Article
Chemistry, Analytical
Han Zhang, Long Huang, Mingyue Tan, Shaoqing Zhao, Hua Liu, Zifeng Lu, Jinhuan Li, Zhongzhu Liang
Summary: Researchers are looking for more innovative 3D printing technologies for glass fabrication, which provides a good solution to the complex traditional glass manufacturing process. However, the application of 3D printing in glass fabrication is still in its infancy and faces many challenges.
Article
Materials Science, Multidisciplinary
Beatriz Araoz, Emine Karakaya, Ana Gonzalez Wusener, Rainer Detsch, Juan Bizzotto, Geraldine Gueron, Aldo R. Boccaccini, Elida B. Hermida
Summary: 3D printing of tissue engineering scaffolds using a combination of PHBV and BG materials allows for the control of infill density to create interconnected pores and channels resembling the extracellular matrix of bone cells. Chemical treatment of BG particles enhances the ductility of the extruded filaments, improving printability. Results demonstrate that scaffolds containing BG particles coated with CTMS exhibit no cytotoxic effects and promote cell spreading, mimicking the mechanical and biological properties of trabecular bone ECM.
JOURNAL OF MATERIALS RESEARCH
(2021)
Review
Polymer Science
Syed Fouzan Iftekar, Abdul Aabid, Adibah Amir, Muneer Baig
Summary: 3D printing has revolutionized industries by enabling production of complex designs and shapes. Recent advancements in new materials have led to increased applications of 3D printing. However, the technology still faces challenges such as high costs, low printing speeds, limited part sizes, and strength. This paper critically reviews recent trends in 3D printing technology, focusing on materials and their applications in manufacturing. It emphasizes the need for further development to overcome limitations and provides insights into prospects through comprehensive overview.
Article
Materials Science, Multidisciplinary
Katharina Schuhladen, Vera Bednarzig, Nadine Rembold, Aldo R. Boccaccini
Summary: 3D printing technology offers the potential to create intricate and customized scaffolds for tissue engineering applications using advanced biomaterial-based inks. This study explores the fabrication of a thermo-sensitive hydrogel by combining methylcellulose and manuka honey, as well as the addition of bioactive glass to enhance ink properties. The composite ink incorporating a matrix of methylcellulose, manuka honey, and borate bioactive glass showed improved printability and mechanical properties, demonstrating potential for tissue engineering applications.
JOURNAL OF MATERIALS RESEARCH
(2021)
Review
Polymer Science
Andrea Martelli, Devis Bellucci, Valeria Cannillo
Summary: Tissue engineering is a promising field in regenerative medicine that utilizes synthetic grafts like scaffolds to regenerate damaged tissues. Polymers and bioactive glasses are popular materials for scaffold production due to their adjustable properties and interaction with the body. Additive manufacturing is a promising method for producing scaffolds, but challenges remain in tailoring mechanical properties and achieving controlled degradation for successful tissue regeneration. This review summarizes the potential and limitations of using additive manufacturing techniques for polymer/bioactive glass scaffold production and emphasizes the importance of addressing current challenges in tissue engineering for reliable strategies.
Article
Engineering, Biomedical
Elisa Fiume, Alessandro Schiavi, Gissur Orlygsson, Cristina Bignardi, Enrica Verne, Francesco Baino
Summary: Proper microstructural and transport properties are crucial for scaffold design in tissue engineering applications. Evaluating permeability remains a challenge, while pore characteristics are relatively easier to assess.
ACTA BIOMATERIALIA
(2021)
Review
Polymer Science
Nurulhuda Arifin, Izman Sudin, Nor Hasrul Akhmal Ngadiman, Mohamad Shaiful Ashrul Ishak
Summary: This article reviews the potential of photo-polymerization 3D printing technique in tissue engineering scaffold fabrication. It also compares this technique with other scaffold fabrication methods. Various parameter settings affecting mechanical properties, biocompatibility, and porosity behavior are discussed in detail.
Article
Automation & Control Systems
Trung Kien Nguyen, Bang Thi Le, Minh Thi Hong Nguyen, Van-Sang Pham, Truong Do, Phuong Tran, Lan Xuan Phung
Summary: This research develops and optimizes a novel design of a direct powder mini-screw extruder (DPSE) through numerical modeling analysis, which enables the printing of PCL-based composite scaffolds by utilizing a combination of PCL powder and other biomaterials. The high potential of the DPSE printer head in fabricating high-quality PCL-based composite scaffolds with minimal wastage and prolonged printability is demonstrated.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Biochemical Research Methods
Sara Simorgh, Neda Alasvand, Mahboobe Khodadadi, Faezeh Ghobadi, Maziar Malekzadeh Kebria, Peiman Brouki Milan, Saeid Kargozar, Francesco Baino, Ali Mobasheri, Masoud Mozafari
Summary: Tissue engineering and regenerative medicine use additive manufacturing technology for 3D printing, with bioactive glasses being one of the most promising raw materials that can improve the bioactivity and antibacterial activity of constructs. This review provides an up-to-date report on the development of 3D printed scaffolds using BG-containing raw biomaterials for tissue regeneration applications, focusing on their advantages and challenges.
