Article
Polymer Science
Beata Niemczyk-Soczynska, Pawel Sajkiewicz, Arkadiusz Gradys
Summary: This study explains the mechanism of gelation in methylcellulose (MC) through differential scanning calorimetry (DSC), and finds that gelation is a multistep reversible thermal process. Three endotherms were observed during heating for low MC concentrations, which provides new insights compared to previous research.
Article
Materials Science, Paper & Wood
Yun Hyeok Choi, Yong Ho Yeo, Dongjin Lee, Su A. Park, Won Ho Park
Summary: The addition of inorganic nanoparticles to a polymer hydrogel can lead to profitable printability and improved mechanical properties for 3D bioprinting. In this study, a novel MC-based biomaterial ink was prepared by combining LP, an inorganic nanosilicate, with a thermosensitive MC hydrogel. The MC/LP nanocomposite biomaterial ink exhibited excellent properties for 3D bioprinting and facilitated cell viability and proliferation.
Article
Engineering, Biomedical
Oju Jeon, Tae-Hee Kim, Eben Alsberg
Summary: This study developed a hydrogel system with reversible dynamic mechanics, demonstrating the tunability of mechanical signals on encapsulated stem cells and providing a promising platform to investigate the effect of dynamic mechanical changes on cell behaviors.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Applied
Ziyi Li, Lixin Liu, Yongming Chen
Summary: A dual crosslinked hydrogel has been developed for direct extrusion printing, showing excellent mechanical properties and thermosensitivity, promising for the fabrication of biomimetic scaffolds for skin repair.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Medicinal
Nobuyuki Natori, Yuki Shibano, Akihiro Hiroki, Mitsumasa Taguchi, Atsushi Miyajima, Kazumi Yoshizawa, Yayoi Kawano, Takehisa Hanawa
Summary: A hydrogel film containing tramadol hydrochloride (TRA) was prepared as an alternative dosage form for oral medication for peripheral neuropathy. The film composed of hydroxypropyl methylcellulose (HPMC) irradiated with electron beams showed transparency and elasticity suitable for TRA. The release and skin permeation of TRA varied with electron beam dose, and the analgesic effects in mice were dose-dependent. This study demonstrated the usefulness of the hydrogel film containing TRA as a new alternative dosage form for peripheral neuropathy.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Thermodynamics
Edyta Leyk, Marek Wesolowski
Summary: This study assessed the impact of cellulose derivatives on the crystallinity of paracetamol, revealing that these derivatives do indeed reduce the crystallinity of paracetamol. The particular polymeric excipients did not show any statistically significant difference in their effect. The degree of paracetamol crystallinity decreases as the content of cellulose derivatives in the mixture increases.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Engineering, Biomedical
Archana Singh, Neha Dalal, Prakriti Tayalia
Summary: Cell-based assays are important tools for understanding cell biology, diseases, and drug actions. Current cancer studies mainly use 2D cell culture methods, but these have limitations such as lack of cell-extracellular matrix interactions and inaccurate representation of cell polarity. This study fabricated PEG and gelatin-based matrices to establish 2D and 3D cell culture methods using breast cancer cells, and found differences in cell adhesion and spreading between the gel surface and gel-embedded cells.
BIOMEDICAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Maximilian Jergitsch, Zoe Allu Allue-Mengual, Roman A. Perez, Miguel A. Mateos-Timoneda
Summary: This study explores the effect of different salt, sucrose, and MC concentrations on the printability of methylcellulose hydrogels. Increasing G' improves shape fidelity, while lowering tan(delta) improves shape fidelity as well. Lowering MC concentration, extrusion rate, and nozzle gauge can increase cell viability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Yong Ho Yeo, Won Ho Park
Summary: Self-healing, thermo-responsive hydrogels have been developed using methylcellulose (MC) and a water-soluble chitosan oligomer (CHI-O) through dual-crosslinking. The copolymer hydrogels exhibited superior gelation rate, mechanical properties, and self-healing capabilities compared to MC hydrogels, making them suitable for cosmetic applications. Release studies of model compounds from the DAMC/CHI-O copolymer hydrogel showed promise for future applications.
CARBOHYDRATE POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Junyan Tan, Yuning Luo, Yuqiong Guo, Yue Zhou, Xinying Liao, Dingxilei Li, Xinyi Lai, Yang Liu
Summary: Natural polysaccharide-based hydrogels, especially alginate, have become a research hotspot due to their abundant source, biodegradability, biocompatibility, solubility, and modification flexibility. Various crosslinking strategies and the application progress of alginate-based hydrogels in drug delivery, wound healing, and tissue engineering are comprehensively discussed in this article. The future prospects, challenges, and development trends of alginate-based hydrogels are also explored.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Nadia Akram, Muhammad Saeed, Muhammad Usman
Summary: The texture and molecular weight of polymers significantly affect the adhesion or tack strength. In this study, waterborne polyurethane dispersions were prepared using different macrodiols and compositions of PPG, and their properties were analyzed. It was found that the variation in polymer composition and Mn had a significant impact on the tack and mechanical properties of the dispersions.
