Article
Respiratory System
Mathew Cherian, Kate M. A. Magner, G. A. Whitmore, Katherine L. Vandemheen, J. Mark FitzGerald, Celine Bergeron, Louis-Philippe Boulet, Andreanne Cote, Stephen K. Field, Erika Penz, R. Andrew McIvor, Catherine Lemiere, Samir Gupta, Irvin Mayers, Mohit Bhutani, Paul Hernandez, M. Diane Lougheed, Christopher J. Licskai, Tanweer Azher, Martha Ainslie, Nicole Ezer, Sunita Mulpuru, Shawn D. Aaron
Summary: This study compares patient and physician characteristics between symptomatic individuals with undiagnosed obstructive lung disease (OLD) and individuals diagnosed with OLD. The results show that undiagnosed OLD patients have poorer lung function, greater psychosocial impacts on quality of life, and are less likely to receive appropriate investigations and specialist referral.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Ophthalmology
Emmanuel Kobia-Acquah, Stephen Ankamah-Lomotey, Ebenezer Owusu, Sedinam Forfoe, Joseph Bannor, Joana Abokoma Koomson, Martin Opoku, Daniel Mensah Dzikpo, Derrick Nii Okaikwei Mensah, Jedidiah N. Amonoo, Prince Kwaku Akowuah
Summary: The study aimed to estimate the prevalence of symptomatic dry eye and associated risk factors in the general non-clinical population of Ghana. The results showed a high prevalence of symptomatic dry eye, with light sensitivity being the most common symptom and windy conditions being the most common environmental trigger. There were significant positive associations between symptomatic dry eye and age, female sex, arthritis, ocular allergy, and regional zone.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Multidisciplinary Sciences
Tarekegn Cheklie Zeleke, Nebiyat Feleke Adimassu, Abiy Maru Alemayehu, Teshager Wondale Dawud, Getasew Alemu Mersha
Summary: This study investigated the prevalence of dry eye and its associated factors among postgraduate students in Ethiopia. The results showed that over half of the postgraduate students experienced symptomatic dry eye disease, which was significantly associated with continuous visual display unit use, duration of use, sleep deprivation, and allergic conjunctivitis.
Article
Medicine, General & Internal
Chunyang Wang, Kelan Yuan, Yujie Mou, Yaying Wu, Xin Wang, Renjian Hu, Jinjin Min, Xiaodan Huang, Xiuming Jin
Summary: High-intensity use of smartphones can significantly increase the diagnostic rate of dry eye and affect the severity of the condition. It disrupts ocular surface homeostasis and leads to a higher false positive rate in diagnosing dry eye.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Yuichi Okumura, Takenori Inomata, Akie Midorikawa-Inomata, Jaemyoung Sung, Kenta Fujio, Yasutsugu Akasaki, Masahiro Nakamura, Masao Iwagami, Keiichi Fujimoto, Atsuko Eguchi, Maria Miura, Ken Nagino, Kunihiko Hirosawa, Tianxiang Huang, Mizu Kuwahara, Reza Dana, Akira Murakami
Summary: This study investigated the reliability, validity, and feasibility of the DryEyeRhythm smartphone application for the diagnosis assistance of dry eye disease (DED). The results showed that the app had good internal consistency, concurrent validity, and discriminant validity for DED diagnosis. The app also demonstrated high precision rate and screening performance.
Article
Ophthalmology
Zhangling Chen, Yan Jia, Ying Xiao, Qiurong Lin, Yu Qian, Zhaoyu Xiang, Lipu Cui, Xinran Qin, Shuli Chen, Chenhao Yang, Haidong Zou
Summary: This study analyzed the characteristics of ocular surface microbial composition in children and adolescents with diabetes mellitus and dry eye through tear analysis. The findings showed that compared to non-DE patients and healthy children, children and adolescents with diabetes mellitus and DE had higher microbial diversity on the ocular surface with unique bacterial phyla and genera composition.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Yi-Ran Chiou, Pei-Yu Lin, Yu-Bai Chou, Po-Wei Huang, Nai-Wen Fan
Summary: This study investigated the characteristics of asymptomatic MGD, symptomatic MGD, and MGD coexisting with DED. The study found that MGD patients coexisting with DED had significantly reduced LLT and higher blink frequency.
