Article
Microbiology
Krista Salli, Johanna Hirvonen, Heli Anglenius, Ashley A. A. Hibberd, Ilmari Ahonen, Markku T. T. Saarinen, Johanna Maukonen, Arthur C. C. Ouwehand
Summary: In this study, the effects of human milk oligosaccharides (HMOs) on infant faecal microbiota and microbial metabolites were evaluated using a semi-continuous colon simulator. The results showed that HMOs decreased diversity and increased the abundance of Bifidobacterium species, which correlated with the production of microbial metabolites. These findings suggest that HMOs and probiotics have benefits for the developing infant gut microbiota.
Article
Nutrition & Dietetics
Ilias Lagkouvardos, Evangelia Intze, Monika Schaubeck, James P. K. Rooney, Christina Hecht, Hugues Piloquet, Thomas Clavel
Summary: This study aimed to investigate the effects of a synbiotic intervention formula (IF) on the fecal microbiome of infants. The results showed that the IF could alter the diversity and composition of the gut microbiota in early life, with some similarities to breastfed infants.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Ana Ramos-Nascimento, Lucia Grenga, Sven-Bastiaan Haange, Alexandra Himmelmann, Franca Sabine Arndt, Yen-Tran Ly, Guylaine Miotello, Olivier Pible, Nico Jehmlich, Beatrice Engelmann, Martin von Bergen, Edwin Mulder, Petra Frings-Meuthen, Christine Elisabeth Hellweg, Jens Jordan, Ulrike Rolle-Kampczyk, Jean Armengaud, Ralf Moeller
Summary: The AGBRESA study examined the effect of simulated weightlessness on the human body and explored the potential benefits of artificial gravity. The study found that simulated microgravity had a mild impact on the gut microbiome, but countermeasure protocols increased the abundance of beneficial short-chain fatty acids. Monitoring the gut microbiome and metabolite profiling can provide valuable information about health disturbances and the outcome of countermeasure protocols.
Article
Gastroenterology & Hepatology
M. A. Azcarate-Peril, J. Roach, A. Marsh, William D. Chey, William J. Sandborn, Andrew J. Ritter, Dennis A. Savaiano, T. R. Klaenhammer
Summary: The study confirmed the significant symptom reduction and alteration of fecal microbiome in lactose intolerant patients with the administration of pure galacto-oligosaccharides. The analysis further suggested long-term benefits when individuals continued consumption of dairy products after the treatment.
Article
Nutrition & Dietetics
Pieter Van den Abbeele, Norbert Sprenger, Jonas Ghyselinck, Benoit Marsaux, Massimo Marzorati, Florence Rochat
Summary: The study found that human milk oligosaccharides can significantly increase the abundance of Bifidobacteriaceae in the gut microbiota fermentation process, promoting the production of beneficial substances such as propionate and butyrate while reducing discomfort.
Article
Biochemistry & Molecular Biology
Jae-Kwon Jo, Gihyun Lee, Cong Duc Nguyen, Seong-Eun Park, Eun-Ju Kim, Hyun-Woo Kim, Seung-Ho Seo, Kwang-Moon Cho, Sun Jae Kwon, Jae-Hong Kim, Hong-Seok Son
Summary: Accumulated evidence suggests that gut microbiota and their metabolites influence brain function and behavior in CNS disorders. This study investigated changes in brain metabolites and fecal microbial community composition after A beta injection and donepezil treatment in mice. The findings indicate that alterations in gut microbiota may impact the development and improvement of A beta-induced cognitive dysfunction through the gut-brain axis.
Article
Microbiology
Esther Ndungo, Johanna B. Holm, Syze Gama, Andrea G. Buchwald, Sharon M. Tennant, Miriam K. Laufer, Marcela F. Pasetti, David A. Rasko
Summary: Shigella continues to be a major contributor to diarrheal illness and dysentery in children under 5 in low- and middle-income countries. This study explored the impact of Shigella infection on the developing gastrointestinal microbiome in infants and found temporal changes in the microbiota associated with the infection. These findings highlight the need for further research on the microbial communities associated with disease susceptibility and resolution.
Article
Nutrition & Dietetics
Maciej Chichlowski, Janna A. van Diepen, Andrei Prodan, Laurentya Olga, Ken K. Ong, Guus A. M. Kortman, David B. Dunger, Gabriele Gross
Summary: This study investigates the associations between infant gut microbiome development, infant age, breastfeeding duration, and human milk oligosaccharides composition in breastmilk. The results show that breastfeeding duration affects infant gut microbiota composition and specific oligosaccharides in breastmilk are associated with bacteria in infant stool.
