Review
Infectious Diseases
Sofia Tejada, Sergio Ramirez-Estrada, Carlos G. Forero, Miguel Gallego, Joan B. Soriano, Pablo A. Cardinal-Fernandez, Stephan Ehrmann, Jordi Rello
Summary: This network meta-analysis aimed to evaluate the effectiveness and safety of different types of aerosol generating devices in adult patients with non-cystic fibrosis bronchiectasis (NCFB). The results showed that administering antibiotics via dry powder inhaler (DPI) significantly improved time to first exacerbation and quality of life compared to nebulizers, while no significant differences were observed in other clinical efficacy and microbiologic response measures between the devices.
Review
Medicine, General & Internal
Sofia Tejada, Laura Campogiani, Candela Sole-Lleonart, Aroa Gomez, Miguel Gallego, Monserrat Vendrell, Joan B. Soriano, Jordi Rello
Summary: Inhaled antibiotics therapy significantly increased eradication of Pseudomonas aeruginosa from sputum and reduced exacerbation rates in stable non-cystic fibrosis bronchiectasis patients. However, there were no significant improvements in patient-centered outcomes observed in our meta-analysis.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Saveria Sangiovanni, Eliana Morales, Liliana Fernandez-Trujillo
Summary: Inhaled tobramycin can temporarily decrease P. aeruginosa density in sputum and reduce hospital admissions in NCFBE patients, but has limited impact on eradicating the bacteria and frequency of exacerbations.
RESPIRATORY MEDICINE
(2021)
Review
Medicine, General & Internal
David de la Rosa-Carrillo, Guillermo Suarez-Cuartin, Oriol Sibila, Rafael Golpe, Rosa-Maria Giron, Miguel-angel Martinez-Garcia
Summary: The use of inhaled antibiotics has expanded beyond cystic fibrosis patients to include non-CF bronchiectasis or chronic obstructive pulmonary disease patients. Inhaled antibiotics provide high concentrations at the site of infection, enhancing their effectiveness and allowing for long-term administration. New formulations of inhaled dry powder antibiotics offer advantages such as faster preparation and administration, as well as eliminating the need for cleaning nebulization equipment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Environmental Sciences
Marwa Adel Afify, Iman Gamal Ghareeb Ahmed, Theeb Ayedh Alkahtani, Raed Ibrahim Altulayhi, Amjad Saud Mhrb Alrowili, Sherief Ghozy, May Bin-Jumah, Mohamed M. Abdel-Daim
Summary: This study aimed to investigate the safety and efficacy of doravirine in HIV-1 patients, particularly focusing on the 100 mg dosage which showed the highest efficacy. The 100 mg doravirine treatment had the highest efficacy score compared to other treatments, indicating its potential as a preferable option for initial therapy in HIV-1 patients.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Immunology
Zejun Li, Shouhuan Liu, Fengming Li, Yifeng Li, Yilin Li, Pu Peng, Sai Li, Li He, Tieqiao Liu
Summary: This study investigated the efficacy, immunogenicity, and safety of COVID-19 vaccines in older people aged > 55 years and found that vaccines were effective in preventing COVID-19 and provided a high level of protection against severe disease in older adults. mRNA vaccines showed the highest efficacy and immunogenicity, but there was a need for surveillance of adverse events associated with mRNA vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lei Zhang, Lihong Jiang, Tian Tian, Wenjing Li, Yonghui Pan, Yongchen Wang
Summary: The objective of this study was to analyze the differences in efficacy and safety of different types of COVID-19 vaccines in different age groups. Eight eligible randomized controlled trials (RCTs) were analyzed using meta-analysis. The results showed that the elderly had significantly higher virus levels compared to the placebo group, and the effect of multiple vaccinations was better than that of single vaccination. However, the incidence of adverse events (AEs) was lower in the elderly compared to young adults. In conclusion, COVID-19 vaccination is effective and safe in the elderly, especially after multiple vaccinations.