Article
Polymer Science
Tianqi Liu, Bo Yang, Wenqing Tian, Xianglin Zhang, Bin Wu
Summary: In this study, a coaxial cryogenic printing technique was developed to fabricate 3D scaffolds with a PCL/SA shell/core structure, which broadens the material range of coaxial printing and shows promising potential in drug release applications.
Review
Pharmacology & Pharmacy
Golara Nasiri, Sepideh Ahmadi, Mohammad-Ali Shahbazi, Vahideh Nosrati-Siahmazgi, Yousef Fatahi, Rassoul Dinarvand, Mohammad Rabiee, Farahnaz Haftlang, Hyoung Seop Kim, Navid Rabiee
Summary: This article discusses the use of three-dimensional printing technology in drug delivery systems, including the incorporation of multiple drugs and the potential for personalized therapy.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Materials Science, Multidisciplinary
Fereshteh Mahmoodiyan Najafabadi, Saeed Karbasi, Soheila Zamanlui Benisi, Shahrokh Shojaei, S. Ali Poursamar, Reyhaneh Nasr Azadani
Summary: This study synthesized magnetic mesoporous bioactive glass using the sol-gel method and incorporated alumina nanowires. The synthesized glass exhibited a mesoporous structure and paramagnetic properties. The 3D printed scaffold showed homogeneous structures with interconnected pores. The addition of alumina nanowires improved the mechanical strength, contact angle, degradation, and bioactivity of the scaffold.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Materials Science, Ceramics
Elisa Fiume, Jonathan Massera, Daniele D'Ambrosio, Enrica Verne, Francesco Baino
Summary: This experimental work describes a new method for manufacturing sol-gel bioactive silicate scaffolds using dried gels as basic material within the ink composition. The scaffolds were characterized in terms of morphological-compositional features and bioactivity in simulated body fluid. The results showed the possibility of using robocast sol-gel-derived scaffolds in bone tissue engineering approaches.
CERAMICS INTERNATIONAL
(2022)
Review
Engineering, Environmental
Jie Zhu, Peiwen Wu, Yanhong Chao, Jiangtao Yu, Wenshuai Zhu, Zhichang Liu, Chunming Xu
Summary: Three-dimensional (3D) printing is revolutionizing the design and manufacturing of 3D objects by transforming digital models into solid models. In the field of catalysis, 3D printing technology offers new possibilities and is widely applied in related catalytic reactions and processes.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Construction & Building Technology
Mahan Motamedi, Romain Mesnil, Robin Oval, Olivier Baverel
Summary: This paper describes the Patching technique for building shells without wasteful support using 3D Printing technology. The technique extends ancient vaulting techniques and formalizes them into a design Grammar, allowing for automatic decomposition of non-traditional shapes into self-standing interconnected components. The presented prototype demonstrates the potential of the Patching technique for printing shells with low-strength materials.
AUTOMATION IN CONSTRUCTION
(2022)
Article
Materials Science, Multidisciplinary
Martina Cazzola, Jacopo Barberi, Sara Ferraris, Andrea Cochis, Grzegorz Cempura, Aleksandra Czyrska-Filemonowicz, Lia Rimondini, Silvia Spriano
Summary: This research aims to develop an antibacterial and osteoconductive Ti6Al4V surface by using chemical etching-oxidation treatment and in situ reduction of silver nanoparticles. The study found that the concentration and addition time of the silver precursor affect the distribution and release of silver in the surface oxide layer. The silver concentration in the samples determines their bactericidal and cytotoxic abilities.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Materials Science, Ceramics
Virginia Alessandra Gobbo, Vijay Singh Parihar, Mirko Prato, Minna Kellomaki, Enrica Verne, Silvia Spriano, Jonathan Massera
Summary: Bioactive glasses have great potential in bone tissue regeneration. In this study, four different types of bioactive glasses were surface-modified and their physicochemical properties were characterized. The aim is to understand how the surface properties affect protein adsorption.
