Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression

(2018) Anne-Clémence Vion et al.   JOURNAL OF CELL BIOLOGY

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

(2018) Filipa Neto et al.   eLife

Autophagy promotes angiogenesis via AMPK/Akt/mTOR signaling during the recovery of heat-denatured endothelial cells

(2018) Pengfei Liang et al.   Cell Death & Disease

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

(2017) Jongshin Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

IKKα controls ATG16L1 degradation to prevent ER stress during inflammation

(2017) Michaela A. Diamanti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

cAMP-dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner

(2016) Pavel I. Nedvetsky et al.   DEVELOPMENT

Inhibition of blood vessel formation in tumors by IL-18-polarized M1 macrophages

(2016) Yanjiang Xing et al.   GENES TO CELLS

Protein kinase A–dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1

(2016) John W. Bullen et al.   Science Signaling

Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease

(2016) Qiulun Lu et al.   PLOS BIOLOGY

Protein kinase A–dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1

(2016) John W. Bullen et al.   Science Signaling

Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine

(2016) Sai-Wang Seto et al.   Journal of Clinical Medicine

ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation

(2015) Huiwen Song et al.   Autophagy

MAP4K4 regulates integrin-FERM binding to control endothelial cell motility

(2015) Philip Vitorino et al.   NATURE

PDE3A mutations cause autosomal dominant hypertension with brachydactyly

(2015) Philipp G Maass et al.   NATURE GENETICS

PKA-regulated VASP phosphorylation promotes extrusion of transformed cells from the epithelium

(2014) K. A. Anton et al.   JOURNAL OF CELL SCIENCE

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

(2014) Aditya Murthy et al.   NATURE

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates

(2014) M. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP-PKA Interactions

(2013) Gesa Schäfer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crucial Role of ROCK2 in Vascular Smooth Muscle Cells for Hypoxia-Induced Pulmonary Hypertension in Mice

(2013) Toru Shimizu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Protein ATG16L1 Suppresses Inflammatory Cytokines Induced by the Intracellular Sensors Nod1 and Nod2 in an Autophagy-Independent Manner

(2013) Matthew T. Sorbara et al.   IMMUNITY

The Role of IL-1  in the Early Tumor Cell-Induced Angiogenic Response

(2013) Y. Carmi et al.   JOURNAL OF IMMUNOLOGY

Rock1 & 2 Perform Overlapping and Unique Roles in Angiogenesis and Angiosarcoma Tumor Progression

(2012) J. Montalvo et al.   CURRENT MOLECULAR MEDICINE

Role of autophagy in angiogenesis in aortic endothelial cells

(2011) Jianhai Du et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Coordinating cell behaviour during blood vessel formation

(2011) I. Geudens et al.   DEVELOPMENT

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

(2011) Max R. Banko et al.   MOLECULAR CELL

Cell-Type Specific Expression of a Dominant Negative PKA Mutation in Mice

(2011) Brandon S. Willis et al.   PLoS One

RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis

(2010) A. Satyanarayana et al.   BLOOD

Interleukin-18 suppresses angiogenesis and lymphangiogenesis in implanted Lewis lung cancer

(2010) Sheng Yang et al.   Chinese Journal of Cancer Research

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes

(2010) Frank Christian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice

(2010) Mara E Pitulescu et al.   Nature Protocols

Phosphorylation of NF-κB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination

(2009) Hui Geng et al.   EMBO REPORTS

Glycogen Synthase Kinase 3β Interaction Protein Functions as an A-kinase Anchoring Protein

(2009) Christian Hundsrucker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Signal-Regulated Kinase 2-Dependent Phosphorylation Induces Cytoplasmic Localization and Degradation of p21Cip1

(2009) C. Y. Hwang et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Phosphorylation of the cAMP-dependent Protein Kinase (PKA) Regulatory Subunit Modulates PKA-AKAP Interaction, Substrate Phosphorylation, and Calcium Signaling in Cardiac Cells

(2008) Sabrina Manni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY