Article
Pharmacology & Pharmacy
Arooj Munir, Danijela Marovic, Liebert Parreiras Nogueira, Roger Simm, Ali-Oddin Naemi, Sander Marius Landro, Magnus Helgerud, Kai Zheng, Matej Par, Tobias T. Taubock, Thomas Attin, Zrinka Tarle, Aldo R. Boccaccini, Havard J. Haugen
Summary: Experimental dental resin composites containing copper-doped mesoporous bioactive glass nanospheres (Cu-MBGN) were developed to impart anti-bacterial properties. The study found that Cu-MBGN showed dose-dependent antibacterial properties, with the composite containing 10% Cu-MBGN demonstrating the best effect on S. mutans. Materials containing 45S5 BG had the highest S. mutans adherence and lower degree of conversion.
Article
Materials Science, Ceramics
Mahboubeh Firuzeh, Sheyda Labbaf, Zahra Sabouri
Summary: Bioactive glass nanoparticles with uniform, spherical and mesoporous structure have enhanced dissolution rate and cell internalization capability, demonstrating good bioactivity. The loaded drug nanoparticles showed nontoxic nature when exposed to MG63 cell line, suggesting potential applications in orthopedic and dental fields.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2021)
Article
Pharmacology & Pharmacy
Sepanta Hosseinpour, Maria Natividad Gomez-Cerezo, Yuxue Cao, Chang Lei, Huan Dai, Laurence J. Walsh, Saso Ivanovski, Chun Xu
Summary: This study compared the capacity of mesoporous bioactive glass nanoparticles and mesoporous silica nanoparticles to deliver miRNA to bone marrow mesenchymal stem cells, demonstrating that mesoporous bioactive glass nanoparticles had a stronger osteogenic effect.
Article
Materials Science, Ceramics
Zhiyan Xu, Emily Keller, Ana M. Beltran, Kai Zheng, Aldo R. Boccaccini
Summary: In this study, a post-impregnation approach was successfully used to incorporate metallic ions into dendritic mesoporous silica nanoparticles, resulting in SiO2-CaO and SiO2-CaO-CeO2 particles. The synthesized particles exhibited high bioactivity and drug loading efficiency, making them suitable for bone regeneration applications.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)
Article
Biotechnology & Applied Microbiology
Juan Ren, Jianping Rao, He Wang, Wenjing He, Jinnan Feng, Danni Wei, Bin Zhao, Xing Wang, Wei Bian
Summary: This study aimed to create a new delivery system for synergistic remineralization of enamel white spot lesions (WSLs). The delivery system, PAA-ACP@aMBG, was prepared using aminated mesoporous bioactive glasses (aMBG) as a carrier loaded with polyacrylic-stabilized amorphous calcium phosphate (PAA-ACP). The effects of demineralization and remineralization were compared using various measurements.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Ceramics
Alesh Kumar, Somesh Banerjee, Partha Roy, Huaizhong Xu, C. R. Mariappan
Summary: This study investigates the osteogenic properties of cerium and gallium doping in mesoporous bioactive glass-ceramics (MBGCs). It is found that Ga doped MBGCs show better osteogenesis properties compared to Ce doped MBGCs.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)
Article
Chemistry, Physical
Ana Carolina Diniz, Jose Bauer, Suzanni do Amaral Rodrigues Veloso, Cesar Augusto Abreu-Pereira, Ceci Nunes Carvalho, Tarcisio Jorge Leitao, Leily Macedo Firoozmand, Etevaldo Matos Maia-Filho
Summary: The study aimed to evaluate the properties of resin-modified glass ionomer cement (RMGIC) incorporated with a bioactive filler (niobium phosphate (NbG) and bioglass (45S5)) for dental remineralization. The alkalizing potential, fluoride and calcium ion release ability, antimicrobial activity, and dentin remineralization properties were analyzed in vitro. The results showed that 45S5 exhibited higher alkalizing and fluoride release potential, and both 45S5 and NbG groups promoted the microhardness of demineralized dentin.
