Article
Neurosciences
Tony Barbay, Emilie Pecchi, Myriam Ducrocq, Nathalie Rouach, Frederic Brocard, Remi Bos
Summary: Neuronal oscillations in the spinal cord are regulated by astrocytic K+ homeostasis, which is mediated by the inward-rectifying K+ channel Kir4.1. Astrocytes display Ca2+ transients that precede and coincide with neighboring neuronal oscillations. Inhibition of astrocytic Ca2+ transients reduces K+ clearance through Kir4.1 channels, leading to disrupted neuronal oscillations and impaired locomotor performance.
Article
Neurosciences
Pengbo Shi, Zhaosu Li, Teng He, Nanqin Li, Xing Xu, Peiyao Yu, Xue Lu, Jiaxun Nie, Dekang Liu, Qinglong Cai, Yun Guan, Feifei Ge, Jun Wang, Xiaowei Guan
Summary: The study revealed that METH withdrawal disrupted spatial memory in mice, associated with increased Glu levels and postsynaptic neuronal activities at dCA1 synapses. METH withdrawal weakened the capacity of Glu clearance in astrocytes, while it did not affect the presynaptic Glu release from dCA3 within dCA1.
Article
Multidisciplinary Sciences
Airi Watanabe, Connie Guo, Per Jesper Sjostrom
Summary: We studied the maturation process of astrocytes in the layer 5 mouse visual cortex from postnatal days 3-50. We observed an increase in resting membrane potential, a decrease in input resistance, and a transition towards more passive membrane responses as the astrocytes matured. Gap-junction coupling increased starting around postnatal day 7. Morphological reconstructions showed increased branch density but shorter branches after postnatal day 20, indicating branch pruning during tiling establishment. Additionally, spontaneous Ca2+ transients became decorrelated, more frequent, and briefer with age, suggesting a shift from cell-wide, synchronous waves to local transients as astrocytes matured. Some astrocyte properties were stably mature by postnatal day 15, coinciding with eye opening, while morphology continued to develop. Our findings provide a descriptive foundation for astrocyte maturation and its impact on visual cortex critical period plasticity.
Review
Multidisciplinary Sciences
Laura D. Lewis
Summary: Sleep is crucial for maintaining brain health and cognitive functions, such as memory and attention. The neural dynamics during sleep are closely linked to blood flow, cerebrospinal fluid dynamics, and waste clearance, revealing the interconnected systems that support brain function during rest.
Article
Psychiatry
Di Yao, Rong Li, Jiahuan Hao, Hongqing Huang, Xubiao Wang, Lusen Ran, Yuanyuan Fang, Yuqin He, Wei Wang, Xinghua Liu, Minghuan Wang
Summary: This study found that melatonin can improve the symptoms of depression by regulating the expression of the circadian protein Per2, maintaining the circadian rhythm of astrocytic AQP4 polarization, and restoring glymphatic function.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Astronomy & Astrophysics
Aleksandr Petrashchuk, S. A. Anfinogentov, V. V. Fedenev, P. N. Mager, D. Yu Klimushkin
Summary: Numerical and analytical analysis of magnetohydrodynamic (MHD) waves in solar coronal arcades is conducted. A semicylinder slab model is used to represent the field lines and magnetic shells. The study considers finite plasma pressure and the 'corrugational' perturbations. The analysis reveals the existence of two oscillation modes, the Alfven and slow magnetosonic modes, coupled due to field line curvature. The results show that the waves are concentrated in the Alfven and magnetosonic transparent regions, bounded by resonance surfaces and cut-off frequencies.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Eleonora Centonze, Antonella Marte, Martina Albini, Anna Rocchi, Fabrizia Cesca, Martina Chiacchiaretta, Thomas Floss, Pietro Baldelli, Stefano Ferroni, Fabio Benfenati, Pierluigi Valente
Summary: Neuron-restrictive silencer factor/repressor element 1 (NRSF/REST) is a transcriptional repressor that regulates the expression of neural genes. In astrocytes, NRSF/REST is highly expressed and plays a role in maintaining intrinsic excitability and synaptic transmission. Its deletion leads to impaired astrocytic homeostatic functions and increased neuronal excitability.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Cell Biology
Juao-Guilherme Rosa, Katherine Hamel, Carrie Sheeler, Ella Borgenheimer, Stephen Gilliat, Alyssa Soles, Ferris J. Ghannoum, Kaelin Sbrocco, Hillary P. Handler, Orion Rainwater, Ryan Kang, Marija Cvetanovic
Summary: This study investigated the spatiotemporal heterogeneity of astrocytes in a mouse model of spinocerebellar ataxia type 1 (SCA1). The researchers found region-specific changes in astrocyte density and gene expression, indicating the potential role of astrocytes in compensating or exacerbating neuronal dysfunction. Late in the disease, astrocyte functions were impaired. There was no obvious correlation between microglial and astrocyte alterations, suggesting a complex orchestration of glial phenotypes in SCA1.
