Article
Chemistry, Multidisciplinary
Leonard Siebert, Eder Luna-Ceron, Luis Enrique Garcia-Rivera, Junsung Oh, JunHwee Jang, Diego A. Rosas-Gomez, Mitzi D. Perez-Gomez, Gregor Maschkowitz, Helmut Fickenscher, Daniela Oceguera-Cuevas, Carmen G. Holguin-Leon, Batzaya Byambaa, Mohammad A. Hussain, Eduardo Enciso-Martinez, Minsung Cho, Yuhan Lee, Nebras Sobahi, Anwarul Hasan, Dennis P. Orgill, Yogendra Kumar Mishra, Rainer Adelung, Eunjung Lee, Su Ryon Shin
Summary: Advanced wound scaffolds integrating active substances have recently gained attention for potential treatment of chronic wounds. The development of a 3D printed hydrogel patch encapsulating VEGF and decorated with t-ZnO microparticles allows for multiple functions to be combined and smart release achieved through chemical modification and photoactivation. This method also enhances the elastic modulus and degradation behavior of the composite hydrogels while maintaining antibacterial properties.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Patricia Monks, Jacek K. Wychowaniec, Eoin McKiernan, Shane Clerkin, John Crean, Brian J. Rodriguez, Emmanuel G. Reynaud, Andreas Heise, Dermot F. Brougham
Summary: This study demonstrates the use of multifunctional nanocomposites based on magnetic hydrogels for heat generation under alternating magnetic field irradiation, as well as the manipulation of spatial heat distribution through 3D printing. The research discusses the dependence of heat induction on various factors, such as particle concentration, gel volume, exposed surface area, and environmental conditions, and explores the potential applications in responsive scaffold remodeling and cargo release for regenerative medicine.
Article
Chemistry, Multidisciplinary
Francesca Cadamuro, Susanna Sampaolesi, Giulia Bertolini, Luca Roz, Francesco Nicotra, Laura Russo
Summary: This study presents the generation of 3D-bioprintable and biocompatible hydrogels based on elastin and hyaluronic acid. The hydrogels were crosslinked using a biocompatible click reaction between maleimide and thiol, allowing for the use of living cells. The hydrogels were tested for their biocompatibility, swelling capacity, and printability, and were found to support the growth and proliferation of lung fibroblasts, bronchial epithelial cells, and endothelial cells.
Article
Materials Science, Multidisciplinary
Eva Baur, Matteo Hirsch, Esther Amstad
Summary: This study presents a method to introduce controllable open pores into hydrogels while maintaining their mechanical properties. The hydrogels are 3D printable and the pore size can be tuned from nanometers to centimeters. This work allows for size-selective infiltration of different substances at specific locations.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Materials Science, Multidisciplinary
Mengfan Zhang, Xiaotong Peng, Yansheng Huang, Kai Li, Jing Zhang, Pu Xiao, Yingshan Zhou
Summary: Photopolymerizable hydrogels based on maleic chitosan (MCS) and thiolated sodium hyaluronate (SHHA) were designed. The Michael addition between MCS and SHHA improved the viscosity of the mixed solution, facilitating the 3D printing process and forming a stable covalent network through photopolymerization. The rheological properties, swelling behaviors, microstructure, and in vitro degradation of the hydrogels were controlled by adjusting the molar ratio of the thiol group and acrylate group. MCS/SHHA hydrogel scaffolds with good accuracy and enhanced structural stability were prepared using extrusion-based 3D printing and photopolymerization technology. The hydrogels exhibited excellent cytocompatibility and supported cell adherence, making them potential materials for tissue engineering applications.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Polymer Science
Ayca Aydogdu Emir, Sevil Cikrikci Erunsal
Summary: This study demonstrates the potential of using light-induced 3D printing with natural photoinitiators and antioxidants for personalized printing of gels. The 3D printed gels showed high printability and retained antioxidant activity. The release of the drug was affected by the geometry of the printed gels.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Cristiana F. Sousa, Catarina A. Saraiva, Tiago R. Correia, Tamagno Pesqueira, Sonia G. Patricio, Maria Isabel Rial-Hermida, Joao Borges, Joao F. Mano
Summary: An alternative approach to bioengineer 3D vascularized constructs has been proposed, embedding bioinstructive 3D multilayered microchannels in photopolymerizable hydrogels, showing promise for tissue engineering and regenerative medicine by improving vascular network functionality.
