Article
Clinical Neurology
Gernot Surges, Joachim Paulus, Theresa Blass, Kerstin Mendryscha, Martin Bettag, Anand Rotte
Summary: Through a single-center retrospective study, it was found that 10kHz cervical or combined cervical and thoracic lead placement for SCS can provide effective and durable pain relief in patients with chronic neuropathic pain, with efficacy and safety comparable to lower thoracic SCS, and can be applied to complex multiarea pain presentations.
Review
Biochemistry & Molecular Biology
Ganesan Baranidharan, Deborah Edgar, Beatrice Bretherton, Tracey Crowther, Abdul-Ghaaliq Lalkhen, Ann-Katrin Fritz, Girish Vajramani
Summary: 10 kHz spinal cord stimulation (SCS) is increasingly used globally for chronic pain syndromes, with most studies showing safe and durable pain relief and potential reduction in opioid intake in pragmatic populations of chronic pain patients.
Review
Clinical Neurology
Ganesan Baranidharan, Beatrice Bretherton, Craig Montgomery, John Titterington, Tracey Crowther, Christopher Vannabouathong, Jason A. Inzana, Anand Rotte
Summary: The study findings suggest that paresthesia-free 10 kHz SCS is a promising, safe, minimally invasive alternative for managing chronic upper limb and neck pain, with a high proportion of patients experiencing significant pain reduction and a reduction in opioid consumption. The potential risks of cervical SCS include pain or discomfort with the implant, lead migration, and infections, but no neurological complications or paresthesia were reported in the included studies.
Article
Anesthesiology
Jordan L. Tate, Thomas Stauss, Sean Li, Anand Rotte, Jeyakumar Subbaroyan
Summary: This study demonstrates that paresthesia-independent 10kHz spinal cord stimulation has a significant pain-relieving effect on patients with CPP without any unexpected adverse events. Over 12 months, the average VAS score decreased by 72%, with the majority of subjects (77%) achieving more than 50% pain relief.
Review
Biochemistry & Molecular Biology
Vinicius Tieppo Francio, Keith F. Polston, Micheal T. Murphy, Jonathan M. Hagedorn, Dawood Sayed
Summary: Since 1967, spinal cord stimulation (SCS) technology has evolved significantly, with the introduction of the 10 kHz SCS system that selectively activates inhibitory interneurons in the dorsal horn. This high-frequency stimulation pattern has demonstrated significant pain control superiority in patients with chronic back pain and neuropathic pain.
Article
Clinical Neurology
Kasra Amirdelfan, Ricardo Vallejo, Ramsin Benyamin, Steven Rosen, Peter Kosek, David Caraway, Anand Rotte, Abram Burgher
Summary: The study found that 10-kHz spinal cord stimulation treatment helped reduce pain and opioid consumption in chronic pain patients with upper limb and neck pain. Overall, reducing opioids did not compromise pain relief in subjects treated with 10-kHz SCS.
Article
Medicine, General & Internal
Peter Pockney, Aya Basam, Liam Ferguson, Lorane Gaborit, Sarah Goh, Amie Hilde, Aiden Jabur, Kaviya Kalyanasundaram, Chui Foong (Kelly) Ong, Melissa Park, Upasana Pathak, Kyle Raubenheimer, Venesa Siribaddana, Chris Varghese, Jennifer Vu, Cameron Wells, William Xu, Ademola Adeyeye, Luis Adrian Alvarez-Lozada, Simran Vinod Benyani, Milos Buhavac, Giacomo Calini, Davina Daudu, Semra Demirli Atici, Mustafa Deniz Tepe, Muhammed Elhadi, Orestis Ioannidis, Nandini Karthikeyan, Laure Taher Mansour, Upanmanyu Nath, Warren Seow, Surya Singh, Zoya Tasi, Ahmad Uzair, Wah Yang, Faseeh Zaidi, Kristy Atherton, Arnab Banerjee, Amanda Dawson, Nagendra Dudi-Venkata, Nicholas Lightfoot, Isabella Ludbrook, Jennifer Martin, Luke Peters, Toby Richards, Rachel Sara, David Watson, Deborah Wright
Summary: This study aims to investigate the prescription and consumption of opioids at 7 days postdischarge after surgery and their impact on patients' postoperative pain.