Review
Endocrinology & Metabolism
Yanyang Zeng, Qingliang Huang, Yunzhi Zou, Jiacong Tan, Wu Zhou, Meihua Li
Summary: This study conducted a systematic review and meta-analysis and found that CV is as effective as cabergoline and bromocriptine in treating hyperprolactinemia, with no significant side effects. Therefore, this drug could be considered as an alternative first-line or rescue treatment in the future.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Nan Jiang, Shangyi Jin, Chen Yu, Jiuliang Zhao, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng
Summary: This study compared the efficacy and safety of different immunosuppressive regimens in adult patients with LN, and found that the combination of TAC, MMF, and GC was the best regimen for total remission rate. It is crucial to select the appropriate treatment regimen based on patients' risk factors.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Chunyang Wang, Wentai Pang, Xuechen Du, Jiani Zhai, Mengyuan Zhong, Ming Zhuang, Jiali An, Lujia Cao, Li Zhang, Wenke Zheng, Junhua Zhang
Summary: The study evaluated the efficacy and safety of Zhibitai (ZBT) in treating patients with hyperlipidemia. The results showed that ZBT, in combination with conventional therapy, was more effective in reducing triglyceride, total cholesterol, low-density lipoprotein cholesterol, and increasing high-density lipoprotein cholesterol levels compared to conventional therapy alone. ZBT alone did not show significant differences in the primary outcomes compared to conventional therapy. Additionally, the ZBT group, whether used alone or in combination with conventional therapy, had better safety outcomes compared to the conventional therapy group. More rigorous randomized controlled trials are needed to further validate these findings.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qing Wang, Zi-Yang Wu, Hui-Lin Tang, Zhan-Miao Yi, Suo-Di Zhai
Summary: This study aimed to evaluate the efficacy and safety of prophylactic antibiotics for post-acute stroke infection. The results showed that prophylactic antibiotics significantly reduced the incidence of infections and urinary tract infections without significant differences in mortality rate and pneumonia.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Junlan Chuan, Lianqiao Liu, Yumei Feng, Mengdan Wang, Gang Li, Qin Lv
Summary: Through the meta-analysis, it was found that brolucizumab is comparable to other anti-VEGF agents in improving vision and reducing sub-field thickness, but it may lead to more serious ocular adverse events.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Aranjit Singh Randhawa, Norhayati Mohd Noor, Mohd Khairi Md Daud, Baharudin Abdullah
Summary: Bilastine is an effective and safe treatment for allergic rhinitis, showing comparable efficacy and safety with other oral antihistamines, with less incidence of somnolence compared to cetirizine.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Rasha Ashmawy, Adel Zaki, Ayman Baess, Iman El Sayed
Summary: This study synthesized the available evidence on the efficacy and safety of inhaled heparin in improving lung functions among asthmatic and COPD patients. The results showed that inhaled heparin has a significant positive effect on lung function and is well-tolerated. The study suggests the need for more large-scale clinical trials, including different types of asthma and COPD patients.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, Research & Experimental
Jing Sun, Shufang Wang, Xin Ma, Qingqing Wei, Yujuan Peng, Ying Bai, Guobin Miao, Chang Meng, Peng Liu
Summary: This study performed a meta-analysis of clinical trials to evaluate the efficacy and safety of baricitinib in COVID-19 patients. The results showed that baricitinib can reduce the mortality rate of COVID-19 patients, but its effectiveness is limited in critically ill patients.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Critical Care Medicine
Amelia Shoemark, Michal Shteinberg, Anthony De Soyza, Charles S. Haworth, Hollian Richardson, Yonghua Gao, Lidia Perea, Alison J. Dicker, Pieter C. Goeminne, Erin Cant, Eva Polverino, Josje Altenburg, Holly R. Keir, Michael R. Loebinger, Francesco Blasi, Tobias Welte, Oriol Sibila, Stefano Aliberti, James D. Chalmers
Summary: Eosinophilic bronchiectasis is a common clinical entity that affects approximately 20% of patients. Blood eosinophil counts are associated with bronchiectasis severity, mortality, and time to exacerbation.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Oriol Sibila, Elena Laserna, Amelia Shoemark, Lidia Perea, Diana Bilton, Megan L. Crichton, Anthony De Soyza, Wim G. Boersma, Josje Altenburg, James D. Chalmers
Summary: Improvements in lung function, symptoms, and exacerbation frequency are not closely correlated in bronchiectasis. FEV1 is not a responsive measure, and clinical parameters are not predictive of treatment response. Biomarkers are needed to identify responders.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Critical Care Medicine
Jeffrey T-J Huang, Erin Cant, Holly R. Keir, Alun K. Barton, Elena Kuzmanova, Morven Shuttleworth, Jennifer Pollock, Simon Finch, Eva Polverino, Mathieu Bottier, Alison J. Dicker, Amelia Shoemark, James D. Chalmers
