期刊
FRONTIERS IN GENETICS
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2019.00962
关键词
spermiogenesis; histone-to-protamine transition; histone variants; histone modification; male infertility
资金
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA16020701]
- National Key R&D Program of China [2016YFA0500901, 2018YFC1004202]
- National Natural Science Foundation of China [31771501, 91649202]
- Youth Innovation Promotion Association CAS [2018109]
Spermiogenesis is a complex cellular differentiation process that the germ cells undergo a distinct morphological change, and the protamines replace the core histones to facilitate chromatin compaction in the sperm head. Recent studies show the essential roles of epigenetic events during the histone-to-protamine transition. Defects in either the replacement or the modification of histones might cause male infertility with azoospermia, oligospermia or teratozoospermia. Here, we summarize recent advances in our knowledge of how epigenetic regulators, such as histone variants, histone modification and their related chromatin remodelers, facilitate the histone-to-protamine transition during spermiogenesis. Understanding the molecular mechanism underlying the modification and replacement of histones during spermiogenesis will enable the identification of epigenetic biomarkers of male infertility, and shed light on potential therapies for these patients in the future.
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