Article
Multidisciplinary Sciences
Devlina Chakravarty, Shwetha Sreenivasan, Liskin Swint-Kruse, Lauren L. Porter
Summary: Although homologous protein sequences are expected to adopt similar structures, this study found that a family of bacterial response regulator proteins exhibited divergent structures in their homologous DNA-binding subunits. This structural transformation was facilitated by amino acid substitutions and likely expanded DNA-binding specificity. The approach used in this study provides a methodology to identify secondary structure switching in other protein families.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Gwendolyn Wirobski, Friederike Range, Evelien A. M. Graat, Rupert Palme, Tobias Deschner, Sarah Marshall-Pescini
Summary: Domestication has affected the social organization of dogs compared to their closest relatives, gray wolves. Wolves rely on coordinated behavior for survival, while dogs have lower dependence on conspecifics, leading to greater cohesion in wolf packs. Hormonal responses differ between wolves and dogs, with oxytocin and glucocorticoid concentrations correlated with territorial behaviors and separation from the pack observed only in wolves.
Article
Multidisciplinary Sciences
Gwendolyn Wirobski, Friederike Range, Evelien A. M. Graat, Rupert Palme, Tobias Deschner, Sarah Marshall-Pescini
Summary: Domestication has altered the social organization of dogs compared to gray wolves. Hormonal responses to territorial threats and separation from the pack differ between wolves and dogs, suggesting stronger emotional activation in wolves. This aligns with their socio-ecology and predicts greater cohesiveness in wolf packs.
Article
Geosciences, Multidisciplinary
Yixin Yu, Chenglin Gong, Dongwei Li, Puyu Liu, Yichao Li
Summary: This study examines greenhouse aggradational to progradational clinothem pairs at different time scales in the Oligocene Qikou and Eocene Dongying sags in the Bohai Bay Basin. It highlights the importance of time scales in predicting sediment dispersal to deepwater and cautions against applying sequence stratigraphy mechanically in lacustrine basins.
MARINE AND PETROLEUM GEOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Beatriz Portinha, Amaury Avril, Christian Bernasconi, Heikki Helantera, Josie Monaghan, Bernhard Seifert, Vitor C. Sousa, Jonna Kulmuni, Pierre Nouhaud
Summary: The study utilized whole-genome resequencing of two wood ant species, Formica polyctena and F. aquilonia, sampled from multiple locations to reconstruct their divergence history, revealing that divergence started in the Pleistocene with continuous asymmetrical gene flow. The research also highlighted that divergence histories reconstructed from a few individuals may be applicable at the species level, but the geographical context of chosen populations may impact estimates of gene flow between species.
Article
Biodiversity Conservation
Maria Kahlert, Bonnie Bailet, Teofana Chonova, Satu Maaria Karjalainen, Susanne C. Schneider, Kalman Tapolczai
Summary: ASVs show better correlation in environmental assessment, encouraging further study on diatom diversity and ecological preferences. The optima of ASV and morphotaxon differ slightly between streams and lakes, but are significantly correlated with each other.
ECOLOGICAL INDICATORS
(2021)
Article
Communication
Zizhong Zhang, Haixin Mu, Sida Huang
Summary: There is gender bias in gaming culture, and female players have formed online communities as safe spaces for social support. This study uses text mining to analyze female player communities on Reddit and Douban, exploring the presentation of social support and how community identity, affection, and gender-related expressions impact the social support received. The relationships are compared between Western individualist and Chinese collectivist cultures.
JOURNAL OF BROADCASTING & ELECTRONIC MEDIA
(2023)
Article
Marine & Freshwater Biology
Luis M. Burciaga, Aldair Alvarez, Guillermina Alcaraz
Summary: The internal structure of shells showed different effects on resource-correlated RHP for hermit crabs, depending on their role as owner or intruder during contests. Owners resisted more evictions in intact shells, while the presence of a columella in intruders' shells did not affect their likelihood of eviction.
