The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway
出版年份 2019 全文链接
标题
The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway
作者
关键词
-
出版物
Scientific Reports
Volume 9, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-10-11
DOI
10.1038/s41598-019-51205-w
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures
- (2019) Lizet M. van der Waals et al. Scientific Reports
- Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity
- (2018) Mohit Narwal et al. BIOCHEMISTRY
- The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress
- (2018) Kazunari Hashiguchi et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Mitotic spindle assembly in animal cells: a fine balancing act
- (2017) Suzanna L. Prosser et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The MTH1 inhibitor TH588 demonstrates anti-tumoral effects alone and in combination with everolimus, 5-FU and gamma-irradiation in neuroendocrine tumor cells
- (2017) Elke Tatjana Aristizabal Prada et al. PLoS One
- A New Mode of Mitotic Surveillance
- (2017) Bramwell G. Lambrus et al. TRENDS IN CELL BIOLOGY
- TH588, an MTH1 inhibitor, enhances phenethyl isothiocyanate‑induced growth inhibition in pancreatic cancer cells
- (2017) Fumiyoshi Ikejiri et al. Oncology Letters
- Expression and function of MutT homolog 1 in distinct subtypes of breast cancer
- (2017) Xiaohui Zhang et al. Oncology Letters
- MTH1 as a Chemotherapeutic Target: The Elephant in the Room
- (2017) Govindi Samaranayake et al. Cancers
- Validation and development of MTH1 inhibitors for treatment of cancer
- (2016) U. Warpman Berglund et al. ANNALS OF ONCOLOGY
- Identification of potent and selective MTH1 inhibitors
- (2016) Alessia Petrocchi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis
- (2016) Bramwell G. Lambrus et al. JOURNAL OF CELL BIOLOGY
- 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration
- (2016) Franz Meitinger et al. JOURNAL OF CELL BIOLOGY
- Reactive Oxygen Species Dictate the Apoptotic Response of Melanoma Cells to TH588
- (2016) Jia Yu Wang et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival
- (2016) Jason G. Kettle et al. JOURNAL OF MEDICINAL CHEMISTRY
- Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival
- (2016) Tatsuro Kawamura et al. Scientific Reports
- 53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis
- (2016) Chii Shyang Fong et al. eLife
- Synergy between Multiple Microtubule-Generating Pathways Confers Robustness to Centrosome-Driven Mitotic Spindle Formation
- (2014) Daniel Hayward et al. DEVELOPMENTAL CELL
- MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
- (2014) Helge Gad et al. NATURE
- Improved vectors and genome-wide libraries for CRISPR screening
- (2014) Neville E Sanjana et al. NATURE METHODS
- STRING v10: protein–protein interaction networks, integrated over the tree of life
- (2014) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- Antioxidants Accelerate Lung Cancer Progression in Mice
- (2014) V. I. Sayin et al. Science Translational Medicine
- Genetic Screens in Human Cells Using the CRISPR-Cas9 System
- (2013) Tim Wang et al. SCIENCE
- Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells
- (2012) Wei-Hsin Chiu et al. BIOCHEMICAL PHARMACOLOGY
- Drugs that target dynamic microtubules: A new molecular perspective
- (2011) Richard A. Stanton et al. MEDICINAL RESEARCH REVIEWS
- ConsensusPathDB: toward a more complete picture of cell biology
- (2010) Atanas Kamburov et al. NUCLEIC ACIDS RESEARCH
- Reactome: a database of reactions, pathways and biological processes
- (2010) D. Croft et al. NUCLEIC ACIDS RESEARCH
- CORUM: the comprehensive resource of mammalian protein complexes—2009
- (2009) Andreas Ruepp et al. NUCLEIC ACIDS RESEARCH
- PID: the Pathway Interaction Database
- (2008) Carl F. Schaefer et al. NUCLEIC ACIDS RESEARCH
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