Article
Endocrinology & Metabolism
Shi Tai, Liyao Fu, Ningjie Zhang, Ying Zhou, Zhenhua Xing, Yongjun Wang
Summary: The triglyceride-glucose (TyG) index is associated with the occurrence of cardiovascular events in patients with type 2 diabetes mellitus (T2DM). High and very high TyG index trajectories are associated with a greater risk of future cardiovascular events.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jung A. Kim, Jinsil Kim, Eun Roh, So-hyeon Hong, You-Bin Lee, Sei Hyun Baik, Kyung Mook Choi, Eunjin Noh, Soon Young Hwang, Geum Joon Cho, Hye Jin Yoo
Summary: This study evaluated the association between pre-pregnancy TyG index and GDM in primipara women, finding that an increased TyG index was linked to a higher risk of GDM. The results suggest that elevation of the TyG index may serve as an early marker for GDM, with a more profound impact in individuals aged 35 years and older, with obesity, impaired fasting glucose, who are current smokers, or have a family history of diabetes mellitus.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Cardiac & Cardiovascular Systems
Qin Zhang, Shucai Xiao, Xiaojuan Jiao, Yunfeng Shen
Summary: A U-shaped association was observed between the baseline TyG index and cardiovascular (CV) and all-cause mortality in CVD patients with diabetes or pre-diabetes in the American population.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Dong Liu, Kaixuan Yang, Hongqiu Gu, Zixiao Li, Yongjun Wang, Yilong Wang
Summary: The study found that the triglyceride-glucose (TyG) index is closely related to the clinical prognosis of acute ischemic stroke (IS) patients with type-2 diabetes mellitus (T2DM). A higher TyG index is associated with increased risk of IS recurrence and all-cause death, and there are interactions with factors such as age, gender, and medication use.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
William B. Horton, Janet K. Snell-Bergeon
Summary: This study found that different HbA1c metrics were positively correlated with coronary artery calcium volume and pericardial adipose tissue volume, and they could independently predict cardiovascular events in individuals with type 1 diabetes. These associations persisted even after adjusting for multiple cardiovascular disease risk factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
He Zhang, Hoshun Chong, Zeshi Li, Kai Li, Bomin Zhang, Yunxing Xue, Dongjin Wang
Summary: This study found that post-CABG T2DM patients with a high TyG index have a higher incidence of major adverse cardiovascular events (MACEs). The TyG index improves the diagnostic accuracy of MACEs, especially in long-term follow-up. A high TyG index may serve as an early warning signal for individuals to undertake lifestyle adjustments to reduce the progression or incidence of MACEs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yingkai Li, Songyuan He, Zheng Wu, Wenzheng Li, Wen Jian, Zichao Cheng, Cong Wang, Yuchen Shi, Jinghua Liu
Summary: The present study aimed to investigate the relationship between the TyG index and cardiovascular risk in chronic total occlusion (CTO) patients. The study revealed that the TyG index was significantly associated with cardiovascular risk in CTO patients and suggested that it could be a feasible predictor of cardiovascular risk in CTO patients.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jining He, Sheng Yuan, Chenxi Song, Yanjun Song, Xiaohui Bian, Guofeng Gao, Kefei Dou
Summary: This study investigated the association between the TyG index and cardiovascular events in patients with bifurcation lesions. The results showed that a high TyG index was associated with an increased risk of cardiovascular events, especially in diabetic patients. Therefore, the TyG index can be used for risk stratification and prognosis in patients with bifurcation lesions.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiaotong Li, Mengzi Sun, Yixue Yang, Nan Yao, Shoumeng Yan, Ling Wang, Wenyu Hu, Ruirui Guo, Yuxiang Wang, Bo Li
