Ghrelin Attenuates Neuroinflammation and Demyelination in Experimental Autoimmune Encephalomyelitis Involving NLRP3 Inflammasome Signaling Pathway and Pyroptosis

Multiple Sclerosis patients carry an increased burden of exceedingly rare genetic variants in the inflammasome regulatory genes

(2019) Lovro Vidmar et al.   Scientific Reports

Ghrelin improves muscle function in dystrophin-deficient mdx mice by inhibiting NLRP3 inflammasome activation

(2019) Leilei Chang et al.   LIFE SCIENCES

Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration

(2018) Rituraj Niranjan   NEUROCHEMISTRY INTERNATIONAL

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin transport across the blood–brain barrier can occur independently of the growth hormone secretagogue receptor

(2018) Elizabeth M. Rhea et al.   Molecular Metabolism

Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways

(2018) Claudia Semino et al.   Cell Death & Disease

Pien Tze Huang Alleviates Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Mice by Regulating Th1 and Th17 Cells

(2018) Xuemei Qiu et al.   Frontiers in Pharmacology

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

(2018) Shuo Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Exosomes derived from mesenchymal stem cells attenuate inflammation and demyelination of the central nervous system in EAE rats by regulating the polarization of microglia

(2018) Zijian Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation

(2017) Ken Howick et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

(2017) Leslie Freeman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ghrelin protects the heart against ischemia/reperfusion injury via inhibition of TLR4/NLRP3 inflammasome pathway

(2017) Qin Wang et al.   LIFE SCIENCES

The neurological effects of ghrelin in brain diseases: Beyond metabolic functions

(2017) Qian Jiao et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

An autophagic mechanism is involved in the 6-hydroxydopamine-induced neurotoxicity in vivo

(2017) Xin He et al.   TOXICOLOGY LETTERS

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies

(2017) Limin Song et al.   Frontiers in Cellular Neuroscience

Progressive multiple sclerosis: from pathogenic mechanisms to treatment

(2016) Jorge Correale et al.   BRAIN

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Treatment with tanshinone IIA suppresses disruption of the blood-brain barrier and reduces expression of adhesion molecules and chemokines in experimental autoimmune encephalomyelitis

(2016) Xue Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroinflammation: the devil is in the details

(2016) Damon J. DiSabato et al.   JOURNAL OF NEUROCHEMISTRY

Ghrelin and Neurodegenerative Disorders—a Review

(2016) Limin Shi et al.   MOLECULAR NEUROBIOLOGY

Glucagon-Like Peptide-1 Analog, Liraglutide, Delays Onset of Experimental Autoimmune Encephalitis in Lewis Rats

(2016) Brian DellaValle et al.   Frontiers in Pharmacology

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Effects of Ghrelin on the Proteolytic Pathways of Alzheimer’s Disease Neuronal Cells

(2015) Valentina Cecarini et al.   MOLECULAR NEUROBIOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Experimental autoimmune encephalomyelitis is a good model of multiple sclerosis if used wisely

(2014) David Baker et al.   Multiple Sclerosis and Related Disorders

Endogenous ghrelin's role in hippocampal neuroprotection after global cerebral ischemia: does endogenous ghrelin protect against global stroke?

(2013) Rachel Kenny et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Therapeutic effect of ghrelin in experimental autoimmune encephalomyelitis by inhibiting antigen-specific Th1/Th17 responses and inducing regulatory T cells

(2013) Luciana Souza-Moreira et al.   BRAIN BEHAVIOR AND IMMUNITY

Ghrelin: An emerging new anticonvulsant neuropeptide

(2012) Jeanelle Portelli et al.   EPILEPSIA

NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

(2012) M. Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin in obesity and endocrine diseases

(2011) Miski Scerif et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Inhibition of Apoptotic Cell Death by Ghrelin Improves Functional Recovery after Spinal Cord Injury

(2010) Jee Y. Lee et al.   ENDOCRINOLOGY

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

(2010) D. Gris et al.   JOURNAL OF IMMUNOLOGY

The extra-hypothalamic actions of ghrelin on neuronal function

(2010) Zane B. Andrews   TRENDS IN NEUROSCIENCES

Neuroprotective Effect of Ghrelin in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson’s Disease by Blocking Microglial Activation

(2009) Minho Moon et al.   NEUROTOXICITY RESEARCH