Article
Integrative & Complementary Medicine
Lijuan Hu, Xiaoqing Xu, Xijuan Chen, Shuai Qiu, Qiuju Li, Dapeng Zhang, Feng Wang
Summary: In this study, it was investigated whether EGCG can decrease HIF-1α expression in pancreatic cancer cells. The results showed that EGCG reduced both the production and stability of HIF-1α, leading to decreased cell growth and tumor development. This study revealed the mechanism of EGCG inhibition in pancreatic cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Chemistry, Applied
Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.
Article
Immunology
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: The study investigated the potential use of catechins derived from green tea as adjuvants for subunit and inactivated vaccines, demonstrating their ability to enhance immune responses and provide protection against vaccines, including influenza virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Chunguang Wang, Meiling Bai, Zhiguang Sun, Nan Yao, Aiting Zhang, Shengyu Guo, Zatollah Asemi
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that affect gene expression and are inappropriately expressed in various cancers. Recent research shows that phytochemicals like EGCG can modulate miRNAs and have potential anticancer effects. Targeting specific miRNAs with EGCG can regulate cancer-related processes and improve current cancer treatments.
CANCER CELL INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Victor Marin, Viviana Burgos, Rebeca Perez, Durvanei Augusto Maria, Paulo Pardi, Cristian Paz
Summary: Breast cancer is a highly prevalent cancer worldwide, with a high mortality rate despite treatment options such as surgery, radiotherapy, chemotherapy, and antibodies. Epigallocatechin-3-gallate (EGCG), found in green tea, has shown promising effects in controlling breast cancer by targeting various cellular processes. It has been proven to have synergistic effects when combined with traditional chemotherapy, increasing treatment efficacy. This review focuses on the impact of EGCG on breast tumor cells, the signaling pathways involved, the potential synergistic effects with current drugs, and the use of nanomaterials to enhance EGCG's bioavailability in breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Sze Wan Hung, Yiran Li, Xiaoyan Chen, Kai On Chu, Yiwei Zhao, Yingyu Liu, Xi Guo, Gene Chi-Wai Man, Chi Chiu Wang
Summary: Green tea, with its main component EGCG, shows potential in suppressing reproductive cancers by regulating autophagy and other cellular processes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Baogui Liu, Zhiyin Chen, Yangling Zhang, Enshuo Liu, Shuming Han, Zhihua Gong, Wenjun Xiao
Summary: The study improved the bioavailability and efficacy of EGCG by preparing EGCG+LTA/βCD inclusion complexes, which significantly enhanced its lipid-lowering and weight loss effects by improving gut microflora and EGCG bioavailability.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Pharmacology & Pharmacy
Tianli Zhang, Mengmeng Liu, Qing Liu, Gary Guishan Xiao
Summary: Wogonin can enhance the sensitivity of pancreatic cancer cells to gemcitabine chemotherapy, possibly by promoting apoptosis through inhibiting the Akt signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Zhiqi Zhang, Haitao Yu, Wenyan Yao, Na Zhu, Ran Miao, Zhiquan Liu, Xuwei Song, Chunhua Xue, Cheng Cai, Ming Cheng, Ke Lin, Dachuan Qi
Summary: This study reveals that RRP9 plays a critical role in inducing gemcitabine chemoresistance in pancreatic cancer through the activation of the IGF2BP1/AKT signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Chemistry, Applied
Jianyong Zhang, Hongchun Cui, Jiahuan Qiu, Xiaoqing Wang, Yixin Zhong, Caiping Yao, Lanying Yao, Qunxiong Zheng, ChunHua Xiong
Summary: This study aimed to improve the stability and bioavailability of EGCG in aqueous solutions and in vivo by preparing EGCG glycosylated arachin nanoparticles and EGCG glycosylated casein nanoparticles. The results showed that the DPPH scavenging activity of the nanoparticles was stable within temperature range of 25-70 degrees Celsius. EGCG enhanced the crosslinking effect of molecular particles in the glycosylation complexes solution. The glycosylated protein nanoparticles were stable to acid-base and enzymolysis in simulated gastrointestinal fluid.
Article
Agriculture, Multidisciplinary
Lijie Jia, Fuming Wang, Ke Zhang, Dongxu Wang, Xiaoxiao Wang, Xiuli Li, Jinsong Zhang
Summary: The study found that L-theanine in tea can inhibit the oxidation of tea catechins by chelating copper, thereby protecting the liver from damage.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cell Biology
Honghui Zhang, Wei Su, Rusong Zhao, Mei Li, Shigang Zhao, Zi-Jiang Chen, Han Zhao
Summary: This study delves into the precise impact and underlying mechanisms of EGCG on aged oocytes. Both in vitro and in vivo experiments demonstrate EGCG's capacity to enhance the quality of aged oocytes. In vitro application of EGCG yields remarkable improvements, including heightened rates of first polar body extrusion, refined spindle morphology, enhanced mitochondrial function, and reduced oxidative stress. Besides, EGCG may enhance Arf6 expression through direct interaction in aged oocytes, consequently promoting the assembly of spindle-associated F-actin and mitigating the aneuploidy induced by the disruption of spindle F-actin. In addition, these positive outcomes are corroborated by enhanced fertility observed in aged mice, providing a therapeutic intervention to address fertility challenges associated with advanced age.
CELL PROLIFERATION
(2023)
Review
Biochemistry & Molecular Biology
Mateusz Kciuk, Manzar Alam, Nemat Ali, Summya Rashid, Pola Glowacka, Rajamanikandan Sundaraj, Ismail Celik, Esam Bashir Yahya, Amit Dubey, Enfale Zerroug, Renata Kontek
Summary: Cellular signaling pathways play a significant role in maintaining the balance between cell proliferation and apoptosis, making them rational targets for cancer prevention and treatment. Epigallocatechin-3-gallate (EGCG), the major phenolic compound in green tea, has been shown to regulate important cellular signaling pathways involved in the pathophysiology of cancer. EGCG has demonstrated anti-proliferative, anti-inflammatory, and apoptosis-inducing effects, as well as the ability to induce epigenetic changes. Preclinical and clinical studies suggest that EGCG may have therapeutic potential for various disorders, including cancer.