Summary: This study evaluated the association between triglyceride glucose (TyG) index and new-onset diabetes under different glycemic states and compared the predictive value of TyG-associated parameters, obesity indices, and lipid ratios. The results showed a positive and linear association between TyG index and new-onset diabetes. TyG-WHtR and TyG-BMI were effective markers for identifying the risks of diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shi Tai, Liyao Fu, Ningjie Zhang, Rukai Yang, Yuying Zhou, Zhenhua Xing, Yongjun Wang, Shenghua Zhou
Summary: The TyG index can serve as a predictive marker for cardiovascular events in patients with type 2 diabetes mellitus, and long-term monitoring of this index can assist in risk stratification and outcome prediction.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Urology & Nephrology
Mathilde Colladant, Melchior Chabannes, Thomas Crepin, Jamal Bamoulid, Cecila Courivaud, Didier Ducloux
Summary: Insulin resistance is strongly associated with cardiovascular events in kidney transplant recipients, and improving insulin sensitivity may help prevent cardiovascular disease and mortality in this high-risk population.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Qing Yang, Huichao Xu, Hongli Zhang, Yanying Li, Shuxiong Chen, Dongye He, Guangzhi Yang, Bo Ban, Mei Zhang, Fupeng Liu
Summary: This study aimed to investigate the predictive value of the TyG index for visceral obesity and body fat distribution in patients with type 2 diabetes mellitus. The results showed that the TyG index was significantly correlated with visceral adipose area, subcutaneous adipose area, and visceral adipose density, and it could be used as an independent factor for visceral obesity. In addition, the combination of the TyG index and BMI improved the prediction of visceral obesity.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Xianxuan Wang, Yanjuan Chen, Zegui Huang, Zefeng Cai, Xinran Yu, Zekai Chen, Linyao Li, Guanzhi Chen, Kuangyi Wu, Huancong Zheng, Shouling Wu, Youren Chen
Summary: This study found that variability in the triglyceride-glucose index is associated with a higher risk of diabetes in the Chinese population.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xinghao Xu, Rihua Huang, Yifen Lin, Yue Guo, Zhenyu Xiong, Xiangbin Zhong, Xiaomin Ye, Miaohong Li, Xiaodong Zhuang, Xinxue Liao
Summary: This study found that higher baseline TyG index levels and higher long-term trajectory of TyG index during young adulthood were significantly associated with an increased risk of incident CVD events and all-cause mortality in later life.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Kun Yang, Wenxian Liu
Summary: The TyG index was associated with MACEs in hypertensive patients, and there was no gender difference in the relationship between the TyG index and MACEs.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Health Care Sciences & Services
Sheng-Wen Niu, Chi-Chih Hung, Hugo Y. -H. Lin, I-Ching Kuo, Jiun-Chi Huang, Jiun-Shiuan He, Zhi-Hong Wen, Peir-In Liang, Yi-Wen Chiu, Jer-Ming Chang, Shang-Jyh Hwang
Summary: Gout patients who use benzbromarone have a lower incidence of stroke compared to non-users. The risk of stroke is significantly reduced in male benzbromarone users. In the age groups of 40-59 years and >= 60 years, benzbromarone users have a significantly lower risk of stroke compared to non-users. This study evaluates the effects of benzbromarone on stroke incidence in gout patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Guan-Yu Chen, Zhi-Fu Wu, Yi-Ting Lin, Kuang- Cheng, Yu-Ting Huang, Shun-Te Huang, Arief Hargono, Chung-Yi Li
Summary: This study investigated the association between general anesthesia and the outcomes of root canal treatment in patients with disability. The results showed that root canal treatment with general anesthesia significantly reduced the risk of treatment failure.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Nutrition & Dietetics
Ya-Chin Huang, Jiun-Hung Geng, Pei-Yu Wu, Jiun-Chi Huang, Szu-Chia Chen, Jer-Ming Chang, Hung-Chun Chen
Summary: The habit of betel nut chewing in Taiwan is significantly associated with metabolic syndrome (MetS) and its components, and long-term betel nut chewing is related to the development of MetS.
