. Yatham, Lin Yang, Tarek Okasha, Aicha Dahdouh, Bjoern Gerdle, Jari Tiihonen, Jae Il Shin, Jinhee Lee, Ahmed Mhalla, Lotfi Gaha, Takoua Brahim, Kuanysh Altynbekov, Nikolay Negay, Saltanat Nurmagambetova, Yasser Abu Jamei, Mark Weiser, Christoph U. Correll
Summary: The COH-FIT survey is a valid instrument to measure global mental health during the COVID-19 pandemic. The study confirmed the validity of COH-FIT items and the internal reliability of the co-primary outcome, the P-score. The survey has been translated into 30 languages and measures various mental health symptoms and factors.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Sameer Jauhar, Paolo Fusar-Poli, David Foreman
Summary: The randomised controlled trial examines the effects of reducing and discontinuing antipsychotics on social functioning and continued use in schizophrenia patients. However, methodological issues mentioned in the trial protocol could potentially impact the interpretation of the findings, such as non-blinded outcome measurement, treatment as usual comparator, and possible sample size problems.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Review
Psychiatry
Andres Estrade, Juliana Onwumere, Jemma Venables, Lorenzo Gilardi, Ana Cabrera, Joseba Rico, Arif Hoque, Jummy Otaiku, Nicholas Hunter, Peter Keri, Lily Kpodo, Charlene Sunkel, Jianan Bao, David Shiers, Ilaria Bonoldi, Elizabeth Kuipers, Paolo Fusar-Poli
Summary: Informal caregivers of individuals with psychotic disorder have significant experiences that deserve recognition and support in the recovery process. Through a bottom-up review of first-person accounts, we identified key themes related to dealing with the disorder, navigating healthcare systems, and fighting stigma. The voices of relatives and carers provide valuable insights throughout the different stages of the disorder, and mental health professionals should actively acknowledge and support their contributions.
Editorial Material
Biochemistry & Molecular Biology
Sameer Jauhar, Danilo Arnone, David S. Baldwin, Michael Bloomfield, Michael Browning, Anthony J. Cleare, Phillip Corlett, J. F. William Deakin, David Erritzoe, Cynthia Fu, Paolo Fusar-Poli, Guy M. Goodwin, Joseph Hayes, Robert Howard, Oliver D. Howes, Mario F. Juruena, Raymond W. Lam, Stephen M. Lawrie, Hamish McAllister-Williams, Steven Marwaha, David Matuskey, Robert A. McCutcheon, David J. Nutt, Carmine Pariante, Toby Pillinger, Rajiv Radhakrishnan, James Rucker, Sudhakar Selvaraj, Paul Stokes, Rachel Upthegrove, Nefize Yalin, Lakshmi Yatham, Allan H. Young, Roland Zahn, Philip J. Cowen
Summary: A recent umbrella review found no consistent evidence linking serotonin to the pathophysiology of depression. However, we argue that this conclusion is overstated due to methodological weaknesses, selective reporting of data, oversimplification, and errors in the interpretation of neuropsychopharmacological findings. We use the examples of tryptophan depletion and serotonergic molecular imaging, the two most relevant research areas, to support our argument.
MOLECULAR PSYCHIATRY
(2023)
Review
Psychiatry
Saskia M. Cooper, Paolo Fusar-Poli, Peter J. Uhlhaas
Summary: Emerging evidence suggests that the duration of risk symptoms may impact clinical outcomes in clinical high-risk for psychosis (CHR-P) individuals. A meta-analysis was conducted to explore this hypothesis based on studies examining the duration of risk symptoms in relation to clinical outcomes in CHR-P populations. The findings suggest that the duration of risk symptoms is not associated with transition to psychosis at 12 months, but may affect remission. However, further research is needed in this area due to the small database.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Medicine, General & Internal
Muhammad Shamim Ahmed, Daisy Kornblum, Dominic Oliver, Paolo Fusar-Poli, Rashmi Patel
Summary: This study aims to investigate the associations between remote mental healthcare and clinical outcomes by analyzing a large electronic health record dataset. The study will analyze clinical and demographic characteristics of patients and compare the clinical outcomes of remote versus in-person assessments. Additionally, natural language processing will be used to analyze the content differences between remote and in-person assessments.
