期刊
STEM CELLS TRANSLATIONAL MEDICINE
卷 9, 期 3, 页码 302-315出版社
OXFORD UNIV PRESS
DOI: 10.1002/sctm.19-0192
关键词
adult stem cells; arthritis; cytotoxic agents; tissue engineering; tissue regeneration
资金
- St Vincent's Hospital (Melbourne) Research Endowment Fund
- Sylvia and Charles Viertel Charitable Foundation [VIERCI2018003]
- Victorian Medical Research Acceleration Fund
Three-dimensional biofabrication using photo-crosslinkable hydrogel bioscaffolds has the potential to revolutionize the need for transplants and implants in joints, with articular cartilage being an early target tissue. However, to successfully translate these approaches to clinical practice, several barriers must be overcome. In particular, the photo-crosslinking process may impact on cell viability and DNA integrity, and consequently on chondrogenic differentiation. In this review, we primarily explore the specific sources of cellular cytotoxicity and genotoxicity inherent to the photo-crosslinking reaction, the methods to analyze cell death, cell metabolism, and DNA damage within the bioscaffolds, and the possible strategies to overcome these detrimental effects.
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