Article
Nutrition & Dietetics
Jung-Hsiu Chang, I-Hua Chen, Jiun-Hung Geng, Pei-Yu Wu, Jiun-Chi Huang, Szu-Chia Chen
Summary: This study found significant associations between metabolic syndrome (MetS) and its components, such as low high-density lipoprotein cholesterol and hyperglycemia, with the risk of cataract. Additionally, there was a gradual increase in the prevalence of cataract corresponding to the number of MetS components.
Article
Biochemistry & Molecular Biology
Yu-Lin Chao, Pei-Yu Wu, Jiun-Chi Huang, Yi-Wen Chiu, Jia-Jung Lee, Szu-Chia Chen, Jer-Ming Chang, Shang-Jyh Hwang, Hung-Chun Chen
Summary: This study aimed to investigate the relationships between white blood cell (WBC) and platelet counts with hepatic steatosis and its severity. The results showed that WBC and platelet counts were associated with hepatic steatosis and its severity.
Article
Health Care Sciences & Services
Ping-Ruey Chou, Pei-Yu Wu, Ping-Hsun Wu, Teng-Hui Huang, Jiun-Chi Huang, Szu-Chia Chen, Su-Chu Lee, Mei-Chuan Kuo, Yi-Wen Chiu, Ya-Ling Hsu, Jer-Ming Chang, Shang-Jyh Hwang
Summary: This study investigated the relationship between circulating cardiovascular biomarkers and brachial-ankle pulse wave velocity (baPWV) in hemodialysis patients. The results showed that high-sensitivity troponin-T (hsTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), Galectin-3, and Cathepsin D were significantly correlated with baPWV.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Wei-Yu Su, I-Hua Chen, Yuh-Ching Gau, Pei-Yu Wu, Jiun-Chi Huang, Yi-Chun Tsai, Szu-Chia Chen, Jer-Ming Chang, Shang-Jyh Hwang, Hung-Chun Chen
Summary: The study found significant associations between metabolic syndrome and high values of obesity-related indices except LAP with high baseline eGFR and a rapid decline in renal function.
Article
Biochemistry & Molecular Biology
Jiun-Chi Huang, Szu-Chia Chen, Wei-An Chang, Wei-Wen Hung, Ping-Hsun Wu, Ling-Yu Wu, Jer-Ming Chang, Ya-Ling Hsu, Yi-Chun Tsai
Summary: Diabetic nephropathy is a growing threat to human health. This study reveals that high glucose or its metabolites, AGEs, increase the expression and secretion of KITLG in glomerular endothelial cells (GECs), leading to endothelial-to-mesenchymal transition (EndoMT) and increased permeability. Inhibition of KITLG's effects prevents AGE-mediated EndoMT in GECs, suggesting its critical role in GEC injury. KITLG levels are found to be higher in GECs and urine of diabetic mice and type 2 diabetic patients, and are correlated with urinary albumin-to-creatinine ratio and estimated glomerular filtration rate. KITLG may serve as a biomarker for DN progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Jui-Hsin Chen, Chun-Chi Tsai, Yi-Hsueh Liu, Pei-Yu Wu, Jiun-Chi Huang, Tung-Ling Chung, Ho-Ming Su, Szu-Chia Chen
Summary: The global prevalence and incidence of chronic kidney disease (CKD) are increasing. This study aimed to investigate whether hyperuricemia is an independent risk factor for renal progression and if there are sex differences in the relationship between serum uric acid (UA) and declining renal function. The study found that hyperuricemia was significantly associated with new-onset CKD, particularly in women.