Article
Neurosciences
Joan Rue-Queralt, Valentina Mancini, Vincent Rochas, Caren Latreche, Peter J. Uhlhaas, Christoph M. Michel, Gijs Plomp, Stephan Eliez, Patric Hagmann
Summary: This study investigated the brain's information processing mechanisms at different spatial scales using Joint Time-Vertex Spectral Analysis. The results demonstrated that different frequency bands correspond to different information processing mechanisms, with low frequencies associated with spatially distributed integration activity and high frequencies associated with localized electrical segregation activity.
Article
Psychiatry
Andreas Sauer, Tineke Grent-'t-Jong, Maor Zeev-Wolf, Wolf Singer, Abraham Goldstein, Peter J. Uhlhaas
Summary: This study aimed to examine the mechanisms underlying dysfunctional mismatch negativity (MMN) in schizophrenia. The researchers found that schizophrenia patients showed reduced amplitude and spectral power in various brain regions, as well as impaired phase coherence and stimulus-specific adaptation. These findings suggest that deficits in theta-/alpha- and gamma-band activity, as well as impaired spectral responses, contribute to dysfunctional MMN generation in schizophrenia.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Shalaila S. Haas, Ruiyang Ge, Ingrid Agartz, G. Paul Amminger, Ole A. Andreassen, Peter Bachman, Inmaculada Baeza, Sunah Choi, Tiziano Colibazzi, Vanessa L. Cropley, Camilo de la Fuente-Sandoval, Bjorn H. Ebdrup, Adriana Fortea, Paolo Fusar-Poli, Birte Yding Glenthoj, Louise Birkedal Glenthoj, Kristen M. Haut, Rebecca A. Hayes, Karsten Heekeren, Christine I. Hooker, Wu Jeong Hwang, Neda Jahanshad, Michael Kaess, Kiyoto Kasai, Naoyuki Katagiri, Minah Kim, Jochen Kindler, Shinsuke Koike, Tina D. Kristensen, Jun Soo Kwon, Stephen M. Lawrie, Irina Lebedeva, Jimmy Lee, Imke L. J. Lemmers-Jansen, Ashleigh Lin, Xiaoqian Ma, Daniel H. Mathalon, Philip McGuire, Chantal Michel, Romina Mizrahi, Masafumi Mizuno, Paul Moller, Ricardo Mora-Duran, Barnaby Nelson, Takahiro Nemoto, Merete Nordentoft, Dorte Nordholm, Maria A. Omelchenko, Christos Pantelis, Jose C. Pariente, Jayachandra M. Raghava, Francisco Reyes-Madrigal, Jan I. Rossberg, Wulf Roessler, Dean F. Salisbury, Daiki Sasabayashi, Ulrich Schall, Lukasz Smigielski, Gisela Sugranyes, Michio Suzuki, Tsutomu Takahashi, Christian K. Tamnes, Anastasia Theodoridou, Sophia I. Thomopoulos, Paul M. Thompson, Alexander S. Tomyshev, Peter J. Uhlhaas, Tor G. Vaernes, Therese A. M. J. van Amelsvoort, Theo G. M. van Erp, James A. Waltz, Christina Wenneberg, Lars T. Westlye, Stephen J. Wood, Juan H. Zhou, Dennis Hernaus, Maria Jalbrzikowski, Rene S. Kahn, Cheryl M. Corcoran, Sophia Frangou
Summary: This case-control study suggests that macroscale neuromorphometric measures may not be sufficient as diagnostic biomarkers for psychosis risk. The study assesses brain morphometric changes in individuals at high risk for psychosis and their association with positive symptoms, cognition, and conversion to a psychotic disorder.