Article
Medicine, General & Internal
Hanan M. Aljammaz, Wijdan M. Aleithan, Amal Mohammad Albalawi, Rabab T. Aljayani, Rawabi T. Aljayani, Manal M. Aljammaz, Saad H. Alenezi, Shaker Alreshidi, Faris Hashem, Naif M. Alali, Hani B. ALBalawi
Summary: This study aimed to assess the prevalence and risk factors of dry eye disease (DED) among medical students at the University of Tabuk. The study found that 18.2% of the medical students had DED. Risk factors associated with DED included eye irritation upon waking up, sleeping with partially opened eyes, redness and irritation of the eyes when swimming in chlorinated water, and the use of prescription eyedrops or other dry eye treatments.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Review
Medicine, General & Internal
Khaloud Al-Marri, Maha Al-Qashoti, Hissa Al-Zoqari, Usra Elshaikh, Alya Naqadan, Raghad Saeed, Jameela Faraj, Mujahed Shraim
Summary: The review found a potential association between smartphone use (SPU) and dry eye disease (DED), with three out of four included studies showing a relationship. However, the evidence is limited by the small number of studies with satisfactory methodological quality. More high-quality research is needed to investigate the relationship between SPU and DED further.
Article
Ophthalmology
Atsuko Eguchi, Takenori Inomata, Masahiro Nakamura, Ken Nagino, Masao Iwagami, Jaemyoung Sung, Akie Midorikawa-Inomata, Yuichi Okumura, Kenta Fujio, Keiichi Fujimoto, Maria Miura, Yasutsugu Akasaki, Hurramhon Shokirova, Kunihiko Hirosawa, Mizu Kuwahara, Jun Zhu, Reza Dana, Akira Murakami, Hiroyuki Kobayashi
Summary: This study investigated the eye drop type and frequency of use in individuals with symptomatic dry eye in Japan, revealing that many participants did not use optimized eye drop treatment and identified risk factors for no eye drop use. The DryEyeRhythm application may help improve dry eye treatment.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Vandana Kamath, Anitha Arvind, K. Bhuvana
Summary: This study investigated lid wiper epithliopathy (LWE) in symptomatic and asymptomatic dry eye subjects, which is the first study conducted among the Indian population. The results showed that the occurrence of LWE was significantly higher in symptomatic dry eye subjects compared to asymptomatic subjects. Assessing and treating LWE is important in routine clinical practice.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Sergio Navarro-Lopez, Manuel Moya-Ramon, Juana Gallar, Gonzalo Carracedo, Adolfo Aracil-Marco
Summary: This literature review aimed to explore the potential association between physical activity or exercise and the objective signs and subjective symptoms of dry-eye disease. The review identified 16 papers that addressed the relationship of physical activity or exercise with changes in tear volume, osmolarity, biochemical composition, and dry-eye associated symptoms. The findings suggest that physical activity may play a role in modulating the tear film and relieving dry-eye symptoms.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Environmental Sciences
Dominika Wrobel-Dudzinska, Natalia Osial, Piotr Witold Stepien, Adrianna Gorecka, Tomasz Zarnowski
Summary: The aim of this study was to investigate the prevalence of dry eye symptoms (DES) and its risk factors among university students in Poland. A cross-sectional survey was conducted among 312 Polish university students, and the results showed that over half of the respondents had symptoms of ocular surface disease. The use of electronic devices, psychotropics, glucocorticosteroids usage, depression, diabetes, allergy, refractive errors, metropolitan living, and stress were found to be associated with dry eye symptoms.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Ophthalmology
Kimberley Yu, Vatinee Bunya, Maureen Maguire, Penny Asbell, Gui-Shuang Ying
Summary: This study found that certain systemic diseases and smoking history were significantly associated with the severity of dry eye disease signs, but not with symptoms. Understanding the systemic conditions that predispose patients to severe dry eye disease can improve management strategies.
Article
Ophthalmology
Elaine Chen, Erin Rueff, Andrew Loc Nguyen
Summary: This study found a significant association between mask use and symptoms of dry eye. Participants with mild initial symptom scores experienced more severe dry eye symptoms during mask wear compared to those with severe symptom scores at baseline. The use of masks with nose wire may provide protection against symptom exacerbation.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Miki Uchino, Norihiko Yokoi, Jun Shimazaki, Yuichi Hori, Kazuo Tsubota
Summary: This study investigated the actual use of eye drops for dry eye disease (DED), the reasons for instillation behavior, and the relationship between instillation behavior and subjective symptoms. The findings revealed that most participants did not use eye drops at the specified frequency to alleviate symptoms. Regular instillation at the specified frequency resulted in better improvement of subjective symptoms, while younger patients who used contact lenses and over-the-counter eye drops were more likely to deviate from the specified frequency.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jun Zhu, Takenori Inomata, Masahiro Nakamura, Keiichi Fujimoto, Yasutsugu Akasaki, Kenta Fujio, Ai Yanagawa, Koichiro Uchida, Jaemyoung Sung, Naoko Negishi, Ken Nagino, Yuichi Okumura, Maria Miura, Hurramhon Shokirova, Mizu Kuwahara, Kunihiko Hirosawa, Akie Midorikawa-Inomata, Atsuko Eguchi, Tianxiang Huang, Hideo Yagita, Sonoko Habu, Ko Okumura, Akira Murakami
Summary: We investigated the effects of anti-CD80/86 antibodies in a murine high-risk corneal transplantation rejection model. The results showed that anti-CD80/86 antibodies significantly reduced T-cell proliferation and inflammatory response, thereby prolonging the survival of corneal grafts.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Ayano Katagiri, Kazuo Tsubota, Lou Mikuzuki, Shigeru Nakamura, Akira Toyofuku, Takafumi Kato, David A. Bereiter, Koichi Iwata
Summary: Repeated application of diquafosol sodium reduces ocular pain in dry eye disease by suppressing peripheral P2Y2 expression. Diquafosol increases tear volume and decreases eyeblink frequency, suggesting its efficacy in relieving dry eye symptoms.