Review
Engineering, Multidisciplinary
Xin Ning Zhang, Qiang Zheng, Zi Liang Wu
Summary: This paper reviews the recent progress in 3D printing of tough hydrogels and their applications. It provides an overview of the advantages and requirements of tough hydrogel systems for specific 3D printing technologies, and summarizes the network structures, mechanical performances, toughening mechanisms, and representative applications of the printed tough hydrogels. It also discusses the recent advances in 4D printing of tough hydrogels as a prospective direction for soft actuators and robots.
COMPOSITES PART B-ENGINEERING
(2022)
Review
Pharmacology & Pharmacy
Lidya Abune, Yong Wang
Summary: Affinity hydrogels offer the potential to stably retain and sustainably release proteins through a binding reaction, different from traditional hydrogels. Future research may focus on developing intelligent affinity hydrogels to mimic human tissue properties and release single or multiple proteins on demand in response to environmental stimuli.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Polymer Science
Sheila Maiz-Fernandez, Leyre Perez-alvarez, Unai Silvan, Jose Luis Vilas-Vilela, Senentxu Lanceros-Mendez
Summary: This study explores the limitations of hydrogel-based inks in 3D printing and successfully achieves direct 3D printing of chitosan structures using NaOH as a gelling media for biomedical and tissue engineering applications. The printed hydrogels exhibit good morphology, chemical interactions, swelling, and mechanical and rheological properties. The influence of printing parameters and cytocompatibility are also analyzed. In addition, the printed gels show electro-induced motion, highlighting their potential as soft actuators and active scaffolds.
Article
Chemistry, Multidisciplinary
Xiaoya Ding, Yunru Yu, Luoran Shang, Yuanjin Zhao
Summary: With the assistance of histidine, low-viscosity GO mixed polymer solutions can be prepared as printable inks through microfluidic 3D printing technique, forming hydrogel microfibers in histidine solutions. These hydrogel fibers support cell survival, exhibit excellent electrical conductivity, and can sense motion changes, offering a new option for the design and application of 3D printable aqueous GO inks in various fields.
Article
Chemistry, Multidisciplinary
Hamed Ramezani, Seyyed Mohammad Mirjamali, Yong He
Summary: This study used multiphysics simulation to predict the printability of chitosan hydrogel in extrusion-based 3D printing. The impact of different velocities and viscosities was investigated, and the model validation confirmed the high-quality printing outcomes. The results provide information for determining the optimum parameters for printing chitosan-based ink with high quality.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Matteo Hirsch, Alvaro Charlet, Esther Amstad
Summary: Many soft natural tissues possess unique mechanical properties achieved through complex interactions between structure and composition. To address the lack of control in soft synthetic materials, a novel 3D printing approach called double network granular hydrogels (DNGHs) has been introduced. These DNGHs are stiff enough to support high tensile loads and significantly tougher than pure polymeric networks. This ink allows for the printing of strong and tough objects with high shape fidelity, opening up new possibilities for soft robotic applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Ji Liu, James Garcia, Liam M. M. Leahy, Rijian Song, Daragh Mullarkey, Ban Fei, Adrian Dervan, Igor V. V. Shvets, Plamen Stamenov, Wenxin Wang, Fergal J. J. O'Brien, Jonathan N. N. Coleman, Valeria Nicolosi
Summary: Direct ink writing (DIW) is a viable 3D printing technology for custom production of functional conductive hydrogels. This study demonstrates a highly 3D printable PEDOT:PSS-based ink made from commercially accessible raw materials. The 3D-printed hydrogel exhibits high electrical conductivity, outstanding elasticity, stability in water, electromagnetic interference shielding, sensing capabilities, and biocompatibility, showing potential for implantable and tissue engineering applications. The fabrication strategy opens up new opportunities to create multifunctional hydrogels with custom features and expand the applications of hydrogel materials.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Gang Ge, Qian Wang, Yi-Zhou Zhang, Husam N. Alshareef, Xiaochen Dong
