期刊
ELIFE
卷 8, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.50482
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资金
- Wellcome [095844/Z/11/Z]
- Fonds de la recherche en sante du Quebec
- Medical Research Council [MR/K020706/1]
- British Academy
- Autism Research Trust
- Cambridge-Montreal Neurological Institute and Hospital
- Guarantors of Brain
- National Institutes of Health
- Healthy Brains, Healthy Lives
- Engineering and Physical Sciences Research Council [EP/N510129/1]
- MQ: Transforming Mental Health [MQF17/24]
- Natural Sciences and Engineering Research Council of Canada [1304413]
- Canadian Institutes of Health Research [FDN-154298]
- Azrieli Center for Autism Research of the Montreal Neurological Institute
- Sick Kids Foundation [NI17-039]
- Fonds de Recherche du Quebec - Sante
- National Institute for Health
- Cambridge NIHR Biomedical Research Centre
- MRC [MR/K020706/1, MR/M009041/1, MR/M024873/1] Funding Source: UKRI
We studied an accelerated longitudinal cohort of adolescents and young adults (n = 234, two time points) to investigate dynamic reconfigurations in myeloarchitecture. Intracortical profiles were generated using magnetization transfer (MT) data, a myelin-sensitive magnetic resonance imaging contrast. Mixed-effect models of depth specific intracortical profiles demonstrated two separate processes i) overall increases in MT, and ii) flattening of the MT profile related to enhanced signal in mid-to-deeper layers, especially in heteromodal and unimodal association cortices. This development was independent of morphological changes. Enhanced MT in mid-to-deeper layers was found to spatially co-localise specifically with gene expression markers of oligodendrocytes. Interregional covariance analysis revealed that these intracortical changes contributed to a gradual differentiation of higher-order from lower-order systems. Depth-dependent trajectories of intracortical myeloarchitectural development contribute to the maturation of structural hierarchies in the human neocortex, providing a model for adolescent development that bridges microstructural and macroscopic scales of brain organisation.
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