Article
Gerontology
Isabel Baumann, Ignacio Madero-Cabib
Summary: The study examines how welfare regimes and health conditions influence retirement trajectories in countries with flexible retirement policies. Early retirement in the early 60s is most common across all countries, but less prevalent in liberal welfare regimes. Adverse health conditions are more common among early retirees in liberal welfare regimes compared to social-democratic regimes.
JOURNAL OF AGING & SOCIAL POLICY
(2021)
Article
Neurosciences
Chiara Spaccasassi, H. Chris Dijkerman, Angelo Maravita, Oscar Ferrante, Maartje C. de Jong
Summary: The study found that visual stimuli with positive and negative valence affect people's cognitive responses to the size of Defensive space, but not Reaching space. Specifically, negative valence stimuli enhanced the activation of the sensorimotor cortex. This indicates that stimuli with different valences have differential effects on the cognitive processing of Reaching and Defensive spaces.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2021)
Article
Psychology, Social
Nathan Lieng, Richard Chang, Angela-MinhTu D. Nguyen, Que-Lam Huynh
Summary: Previous research has shown that bicultural harmony is related to better psychological adjustment, while bicultural compartmentalization is not. However, this study found that dialectical thinking moderates the relationship between compartmentalization and adjustment. For biculturals with high levels of dialectical thinking, perceiving their cultural identities as more compartmentalized was linked to better psychological adjustment.
INTERNATIONAL JOURNAL OF INTERCULTURAL RELATIONS
(2022)
Article
Psychology, Clinical
Yvette To, Yuk Wah Chan
Summary: This article examines the impacts of new Christian immigrants from Hong Kong on Chinese Christian churches in the United Kingdom. While the new arrivals have helped boost the vitality of Chinese immigrant churches, they also pose new challenges to the established Chinese Christian communities. We argue that Christian immigrants from Hong Kong are creating a new landscape of Christianity and a distinctive religious diaspora in the United Kingdom.
AMERICAN BEHAVIORAL SCIENTIST
(2023)
Article
Management
Eric Michael Laviolette, Sebastien Arcand, L. Martin Cloutier, Laurent Renard
Summary: This article analyzes the activities of a meta-organization (M-O) in shaping a coherent collective identity, using a case study of an association of cider producers in Quebec over a 23-year period. The study proposes a dynamic model of collective identity dynamics, highlighting the dual and continuous role of an M-O in balancing internal identity claims and assembling external legitimacy among institutional actors.
Article
Communication
Yuting Lin, Meilin Chen, John Flowerdew
Summary: This study analyzes representations of Chinese mainlanders and Hongkongers in English-language media in Hong Kong after the 1997 handover, focusing on the differentiation and stereotypical characterizations associated with the two groups. The research demonstrates how the process of "othering" or discrimination against mainland migrants/visitors has contributed to reinforcing the distinctive identity of 'Hongkongers' in Hong Kong's English-language newspaper.
CRITICAL DISCOURSE STUDIES
(2022)
Article
Virology
Jesus Aaron Avalos-Calleros, Guillermo Pastor-Palacios, Omayra C. Bolanos-Martinez, Armando Mauricio-Castillo, Josefat Gregorio-Jorge, Nadia Martinez-Marrero, Bernardo Banuelos-Hernandez, Jesus Mendez-Lozano, Gerardo Rafael Arguello-Astorga
Summary: By comparing two strains of RhGMSV, it was identified that amino acid residues at positions 71 and 74 in the Rep protein are likely responsible for differences in replication specificity. This study provides direct support for the idea that geminivirus Rep proteins contain separate SPDs in their N-terminal domain, especially in the beta-5 strand structural element.
