Tau mis-splicing in the pathogenesis of neurodegenerative disorders

Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease

(2016) Chang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel tau mutation, p.K317N, causes globular glial tauopathy

(2015) Pawel Tacik et al.   ACTA NEUROPATHOLOGICA

Closing the tau loop: the missing tau mutation

(2015) Allan McCarthy et al.   BRAIN

Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I

(2015) Nana Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of human MAPT gene expression

(2015) Marie-Laure Caillet-Boudin et al.   Molecular Neurodegeneration

Invited review: Frontotemporal dementia caused bymicrotubule-associated protein taugene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

(2015) Bernardino Ghetti et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The alternative role of DNA methylation in splicing regulation

(2015) Galit Lev Maor et al.   TRENDS IN GENETICS

Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

(2015) Maxime Derisbourg et al.   Scientific Reports

Template-directed synthesis of a small molecule-antisense conjugate targeting an mRNA structure

(2014) Yang Liu et al.   BIOORGANIC CHEMISTRY

Huntington's disease is a four-repeat tauopathy with tau nuclear rods

(2014) Marta Fernández-Nogales et al.   NATURE MEDICINE

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones

(2014) J. Robin Highley et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Mitochondrial Complex 1 Inhibition Increases 4-Repeat Isoform Tau by SRSF2 Upregulation

(2014) Julius Bruch et al.   PLoS One

Regulation of alternative splicing of tau exon 10

(2014) Wei Qian et al.   Neuroscience Bulletin

An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy

(2014) Yun Li et al.   PLoS Genetics

Neurodegenerative Disorder FTDP-17–Related Tau Intron 10 +16C→T Mutation Increases Tau Exon 10 Splicing and Causes Tauopathy in Transgenic Mice

(2013) Tomohiro Umeda et al.   AMERICAN JOURNAL OF PATHOLOGY

Cyclic AMP-Dependent Protein Kinase Enhances SC35-Promoted Tau Exon 10 Inclusion

(2013) Caoyi Chen et al.   MOLECULAR NEUROBIOLOGY

Variation in tau isoform expression in different brain regions and disease states

(2013) Elisa Majounie et al.   NEUROBIOLOGY OF AGING

Tau alternative splicing in familial and sporadic tauopathies

(2012) Michael Niblock et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Loss of fused in sarcoma (FUS) promotes pathological Tau splicing

(2012) Denise Orozco et al.   EMBO REPORTS

Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10

(2012) Jianlan Gu et al.   FEBS LETTERS

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

(2012) Daniah Trabzuni et al.   HUMAN MOLECULAR GENETICS

Tau Isoform Composition Influences Rate and Extent of Filament Formation

(2012) Qi Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mis-splicing of Tau exon 10 in myotonic dystrophy type 1 is reproduced by overexpression of CELF2 but not by MBNL1 silencing

(2011) C.M. Dhaenens et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy

(2011) Pascal Y. Smith et al.   HUMAN MOLECULAR GENETICS

RNA Helicase p68 (DDX5) Regulates tau Exon 10 Splicing by Modulating a Stem-Loop Structure at the 5' Splice Site

(2011) A. Kar et al.   MOLECULAR AND CELLULAR BIOLOGY

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43

(2011) James R Tollervey et al.   NATURE NEUROSCIENCE

Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A

(2011) Shaohong Ding et al.   NEUROBIOLOGY OF AGING

CAG repeats mimic CUG repeats in the misregulation of alternative splicing

(2011) Agnieszka Mykowska et al.   NUCLEIC ACIDS RESEARCH

Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A

(2011) W. Qian et al.   NUCLEIC ACIDS RESEARCH

Amyloid-β peptide alteration of tau exon-10 splicing via the GSK3β-SC35 pathway

(2010) Kun-Lin Chen et al.   NEUROBIOLOGY OF DISEASE

Three Repeat Isoforms of Tau Inhibit Assembly of Four Repeat Tau Filaments

(2010) Stephanie J. Adams et al.   PLoS One

TARDBP 3′-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy

(2009) Michael A. Gitcho et al.   ACTA NEUROPATHOLOGICA

Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations

(2009) Yan Wang et al.   GENE

Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing

(2009) T. Rodriguez-Martin et al.   HUMAN MOLECULAR GENETICS

Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

(2009) Will Stoothoff et al.   JOURNAL OF NEUROCHEMISTRY

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

(2009) Kurt R. Brunden et al.   NATURE REVIEWS DRUG DISCOVERY

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome

(2008) Jianhua Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau isoform regulation is region- and cell-specific in mouse brain

(2008) Pamela McMillan et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE

Haplotype-specific expression of the N-terminal exons 2 and 3 at the human MAPT locus

(2007) Tara M. Caffrey et al.   NEUROBIOLOGY OF AGING