Article
Chemistry, Physical
Aerin Choi, Kyung-Hyeon Yoo, Seog-Young Yoon, Bong-Soo Park, In-Ryoung Kim, Yong-Il Kim
Summary: The study demonstrated that incorporating mesoporous bioactive glass nanoparticles (MBN) into self-adhesive resins (SARs) can enhance physical properties and remineralization ability, increase microhardness and shear bond strength, while also showing significant antibacterial effects.
Article
Engineering, Biomedical
M. Schumacher, P. Habibovic, S. van Rijt
Summary: Mesoporous bioactive glasses have promising properties for regenerative medicine due to their bioactivity and degradability, which are influenced by synthesis parameters and glass stoichiometry. Control of degradation and bioactivity over a broad range can be achieved through glass stoichiometry, allowing targeted material selection for specific regenerative medicine applications.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Baiyan Sui, Jiao Zhao, Tingting Ding, Min Ruan, Jiao Sun, Xin Liu
Summary: Breast cancer is a significant health threat, accounting for 11.7% of all cancer cases globally. This study proposes an intelligent biomimetic nano-platform based on mesoporous bioactive glass nanoparticles (MBG NPs) for targeted breast cancer therapy, combining cell membrane camouflage and enzyme-catalyzed killing.
APPLIED MATERIALS TODAY
(2023)
Article
Chemistry, Physical
Shu-Min Hsu, Muhammad Alsafadi, Christina Vasconez, Chaker Fares, Valentin Craciun, Edgar O'Neill, Fan Ren, Arthur Clark, Josephine Esquivel-Upshaw
Summary: The experimental results suggest that toothpaste containing NovaMin has a strong potential for remineralization, which can effectively promote the repair and remineralization of teeth.
Article
Dentistry, Oral Surgery & Medicine
Mona A. Abbassy, Ahmed Ibrahim Masoud, Fahd Faiz Alsulaimani, Ahmed S. Bakry
Summary: This study examined the ability of a borate adhesive to protect enamel/dentin surfaces from acidic erosion and its effect on the shear bond strength of enamel/dentin to resin composite. The results showed that the borate adhesive effectively protected enamel and dentin from erosion without compromising the bond strength to resin composite.
JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ibrahim Ayberk Yelken, Aslihan Zeynep Oz
Summary: This study evaluated the effects of two different adhesive-precoated bracket systems on white spot lesions (WSLs), and found that there was no difference in effectiveness between FF and conventional brackets in patients undergoing fixed orthodontic treatment. However, the use of FF brackets significantly shortened the bonding time.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2023)
Review
Medicine, General & Internal
Luminita Lazar, Alexandru Vlasa, Liana Beresescu, Anamaria Bud, Ana Petra Lazar, Larisa Matei, Eugen Bud
Summary: This article reviews the current evidence on the diagnosis, risk assessment, prevention, management, and post-orthodontic treatment of white spot lesions (WSLs). The review found that WSLs remain a significant problem during orthodontic treatment, and the severity of WSLs correlates with treatment duration. The use of toothpaste with more than 1000 ppm fluoride at home and regular application of varnishes in the office can reduce the frequency of WSL occurrence. There is no difference in the appearance of WSLs between different types of brackets or ligatures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Parichart Naruphontjirakul, Piyaphong Panpisut, Somying Patntirapong
Summary: The global population is increasingly aging, leading to tissue disorder and organ dysfunction, especially in regards to bone-related injuries. The demand for alternative bone replacement materials has grown, with alginate showing potential as a cell scaffold for bone tissue engineering due to its high bio-compatibility. Incorporating zinc- and strontium-containing sol-gel-derived bioactive glass nanoparticles (Zn-Sr-BGNPs) into alginate scaffolds can improve their bioactivity. The synthesized Zn-Sr-BGNPs have a high surface-to-volume ratio, resulting in faster degradation and the release of therapeutic bivalent ions that strengthen the cell scaffold and stimulate bone cell production. The composition of the Zn-Sr-BGNPs and their ratio in the scaffolds impact the physical and biological properties of the composite scaffolds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Youna Paik, Jae-Hoon Kim, Kyung-Hyeon Yoo, Seog-Young Yoon, Yong-Il Kim
Summary: The effects of flavonoids and calcium phosphate ion clusters on dentin bonding stability were evaluated in this study. The results showed that the combination of flavonoids and CPIC improved dentin bond strength and maintained stability after thermocycling.