ARCHIVES OF VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Lauren L. Porter, Loren L. Looger
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Lauren L. Porter, George D. Rose
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Multidisciplinary Sciences
Lauren L. Porter, George D. Rose
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Biochemistry & Molecular Biology
Soumya Mishra, Loren L. Looger, Lauren L. Porter
Article
Biochemistry & Molecular Biology
Allen K. Kim, Loren L. Looger, Lauren L. Porter
Summary: The study introduces a method for identifying sequence-similar fold switchers using homology-based secondary structure predictions from amino acid sequences. The method can discriminate different conformations of proteins and has the potential for applications in disease-related protein research.
Review
Biochemistry & Molecular Biology
Allen K. Kim, Lauren L. Porter
Summary: The review compares fold-switching proteins with other types of proteins and provides examples of how proteins can change their functions through fold switching. Additionally, it discusses the regulation of biological processes by fold-switching proteins through case studies of RfaH and KaiB. Finally, the review speculates on the future advancements in the field of protein fold switching.
Article
Biochemistry & Molecular Biology
Lauren L. Porter
Summary: Fold-switching proteins can alter their functions by remodeling their secondary structures in response to environmental cues. High-throughput predictive methods have been developed to accurately identify such proteins, offering new insights into disease treatment possibilities.
Article
Biochemistry & Molecular Biology
Devlina Chakravarty, Lauren L. Porter
Summary: AlphaFold2 revolutionized protein structure prediction, but its predictions tend to be inaccurate for structurally heterogeneous proteins. Analysis of sequence variation showed that fold-switching regions have similar conservation rates to canonical single-fold proteins, while intrinsically disordered regions have lower prediction confidences.
Article
Multidisciplinary Sciences
Lauren L. Porter, Allen K. Kim, Swechha Rimal, Loren L. Looger, Ananya Majumdar, Brett D. Mensh, Mary R. Starich, Marie-Paule Strub
Summary: This study predicts fold switching in the NusG transcription factor family using a comparative sequence-based approach and confirms the predictions through experiments. It reveals that fold switching may be a widespread mechanism of transcriptional regulation in all kingdoms of life.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Devlina Chakravarty, Joseph W. Schafer, Lauren L. Porter
Summary: Some proteins can change their functions by remodeling their secondary and tertiary structures in response to cellular stimuli. These fold-switching proteins are associated with autoimmune dysfunction, severe acute respiratory syndrome coronavirus-2 infection, and more. This review discusses the features that distinguish fold-switching proteins from single-fold and intrinsically disordered proteins, with the aim of advancing computational prediction and experimental characterization of fold switchers.
Article
Multidisciplinary Sciences
Devlina Chakravarty, Shwetha Sreenivasan, Liskin Swint-Kruse, Lauren L. Porter
Summary: Although homologous protein sequences are expected to adopt similar structures, this study found that a family of bacterial response regulator proteins exhibited divergent structures in their homologous DNA-binding subunits. This structural transformation was facilitated by amino acid substitutions and likely expanded DNA-binding specificity. The approach used in this study provides a methodology to identify secondary structure switching in other protein families.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Lauren L. Porter
Summary: Fold-switching proteins remodel their structures in response to cellular stimuli, challenging the assumption that protein fold space is discrete. Three recent observations support the concept of fluid fold space: interconversion between folds with different secondary structures, fold switching by stepwise mutation, and evolutionary selection of fold switching. These observations highlight the potential of minor amino acid sequence modifications to transform protein structure and expand proteomic diversity through alternative splicing, nucleotide polymorphisms, post-translational modifications, and translation rate modifications.
Article
Multidisciplinary Sciences
Joseph W. Schafer, Lauren L. Porter
Summary: This study reveals the widespread phenomenon of dual-fold coevolution, demonstrating that some proteins can switch between two stable structures. The researchers developed a method to predict multiple protein structures from a single sequence using this coevolution information, providing important insights into the function and evolution of proteins.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Biophysics
Lauren L. Perskie, George D. Rose
BIOPHYSICAL JOURNAL
(2011)