Article
Multidisciplinary Sciences
Hisayo Nishida-Fukuda, Keizo Tokuhiro, Yukio Ando, Hiroaki Matsushita, Morimasa Wada, Hiromitsu Tanaka
Summary: HASPIN, a kinase regulating mitosis, is associated with tumor malignancy and poor survival in various cancers. CHR-6494, a potent HASPIN inhibitor, showed antiproliferative effects in breast cancer cell lines and mammary epithelial cells, suggesting potential as an anticancer agent in breast cancer patients.
Article
Cell Biology
Yingying Gao, Bin Ma, Yifan Li, Xiangyu Wu, Shifeng Zhao, Huiping Guo, Yiwei Wang, Lihua Sun, Jing Xie
Summary: The study shows that Haspin is essential for maintaining a balanced ratio of asymmetric cell division (ACD) in mouse embryonic stem cells (mESCs). Knockout of Haspin leads to an increased ratio of ACD. This imbalance is rescued by overexpression of Wnt5a, suggesting that Haspin regulates ACD through the Wnt5a pathway.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Li-Xia Peng, Ming-Dian Wang, Ping Xie, Jun-Ping Yang, Rui Sun, Li-Sheng Zheng, Yan Mei, Dong-Fang Meng, Xing-Si Peng, Yan-Hong Lang, Yuan-Yuan Qiang, Chang-Zhi Li, Liang Xu, Zhi-Jie Liu, Ling-Ling Guo, De-Huan Xie, Di-Tian Shu, Si-Ting Lin, Fei-Fei Luo, Bi-Jun Huang, Chao-Nan Qian
Summary: Nasopharyngeal carcinoma (NPC) originates in the nasopharyngeal epithelium and is known for its high metastatic rate. The study found elevated expression of LACTB in tumor tissues of NPC, which correlated with poorer patient survival. The role of LACTB in promoting NPC metastasis is dependent on the activation of ERBB3/EGFR-ERK signaling pathway.
Article
Cell Biology
Hiromitsu Tanaka, Hisayo Nishida-Fukuda, Morimasa Wada, Keizo Tokuhiro, Hiroaki Matsushita, Yukio Ando
Summary: It has been discovered that the HASPIN inhibitor CHR-6494 can suppress the growth of pancreatic cancer cells, making it a potential treatment for pancreatic cancer.
Article
Chemistry, Medicinal
Hualong Mo, Ruiqiang Zhang, Yajun Chen, ShuTing Li, Yao Wang, Wenbo Zou, Qiman Lin, Deng-Gao Zhao, Yarong Du, Kun Zhang, Yan-Yan Ma
Summary: Compound 21 is an effective anticancer agent that inhibits tumor growth by inhibiting autophagy and inducing cell apoptosis.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
K. N. Chidambara Murthy, G. K. Jayaprakasha, Stephen Safe, Bhimanagouda S. Patil
Summary: The study demonstrated the cytotoxic effects of limonoids on human pancreatic cancer cells by modulating genes involved in proliferation and survival.
Article
Chemistry, Medicinal
Aitor Rizo-Liendo, Inigo Arberas-Jimenez, Endika Martin-Encinas, Ines Sifaoui, Maria Reyes-Batlle, Javier Chao-Pellicer, Concepcion Alonso, Francisco Palacios, Jose E. Pinero, Jacob Lorenzo-Morales
Summary: The study found that naphthyridines fused with chromenes or chromenones have good anti-Naegleria activity and may induce programmed cell death in the amoebae, indicating their potential as therapeutic agents against PAM.
Article
Biotechnology & Applied Microbiology
Qian Xu, Feimei Zhu, Yixuan Pan, Yanlin Ren, Jingyu Li, Ning Huang, Keyun Liu, Yi Wang
Summary: Histone H3 is linked to carcinogenesis, while free histones in cells can induce immune responses and cell death. This study connected cell-penetrating peptide HIV Tat to a histone H3 fragment and found that it caused cell death in lung and breast cancer cells. Mechanistic studies showed that the Tat-conjugated histone peptides activated MAPK signaling and ROS production. Inhibition of AP-1 and ROS reduced the cytotoxicity of the peptide. These results suggest that Tat-conjugated H3 peptides have the potential to be antitumor agents by inducing cell death through increased cellular stress response.