Summary: This study investigated the sputum microbiome and proteome in patients with bronchiectasis, COPD, and the COPD-bronchiectasis association, proposing five endotypes with differential inflammatory, mucin, and microbiological features. The key traits related to the COPD-bronchiectasis association include neutrophilic inflammation, differential mucin expression, and Gram-negative infection.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Myrofora Goutaki, Amelia Shoemark
CLINICS IN CHEST MEDICINE
(2022)
Article
Respiratory System
Amelia Shoemark, Helen Griffin, Gabrielle Wheway, Claire Hogg, Jane S. Lucas, Genomics England Research Genomics England Res Consortium, Carme Camps, Jenny Taylor, Mary Carroll, Michael R. Loebinger, James D. Chalmers, Deborah Morris-Rosendahl, Hannah M. Mitchison, Anthony De Soyza
Summary: This study suggests that motile ciliopathies are often underdiagnosed as a cause of bronchiectasis. Increased utilization of genetic testing can help identify bronchiectasis caused by motile ciliopathies and ensure appropriate management.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Raja Dhar, Sheetu Singh, Deepak Talwar, B. V. Murali Mohan, Surya Kant Tripathi, Rajesh Swarnakar, Sonali Trivedi, Srinivas Rajagopala, George D'Souza, Arjun Padmanabhan, B. Archana, P. A. Mahesh, Babaji Ghewade, Girija Nair, Aditya Jindal, Gayathri Devi H. Jayadevappa, Honney Sawhney, Kripesh Ranjan Sarmah, Kaushik Saha, Suresh Anantharaj, Arjun Khanna, Samir Gami, Arti Shah, Arpan Shah, Naveen Dutt, Himanshu Garg, Sunil Vyas, Kummannoor Venugopal, Rajendra Prasad, Naveed M. Aleemuddin, Saurabh Karmakar, Virendra Singh, S. K. Jindal, Shubham Sharma, Deepak Prajapat, Sagar Chandrashekar, Michael Loebinger, Aditi Mishra, Francesco Blasi, Ramanathan Palaniappan Ramanathan, Pieter C. Goeminne, Preethi Vasudev, Amelia Shoemark, B. S. Jayaraj, Rahul Kungwani, Akanksha Das, Mehneet Sawhney, Eva Polverino, Tobias Welte, Nayan Sri Gulecha, Michal Shteinberg, Anshul Mangala, Palak Shah, Nishant Kumar Chauhan, Nikita Jajodia, Ashutosh Singhal, Sakshi Batra, Ashfaq Hasan, Stefano Aliberti, Megan L. Crichton, Sneha Limaye, Sundeep Salvi, James D. Chalmers
Summary: This study investigated the risk factors for poor outcome in a large population of bronchiectasis patients enrolled in India. The study found that frequent exacerbations at baseline were associated with an increased risk of mortality, severe exacerbations, future exacerbations, and lung function decline. Coexisting COPD, dyspnoea, and current cigarette smoking were similarly associated with a worse outcome.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Editorial Material
Respiratory System
Charlotte O. Pioch, David W. Connell, Amelia Shoemark
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Letter
Critical Care Medicine
Lidia Perea, Rosa Faner, Belen Solarat, Amelia Shoemark, Stefano Aliberti, James D. Chalmers, Oriol Sibila
Editorial Material
Critical Care Medicine
James D. Chalmers, Amelia Shoemark
Editorial Material
Respiratory System
James D. Chalmers, Stefano Aliberti, Josje Altenburg, Francesco Blasi, Clare Clarke, Sanjay H. Chotirmall, Megan L. Crichton, Raja Dhar, Pieter Goeminne, Charles Haworth, Michael R. Loebinger, Natalie Lorent, Eva Polverino, Felix C. Ringshausen, Amelia Shoemark, Michal Shteinberg, Oriol Sibila, Arietta Spinou, Tobias Welte
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Biotechnology & Applied Microbiology
Nicholas W. Keiser, Erin Cant, Sneha Sitaraman, Amelia Shoemark, Maria P. Limberis
Summary: Primary ciliary dyskinesia (PCD) is a genetic disease characterized by defects in motile cilia, particularly in the lungs. Diagnosis of PCD is complex and often overlaps with other respiratory diseases. PCD is more common than previously thought and currently has no cure, but gene therapy is a promising treatment strategy.
HUMAN GENE THERAPY
(2023)
Article
Respiratory System
Tom Wilkinson, Anthony De Soyza, Miles Carroll, James D. Chalmers, Michael G. Crooks, Gareth Griffiths, Manu Shankar-Hari, Ling-Pei Ho, Alex Horsley, Chris Kell, Beatriz Lara, Biswa Mishra, Rachel Moate, Clive Page, Hitesh Pandya, Jason Raw, Fred Reid, Dinesh Saralaya, Ian C. Scott, Salman Siddiqui, Andy Ustianowski, Natalie van Zuydam, Ashley Woodcock, Dave Singh
Summary: This study investigated the efficacy and safety of the anti-IL-33 monoclonal antibody tozorakimab in COVID-19 patients. The results suggest that tozorakimab could be a novel therapy for hospitalized COVID-19 patients.
Meeting Abstract
Critical Care Medicine
H. R. Keir, M. B. Long, H. Abo Leyah, Y. Giam, T. Vadiveloo, T. Pembridge, R. Hull, L. Delgado, M. Band, F. McLaren-Neill, S. Adamson, E. Lahnsteiner, A. Gilmour, C. Hughes, J. M. New, D. Connell, R. Dowey, H. Turton, H. Richardson, D. Cassidy, J. Cooper, J. Suntharalingam, L. Diwakar, P. Russell, J. Underwood, A. Hicks, D. P. Dosanjh, E. Sage, D. Dhasmana, M. Spears, R. Thompson, C. Brightling, M. Patel, J. George, A. M. Condliffe, A. Shoemark, G. Maclennan, J. D. Chalmers
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
M. Bottier, L. Delgado, M. K. Shuttleworth, D. M. Cassidy, M. L. Crichton, S. Gallant, L. Perrea, S. Aliberti, J. Altenburg, M. Shteinberg, T. Welte, F. Blasi, P. C. Goeminne, O. Sibila, E. Polverino, C. Hogg, S. Ollosson, M. R. Loebinger, N. Lorent, J. D. Chalmers, A. Shoemark
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
E. Cant, M. Bottier, R. Urquhart, A. Gilmour, M. Crichton, D. Cassidy, M. Shuttleworth, H. Keir, J. Huang, A. Shoemark, J. D. Chalmers
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)