FRONTIERS IN NUTRITION
(2023)
Article
Immunology
Scott J. J. Dos Santos, Zahra Pakzad, Arianne Y. K. Albert, Chelsea N. N. Elwood, Kirsten Grabowska, Matthew G. G. Links, Jennifer A. A. Hutcheon, Evelyn J. J. Maan, Amee R. R. Manges, Tim J. J. Dumonceaux, Zoe G. Hodgson, Janet Lyons, Sheona M. M. Mitchell-Foster, Soren Gantt, K. S. Joseph, Julie E. E. Van Schalkwyk, Janet E. E. Hill, Deborah M. M. Money
Summary: Birth mode has a significant effect on the composition of neonatal gut microbiome within 10 days postpartum, but this effect is not influenced by maternal vaginal microbiome composition. There is no correlation between the vaginal and stool microbiome communities of newborns. Intrapartum antibiotic administration is associated with lower abundances of specific bacterial strains in infant stool.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Microbiology
Xing-Xing Liao, Xiao-Yun Wu, Yu-Long Zhou, Jia-Jun Li, You-Liang Wen, Jun-Jie Zhou
Summary: Cardiovascular diseases and depression have a high comorbidity rate, but previous studies have mainly focused on individual diseases and lack research on the common pathophysiology of both diseases in comorbid states. Modern high-throughput technologies have shown that gut microbiome metabolites play important roles in the pathophysiology of AS and depression. This review summarizes the important findings on the role of gut microbiome metabolites in depression and AS disease, aiming to identify potential biological targets for the early diagnosis and treatment of AS co-depression disorders.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Environmental Sciences
Hannah E. Laue, Yuka Moroishi, Thomas J. Palys, Brian P. Jackson, Juliette C. Madan, Margaret R. Karagas
Summary: Gut bacteria are associated with the impact of environmental exposures on human systems. The study found a correlation between arsenic-metabolizing bacteria in the infant gut microbiome and urinary arsenic excretion. Some arsenic-related gene pathways were associated with arsenic exposure and speciation, with stronger associations observed in infants delivered by caesarean section.
ENVIRONMENTAL RESEARCH
(2022)
Article
Pediatrics
Jacob A. F. Westaway, Roger Huerlimann, Yoga Kandasamy, Catherine M. Miller, Robert Norton, David Watson, Sandra Infante-Vilamil, Donna Rudd
Summary: Probiotic prophylaxis can reduce the risk of acute diseases in preterm infants by modulating the gut microbiome. However, the effects of probiotic species and modulation do not seem to persist beyond discharge.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Chemistry, Multidisciplinary
Weifeng Lin, Louis P. Conway, Miroslav Vujasinovic, J-Matthias Lohr, Daniel Globisch
Summary: The study developed a new chemical biology tool to overcome analytical challenges in metabolite analysis, enabling detection of over 200 metabolites in human fecal, urine, and plasma samples. This comprehensive mass spectrometric analysis enhances metabolomics-driven biomarker discovery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Nutrition & Dietetics
Mary E. Kable, Elizabeth L. Chin, Liping Huang, Charles B. Stephensen, Danielle G. Lemay
Summary: The study aimed to estimate lactose consumption and explore the interaction between lactose consumption, LP genotype, and gut microbiome in healthy adults in the US. The results showed that individuals with the LNP genotype consumed more lactose and had increased abundance of Lactobacillaceae and Lachnospiraceae taxa.
JOURNAL OF NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Kaitlyn Oliphant, Mehneez Ali, Mark D'Souza, Patrick D. Hughes, Dinanath Sulakhe, Annie Z. Wang, Bingqing Xie, Rummanu Yeasin, Michael E. Msall, Bree Andrews, Erika C. Claud
Summary: The study investigated the association between gut microbiome succession and head circumference growth in preterm infants, finding that depletion of Bacteroidota and Lachnospiraceae was associated with suboptimal neurodevelopment. Early integration of these core taxa is crucial for optimal neurodevelopment.
