Article
Critical Care Medicine
Sarah L. Gorst, Nina Seylanova, Susanna R. Dodd, Nicola L. Harman, Margaret O'Hara, Caroline B. Terwee, Paula R. Williamson, Dale M. Needham, Daniel Munblit, Timothy R. Nicholson
Summary: Post-COVID-19 condition is a complex and poorly understood disorder, and it is important to establish core outcomes and measurement instruments for its evaluation. Through an international consensus study, certain measurement instruments have been identified, but further research and evaluation are needed.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Critical Care Medicine
Richard K. Albert
Summary: This Perspective summarizes the mechanisms by which continuous volume-targeted ventilation (CVTV) causes ventilator-induced lung injury (VILI) by affecting surfactant function.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Annia F. Schreiber, Jacopo Garlasco, Martin Urner, Amanda McFarlan, Andrew Baker, Andrea Rigamonti, Jeffrey M. Singh, Demetrios James Kutsogiannis, Laurent J. Brochard
Summary: This study aims to investigate predictors of weaning outcomes for patients with traumatic spinal cord injury (tSCI) and develop and validate a prognostic model and score for weaning success. Factors associated with weaning success were identified and a prediction score for weaning success at ICU discharge was derived and found to have better predictive ability than the Injury Severity Score (ISS). In conclusion, readily available admission characteristics can reasonably predict weaning success and help prognostication for tSCI patients.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Critical Care Medicine
Ari Moskowitz, Matthew S. Shotwell, Kevin W. Gibbs, Michelle Harkins, Yves Rosenberg, James Troendle, Lisa H. Merck, D. Clark Files, Marjolein de Wit, Kristin Hudock, B. Taylor Thompson, Michelle N. Gong, Adit A. Ginde, David J. Douin, Samuel M. Brown, Eileen Rubin, Meghan Morrison Joly, Li Wang, Christopher J. Lindsell, Gordon R. Bernard, Wesley H. Self, Sean P. Collins, Matthew W. Semler
Summary: Traditionally, mortality has been the primary outcome measure in acute and critical care clinical trials. However, relying solely on mortality limits the scope of trials that can be conducted. Oxygen-free days (OFDs), a novel outcome measure, combines mortality and duration of new supplemental oxygen use to assess recovery from acute lung injury in populations with high prevalence of hypoxemia and oxygen use.
Review
Physiology
Guido Musch
Summary: This review discusses four different methods to image acute lung inflammation with Positron Emission Tomography (PET), which differ in terms of the PET reporter probe, radiotracer, and the specific aspect of the inflammatory response targeted. These methods include measuring metabolic activation of inflammatory cells using 2-[F-18]fluoro-2-deoxy-D-glucose ([F-18]FDG), measuring edema and vascular permeability using H-2 O-15 and radiolabeled plasma proteins, probing expression of targets induced by inflammatory stimuli using tagged enzyme or receptor inhibitors, and developing cell-specific tracers to differentiate cell types contributing to the inflammatory response. Overall, PET imaging proves to be a versatile and quantitative tool for noninvasively measuring inflammation during acute and ventilator-induced lung injury.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cell Biology
Di Zhang, Zhi Liu, Qianqian Liu, Honghai Lan, Jinjin Peng, Xiaowei Liu, Wei Liu
Summary: This study demonstrates that TNC plays a significant role in paraquat-induced lung injury, and its function in this process is closely related to the TLR4 and TGF-beta signaling pathways.
Review
Chemistry, Multidisciplinary
Dong Liu, Mengmeng Long, Leilei Gao, Yanjun Chen, Fang Li, Yang Shi, Ning Gu
Summary: The respiratory system is crucial in vertebrate biology, but viral infections can cause severe damage. Currently, there are no effective treatments, but nanomedicine shows potential. This review provides a summary of the pathology and clinical treatments of respiratory injuries, focusing on nanomedicine formulations tested in preclinical models.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Critical Care Medicine
Benjamin Coiffard, Stephen Riegler, Michael C. Sklar, Martin Dres, Stefannie Vorona, W. Darlene Reid, Laurent J. Brochard, Niall D. Ferguson, Ewan C. Goligher
Summary: The study found that diaphragm echodensity increased in mechanically ventilated patients at the outset, and this increase in echodensity during the early course of mechanical ventilation was associated with prolonged mechanical ventilation. Moreover, both decreases and increases in diaphragm thickness were also associated with increased echodensity.
Article
Plant Sciences
Yahui Tang, Kaiyuan Chen, Zhong Xiao, Guangliang Hong, Lufeng Hu, Jianping Cai, Zhongqiu Lu
Summary: Acute lung injury (ALI) caused by paraquat (PQ) is rapidly progressing and has a high mortality rate, but there is no specific antidote. The toxicological mechanisms of PQ are not well understood, which has hindered the development of treatments against PQ exposure. In this study, we investigated the effects of PQ on lung tissues and found that PQ induced proteolytic cleavage of gasdermin E (GSDME), leading to cell death.