Article
Engineering, Chemical
Yeon Joo Lee, Sun-Woo Kang, Kyung-Hyeon Yoo, Seog-Young Yoon, Hyeryeong Kim, Yong-Il Kim
Summary: This study investigated the potential of a calcium phosphate ion cluster-incorporating phosphoric acid solution to enhance remineralization of the hybrid layer and prevent nanoleakage at the dentin-resin interface, resulting in improved long-term bonding strength.
JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
So-Min Kim, Kyung-Hyeon Yoo, Hyeonjin Kim, Yong-Il Kim, Seog-Young Yoon
Summary: The study focuses on modifying physicochemical and biological properties of beta-TCP through essential ion co-substitution (Fe and Sr), results show changes in Ca-O and P-O bond lengths of the co-substituted samples, VSM exhibits a combination of diamagnetic and ferromagnetic properties, TRIS-HCl solution immersion test demonstrates synergistic degradation and resorption functions on the surface of the substituted sample, cell adhesion tests reveal that Fe enhances the initial adhesion and proliferation behavior of hDPSCs.
Article
Chemistry, Multidisciplinary
Heetae Park, Kazuyoshi Hosomichi, Yong-Il Kim, Atsushi Tajima, Tetsutaro Yamaguchi
Summary: This study used whole-exome sequencing (WES) to investigate the genetic background of dental abnormality called dens evaginatus (DE). The study identified gene variants of TLR3 and MDC1 as etiologic factors for DE. The findings contribute to understanding the etiology of DE and can potentially improve treatment and preventive measures, as well as aid in the development of regenerative medicine and gene therapy strategies.
APPLIED SCIENCES-BASEL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jeonghwa Cho, Hyeryeong Kim, Kyung-Hyeon Yoo, Youna Paik, In-Ryoung Kim, Seog-Young Yoon, Yong-Il Kim
Summary: This study investigated the effect of pretreating demineralized dentin with the flavonoid kaempferol (KEM) on dentin bond stability and nanoleakage at the dentin-resin interface. The results demonstrated that KEM enhanced the bond strength between dentin and resin, reduced nanoleakage, and achieved these effects by inhibiting MMPs activity and enhancing collagen crosslinking.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Heetae Park, Kazuyoshi Hosomichi, Yong-Il Kim, Yu Hikita, Atsushi Tajima, Tetsutaro Yamaguchi
Summary: This study investigated the genetic background of patients with fused teeth using whole exome sequencing and identified four candidate gene variants associated with fused teeth.
APPLIED SCIENCES-BASEL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Youn-Kyung Choi, Jung Joo Park, Hyeran Helen Jeon, Yong-Il Kim
Summary: This retrospective study aimed to evaluate the skeletal and dental effects of miniscrew-anchored facemask treatment in skeletal Class III growing patients and compare them with those of conventional tooth-anchored facemask treatment. The results showed that miniscrew-anchored facemask treatment increased the amount of maxillary protraction and reduced the dental side effects compared with conventional tooth-anchored facemask treatment.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2023)
Article
Medicine, General & Internal
Yuki Hikosaka, So Koizumi, Yong-Il Kim, Mohamed Adel, Mohamed Nadim, Yu Hikita, Tetsutaro Yamaguchi
Summary: The purpose of this study was to investigate which region is responsible for the volume difference between the non-deviated and deviated sides in patients with mandibular asymmetry. By measuring the volume and performing linear analysis of the mandibular body, ramus, and condyle, it was found that the non-deviated side showed significantly larger values than the deviated side. These results were consistent regardless of sex or ethnicity, suggesting that the pathophysiology of mandibular asymmetry may not have specific regional specificity.