Review
Medicine, General & Internal
Arthur C. Ouwehand, Sofia Forssten, Ashley A. Hibberd, Anna Lyra, Buffy Stahl
ANNALS OF MEDICINE
(2016)
Article
Microbiology
Wesley Morovic, Ashley A. Hibberd, Bryan Zabel, Rodolphe Barrangou, Buffy Stahl
FRONTIERS IN MICROBIOLOGY
(2016)
Article
Biochemical Research Methods
Santosh Lamichhane, Christian C. Yde, Henrik Max Jensen, Wesley Morovic, Ashley A. Hibberd, Arthur C. Ouwehand, Markku T. Saarinen, Sofia D. Forssten, Lars Wiebe, Jorn Marcussen, Kresten Bertelsen, Sebastian Meier, Jette F. Young, Hanne Christine Bertram
JOURNAL OF PROTEOME RESEARCH
(2018)
Article
Multidisciplinary Sciences
Ghulam Shere Raza, Heli Putaala, Ashley A. Hibberd, Esa Alhoniemi, Kirsti Tiihonen, Kari Antero Makela, Karl-Heinz Herzig
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Markus J. Lehtinen, Ashley A. Hibberd, Sofia Mannikko, Nicolas Yeung, Tommi Kauko, Sofia Forssten, Liisa Lehtoranta, Sampo J. Lahtinen, Buffy Stahl, Anna Lyra, Ronald B. Turner
SCIENTIFIC REPORTS
(2018)
Article
Agriculture, Multidisciplinary
Ghulam Shere Raza, Johanna Maukonen, Markus Makinen, Piritta Niemi, Laura Niiranen, Ashley A. Hibberd, Kaisa Poutanen, Johanna Buchert, Karl-Heinz Herzig
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Microbiology
A. A. Hibberd, C. C. Yde, M. L. Ziegler, A. H. Honore, M. T. Saarinen, S. Lahtinen, B. Stahl, H. M. Jensen, L. K. Stenman
BENEFICIAL MICROBES
(2019)
Article
Microbiology
Liisa Lehtoranta, Ashley A. Hibberd, Jenni Reimari, Jouni Junnila, Nicolas Yeung, Johanna Maukonen, Gordon Crawford, Arthur C. Ouwehand
Article
Multidisciplinary Sciences
Markku Tapani Saarinen, Olli Karkkainen, Kati Hanhineva, Kirsti Tiihonen, Ashley Hibberd, Kari Antero Makela, Ghulam Shere Raza, Karl-Heinz Herzig, Heli Anglenius
SCIENTIFIC REPORTS
(2020)
Article
Immunology
Liisa Lehtoranta, Ashley A. Hibberd, Nicolas Yeung, Arja Laitila, Johanna Maukonen, Arthur C. Ouwehand
Summary: The study characterized the vaginal mycobiota in healthy women and those with BV infection, finding a diverse range of yeast and filamentous fungi species with Candida as the dominant genus. The abundance of C. albicans was inversely correlated with fungal diversity and oral metronidazole treatment did not significantly impact its relative abundance. The results underscore the importance of further exploring the diversity of the fungal community in both healthy and BV-infected women.
MICROBIAL PATHOGENESIS
(2021)
Article
Cell Biology
Ritesh Kumar, Helene Kane, Qiong Wang, Ashley Hibberd, Henrik Max Jensen, Hye-Sook Kim, Steffen Yde Bak, Isabelle Auzanneau, Stephanie Bry, Niels Christensen, Andrew Friedman, Pia Rasinkangas, Arthur C. Ouwehand, Sofia D. Forssten, Oliver Hasselwander
Summary: This study identifies and characterizes a novel Akkermansia species, which shows significant differences in fatty acid profile and carbon utilization compared to a known type strain. The study finds that this novel strain improves metabolic markers and suggests a potential novel mechanism for supporting metabolic and cognitive health through the production of agmatine. The findings highlight the therapeutic potential of this novel Akkermansia species for managing metabolic diseases.
Article
Microbiology
Anna Lyra, Reeta Ala-Jaakkola, Nicolas Yeung, Neeta Datta, Kara Evans, Ashley Hibberd, Markus J. Lehtinen, Sofia D. Forssten, Alvin Ibarra, Tommi Pesonen, Jouni Junnila, Arthur C. Ouwehand, Keith Baranowski, Johanna Maukonen, Gordon Crawford, Liisa Lehtoranta
Summary: The objective of this study was to assess the colonization of Lactobacillus acidophilus La-14 and Lacticaseibacillus rhamnosus HN001 in the healthy human vagina and their potential effects on vaginal microbiota and immune markers. The results showed stable vaginal microbiota dominated by lactobacilli and optimal vaginal pH throughout the intervention. Immune markers elafin and human beta-defensin 3 (HBD-3) significantly decreased in the verum group but were not correlated with any microbiota changes. No adverse events or undesired changes in the vaginal microbiota or immune markers were detected.
Article
Medicine, General & Internal
Ronald B. Turner, Liisa Lehtoranta, Ashley Hibberd, Sofia Mannikko, Bryan Zabel, Nicholas Yeung, Teppo Huttunen, Frank R. Burns, Markus J. Lehtinen
Summary: This study assessed the efficacy of Bifidobacterium animalis ssp. lactis (Bl-04) for prevention of rhinovirus colds, finding no significant effect on the occurrence of RV-associated illness. No adverse events related to the study product were reported during the research.