Article
Plant Sciences
Qianjin Xie, Xiaqiang Cai, Xu Dong, Ying Wang, Minghui Sun, Lingling Tai, Yan Xu
Summary: The combination of EGCG with Vc and glycerol could effectively increase its stability and uric acid-lowering activity, which sheds light on the development and application of EGCG in the fields of food and medicine.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Oncology
Feng Li, Syeda Qasim, Dapeng Li, Q. Ping Dou
Summary: In-depth insights on cancer biology have highlighted the important roles of epigenetic mechanisms in tumorigenesis. Targeting the cancer epigenome with epi-drugs, including phytochemicals like EGCG, offers promising strategies for cancer chemoprevention and therapy. However, there are limitations to using EGCG as an epigenetic modulator in cancer treatment.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kamil Borkowski, Sun J. Yim, Roberta R. Holt, Robert M. Hackman, Carl L. Keen, John W. Newman, Gregory C. Shearer
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2019)
Article
Oncology
Dingyuan Luo, Matthew G. DiGiovanni, Ran Wei, Joseph F. LaComb, Jennie L. Williams, Basil Rigas, Gerardo G. Mackenzie
Article
Oncology
Ran Wei, Robert M. Hackman, Yuefei Wang, Gerardo G. Mackenzie
Article
Biochemistry & Molecular Biology
Ran Wei, Joanna Wirkus, Zixuan Yang, Jazmin Machuca, Yasmin Esparza, Gerardo G. Mackenzie
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Food Science & Technology
Nuchanart Suealek, Thipaporn Tharavanij, Robert M. Hackman, Carl L. Keen, Roberta R. Holt, Benjapun Burawat, Ammara Chaikan, Rattana Tiengtip, Panadda Rojpibulstit
Summary: The study shows that Thai tea seed oil can be a healthy alternative oil for high-temperature cooking, and daily intake of tea seed oil or virgin olive oil in healthy adults can significantly reduce total cholesterol and low-density lipoprotein cholesterol levels.
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yousef A. Al-Dashti, Roberta R. Holt, Carl L. Keen, Robert M. Hackman
Summary: Research on cardioprotective foods like dates is essential for addressing global public health needs. While animal studies show promising results, more human research is needed to fully understand the potential benefits of date fruit on vascular health. Conducting thorough clinical trials and assessing functional markers of vascular disease will provide valuable information for human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Xiang Li, Roberta R. Holt, Carl L. Keen, Lawrence S. Morse, Glenn Yiu, Robert M. Hackman
Summary: Regular intake of Z-rich goji berries can increase MPOD and skin carotenoids in healthy middle-aged individuals, which may help prevent or delay the development of AMD.
Article
Oncology
Cecilia Rodriguez Lanzi, Ran Wei, Dingyuan Luo, Gerardo G. Mackenzie
Summary: MDC-22 demonstrates significant inhibitory effects on pancreatic cancer by reducing tumor growth and extending survival time in preclinical models, as well as potentially synergizing with irinotecan for combination therapy.
Review
Nutrition & Dietetics
Vivien W. Fam, Prae Charoenwoodhipong, Raja K. Sivamani, Roberta R. Holt, Carl L. Keen, Robert M. Hackman
Summary: Plant-based foods are rich in bioactive compounds that are beneficial for skin health, such as vitamin C and polyphenols. Studies have shown a positive correlation between higher intake of certain fruits and vegetables and skin health. While plant-based dietary interventions show promise in promoting skin health, further research is needed to address issues such as intake quantity, quality, and mechanisms of action.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2022)
Article
Food Science & Technology
Kayama Kayama, Ran Wei, Yuanping Zhang, Fenghua Wu, Zhucheng Su, Junjie Dong, Xingquan Liu
Summary: This study found that the addition of tea powder improved the quality of tea noodles and increased their antioxidative potential. The addition of tea powder reduced the cooking time and cooking loss of the noodles, and increased their water absorption. Tea powder also changed the color and volatile profiles of the noodles, enhancing their flavor.
Article
Biochemistry & Molecular Biology
Ran Wei, Zhucheng Su, Gerardo G. Mackenzie
Summary: This study evaluated the gut protecting effect of CGA and EGCG, major constituents of coffee and green tea, on d-galactose-induced aging mice. CGA plus EGCG improved cognition deficits and protected gut barrier function more effectively compared to the agents alone. Additionally, CGA and EGCG modulated the gut microbiome and reduced gut inflammation.
Article
Biochemistry & Molecular Biology
Ran Wei, Xingquan Liu, Yuefei Wang, Junjie Dong, Fenghua Wu, Gerardo G. Mackenzie, Zhucheng Su
Summary: Cyclophosphamide (CTX) is a widely used antitumor drug, but its toxic side effects can impact patient outcomes. This study found that epigallocatechin-3-gallate (EGCG) from green tea can improve the gut injury induced by CTX, including repairing intestinal structure, regulating immune cytokines, and restoring tight junction proteins.
Article
Nutrition & Dietetics
Vivien W. Fam, Roberta R. Holt, Carl L. Keen, Raja K. Sivamani, Robert M. Hackman
Review
Biochemistry & Molecular Biology
Roberta R. Holt, Michelle L. Zuelch, Prae Charoenwoodhipong, Yousef A. Al-Dashti, Robert M. Hackman, Carl L. Keen