Article
Chemistry, Multidisciplinary
Reza Rasouli, Maryam Tabrizian
Summary: 3D cell spheroid culture provides a faithful recreation of cell growth environment compared to 2D culture, with a new boundary-driven acoustic microstreaming tool that accelerates spheroid production, showing versatility in producing different types of spheroids.
Article
Biochemistry & Molecular Biology
Megan G. Roberts, Valerie J. Facca, Rachel Keunen, Qing Yu, Raymond M. Reilly, Mitchell A. Winnik
Summary: The study shows that nanoparticles coated with poly(oligoethyleneglycol methacrylate) (POEGMA) can penetrate deeper into tumor spheroids compared to nanoparticles coated with linear polyethylene glycol (PEG). The penetration is associated with interstitial diffusion through the extracellular matrix.
Review
Biochemical Research Methods
Marta M. Maciel, Tiago R. Correia, Mariana Henriques, Joao F. Mano
Summary: The modulation of cell response in tissue engineering is challenging, but the potential of microparticles in controlling cellular response has been overlooked. However, microparticles designed with biophysical and biochemical cues can effectively modulate cell response.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cian-Ru Yang, Chu-Ting Liang, Shih-Chieh Tsai, Yu-Chun Wu, Ching-Wen Liu, Hui-Hua Yang, Ting-Yuan Tu, Yueh-Chun Lee, Kuei-Yang Hsiao, Wei-Chun Chang, Wen-Lung Ma
Summary: The ACD 3D culture system is an efficient tool for supporting and evaluating the formation of tumor spheroids and tumoroids, providing good control and consistency, and mimicking the characteristics of the tumor microenvironment, especially suitable for cancer stem cell research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Biomaterials
Nobuyuki Morimoto, Keisuke Ota, Yuki Miura, Heungsoo Shin, Masaya Yamamoto
Summary: The study demonstrates that the sulfobetaine polymer P(OH-MAAmSB) with hydroxy groups is a highly permeable nanocarrier, capable of penetrating tumor spheroids quickly and reaching the central region.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Multidisciplinary Sciences
Mathangi Madhavan, Devina Jaiswal, Sarah Karlberg, Alexis Duggan, Hassan A. A. Almarshad, Kevin P. P. Claffey, Kazunori Hoshino
Summary: Multicellular cancer spheroids are an in vitro tissue model that simulates the three-dimensional microenvironment. Older spheroids are found to have a denser internal structure, resulting in increased stiffness. This study is of great significance in understanding tumor development and treatment response.
Review
Pharmacology & Pharmacy
Sayoni Maitra Roy, Purvi Kishore, Disha Saha, Priyanka Ghosh, Rishav Kar, Sourav Barman, Vishal Agrawal, Abhishek Roy, Ratnadip Deb, Shrestha Sherry Chakraborty, Pousali Bag, Partha Sona Maji, Arnab Basu, Tapas Ghatak, Rupam Mukherjee, Amit Ranjan Maity
Summary: The tumor microenvironment complicates the delivery of anticancer therapeutics, but tumor spheroids offer a promising platform for rapid and cost-effective screening and assessment. The inclusion of 3D in vitro models can improve the efficacy of nanomedicine.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Elisabetta Colombo, Maria Grazia Cattaneo
Summary: 2D cell cultures have been the standard in various applications, but they cannot replicate the complex and dynamic interactions of the tumor microenvironment (TME). Multicellular 3D models are important for studying the spatial dimension, cellular heterogeneity, and molecular networks of the TME.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Karl Olofsson, Valentina Carannante, Madoka Takai, Bjorn onfelt, Martin Wiklund
Summary: Ultrasound-based MCTS culture platform was utilized to connect nuclear segmentation to biological information in A498 renal carcinoma MCTSs, showing potential for cell cycle state classification and nuclear volumetric characterization.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Multidisciplinary
Yong Hu, Chunhai Fan
Summary: The innovation of DNA hydrogels has led to the development of programmable nanocomposite DNA hydrogels that have potential applications in materials and life sciences. These hydrogels can be designed with tunable physiochemical properties and integrated functionalities, allowing them to respond to external physical cues, exhibit catalytic activities, and be used in cell-substrate engineering and therapeutic agents. The integration of nanocomposite DNA hydrogels with microfluidic systems or DNA surface technology could facilitate the development of modern integrated systems and platforms.
Article
Biochemistry & Molecular Biology
Jeonghyun Kim, Takashi Inagaki, Junko Sunaga, Taiji Adachi, Takeo Matsumoto
Summary: This study elucidated the multicellular behaviors of osteocytic spheroids in response to osteogenesis supplements. The results showed that the supplements altered the spheroids' behaviors by affecting their size, fusion speed, and collagen embedding. Actin filaments were identified as the driving force behind these changes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Samantha M. M. McCabe, Gregory Q. Q. Wallace, Sian Sloan-Dennison, William J. J. Tipping, Neil C. C. Shand, Duncan Graham, Marie Boyd, Karen Faulds
Summary: This study investigates the uptake and distribution of silica coated gold nanoparticles (AuNP-SHINs) in three-dimensional multicellular tumour spheroids derived from glioblastoma cells. The results show that the localization of nanoparticles within the spheroids is influenced by factors such as size, quiescence, and hypoxia.