Article
Engineering, Manufacturing
Huijun Li, Yu Jun Tan, Raj Kiran, Shu Beng Tor, Kun Zhou
Summary: This study introduces two extrusion-based bioprinting approaches using a combination of cell-laden GelMA and Alg/MC, which effectively produce structures with geometric complexity while maintaining high structural integrity and cell viability. The methods involve alternate layer-by-layer printing and submerging the extrusion nozzle into a bath of Alg/MC to demonstrate improved printability and cell protection during UV exposure.
ADDITIVE MANUFACTURING
(2021)
Review
Engineering, Biomedical
Jiayue Shi, Lin Yu, Jiandong Ding
Summary: This paper outlines the recent progress of poly(ethylene glycol) (PEG)-based biodegradable thermosensitive hydrogels in the biomedical field, emphasizing their potential applications in drug release and cell growth. Thermosensitive hydrogels with designed and regulated properties exhibit excellent biocompatibility and degradability, providing a demonstration for the design of new thermogelling systems.
ACTA BIOMATERIALIA
(2021)
Review
Biochemistry & Molecular Biology
Yuning Luo, Junyan Tan, Yue Zhou, Yuqiong Guo, Xinying Liao, Li He, Dingxilei Li, Xinxin Li, Yang Liu
Summary: Hyaluronic acid (HA) is a natural polysaccharide with excellent biocompatibility and moisturizing effect, which can affect angiogenesis, inflammation, and cell behavior. HA-based hydrogels formed by physical or chemical crosslinking strategies have both the physiological function of HA and the skeleton function of hydrogel. However, natural HA-based hydrogels have limitations such as insufficient mechanical strength and susceptibility to degradation. Researchers have developed various HA-based multifunctional hydrogels with notable properties by modifying the structure, using novel crosslinking strategies, and introducing reactive molecules. These hydrogels have extended the application scope in anticancer drug delivery, cartilage repair, three-dimensional cell culture, skin dressing, and other fields.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Hao Li, Liujun Pei, Hongjuan Zhang, Zhiwen Wang, Muhammad Asad Saleem, Omer Kamal Alebeid, Jiping Wang
Summary: Research has shown that reducing the oligomer content in polyester fibers in a silicone waterless dyeing system can improve the dyeing effect of polyester and enhance dyeing quality.
Article
Materials Science, Multidisciplinary
Pawel Peczkowski, Maciej Luszczek, Elzbieta Szostak, Naveen Kumar Chogondahalli Muniraju, Anna Krzton-Maziopa, Lukasz Gondek
Summary: This paper reports comprehensive studies of the electronic properties of Ba(1-x)K(x)Bi(1-y)REyO(3) bismuth perovskites (REBKBO, RE = Y , La or Pr), showing that these materials can have their electronic properties tailored by doping, with significant differences observed in the spectrum of PrBKBO due to the magnetic contribution of Pr3+ multiplet. A negative magnetocaloric effect was observed below 30 K, highlighting the peculiar properties of these materials.
Article
Polymer Science
Beata Niemczyk-Soczynska, Pawel Sajkiewicz, Arkadiusz Gradys
Summary: This study explains the mechanism of gelation in methylcellulose (MC) through differential scanning calorimetry (DSC), and finds that gelation is a multistep reversible thermal process. Three endotherms were observed during heating for low MC concentrations, which provides new insights compared to previous research.
Article
Multidisciplinary Sciences
Magdalena M. Mrokowska, Anna Krzton-Maziopa
Summary: This paper presents a dataset on the settling behavior of solid spheres and disks in shear-thinning and viscoelastic aqueous solutions of xanthan gum with sodium chloride addition. The dataset includes the position of the particles in time and enables the evaluation of settling velocity. Rheological measurements were carried out to assess flow properties and viscoelasticity. The dataset can be useful in various areas of fluid mechanics and rheology.
Review
Biochemistry & Molecular Biology
Olga Urbanek, Maryla Moczulska-Heljak, Mikolaj Wrobel, Andrzej Mioduszewski, Dorota Kolbuk
Summary: Based on the analysis of the PubMed database, it was found that there is a high interest in collagen for ACL graft development and an increasing interest in hybrid grafts. The development of biodegradable and nonbiodegradable grafts is relatively balanced, and there is a limited number of clinical trials. Many studies focus on specific details and fundamental science, while only a few suggest the possibility of creating healthy tissue. Grafts exhibit a wide range of mechanical properties due to polymer types and graft morphology. Most of the research is in the in vitro stage and uses non-certificated polymers, which delays the introduction of medical devices to the market. Scientific concerns and official regulations also restrict the immediate introduction of artificial grafts to the market.