HUMAN GENE THERAPY
(2023)
Article
Endocrinology & Metabolism
Yiyin Zhang, Zhengze Huang, Jiaxi Cheng, Haoqi Pan, Tianyu Lin, Xuqiu Shen, Wenchao Chen, Qi Chen, Chenhui Gu, Qijiang Mao, Yuelong Liang
Summary: This study demonstrates the potential of using human platelet vesicles as a drug delivery system to enhance the effectiveness of RSL-3 in treating pancreatic ductal adenocarcinoma. By deteriorating tumor vessels and inducing ferroptosis, this combination therapy shows promise in improving the outcome of PDAC.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Katerina Soupsana, Eleftheria Karanika, Fani Kiosse, Anastasia Christogianni, Yiorgos Sfikas, Pantelis Topalis, Anna Batistatou, Zoi Kanaki, Apostolos Klinakis, Anastasia S. Politou, Spyros Georgatos
Summary: The kinase haspin plays a critical role in phosphorylating histone H3 during mitosis, affecting chromosome alignment and male gametogenesis. While the dosage of haspin impacts the expression levels of genes involved in male gametogenesis, its absence or overexpression does not affect the division, expansion, and differentiation of mouse embryonic stem cells. Furthermore, the unique spatio-temporal pattern of histone H3 modifications suggests a role for haspin in the epigenetic control of spermiogenesis.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Derek K. Cheng, Tobiloba E. Oni, Jennifer S. Thalappillil, Youngkyu Park, Hsiu-Chi Ting, Brinda Alagesan, Nadia V. Prasad, Kenneth Addison, Keith D. Rivera, Darryl J. Pappin, Linda Van Aelst, David A. Tuveson
Summary: The study identified protein interactors of active KRAS in PDAC cells using proximity labeling, revealing that RSK1 selectively interacts with membrane-bound KRASG12D through NF1 and SPRED2. It was found that membrane RSK1 mediates negative feedback on WT RAS signaling and impedes the proliferation of pancreatic cancer cells upon the ablation of mutant KRAS in PDAC, highlighting the role of WT RAS signaling in promoting adaptive resistance to mutant KRAS-specific inhibitors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Haitao Xu, Zhichang Ba, Chunxun Liu, Xuefeng Yu
Summary: This study found that LncRNA DLEU1 recruited SMYD2 to upregulate APOC1 expression, thus boosting gastric cancer cell proliferation and glycolysis.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hiroyuki Inoue, Shun-ichiro Asahara, Yumiko Sugiura, Yukina Kawada, Asuka Imai, Chisako Hara, Ayumi Kanno, Maki Kimura-Koyanagi, Yoshiaki Kido
Summary: In this study, the role of histone deacetylases (HDACs) in regulating insulin signaling in pancreatic beta cells was examined. Findings showed that HDAC6 plays an important role in downregulating insulin signaling in pancreatic beta cells and its expression is decreased in a type 2 diabetes mouse model. This suggests that targeting HDAC6 could be a valuable approach for the treatment of type 2 diabetes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Birgit Lohberger, Heike Kaltenegger, Nicole Eck, Dietmar Glaenzer, Patrick Sadoghi, Andreas Leithner, Rudolf Bauer, Nadine Kretschmer, Bibiane Steinecker-Frohnwieser
Summary: This study investigated the effects of shikonin derivatives on inflammation, MMP expression, and MAPK signaling in healthy and osteoarthritis chondrocytes. The results demonstrate that shikonin can reduce the inflammatory response and affect downstream regulation, potentially providing a therapeutic approach for osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Haohao Wang, Di Wu, Chunyu Gao, Hongbo Teng, Yan Zhao, Zhongmei He, Weijia Chen, Ying Zong, Rui Du
Summary: In this study, 70 new seco-lupane triterpene derivatives were designed, synthesized, and evaluated for their anticancer activities. Compound 21 showed the strongest inhibitory effect on HepG2 cells and could regulate the cell death process. It has the potential to become an effective new drug for the treatment of hepatocellular carcinoma.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)