Review
Cell & Tissue Engineering
Hyeonyu Kim, Roger D. Kamm, Gordana Vunjak-Novakovic, Joseph C. Wu
Summary: Advances in self-organizing cardiac organoids have provided a powerful tool for studying human cardiac development, cardiovascular diseases, drug testing, and transplantation. This review highlights the recent progress on multicellular cardiac organoids and introduces key readouts and tools for assessing their clinical applications.
Article
Engineering, Biomedical
Ecem Saygili, Utku Devamoglu, Bakiye Goker-Bagca, Ozlem Goksel, Cigir Biray-Avci, Tuncay Goksel, Ozlem Yesil-Celiktas
Summary: A multicellular spheroid model incorporating human bronchial epithelial cells and human lung fibroblasts was generated and treated with bleomycin to mimic drug-induced pulmonary fibrosis. The findings successfully reflected the fibrotic disease and provided insights into the underlying mechanism of fibrosis.
BIOMEDICAL MATERIALS
(2022)
Article
Biochemical Research Methods
Feng Yan, Gokhan Gunay, Trisha Valerio, Chen Wang, Jayla A. Wilson, Majood S. Haddad, Maegan Watson, Michael O. Connell, Noah Davidson, Kar-Ming Fung, Handan Acar, Qinggong Tang
Summary: The study focused on visualizing and characterizing 3D morphological and physiological information of multicellular ovarian tumor spheroids using swept-source optical coherence tomography (SS-OCT). Different growth curves and rates were observed in ovarian tumor spheroids with varying initial cell numbers over 18 days. Among the four mathematical models tested, the Boltzmann model showed the best fitting performance for the growth of tumor spheroids and necrotic tissues.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Pharmacology & Pharmacy
Maria F. Acosta, Priya Muralidharan, Samantha A. Meenach, Don Hayes, Stephen M. Black, Heidi M. Mansour
CURRENT PHARMACEUTICAL DESIGN
(2016)
Article
Oncology
Samantha A. Meenach, Alexandra N. Tsoras, Ronald C. McGarry, Heidi M. Mansour, J. Zach Hilt, Kimberly W. Anderson
INTERNATIONAL JOURNAL OF ONCOLOGY
(2016)
Article
Pharmacology & Pharmacy
Zimeng Wang, Julie L. Cuddigan, Sweta K. Gupta, Samantha A. Meenach
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2016)
Article
Chemistry, Multidisciplinary
Zimeng Wang, Samantha A. Meenach
PHARMACEUTICAL RESEARCH
(2016)
Article
Oncology
Sweta K. Gupta, Elisa A. Torrico Guzman, Samantha A. Meenach
INTERNATIONAL JOURNAL OF CANCER
(2017)
Article
Pharmacology & Pharmacy
Zimeng Wang, Sweta K. Gupta, Samantha A. Meenach
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Chemistry, Medicinal
Zimeng Wang, Samantha A. Meenach
JOURNAL OF PHARMACEUTICAL SCIENCES
(2017)
Article
Pharmacology & Pharmacy
Nishan K. Shah, Sweta K. Gupta, Zimeng Wang, Samantha A. Meenach
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2019)
Article
Pharmacology & Pharmacy
Nishan K. Shah, Zimeng Wang, Sweta K. Gupta, Andrew Le Campion, Samantha A. Meenach
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2019)
Article
Engineering, Chemical
Nishan K. Shah, Ryan Ivone, Jie Shen, Samantha A. Meenach
Article
Nanoscience & Nanotechnology
Muzahidul I. Anik, Animesh Pan, Md Golam Jakaria, Samantha A. Meenach, Geoffrey D. Bothun
Summary: Core/shell gold raspberry nanostructures with multiple therapeutic functionalities were synthesized and showed high photothermal conversion efficiency. They inhibited lung cancer cells through intracellular hyperthermia and detected reactive oxygen species using surface-enhanced Raman scattering. These safe-by-design nanostructures have potential for simultaneous therapeutic applications and monitoring therapeutic efficacy.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Animesh Pan, Md Golam Jakaria, Samantha A. Meenach, Geoffrey D. Bothun
ACS APPLIED BIO MATERIALS
(2020)
Article
Pharmacology & Pharmacy
Sarah Brousseau, Zimeng Wang, Sweta K. Gupta, Samantha A. Meenach
Proceedings Paper
Engineering, Biomedical
Zimeng Wang, Samantha A. Meenach
2015 41ST ANNUAL NORTHEAST BIOMEDICAL ENGINEERING CONFERENCE (NEBEC)
(2015)