Article
Immunology
Lei Wang, Pengfei Li, Yu Zhou, Renjun Gu, Ge Lu, Chunbing Zhang
Summary: This study investigated the effects of Magnoflorine (Mag) on rheumatoid arthritis (RA) and the underlying mechanism using mouse models. The results showed that Mag could reduce arthritis severity, joint destruction, and macrophage infiltration. Further analysis revealed that Mag exerted its anti-arthritic and anti-inflammatory effects by inhibiting the activation of NF-kappa B and MAPK signaling pathways.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Minjun Yao, Caihua Zhang, Lingzhi Ni, Xiaoxiao Ji, Jianqiao Hong, Yazhou Chen, Jie Wang, Congsun Li, Jiyan Lin, Tingting Lu, Yihao Sheng, Menghao Sun, Mingmin Shi, Chenhe Zhou, Xunzi Cai
Summary: This study demonstrated for the first time the protective medicinal efficacy of cepharanthine (CEP) in osteoarthritis. CEP suppressed inflammation and increased protein expression in joint tissues while restoring cellular autophagy. The mouse model confirmed the therapeutic potential of CEP in osteoarthritis treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Shouye Hu, Yanqi Li, Bo Wang, Kan Peng
Summary: The study showed that TRIM38 can alleviate IL-1 beta-induced apoptosis and degeneration of chondrocytes by suppressing the NF-kappa B signaling pathway. This work suggests a potential role of TRIM38 in osteoarthritis and proposes it as a new therapeutic target for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Zhousheng Yang, Tianyu Li, Chunyan Wang, Mingyu Meng, Shenglan Tan, Lei Chen
Summary: Dihydromyricetin (DMY), a natural flavonoid compound extracted from Ampelopsis grossedentata, has been identified as a potential therapeutic chemical for treating atherosclerosis. This study investigates the mechanism by which DMY suppresses M1 macrophage polarization in atherosclerosis. The results showed that DMY treatment significantly reduced M1 macrophage markers and p65-positive macrophage numbers in the vessel wall of Apoe-deficient (Apoe(-/-)) mice.
MEDIATORS OF INFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Haijun Zhao, Weijie Zhu, Wude Mao, Chengkai Shen
Summary: The study demonstrates that PRP can protect chondrocytes from doxorubicin-induced damage, inhibiting apoptosis and inflammation, and improving cartilage destruction. This research provides a new theoretical basis for the clinical treatment of osteoarthritis caused by doxorubicin.
MOLECULAR MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Wei-cheng Chan, Liangyu Tan, Jie Liu, Qin Yang, Jiajia Wang, Min Wang, Yuan Yue, Liang Hao, Yi Man
Summary: The study found that inhibition of Rgs10 in mice with both periodontitis and rheumatoid arthritis can aggravate the development of periodontitis, indicating the potential therapeutic role of Rgs10 in this condition.
