Article
Biotechnology & Applied Microbiology
Chang Cui, Xiaona Wang, Siyu Zhang, Hui Wu, Meijie Li, Luoxiao Dong, Chongshuai Yan, Dongliang Li
Summary: This study aimed to investigate the mechanism of progesterone inhibiting the scorch death of SH-SY5Y cells induced by exogenous adenosine triphosphate (ATP). The results showed that progesterone can improve cell survival and inhibit cell death by reducing the expression of P2X(7) receptor, inhibiting the conduction pathway of cell death, and reducing the release of inflammatory factor IL-1 beta.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Neurosciences
Lei Wang, Kunliang Lu, Xingyue Lou, Shenghui Zhang, Wenxin Song, Ranran Li, Lujing Geng, Binfeng Cheng
Summary: This study found that astaxanthin (AST) significantly enhanced cell survival, suppressed apoptosis and oxidative stress in a Parkinson's disease (PD) model. It also improved behavioral disorders and protected dopaminergic neurons in the substantia nigra pars compacta (SNpc). The neuroprotective effects of AST were mediated through the inhibition of MAPK signaling.
BRAIN RESEARCH BULLETIN
(2023)
Article
Neurosciences
Lilia A. Koza, Claudia Pena, Madison Russell, Alec C. Smith, Jacob Molnar, Maeve Devine, Natalie J. Serkova, Daniel A. Linseman
Summary: Successive traumatic brain injuries exacerbate neuroinflammation and oxidative stress. No therapeutics exist for populations at high risk of repetitive mild TBIs (rmTBIs). The preventative therapeutic effects of Immunocal & REG; for rmTBI and rmmTBI were explored.
Article
Chemistry, Medicinal
Xueyang Xiao, Zhou Tong, Yuexing Zhang, Hui Zhou, Mengying Luo, Tianhui Hu, Ping Hu, Luqi Kong, Zeqin Liu, Chan Yu, Zhiyong Huang, Linzhen Hu
Summary: Two novel prenylated indole alkaloids, asperpenazine and asperpendoline, exhibit potential neuroprotective activity against oxidative stress in Parkinson's disease. Asperpendoline inhibits Keap1 expression, promoting the translocation of Nrf2 to the nucleus and the expression of downstream genes, leading to a reduction in reactive oxygen species and an increase in glutathione levels.
Article
Biochemistry & Molecular Biology
Muganti Rajah Kumar, Swee Keong Yeap, Han Chung Lee, Nurul Elyani Mohamad, Muhammad Nazirul Mubin Aziz, Melati Khalid, Mas Jaffri Masarudin, Adam Thean Chor Leow, Janna Ong Abdullah, Noorjahan Banu Alitheen
Summary: The study found that Kefir B in kefir water exhibited the highest antioxidant and anti-apoptotic activities, providing significant cell protection and maintaining cellular morphology. The results suggest that kefir water can exert its antioxidative, anti-apoptotic, and neuroprotective effects through upregulating enzymes like SOD and catalase.
Article
Environmental Sciences
Luis Barrios-Arpi, Yurie Arias, Bernardo Lopez-Torres, Mariella Ramos-Gonzalez, Giulio Ticli, Ennio Prosperi, Jose-Luis Rodriguez
Summary: Flumethrin, a synthetic pyrethroid, induces neurotoxicity through oxidative stress and apoptosis. This study provides evidence for the cytotoxicity effects, oxidative stress markers, and apoptosis-related gene expressions associated with flumethrin exposure.
Article
Biochemistry & Molecular Biology
Chaemoon Lim, Ao Xuan Zhen, Sungwoo Ok, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Mei Jing Piao, Kyoung Ah Kang, Jin Won Hyun
Summary: This study found that hesperidin can inhibit high glucose-induced apoptosis and mitigate oxidative stress and endoplasmic reticulum stress. It also promotes cell survival through modulation of the mitogen-activated protein kinase signaling pathway.
Article
Neurosciences
Yujian Lin, Jingjing Zhang, Dongqing Lu, Yuzheng Zhang, Jinwen Xu, Sheng Wang, Xiang Cheng, Jianbing Qin, Lei Zhang, Haoming Li, Xinhua Zhang, Wen Li
Summary: Uqcr11 overexpression can protect against oxidative stress and neuronal apoptosis in traumatic brain injury (TBI), leading to the restoration of motor, learning, and memory capabilities. It holds potential as a therapeutic target for TBI.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Min Xu, Wenhua Wang, Wei Lu, Xiaoyang Ling, Qin Rui, Haibo Ni
Summary: This study demonstrates that evodiamine (Evo) improves outcomes after traumatic brain injury (TBI) by targeting the PGK1/NRF2 signaling pathway to regulate oxidative stress.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biology
Naveen Kumar Kalagatur, Elsayed Fathi Abd-Allah, Sudhakar Poda, Krishna Kadirvelu, Abeer Hashem, Venkataramana Mudili, Chandranayaka Siddaiah
Summary: The study revealed that DON induces apoptotic demise in neuronal cells through oxidative stress, while pre-treatment with 1mM of quercetin (QUE) can counteract the neurotoxic effects of DON and protect cells from damage.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Renata Perlikowska, Joana Silva, Celso Alves, Patricia Susano, Rui Pedrosa
Summary: This study investigates the neuroprotective properties of four naturally occurring peptides. The results show that endomorphin-1 and endomorphin-2 can inhibit neuronal cell death induced by 6-hydroxydopamine, reducing mitochondrial membrane potential and Caspase-3 activity. Meanwhile, rubiscolin-6 shows antioxidant potential and can recover neurotoxicity by reducing reactive oxygen species levels and improving mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Ezgi Oztas, Mehtap Kara, Tugce Boran, Enes Bisirir, Ecem Fatma Karaman, Engin Kaptan, Gul Ozhan
Summary: Acetamiprid, a widely used neonicotinoid insecticide, has been found to be associated with neurological symptoms and cell death in neural cells by increasing cellular stress and promoting apoptosis. Additional studies are needed to fully understand its molecular mechanisms and the potential harm it may cause to mammals.
Article
Cell Biology
Wenqian Zhang, Jun Hong, Hanwen Zhang, Wencheng Zheng, Ying Yang
Summary: The study found that astrocyte-derived exosomes can protect against traumatic brain injury-induced oxidative stress and neuronal apoptosis by activating the Nrf2 signaling pathway.
Review
Biochemistry & Molecular Biology
Charles K. Davis, Raghu Vemuganti
Summary: Oxidative stress plays a crucial role in the pathogenesis of traumatic brain injury, leading to cell death and secondary brain damage. Antioxidant therapies show promising outcomes in reducing damage and promoting functional recovery.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Nanoscience & Nanotechnology
Shintaro Yamaguchi, Ryo Isaka, Yuji Sakahashi, Hirofumi Tsujino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi
Summary: Research has found that silver nanoparticles with a diameter of 10 nm can inhibit retinoic acid-induced neuronal differentiation. This inhibitory effect may be achieved through the oxidative stress pathway, induction of mitochondrial ROS production, and decreased expression of mitochondrial fusion-related genes.
ACS APPLIED NANO MATERIALS
(2022)