期刊
PROTEIN & CELL
卷 10, 期 12, 页码 864-882出版社
OXFORD UNIV PRESS
DOI: 10.1007/s13238-019-0653-9
关键词
histone methylation; JMJD3; epigenetics; human diseases
类别
资金
- National Natural Science Foundation of China [81602492]
- National Key Research, Development Program of China [2016YFA0201402]
- National Major Scientific and Technological Special Project for Significant New Drugs Development [2018ZX09733001]
In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyl-lysine 27 on histone H3 (H3K27me2/3), has been widely studied in immune diseases, infectious diseases, cancer, developmental diseases, and aging related diseases. We will focus on the recent advances of JMJD3 function in human diseases, and looks ahead to the future of JMJD3 gene research in this review.
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