Review
Medicine, General & Internal
Guillaume Carteaux, Melodie Parfait, Margot Combet, Anne-Fleur Haudebourg, Samuel Tuffet, Armand Mekontso Dessap
Summary: This review details the main pathophysiological mechanisms by which the patient's respiratory effort could become deleterious, including excessive over-distension, inhomogeneous distribution of pressure variations across the lung, and increase in transvascular pressure leading to aggravated pulmonary edema. Harmful patient-ventilator interactions are also discussed, along with practical ways to detect situations at risk for P-SILI in clinical settings and personalize treatment strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Critical Care Medicine
Irene Telias, Laurent J. Brochard, Simone Gattarello, Hannah Wunsch, Detajin Junhasavasdikul, Karen J. Bosma, Luigi Camporota, Daniel Brodie, John J. Marini, Arthur S. Slutsky, Luciano Gattinoni
Summary: Treatment of respiratory failure has significantly improved since the polio epidemic in the 1950s due to the use of invasive techniques such as mechanical ventilation and extracorporeal respiratory support. However, these invasive respiratory support methods can cause substantial harm, and it is the responsibility of clinicians to minimize these risks. Increased understanding of the mechanisms of injury has led to a shift in care philosophy, focusing on minimizing harm rather than normalizing gas exchange. Lung (and diaphragm) protective ventilation strategies, including the use of extracorporeal respiratory support, are now being implemented to reduce the risks associated with excessive ventilation.
INTENSIVE CARE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Lulu Jiang, Yang Zhang, Dahao Lu, Tianfeng Huang, Keshi Yan, Wenjun Yang, Ju Gao
Summary: This study found that excessive mechanical stretch during ARDS induces the activation of Piezo1 channel and its downstream target, calpain, leading to the disassembly of endothelial adherens junctions and further facilitating lung endothelial barrier breakdown and increased vascular permeability.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Respiratory System
Masako Kawai, Erquan Zhang, Jane Chanda Kabwe, Amphone Okada, Junko Maruyama, Hirofumi Sawada, Kazuo Maruyama
Summary: In this study, rats with monocrotaline-induced pulmonary hypertension were found to have reduced damage from high tidal volume ventilation compared to normal rats. The findings suggest that structural changes in hypertensive pulmonary vasculature may protect against ventilator-induced lung injury, regardless of the type of pulmonary hypertension.
BMC PULMONARY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Chin-Kuo Lin, Tzu-Hsiung Huang, Cheng-Ta Yang, Chung-Sheng Shi
Summary: The study found that lung-recruited monocytes post-VILI are predominantly Ly6C(+low), and pulmonary VEGF decreases initially but increases significantly on days 7 and 14 after injury. There is a strong positive correlation between VEGF expression and alveolar epithelial cell proliferation, and the restoration of pulmonary VEGF by monocytes may play a crucial role in post-VILI lung repair.
Article
Physiology
Thijs A. Lilien, David M. P. Van Meenen, Marcus J. Schultz, Lieuwe D. J. Bos, Reinout A. Bem
Summary: The interest in oxygen toxicity has led to numerous studies, but there is still no consensus on the clinical impact of hyperoxia and hyperoxemia. This article explores the importance of hyperoxia-induced lung injury in current critical care practice, suggesting that it may be less important than other ventilator-related factors in patients with acute respiratory distress syndrome.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Letter
Public, Environmental & Occupational Health
Hossein Sanaei-Zadeh, Sayed Mahdi Marashi
Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology
(2016)
Letter
Medicine, General & Internal
Hossein Sanaei-Zadeh
IRANIAN RED CRESCENT MEDICAL JOURNAL
(2017)
Article
Biochemistry & Molecular Biology
Sayed Mahdi Marashi, Seyede Fatemeh Hosseini, Massood Hosseinzadeh, Muhammad Farhan Qadir, Forouzan Khodaei
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2019)
Letter
Public, Environmental & Occupational Health
Mehran Shahi, Hossein Sanaei-Zadeh
Summary: The genus Hemiscorpius of scorpions in Iran, particularly the species H. lepturus and H. acanthocercus, have been identified as among the most dangerous due to their venom causing hemoglobinuria and acute renal failure. Characteristics of H. acanthocercus include bright to dark yellow coloration, bulky pedipalps, and brownish fingers tips, with males having elongated metasoma segments than females.
JOURNAL OF ARTHROPOD-BORNE DISEASES
(2021)
Review
Transplantation
S. P. Khazraee, S. M. Marashi, M. Kaviani, N. Azarpira
INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE
(2018)
Article
Medicine, General & Internal
Hassan Solhi, Hossein Sanaei-Zadeh, Sadra Solhi, Dariush Badakhshan, Shahab Ghasemi, Bahman Sadeghi Sedeh
NATIONAL MEDICAL JOURNAL OF INDIA
(2018)
Letter
Critical Care Medicine
Maryam Vasheghani Farahani, Sayed Mahdi Marashi
INDIAN JOURNAL OF CRITICAL CARE MEDICINE
(2017)
Article
Critical Care Medicine
Vahid Shakoori, Mahsa Agahi, Maryam Vasheghani-Farahani, Sayed Mahdi Marashi
INDIAN JOURNAL OF CRITICAL CARE MEDICINE
(2016)
Letter
Emergency Medicine
Hossein Sanaei-Zadeh
Letter
Gastroenterology & Hepatology
Sayed Mahdi Marashi
INDIAN JOURNAL OF GASTROENTEROLOGY
(2016)
Article
Emergency Medicine
Hassan Solhi, Hossein Sanaei-Zadeh, Sadra Solhi, Mohammad Ali Azizi Nadian, Morteza Gharibi, Bahman Sadeghi Sedeh
OPEN ACCESS EMERGENCY MEDICINE
(2016)