NEUROSCIENCE RESEARCH
(2023)
Article
Medicine, General & Internal
Murat Dogru, Takashi Kojima, Kazunari Higa, Ayako Igarashi, Haruka Kudo, Wolfgang G. K. Mueller-Lierheim, Kazuo Tsubota, Kazuno Negishi
Summary: The study found that a novel high molecular weight hyaluronic acid and Latanoprost eye drop had similar intraocular pressure-lowering effects compared to commercially available Latanoprost eye drops, while also reducing ocular surface inflammation. This suggests that the new eye drop formulation provides comparable IOP lowering effects to the market product, while also reducing ocular surface alterations and inflammatory reactions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Ken Nagino, Takenori Inomata, Masahiro Nakamura, Jaemyoung Sung, Akie Midorikawa-Inomata, Masao Iwagami, Kenta Fujio, Yasutsugu Akasaki, Yuichi Okumura, Tianxiang Huang, Keiichi Fujimoto, Atsuko Eguchi, Maria Miura, Shokirova Hurramhon, Jun Zhu, Mizu Ohno, Kunihiko Hirosawa, Yuki Morooka, Reza Dana, Akira Murakami, Hiroyuki Kobayashi
Summary: This study tested the feasibility of a symptom stratification algorithm for dry eye disease (DED) in ophthalmology patients. The algorithm successfully stratified patients into seven clusters and revealed differences in clinical characteristics among different clusters.
Article
Biochemistry & Molecular Biology
Yifan Liang, Shin-ichi Ikeda, Junhan Chen, Yan Zhang, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara
Summary: Myopia is a leading cause of vision impairment, and an effective intervention is needed. This study examined the effects of different forms of lactoferrin (LF) on myopia in mice and found that digested LF and holo-LF were more effective in suppressing myopia compared to native LF. The results also revealed that mice given digested LF or holo-LF had a less elongated axial length and thinner choroid, as well as lower levels of certain cytokines and growth factors associated with myopia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Satoshi Imanishi, Yohei Tomita, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara
Summary: Disorders in the development and regulation of blood vessels are involved in various ocular disorders. Understanding the developing choroidal circulation system expands our knowledge of ocular development and supports our understanding of ocular disorders. This review examines studies on regulating the developing choroidal circulation system and discusses its relevance to human diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
James S. Wolffsohn, Gareth Lingham, Laura E. Downie, Byki Huntjens, Takenori Inomata, Saleel Jivraj, Emmanuel Kobia-Acquah, Alex Muntz, Karim Mohamed-Noriega, Sotiris Plainis, Michael Read, Rony R. Sayegh, Sumeer Singh, Tor P. Utheim, Jennifer P. Craig
Summary: Eye strain caused by tasks in a digital environment can lead to discomfort and lower productivity and quality of life. Digital eye strain, characterized by recurrent ocular symptoms and/or signs related to digital device screen viewing, is highly prevalent due to lack of agreed definition and limitations of current questionnaires. Objective signs like blink rate or critical flicker frequency changes are not diagnostic. Reduced blink rate, refractive errors, binocular vision anomalies, and differences in task demands and visual stimuli contribute to ocular surface disease exacerbation. There is no well-established intervention, but full refractive correction, improving blinking, optimizing the work environment, and taking regular breaks may help. Blue-light blocking interventions are not effective, while artificial tears, secretagogues, warm compress, humidity goggles, ambient humidifiers, and nutritional supplementation like omega-3 fatty acids and berry extracts show promise. More clinical trials are needed for accurate evaluation.