Article
Biochemistry & Molecular Biology
Yinzhong Chen, Wei Guo, Weizhao Lu, Xiucheng Guo, Weilu Gao, Zongsheng Yin
Summary: This study found that SNIP1 plays an inhibitory role in the progression of osteoarthritis, alleviating inflammation by inhibiting the activation of NF-kappa B. This discovery may provide new insights into the treatment of osteoarthritis.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Immunology
Binbin Xie, Faquan Lin, Wei Bao, Yangyang Zhang, Yi Liu, Xiaohui Li, Wei Hou, Qiyan Zeng
Summary: This study investigated the association between noncoding RNA linc00324 and rheumatoid arthritis (RA) and proposed a potential mechanism. The results showed that linc00324 was upregulated in RA patients and positively correlated with rheumatoid factor and CD4(+) T cells. Overexpression of linc00324 promoted CD4(+) T cell proliferation, increased chemokine MIP-1a secretion and NF-κB phosphorylation, while knockout of linc00324 blocked CD4(+) T cell proliferation and NF-κB phosphorylation. Overexpression of miR-10a-5p reduced CD4(+) T cell proliferation and NF-κB phosphorylation, and reversed the effects of linc00324 on cell proliferation and NF-κB activity.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Pharmacology & Pharmacy
Xiao Wang, Xiaoping Huang, Pingzhang Gao, Yanxuan Ren, Xiaokun Li, Yong Diao
Summary: In this study, the protective role of kallistatin against rheumatoid arthritis (RA) was analyzed, and it was found that kallistatin can mitigate chondrocyte apoptosis mediated by IL-1 beta and inhibit the synthesis of ECM-degrading enzymes. It also suppressed IL-1 beta-mediated inflammation through the NF-kappa B pathway. In animal models, kallistatin administration significantly reduced the severity of RA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Jinrong Bai, Na Xie, Ya Hou, Xiaorui Chen, Yao Hu, Yi Zhang, Xianli Meng, Xiaobo Wang, Ce Tang
Summary: The study found that Cantleyoside (CA) has anti-inflammatory and pro-apoptotic effects on human rheumatoid arthritis fibroblast synovial cells (HFLS-RA) by activating the AMPK/Sirt 1/NF-kappa B pathway. This suggests that CA may be a potential drug for the treatment of rheumatoid arthritis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Qiubo Wang, Yapeng Wang, Qingyang Liu, Ying Chu, Rui Mi, Fengying Jiang, Jingjing Zhao, Kelong Hu, Ran Luo, Yufeng Feng, Harrison Lee, Dong Zhou, Jingyi Mi, Ruoyu Deng
Summary: This study investigates the role of MALT1 in rheumatoid arthritis (RA) and its effect on Th1/2/17 cell differentiation. The results show that MALT1 is increased in RA patients and correlates with disease activity. MALT1 overexpression promotes Th17 differentiation and inhibits Th2 differentiation, while its knockdown has the opposite effect. Furthermore, MALT1's effect on Th2 and Th17 differentiation can be attenuated by NF-kappa B and JNK pathway inhibitors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Feng Cao, Cheng Huang, Jiwei Cheng, Zhaochun He
Summary: The study demonstrated that upregulation of beta Arr2 levels can improve symptoms and pathological damage in RA, attenuate inflammatory responses, and effectively alleviate ankle inflammation in CIA mice via the NF-kappa B/NLRP3 inflammasome pathway.
Article
Immunology
Xiaolin Wang, Zhou Guo, Jiamin Lin, Kai Sun, Genchun Wang, Liangcai Hou, Jingting Xu, Jiachao Guo, Xiong Zhang, Fengjing Guo, Youxiu Wei
Summary: The aim of this study was to investigate the inhibitory effect of indirubin on arthritis and its cellular-level processes. The results showed that indirubin can reduce chondrocyte inflammation and improve cartilage degradation. It also inhibited the abnormal activation of NF-Kappa B and MAPK signaling pathways. These findings suggest the potential of indirubin as an anti-arthritis drug.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Peraphan Pothacharoen, Rujirek Chaiwongsa, Theerawut Chanmee, Orapin Insuan, Thanchanok Wongwichai, Phornpimon Janchai, Pilanee Vaithanomsat
Summary: Bromelain, a protease mixture found in pineapple, has beneficial biological properties and exhibits anti-arthritic activities. It protects cartilage from degradation and decreases the expression of inflammatory cytokines in synovial fibroblasts by suppressing NF-kappa B and MAPK signaling pathways.
Article
Biochemistry & Molecular Biology
Dandan Guo, Liming He, Yaoxin Gao, Chenxu Jin, Haizhen Lin, Li Zhang, Liting Wang, Ying Zhou, Jie Yao, Yixin Duan, Renzheng Yang, Wenwei Qiu, Wenzheng Jiang
Summary: T-2054 has anti-inflammatory properties, inhibits the release of inflammatory cytokines, promotes ECM synthesis, and shows potential as a therapeutic agent for OA in mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)