Article
Neurosciences
Arturo Tozzi, Muhammad Zubair Ahmad, James F. Peters
Summary: The relationship among near set theory, shape maps, and recent accounts of the Quantum Hall effect opens up the possibility of neural networks computations in higher dimensions, enabling detection and quantification of a fourth spatial dimension. The operational procedure to build a real or artificial neural network to achieve this has been illustrated, showing that starting from two-dimensional shapes, it is possible to achieve corresponding four-dimensional shapes with more information content. The synthesis of surface shape components and topological view of shape descriptions leads to a 4D view of cerebral activity, allowing for an increase in the amount of available qbits in a fixed volume.
COGNITIVE NEURODYNAMICS
(2021)
Article
Biology
Andrea Alamia, Lucie Terral, Malo Renaud D'ambra, Rufin VanRullen, Jonas Obleser
Summary: Previous research has linked alpha-band oscillations with inhibitory functions, but contradictory findings suggest different underlying processes. Using traveling wave analysis, the present study reveals two distinct alpha-band oscillations propagating in opposite directions. These findings highlight the importance of considering oscillations as traveling waves when studying their functional role.
Article
Astronomy & Astrophysics
Naga Varun Yelagandula
Summary: This study demonstrates the possibility of generating quasiperiodic pulsations (QPPs) through a nonlinear fast sausage mode in a coronal loop, explaining the phenomenon caused by it. The frequency-renormalized plane wave solution transforms into a series of quasiperiodic oscillations under certain conditions, leading to the emergence of corresponding pulsations in the electromagnetic spectrum.
ASTROPHYSICAL JOURNAL
(2021)
Article
Physics, Multidisciplinary
Qidong Fu, Peng Wang, Yaroslav V. Kartashov, Vladimir V. Konotop, Fangwei Ye
Summary: This study investigates the one-dimensional topological pumping of matter waves in two overlaid optical lattices with attractive nonlinearity. It reveals that there is a threshold nonlinearity level where matter transfer completely halts. Below this threshold, both dispersive wave packets and solitons follow the predictions of linear theory, quantized and determined by the linear dynamical Chern numbers of the lowest bands. The breakdown of transport is justified by the nontrivial topology of the bands, where nonlinearity induces Rabi oscillations of atoms between the lowest bands. The direction and magnitude of the average velocity of matter solitons, which remain quantized and allow fractional values, are determined by the sum of the Chern numbers of the nonlinearity-excited bands. The study emphasizes the role of the topology of linear bands in the evolution of solitons, even in the strongly nonlinear regime. The transition between different dynamical regimes is accurately described by perturbation theory for solitons.
PHYSICAL REVIEW LETTERS
(2022)
Article
Neurosciences
Joan Rue-Queralt, Valentina Mancini, Vincent Rochas, Caren Latreche, Peter J. Uhlhaas, Christoph M. Michel, Gijs Plomp, Stephan Eliez, Patric Hagmann
Summary: This study investigated the brain's information processing mechanisms at different spatial scales using Joint Time-Vertex Spectral Analysis. The results demonstrated that different frequency bands correspond to different information processing mechanisms, with low frequencies associated with spatially distributed integration activity and high frequencies associated with localized electrical segregation activity.