Article
Clinical Neurology
Jonathan M. Hagedorn, Jordan Tate, Manish Bharara
Summary: This study investigated the satisfaction and convenience of using rechargeable IPG in patients implanted with 10 kHz SCS devices for chronic pain relief. The results showed that most patients were satisfied with the efficacy of 10 kHz SCS and did not find IPG recharging to be inconvenient or burdensome. Therefore, IPG recharging does not hinder the majority of patients from benefiting from long-term pain relief with 10 kHz SCS.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Medicine, General & Internal
Eran Bornstein, Gregg Husk, Erez Lenchner, Amos Grunebaum, Therese Gadomski, Cristina Zottola, Sarah Werner, Jamie S. Hirsch, Frank A. Chervenak
Summary: Transitioning to a standardized multimodal combination analgesic therapy after cesarean delivery significantly reduces opioid use, decreases average opioid dose, increases acetaminophen dose, and improves pain control. This approach can be effectively implemented on a large scale through incorporation of a multimodal order set in the electronic medical record system.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Honghui Feng, Patrick Doherty, Anand Rotte, Christopher Bovinet
Summary: Three patients who received permanent implantation of 10 kHz SCS devices experienced sustained improvements in lower back and leg pain, foot mechanics and function, leading to increased mobility and cessation of opioid use for pain management. This treatment option may be a promising alternative for patients with foot drop and associated lower back and/or leg pain.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Anesthesiology
Eva Rivas, Barak Cohen, Xuan Pu, Li Xiang, Wael Saasouh, Guangmei Mao, Paul Minko, Lauretta Mosteller, Andrew Volio, Kamal Maheshwari, Daniel Sessler, Alparslan Turan
Summary: Postoperative pain and opioid consumption have an impact on the postoperative mobilization of patients recovering from abdominal surgery, while lower pain scores are associated with increased mobility and fewer complications.
Review
Biochemistry & Molecular Biology
Bryan C. Hoelzer, Deborah Edgar, Shiao-Ping Lu, Rod S. Taylor
Summary: This study systematically reviewed the application of spinal cord stimulation (SCS) in patients with painful diabetic neuropathy (PDN) and compared the high-frequency and low-frequency modalities. The results showed that 10 kHz SCS treatment provided superior pain relief and responder rate compared to low-frequency SCS in PDN patients.
Article
Clinical Neurology
Leonardo Kapural, Jessica Jameson, Curtis Johnson, Daniel Kloster, Aaron Calodney, Peter Kosek, Julie Pilitsis, Markus Bendel, Erika Petersen, Chengyuan Wu, Taissa Cherry, Shivanand P. Lad, Cong Yu, Dawood Sayed, Johnathan Goree, Mark K. Lyons, Andrew Sack, Diana Bruce, Frances Rubenstein, Rose Province-Azalde, David Caraway, Naresh P. Patel
Summary: The study results provide important insights into the durability of 10-kHz SCS therapy for chronic refractory back pain, physical function, quality of life, and opioid use, informing current clinical practice for pain management in patients with NSRBP.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Review
Anesthesiology
Jan Willem Kallewaard, Ismail Gultuna, Vincent Hoffmann, Lars Elzinga, Renate Munnikes, Lisette Verbrugge, Veerle Minne, Pascalle Reiters, Jeyakumar Subbaroyan, Angela Santos, Anand Rotte, David Caraway
Summary: This study evaluated the safety and efficacy of 10 kHz SCS in FBSS patients with predominant leg pain, showing that the therapy is both safe and effective, leading to improved quality of life for patients.
Article
Medicine, General & Internal
Akihiro Tokoro, Hisao Imai, Soichi Fumita, Toshiyuki Harada, Toshio Noriyuki, Makio Gamoh, Masaharu Okamoto, Yusaku Akashi, Yoshiyuki Kizawa
Summary: The study found that age and comorbidities may be associated with opioid-induced constipation, while effective communication between patients and healthcare providers is essential for improving satisfaction with constipation treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
Jordan L. Tate, Thomas Stauss, Sean Li, Anand Rotte, Jeyakumar Subbaroyan
Summary: This study demonstrates that paresthesia-independent 10kHz spinal cord stimulation has a significant pain-relieving effect on patients with CPP without any unexpected adverse events. Over 12 months, the average VAS score decreased by 72%, with the majority of subjects (77%) achieving more than 50% pain relief.
Letter
Anesthesiology
Adnan Al-Kaisy, Jonathan Royds, Omar Al-Kaisy, Stefano Palmisani, David Pang, Tom Smith, Nicholas Padfield, Stephany Harris, Samuel Wesley, Thomas Lamar Yearwood, Stephen Ward
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2021)
Article
Neurosciences
Gerrit Eduard Gmel, Rosana Santos Escapa, John L. Parker, Dave Mugan, Adnan Al-Kaisy, Stefano Palmisani
Summary: The study investigated the effect of stimulus frequency on ECAP amplitude and perceived stimulus sensation in patients undergoing SCS therapy, showing an inverse relationship between frequency and both amplitude and sensation strength. This suggests that frequency coding and population coding play important roles in conveying SCS-induced sensation.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Clinical Neurology
Mayank Gupta, Alaa Abd-Elsayed, Meghan Hughes, Anand Rotte
Summary: This retrospective study evaluated the incidence of clinically significant percutaneous lead migration in patients with a 10 kHz SCS system, showing no cases of migration at the 6-month follow-up. Most patients experienced significant pain relief, improved function, and decreased medication usage. Surgeons' techniques and new SCS systems may contribute to the prevention of lead migration.