Article
Polymer Science
Michael J. Silva, Yasmin J. Dias, Angelika Zaszczynska, Dorota Kolbuk, Tomasz Kowalczyk, Pawel L. Sajkiewicz, Alexander L. Yarin
Summary: This study developed a bio-nanocomposite fibrous mat based on natural rubber, bioglass particles, and cellulose nanowhiskers, which exhibited excellent mechanical properties, biocompatibility, and bioactivity. The incorporation of bioglass particles and cellulose nanowhiskers significantly improved the ultimate mechanical properties of the fibrous membranes. The fibrous mats promoted cellular growth and showed promise for tissue engineering applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Materials Science, Composites
Michael J. Silva, Yasmin J. Dias, Angelika Zaszczynska, Jaqueline Rojas Robles, Jeremiah Abiade, Tomasz Kowalczyk, Dorota Kolbuk, Pawel L. Sajkiewicz, Alexander L. Yarin
Summary: The solution blow spinning technique was used to fabricate a new biocomposite fibrous mat consisting of natural rubber (NR) and polyhydroxybutyrate (PHB) bioblend, with various loads of 45S5 bioglass (BG) particles. The addition of PHB resulted in improved fiber formation and a reduction in their diameter. The NR-PHB/BG biocomposites exhibited a lower stage i degradation peak compared to pure PHB, possibly due to the surface location of PHB in the fibers. The NR-PHB/BG biocomposites possessed increased stiffness and enhanced cell growth, showing great promise for tissue engineering applications.
POLYMER COMPOSITES
(2023)
Article
Pharmacology & Pharmacy
Mohamed S. El-Okaily, Amany A. Mostafa, Judyta Dulnik, Piotr Denis, Pawel Sajkiewicz, Azza A. Mahmoud, Reham Dawood, Amr Maged
Summary: Nanofiber membranes made of polycaprolactone and bioactive glass nanoparticles were prepared using electrospinning. The incorporation of bioactive glass increased the crystallinity of polycaprolactone, and nanofibers containing 5% bioactive glass showed the best mechanical properties. Atorvastatin-loaded nanofibers with a 10% coating polymer exhibited gradual drug release and promoted wound closure in human skin fibroblast cells.
Article
Materials Science, Biomaterials
Altangerel Amarjargal, Zahra Moazzami Goudarzi, Olga Cegielska, Arkadiusz Gradys, Dorota Kolbuk, Bartlomiej Kalaska, Anna Ruszczynska, Pawel Sajkiewicz
Summary: This study presents a facile approach for designing nanofibrous scaffolds with enhanced antibacterial activity to treat chronic diabetic wounds. The 3D scaffold demonstrated sustained release of antimicrobial agent and showed excellent biocompatibility, promoting wound healing and skin repair.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Beata Niemczyk-Soczynska, Dorota Kolbuk, Grzegorz Mikulowski, Iwona A. Ciechomska, Pawel Sajkiewicz
Summary: This research developed a smart thermosensitive injectable hydrogel system using a combination of methylcellulose and agarose, with short electrospun bioactive PLLA/laminin fibers as a scaffold. The scaffold exhibited ECM-mimicking morphology and chemical composition, providing a favorable environment for cell adhesion, proliferation, and differentiation. The hydrogel showed shear-thinning behavior and demonstrated excellent injectability with a high amount of loaded fibers. Biological studies confirmed the non-toxic nature of the composite material and its suitability for tissue engineering and 3D tumor culture models.
Article
Chemistry, Multidisciplinary
Beata Niemczyk-Soczynska, Arkadiusz Gradys, Dorota Kolbuk, Anna Krzton-Maziopa, Piotr Rogujski, Luiza Stanaszek, Barbara Lukomska, Pawel Sajkiewicz
Summary: In situ crosslinked materials, such as methylcellulose (MC) hydrogel, have attracted considerable interest in both scientific and industrial research. However, the slow crosslinking rate of MC alone limits its application in tissue engineering. One approach to overcome this limitation is blending MC with agarose (AGR), which accelerates the beginning of MC crosslinking. The resulting hydrogel system shows excellent mechanical and biological properties and has potential for the design of innovative scaffold/cell delivery systems in tissue engineering applications.
Article
Chemistry, Multidisciplinary
Oliwia Jeznach, Dorota Kolbuk, Mateusz Marzec, Andrzej Bernasik, Pawel Sajkiewicz
Summary: This study investigated the impact of reaction parameters on the properties of electrospun fibers and cell response through aminolysis. The concentration of NH2 groups increased with reaction time and concentration, and different polymers required different conditions. Aminolysis was not limited to the surface and resulted in global molecular weight reduction. Despite minimal changes in water contact angle, aminolysis improved cell shape.