Article
Ophthalmology
Ziyan Ma, Heonuk Jeong, Yajing Yang, Xiaoyan Jiang, Shin-ichi Ikeda, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota
Summary: This study aimed to investigate the contralateral effects of monocular experimental myopia and recovery, which could not be explained by local mechanisms. The results showed that complete recovery of the eyes that wore -30 D lenses was observed after 1 week of lens removal. Both eyes in the PLC and NLC groups exhibited a myopic shift and choroidal thinning after lens removal. The eye wearing the -30 D lens had a significant increase in axial length after 3 weeks of lens wear, while the fellow eyes in the PLC and NLC groups continued to increase in axial length and the binocular axial lengths gradually converged.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Allergy
Ken Nagino, Jaemyoung Sung, Akie Midorikawa-Inomata, Atsuko Eguchi, Keiichi Fujimoto, Yuichi Okumura, Alan Yee, Kenta Fujio, Yasutsugu Akasaki, Tianxiang Huang, Maria Miura, Shokirova Hurramhon, Kunihiko Hirosawa, Mizu Ohno, Yuki Morooka, Hiroyuki Kobayashi, Takenori Inomata
Summary: This study assessed the minimal clinically important difference (MCID) of nasal symptom score (NSS), non-nasal symptom score (NNSS), and total symptoms score (TSS) for app-based hay-fever monitoring, and obtained the MCID ranges from the data collected through a smartphone application. These estimates may be useful for monitoring the subjective symptoms of Japanese patients with hay fever through mobile platforms.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Review
Medicine, General & Internal
Yasufumi Tomioka, Koji Kitazawa, Yohei Yamashita, Kohsaku Numa, Takenori Inomata, Jun-Wei B. Hughes, Rina Soda, Masahiro Nakamura, Tomo Suzuki, Norihiko Yokoi, Chie Sotozono
Summary: Dry eye is a common age-related ocular surface disease with multiple factors involved. Dyslipidemia, specifically high total cholesterol (TC) and high triglycerides (TG), are significant risk factors for meibomian gland dysfunction (MGD), while high low-density lipoprotein (LDL) and low high-density lipoprotein (HDL) are not identified as risk factors. This systematic review and meta-analysis provide further evidence on the relationship between lipid abnormalities and MGD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yusuke Yoshimura, Junko Kanda-Kikuchi, Takayuki Hara, Izumi Sugimoto
Summary: A man in his early 70s with a history of DLBCL presented with diplopia and achromatopsia. MRI revealed hypertrophic pachymeningitis, and open dural biopsy confirmed the diagnosis as idiopathic HP. Treatment with methylprednisolone and prednisolone resulted in gradual improvement of neurological abnormalities.
Article
Biochemistry & Molecular Biology
Sayoko Kuroha, Yusaku Katada, Yosuke Isobe, Haruki Uchino, Kyosuke Shishikura, Takashi Nirasawa, Kazuo Tsubota, Kazuno Negishi, Toshihide Kurihara, Makoto Arita
Summary: Docosahexaenoic acid (DHA) and ultra-long-chain polyunsaturated fatty acids (ULC-PUFAs) are enriched in retinal photoreceptor membrane phospholipids. The enzyme ACSL6 plays a crucial role in the synthesis and enrichment of these lipids. Genetic deletion of ACSL6 leads to depletion of di-DHA and ULC-PUFA-containing phospholipids, resulting in visual impairment and progressive decrease of retinal thickness.
Article
Health Care Sciences & Services
Takenori Inomata, Jaemyoung Sung, Masahiro Nakamura, Masao Iwagami, Yasutsugu Akasaki, Kenta Fujio, Masahiro Nakamura, Nobuyuki Ebihara, Takuma Ide, Masashi Nagao, Yuichi Okumura, Ken Nagino, Keiichi Fujimoto, Atsuko Eguchi, Kunihiko Hirosawa, Akie Midorikawa-Inomata, Kaori Muto, Kumiko Fujisawa, Yota Kikuchi, Shuko Nojiri, Akira Murakami
Summary: This study investigates the association between comorbidities of dry eye (DE) and hay fever (HF) and related risk factors. Severe DE symptoms were found to be significantly associated with severe HF symptoms. Risk factors for comorbid symptomatic DE in individuals with HF include female sex, lower BMI, medicated hypertension, history of hematologic, collagen, heart, liver, respiratory, or atopic disease, tomato allergy, current and previous mental illness, pet ownership, living room and bedrooms furnished with materials other than hardwood, carpet, tatami, and vinyl, discontinuation of contact lens use during the HF season, current contact lens use, smoking habits, and sleep duration of <6 hours per day.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)