期刊
BLOOD
卷 129, 期 7, 页码 811-822出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2016-09-670224
关键词
-
类别
资金
- Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute
- National Health Service Blood and Transplant
- Marie Curie Career Integration Grant from Horizon [H2020-MSCA-IF-2015-708411, ERC-2014-CoG-64765]
Research in the last few years has revealed a sophisticated interaction network between multiple bone marrow cells that regulate different hematopoietic stem cell (HSC) properties such as proliferation, differentiation, localization, and self-renewal during homeostasis. These mechanisms are essential to keep the physiological HSC numbers in check and interfere with malignant progression. In addition to the identification of multiple mutations and chromosomal aberrations driving the progression of myeloid malignancies, alterations in the niche compartment recently gained attention for contributing to disease progression. Leukemic cells can remodel the niche into a permissive environment favoring leukemic stem cell expansion over normal HSC maintenance, and evidence is accumulating that certain niche alterations can even induce leukemic transformation. Relapse after chemotherapy is still amajor challenge during treatment of myeloid malignancies, and cure is only rarely achieved. Recent progress in understanding the nicheimposed chemoresistancemechanisms will likely contribute to the improvement of current therapeutic strategies. This article discusses the role of different niche cells and their stage-and disease-specific roles during progression of myeloid malignancies and in response to chemotherapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据