Article
Nanoscience & Nanotechnology
Youna Paik, Min Joo Kim, Hyeryeong Kim, Sun-Woo Kang, Youn-Kyung Choi, Yong-Il Kim
Summary: The study aimed to evaluate the remineralization effect of calcium phosphate ion clusters (CPICs) on demineralized enamel surfaces and their effects on bracket shear bond strength. The results showed that CPIC treatment led to epitaxial growth of enamel, a decrease in demineralized enamel thickness, an increase in Ca/P ratio, and an improvement in microhardness. The radiolucency gradually decreased with longer CPIC treatment. The shear bond strength and adhesive remnant index results indicated improved bonding stability after CPIC treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yeon Kim, Hoyong Lee, Hyun-Joo Park, Mi-Kyoung Kim, Yong-Il Kim, Hyung Joon Kim, Soo-Kyung Bae, Yung-Jin Kim, Moon-Kyoung Bae
Summary: This study found that hispidulin can inhibit the vascular inflammation induced by P. gingivalis LPS by suppressing the NF-kappa B, MAPKs, and AKT signaling pathways. It achieves this by reducing the adhesion and migration of monocytes to endothelial cells.
Article
Dentistry, Oral Surgery & Medicine
Yong-Il Kim, Seong-Sik Kim, Soo-Byung Park, Sung-Hun Kim
Summary: This study utilized root apices to identify maxillary basal arch forms and found that patients with cleft lip and palate had narrower basal arch forms compared to the normal group. The bilateral cleft lip and palate group had narrower basal arch forms than the unilateral cleft lip and palate group.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Jong-Chan Baik, Youn-Kyung Choi, Hyeran Helen Jeon, Sung-Hun Kim, Seong-Sik Kim, Soo-Byung Park, Yong-Il Kim
Summary: This retrospective study compared the skeletal and dental changes after treatment in skeletal Class III malocclusion patients using different fixation methods (tooth-anchored and miniscrew-anchored). The results showed that miniscrew-anchored treatment was more effective in improving the anteroposterior relationship and reducing dental and skeletal relapses in growing patients with hyperdivergent patterns and skeletal Class III malocclusion.
APPLIED SCIENCES-BASEL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sewoong Oh, Youn-Kyung Choi, Sung-Hun Kim, Ching-Chang Ko, Ki Beom Kim, Yong-Il Kim
Summary: This finite element method study analyzed the biomechanical differences and tooth displacement patterns of mandibular dentition total distalization using clear aligner treatment. The study found that individual teeth showed more mesiodistal tipping than bodily movements, and the traction site had a greater impact on the initial tooth displacement pattern than the traction method. The elastic deformation of clear aligners was attributed to unintentional lingual tipping or extrusion of the mandibular anterior teeth. Therefore, proper selection of traction sites and directions is necessary for mandibular total distalization using clear aligner treatment.
KOREAN JOURNAL OF ORTHODONTICS
(2023)
Article
Chemistry, Multidisciplinary
Sewoong Oh, Youn-Kyung Choi, Yong-Il Kim, Seong-Sik Kim, Soo-Byung Park, Sung-Hun Kim
Summary: The aim of this study was to calculate the center of resistance (COR) of an impacted maxillary canine according to the stages of pericoronal tissue healing using the finite element method (FEM). The study found that the COR of the impacted maxillary canine gradually shifts to the coronal side as the healing of the pericoronal tissue occurs.
APPLIED SCIENCES-BASEL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jong Hyun Shin, Sewoong Oh, Hyejin Kim, Eungyung Lee, Seung-Min Lee, Ching-Chang Ko, Yong-Il Kim
Summary: By comparing the normal eruption and impaction of maxillary canines, differences in angulation patterns were identified, highlighting the need for early intervention or regular follow-up to prevent maxillary canine impaction.
ANGLE ORTHODONTIST
(2022)