Summary: In the development of flexible electronics, particularly hydrogel-based stretchable ionotronic devices, researchers are exploring the potential of 3D printing for its excellent patterning capability and design complexity. Despite facing challenges in balancing printability, conductivity, and stretchability, this review offers guidelines on utilizing 3D printing to create high-performance devices, focusing on material considerations and printing quality. Various 3D printing methods for hydrogels and design principles are discussed, along with the potential applications in flexible sensors, soft robots, and other devices.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Biomedical
Xuanyi Ma, Sukriti Dewan, Justin Liu, Min Tang, Kathleen L. Miller, Claire Yu, Natalie Lawrence, Andrew D. McCulloch, Shaochen Chen
ACTA BIOMATERIALIA
(2019)
Article
Engineering, Biomedical
Jie Tao, Jiumeng Zhang, Ting Du, Xin Xu, Xianming Deng, Shaochen Chen, Jinlu Liu, Yuwen Chen, Xuan Liu, Meimei Xiong, Yi Luo, Hao Cheng, Jian Mao, Ludwig Cardon, Maling Gou, Yuquan Wei
ACTA BIOMATERIALIA
(2019)
Article
Chemistry, Multidisciplinary
Pengrui Wang, David B. Berry, Zhaoqiang Song, Wisarut Kiratitanaporn, Jacob Schimelman, Amy Moran, Frank He, Brian Xi, Shengqiang Cai, Shaochen Chen
ADVANCED FUNCTIONAL MATERIALS
(2020)
Review
Chemistry, Multidisciplinary
Claire Yu, Jacob Schimelman, Pengrui Wang, Kathleen L. Miller, Xuanyi Ma, Shangting You, Jiaao Guan, Bingjie Sun, Wei Zhu, Shaochen Chen
Article
Chemistry, Multidisciplinary
Min Tang, Jeremy N. Rich, Shaochen Chen
Summary: 3D-bioprinted GBM and BBB models offer promising systems and biomimetic alternatives to traditional models for more reliable mechanistic studies and preclinical drug screenings, which may eventually accelerate the drug development process for GBM.
ADVANCED MATERIALS
(2021)
Review
Toxicology
Yi Xiang, Kathleen Miller, Jiaao Guan, Wisarut Kiratitanaporn, Min Tang, Shaochen Chen
Summary: This article introduces the application of 3D bio-printing technology in modeling complex human tissues. By controlling factors such as cell population, extracellular matrix, microenvironment, and microstructure, 3D bio-printing technology plays an important role in pharmacology and toxicology research. The article also mentions recent advancements in printing techniques and bio-ink sources, as well as specialized research in the fields of cancer, heart, muscle, and liver.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Daniel Wangpraseurt, Shangting You, Yazhi Sun, Shaochen Chen
Summary: 3D bioprinting has revolutionized tissue engineering and is now also being used for the fabrication of living tissues powered by microorganisms. These biomimetic 3D living materials have great potential in biomedicine, biotechnology, living device fabrication, and ecosystem restoration.
TRENDS IN BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Debika Datta, Elliot L. L. Weiss, Daniel Wangpraseurt, Erica Hild, Shaochen Chen, James W. W. Golden, Susan S. S. Golden, Jonathan K. K. Pokorski
Summary: In this study, a cyanobacterial biocomposite material capable of producing multiple functional outputs in response to an external chemical stimulus was fabricated using 3D printing. The advantages of utilizing additive manufacturing techniques in controlling the shape of the material were demonstrated. Genetically engineered cyanobacteria were integrated into 3D-printed designs to create programmable photosynthetic biocomposite materials capable of producing functional outputs such as bioremediation.
NATURE COMMUNICATIONS
(2023)
Article
Polymer Science
John J. Warner, Pengrui Wang, William M. Mellor, Henry H. Hwang, Ji Hoon Park, Sang-Hyun Pyo, Shaochen Chen
