Article
Hematology
Simon J. Stanworth, Andrew D. Mumford
Summary: Neonatal thrombocytopenia is a common abnormality in babies admitted to neonatal intensive care units, with various potential causes including bacterial sepsis, viral infection, and genetic disorders. Accurate diagnosis is crucial for assessing adverse events and selecting appropriate treatments, such as platelet transfusion. Recent advances in genomic technology and clinical trials have influenced the landscape of diagnosis and management, with an increasing emphasis on judicious and restricted use of platelet transfusions.
Article
Pediatrics
Timothy M. Bahr, Thomas R. Christensen, Erick Henry, Mark Astin, Sarah J. Ilstrup, Robin K. Ohls, Robert D. Christensen
Summary: The objective of this study was to evaluate whether implementing more restrictive neonatal intensive care unit (NICU) platelet transfusion guidelines was associated with a reduction in the number of NICU patients receiving a platelet transfusion without adverse effects. The study found that implementing more restrictive guidelines did not significantly reduce the number of neonates receiving a platelet transfusion, but did lower the average platelet count triggering a transfusion.
JOURNAL OF PEDIATRICS
(2023)
Article
Medicine, General & Internal
Xiao-xiao Li, Guan-ru Wang, Chao Li, Na He, Peng Yao, Yin-chu Cheng, Chu-hui Wang, Qing-gang Ge, Min Yi, Zong-yu Wang, Lu-wen Shi, Rong-sheng Zhao
Summary: Thrombocytopenia can have severe consequences in critically ill patients, with drug-induced thrombocytopenia (DITP) being an important factor. In this case, severe thrombocytopenia during ICU hospitalization was likely associated with vancomycin. By understanding the process of identifying DITP and reviewing clinical studies, a risk alert for vancomycin-related severe hematotoxicity should be considered.
FRONTIERS IN MEDICINE
(2022)
Review
Hematology
Alessandro Casini, Philippe de Moerloose
Summary: Congenital dysfibrinogenemia is a disorder caused by structural changes in fibrinogen, leading to bleeding tendencies and thrombosis. Most patients are asymptomatic at diagnosis and genetic testing is needed for confirmation. Treatment involves fibrinogen supplementation and the use of antifibrinolytic agents in certain clinical settings.
Review
Health Care Sciences & Services
Jean-Philippe Rigaud, Fiona Ecarnot, Jean-Pierre Quenot
Summary: In this paper, the ethical issues surrounding information provision and consent in the intensive care unit are reviewed. The obligations of physicians in treating vulnerable patients are discussed, along with the challenges of providing clear information in critical illness situations. The specificities of intensive care, including the selection of a contact person and the considerations for the family of critically ill patients, are explored. Additionally, the cases of consent to research and patients who refuse care are discussed.
Article
Hematology
Giovanni Palladini, Giampaolo Merlini
Summary: The treatment of AL amyloidosis is a challenge for hematologists, but early diagnosis and personalized therapy can improve patient outcomes.
Article
Critical Care Medicine
Reina Suzuki, Shigehiko Uchino, Yusuke Sasabuchi, Alan Kawarai Lefor, Masamitsu Sanui
Summary: Dopamine is widely used in Japan to treat patients with shock, but high dose dopamine use may have detrimental effects.
Article
Medicine, General & Internal
Denise Battaglini, Lorenzo Ball, Chiara Robba, Simona Maiani, Iole Brunetti, Luana Benedetti, Lucio Castellan, Gianluigi Zona, Giampaola Pesce, Patricia R. M. Rocco, Paolo Pelosi
Summary: This study reports on five patients who experienced severe adverse reactions following COVID-19 vaccination. The patients had different clinical manifestations depending on the type of vaccine administered. All patients required admission to the ICU, highlighting the importance of prompt evaluation of symptoms and personalized clinical management for improved outcomes.
FRONTIERS IN MEDICINE
(2022)
Article
Nursing
Leah B. Chapman, Kathleen E. Kopp, Michael G. Petty, Jodi L. A. Hartwig, Kathryn M. Pendleton, Kimberly Langer, Sonia J. Meiers
Summary: Implementing collaborative patient care rounds in the intensive care unit can increase practice consistency with common considerations and improve nursing perceptions of collaboration.
INTENSIVE AND CRITICAL CARE NURSING
(2021)
Article
Medicine, General & Internal
Jiqian Xu, Xiaobo Yang, Zheng Lv, Ting Zhou, Hong Liu, Xiaojing Zou, Fengsheng Cao, Lu Zhang, Boyi Liu, Wei Chen, Yuan Yu, Huaqing Shu, Shiying Yuan, Ming Hu, Chaolin Huang, You Shang
Summary: This study found that thrombocytopenia, vasopressor use, and corticosteroid treatment were significantly associated with an increased risk of incident IPA in COVID-19 patients admitted to ICUs. The occurrence of CAPA may lead to longer ICU stays and higher 180-day mortality compared to those without CAPA.
FRONTIERS IN MEDICINE
(2021)
Article
Critical Care Medicine
Geoffroy Hariri, Vincent Belossi, Louis Perol, Louai Missri, Paul Gabarre, Vincent Bonny, Tomas Urbina, Jean-Luc Baudel, Bertrand Guidet, Jeremie Joffre, Eric Maury, Guillaume Dumas, Hafid Ait-Oufella
Summary: This study found that plasma urea levels and the presence of skin purpura are helpful in identifying thrombocytopenic patients at high-risk of bleeding during ICU stay.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jeremy M. Kahn, Jonathan G. Yabes, Leigh A. Bukowski, Billie S. Davis
Summary: A retrospective cohort study was conducted to determine the relationship between intensivist-to-patient ratios and mortality among ICU patients. The study found no association between the intensivist-to-patient ratio and mortality, suggesting that high intensivist caseloads may not affect ICU patient mortality.
INTENSIVE CARE MEDICINE
(2023)
Review
Hematology
Robert A. Brodsky
Summary: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare complement-mediated hemolytic anemia with diverse manifestations, requiring differentiated treatment approaches; terminal complement inhibition is effective for intravascular hemolysis treatment but not bone marrow failure; novel complement inhibitors under clinical development show promising prospects for future applications.
Article
Hematology
Efstathios Kastritis, Evangelos Terpos, Meletios A. Dimopoulos
Summary: Multiple myeloma is an incurable disease, and patients require long-term treatment. Despite the introduction of new therapies, drug resistance remains the most critical factor in choosing the appropriate treatment. Currently, three-drug regimens are the standard approach for managing relapsed disease.
Review
Hematology
Sigbjorn Berentsen
Summary: Significant progress has been made in the treatment of CAD in recent decades, with recommendations mainly based on nonrandomized trials and personal experience due to the lack of comparative trials. Individualized treatment options tailored to patients' symptoms and disease characteristics are crucial to avoid ineffective therapies.