Article
Biochemistry & Molecular Biology
Yi-Hsueh Liu, Po Peng, Wei-Chun Hung, Ping-Hsun Wu, Cheng-Yuan Kao, Pei-Yu Wu, Jiun-Chi Huang, Chih-Hsing Hung, Ho-Ming Su, Szu-Chia Chen, Chao-Hung Kuo
Summary: Gut dysbiosis is associated with chronic inflammation and contributes to atherosclerosis and vascular calcification. This study compared the microbiota composition between patients with chronic diseases and high or low AoAC scores. The results showed that patients with a higher AoAC score had lower microbial species diversity and increased microbial dysbiosis compared to those with a lower AoAC score. These findings support the link between gut dysbiosis and the severity of AoAC in patients with chronic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Lu-Heng Lu, Chun-Chi Tsai, Chih-Yi Lin, Chih-Wen Wang, Pei-Yu Wu, Jiun-Chi Huang, Szu-Chia Chen, Jer-Ming Chang
Summary: The prevalence of hyperuricemia in Taiwan is high and it has been associated with several risk factors. This study investigated the relationship between hyperuricemia and heavy metals and found a significant association between high urine arsenic levels and hyperuricemia. Other factors such as young age, male sex, high BMI, high hemoglobin, high triglycerides, and low eGFR were also significantly associated with hyperuricemia.
Article
Health Care Sciences & Services
Yu-Lin Tsai, Hao-Ping Wang, Da-Wei Wu, Jiun-Chi Huang, Pei-Yu Wu, Szu-Chia Chen
Summary: Osteoporosis is increasingly prevalent in patients with chronic respiratory diseases, and is associated with fractures, hospitalization, and death. A study on Taiwanese population with no history of smoking, bronchitis, emphysema, or asthma found that lower lung function was associated with low baseline T-score and rapid decline in T-score.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ya-Chin Huang, Jiun-Chi Huang, Hsu-Han Chien, Chia- Lin, Yun-Shiuan Chuang, Han-Yun Cheng, Wei-Ting Lin, Yu-Yin Lin, Hung-Yi Chuang, Chao-Ling Wang, Chia-Yen Dai
Summary: NAFLD was a significant risk factor for an elevated ASCVD risk. NAFLD fibrosis score >0.676 was associated with increased ASCVD risk in individuals with NAFLD. When compared to anthropometric indices, NAFLD fibrosis score demonstrated the best performance in estimating an elevated ASCVD risk among those with NAFLD.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Nutrition & Dietetics
Shih-Yao Su, Tsung-Han Lin, Yi-Hsueh Liu, Pei-Yu Wu, Jiun-Chi Huang, Ho-Ming Su, Szu-Chia Chen
Summary: Hyperuricemia is associated with diabetes, gout, kidney, and cardiovascular diseases, but there is limited data on sex differences in this association. This study aimed to explore sex differences in the correlations between obesity indices and hyperuricemia in Taiwan. The results showed that obesity-related indices were significantly associated with hyperuricemia in both men and women, with stronger associations found in women. This large Taiwanese study provides important insights into the relationship between obesity and hyperuricemia, highlighting the need for considering sex differences in these associations.
Article
Urology & Nephrology
Chung-Feng Huang, Chia-Yen Dai, Chih-Wen Wang, Po-Cheng Liang, Yu-Ju Wei, Pei-Chien Tsai, Tyng-Yuan Jang, Po-Yao Hsu, Jia-Jung Lee, Sheng-Wen Niu, Jiun-Chi Huang, Ming-Lun Yeh, Ching- Huang, Ming-Yen Hsieh, Yi-Hung Lin, Szu-Chia Chen, Yi-Wen Chiu, Jee-Fu Huang, Jer-Ming Chang, Shang-Jyh Hwang, Wan-Long Chuang, Ming-Lung Yu, FORMOSA-LIKE investigators
Summary: The study demonstrated the concept of treatment as prevention by implementing an HCV elimination program for hemodialysis patients. Universal HCV screening and prompt treatment with DAAs effectively reduced the prevalence of HCV viremia and prevented reinfection and new infections.
CLINICAL KIDNEY JOURNAL
(2023)