Article
Mathematics, Applied
Adriane S. Reis, Eduardo L. Brugnago, Ibere L. Caldas, Antonio M. Batista, Kelly C. Iarosz, Fabiano A. S. Ferrari, Ricardo L. Viana
Summary: The study focuses on neuronal synchronization in the brain, highlighting the relationship between synchronized activities in neurons and cognitive processes, as well as synchronous oscillations in brain disorders. Mathematical modeling and experimental research have shown the presence of scale-free networks in some regions of the cortex. By using the Rulkov model and external perturbation, the study aims to suppress neuronal burst synchronization and achieve better results compared to the time-delayed feedback method.
Article
Optics
M. A. Pinto, P. A. Brandao
Summary: This paper introduces a possible theoretical framework of the partially coherent version of frozen spatial coherence inspired by the concept of coherent frozen waves. By superposing partially coherent zero-order Bessel beams, a desired two-point correlation structure of an optical field is created on the propagation axis. The cross-spectral density is described using a two-dimensional Fourier series, similar to the one-dimensional approach of coherent frozen waves. The formalism is applied to design a partially coherent field that is highly coherent within a predetermined and finite range on the propagation axis, and highly incoherent outside that range.
Article
Biochemistry & Molecular Biology
Mohammad S. Zaman, Adam J. Johnson, Gabriele Bobek, Sindy Kueh, Cindy Kersaitis, Trevor D. Bailey, Yossi Buskila, Ming J. Wu
Article
Neurosciences
Morven A. Cameron, Amr Al Abed, Yossi Buskila, Socrates Dokos, Nigel H. Lovell, John W. Morley
JOURNAL OF NEUROPHYSIOLOGY
(2017)
Review
Neurosciences
Dzung Do-Ha, Yossi Buskila, Lezanne Ooi
MOLECULAR NEUROBIOLOGY
(2018)
Review
Behavioral Sciences
Alba Bellot-Saez, Orsolya Kekesi, John W. Morley, Yossi Buskila
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2017)
Article
Multidisciplinary Sciences
Morven A. Cameron, Orsolya Kekesi, John W. Morley, Alba Bellot-Saez, Sindy Kueh, Paul Breen, Andre van Schaik, Jonathan Tapson, Yossi Buskila
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Article
Multidisciplinary Sciences
Morven Cameron, Orsolya Kekesi, John W. Morley, Jonathan Tapson, Paul P. Breen, Andre van Schaik, Yossi Buskila
Article
Multidisciplinary Sciences
Alba Bellot-Saez, Greg Cohen, Andre van Schaik, Lezanne Ooi, John W. Morley, Yossi Buskila
SCIENTIFIC REPORTS
(2018)
Article
Cell Biology
Yossi Buskila, Orsolya Kekesi, Alba Bellot-Saez, Winston Seah, Tracey Berg, Michael Trpceski, Justin J. Yerbury, Lezanne Ooi
CELL DEATH & DISEASE
(2019)
Article
Anatomy & Morphology
Orsolya Kekesi, Huazheng Liang, Gerald Munch, John W. Morley, Erika Gyengesi, Yossi Buskila
BRAIN STRUCTURE & FUNCTION
(2019)
Review
Neurosciences
Rebecca Stevenson, Evgeniia Samokhina, Ilaria Rossetti, John W. Morley, Yossi Buskila
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Alba Bellot-Saez, Rebecca Stevenson, Orsolya Kekesi, Evgeniia Samokhina, Yuval Ben-Abu, John W. Morley, Yossi Buskila
Summary: Potassium homeostasis is crucial for brain function, with astrocytes playing a key role in clearing excessive K+. Neuromodulators can affect astrocytic clearance process, modulating network oscillatory activity through parallel activation of neurons and astrocytes to maximize synchronous network activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Neurosciences
Yossi Buskila, Erika Gyengesi, John W. Morley
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Rebecca Stevenson, Evgeniia Samokhina, Armaan Mangat, Ilaria Rossetti, Sushmitha S. Purushotham, Chandra S. Malladi, John W. Morley, Yossi Buskila
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of motor neurons. Recent studies have shown that astrocytes, a type of glial cells, also contribute to the onset and progression of ALS. This study investigates the role of astrocytes in maintaining K+ homeostasis in the brain and demonstrates region-specific alterations in K+ clearance rate in an ALS mouse model. The findings suggest that impaired astrocytic function may contribute to the vulnerability of motor neurons in ALS.
Proceedings Paper
Engineering, Biomedical
Paul P. Breen, Yossi Buskila
2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2014)