PAIN RESEARCH & MANAGEMENT
(2021)
Article
Medicine, Research & Experimental
Adnan Al-Kaisy, Stefano Palmisani, Roy Carganillo, Samuel Wesley, David Pang, Anand Rotte, Angela Santos, Giorgio Lambru
Summary: The 10 kHz spinal cord stimulation may be a safe and effective neurostimulation option for patients with refractory chronic migraine, resulting in significant reductions in headache and migraine symptoms, and improvement in quality of life.
Article
Medicine, Research & Experimental
Adnan Al-Kaisy, Ganesan Baranidharan, Haggai Sharon, Stefano Palmisani, David Pang, Onita Will, Samuel Wesley, Tracey Crowther, Karl Ward, Paul Castino, Adil Raza, Yagna J. Pathak, Filippo Agnesi, Thomas Yearwood
Summary: The study demonstrated that equivalent clinical benefits could be achieved with burst SCS using either paresthesia mapping or anatomic landmark-based approaches for lead placement in chronic low back pain patients. Nonparesthesia-based approaches, like the anatomic landmark-based lead placement investigated in this study, have the potential to simplify SCS implantation and improve current surgical practices.
Article
Clinical Neurology
Honghui Feng, Patrick Doherty, Anand Rotte
Summary: Treatment with 10 kHz SCS can reduce opioid consumption, effectively relieve pain, and is more beneficial for patients who have been using it for 1 year or longer. This therapy also improves sleep and function in patients.
JOURNAL OF PAIN RESEARCH
(2021)
Review
Clinical Neurology
Krishnan Chakravarthy, Rajiv Reddy, Adnan Al-Kaisy, Thomas Yearwood, Jay Grider
Summary: Spinal cord stimulation has experienced significant growth in the past 50 years, but optimization of electrical dosing remains a challenge. Current research findings can offer insight for developing more rational approaches in the future.
JOURNAL OF PAIN RESEARCH
(2021)
Review
Clinical Neurology
Ganesan Baranidharan, Beatrice Bretherton, Craig Montgomery, John Titterington, Tracey Crowther, Christopher Vannabouathong, Jason A. Inzana, Anand Rotte
Summary: The study findings suggest that paresthesia-free 10 kHz SCS is a promising, safe, minimally invasive alternative for managing chronic upper limb and neck pain, with a high proportion of patients experiencing significant pain reduction and a reduction in opioid consumption. The potential risks of cervical SCS include pain or discomfort with the implant, lead migration, and infections, but no neurological complications or paresthesia were reported in the included studies.
Article
Clinical Neurology
Gernot Surges, Joachim Paulus, Theresa Blass, Kerstin Mendryscha, Martin Bettag, Anand Rotte
Summary: Through a single-center retrospective study, it was found that 10kHz cervical or combined cervical and thoracic lead placement for SCS can provide effective and durable pain relief in patients with chronic neuropathic pain, with efficacy and safety comparable to lower thoracic SCS, and can be applied to complex multiarea pain presentations.
Review
Biochemistry & Molecular Biology
Anand Rotte, Srikumar Sahasranaman, Nageshwar Budha
Summary: Immune checkpoint blockers have improved survival chances in patients with metastatic cancer, but only a subset of patients respond to treatment. Inhibiting TIGIT has shown promise in pre-clinical and early clinical studies, but challenges remain in identifying beneficial patients and obtaining payer coverage.
Review
Biochemistry & Molecular Biology
Ashley Bailey-Classen, Amar Parikh, Nima Adimi, Deborah Edgar, Alice Yan, Anand Rotte, David Caraway
Summary: This article introduces the concept of number needed to treat (NNT) and its application in the field of spinal cord stimulation (SCS). Through reviewing literature and analyzing 10 clinical studies, the researchers found that NNT estimates can help understand the effect size difference between different treatments, but its interpretation should consider the full context and avoid interpretation biases.
Review
Oncology
Matthew Frigault, Anand Rotte, Ayub Ansari, Bradford Gliner, Christopher Heery, Bijal Shah
Summary: CAR-T cells have the potential to successfully treat hematologic cancers, but severe adverse events are a concern. This study aims to assess whether dividing the dose of CAR-T cells reduces toxicity without affecting efficacy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Honghui Feng, Patrick Doherty, Anand Rotte, Christopher Bovinet
Summary: Three patients who received permanent implantation of 10 kHz SCS devices experienced sustained improvements in lower back and leg pain, foot mechanics and function, leading to increased mobility and cessation of opioid use for pain management. This treatment option may be a promising alternative for patients with foot drop and associated lower back and/or leg pain.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)