CERAMICS INTERNATIONAL
(2023)
Article
Materials Science, Multidisciplinary
Sara Ferraris, Ingrid Corazzari, Francesco Turci, Andrea Cochis, Lia Rimondini, Silvia Spriano, Jonathan Massera, Enrica Verne
Summary: In this study, silicate and borosilicate bioactive glasses were synthesized and characterized. The antioxidant activity of the glasses was correlated to their surface properties, and it was found that boron enhanced glass reactivity while strontium and magnesium played a stabilizing role. The glasses were also found to have a scavenging potential against reactive oxygen species, and they exhibited a protective effect on viable cells.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Materials Science, Ceramics
Jacopo Barberi, Luisa Mandrile, Andrea M. Giovannozzi, Marta Miola, Lucia Napione, Andrea M. Rossi, Alessandra Vitale, Seiji Yamaguchi, Silvia Spriano
Summary: This paper reports the effect of silver doping on the interaction between a silica-based bioactive glass and albumin and fibronectin. The presence of silver significantly increases the adsorption of albumin and fibronectin and leads to a higher loss of secondary structure. It is also observed that proteins are embedded inside the surface reaction layer during adsorption due to the formation of a hydrated silica gel layer.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Biomedical
Elisa Piatti, Marta Miola, Liliana Liverani, Enrica Verne, Aldo R. Boccaccini
Summary: In this study, composite electrospun fibers containing innovative bioactive glass nanoparticles were successfully produced and characterized. The retention of bioactive glass nanoparticles in the polymer matrix, the electrospinnability of the novel solution, and the properties of the obtained electrospun composites were extensively investigated. The results showed that the produced composite fibers exhibited biocompatibility, bioactivity, and overall properties suitable for tissue engineering applications.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Chemistry, Physical
Marta Miola, Giovanni Lucchetta, Enrica Verne
Summary: In this study, an antibacterial composite bone cement was developed by incorporating a bioactive and antibacterial glass into a commercial formulation. The addition of glass particles affected the polymerization kinetics of the cement, but still met the ISO standard. The properties of the composite, including dispersion of glass particles, mechanical strength, bioactivity, and antibacterial effect, were evaluated. By carefully controlling the amount and size of the glass particles, a multifunctional device for various medical applications can be obtained.
Article
Materials Science, Ceramics
Francesco Baino, Joana Dias, Mojtaba Alidoost, Martin Schwentenwein, Enrica Verne
Summary: This study investigates the feasibility of using stereolithographic technology to fabricate bioactive glass scaffolds. The aim is to replicate the trabecular architecture of cancellous bone. The results show that well-densified foam-like glass scaffolds with suitable mechanical properties for bone-contact applications can be obtained through the process. The printed structures also demonstrate in vitro bioactivity.
Article
Materials Science, Ceramics
Mari Lallukka, Amel Houaoui, Marta Miola, Susanna Miettinen, Jonathan Massera, Enrica Verne
Summary: Fighting the formation of bacterial biofilm and providing a bioactive environment for bone regeneration is a significant challenge in surgery. Bioactive glasses doped with silver (Ag) or copper (Cu) ions offer a potential non-antibiotic solution. This study evaluates the cytocompatibility of Ag and Cu-doped bioactive glasses and finds that fibronectin adsorption improves the cytocompatibility of Ag-doped glass.
CERAMICS INTERNATIONAL
(2023)
Article
Materials Science, Ceramics
Marta Miola, Fabrizio Barberis, Alberto Lagazzo, Enrica Verne
Summary: PMMA-based composite bone cements with bioactive and ferrimagnetic glass-ceramic particles have been prepared and characterized. The study investigated their bioactivity, wettability, density, curing parameters, viscoelastic behavior, bending strengths, and creep at 37 degrees C. The presence of glass-ceramic particles improved the wetting behavior of the composite cements. The mechanical properties of the composite bone cements were almost unaffected compared to that of plain commercial cement, and radiographic imaging confirmed their radiopacity.
CERAMICS INTERNATIONAL
(2023)
Article
Materials Science, Ceramics
Marta Miola, Giovanni Lucchetta, Enrica Verne
Summary: In this study, bioactive and antibacterial glass was added to a commercial PMMA-based bone cement to improve bone-cement integration and reduce bacterial contamination. The impact of the amount and size of glass powders on the mechanical properties, radio-opacity, bioactivity, and antibacterial effect of the composite cements was evaluated. The results showed that both the amount and size of the filler influenced the bending strength of the samples. The radio-opacity of the composites could be adjusted by varying the amounts of glass and radio-opaque agent. Introduction of 10 wt.% glass conferred bioactive behavior to the PMMA-based matrix and limited bacterial contamination. A proposed approach for technological transfer with controlled process parameters was also presented.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)
Article
Materials Science, Coatings & Films
S. Spriano, G. Riccucci, G. Orlygsson, C. H. Ng, E. Verne, F. P. Sehn, P. T. de Oliveira, S. Ferraris
Summary: Two bioactive glasses (SCNB and SCNA) were coated with chitosan using different methods of coating. The effects of these coatings were evaluated through various tests and experiments. The results showed that the coatings had different effects on the stability and bioactivity of the glasses, as well as on the biological outcome of cell cultures.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Polymer Science
Matteo Bergoglio, Ziba Najmi, Andrea Cochis, Marta Miola, Enrica Verne, Marco Sangermano
Summary: This study presents a novel approach for fabricating bioactive glass reinforced scaffolds using 3D printing technology. The composite scaffold, made from a bio-based acrylate resin derived from soybean oil and a reactive diluent called isobornyl acrylate, showed improved mechanical behavior compared to traditional mould-synthetized samples. The addition of bioactive glass particles did not significantly affect the curing process or the cytocompatibility of the scaffold, but resulted in higher metabolic activity and increased cell attachment on the scaffold surfaces.
Article
Materials Science, Multidisciplinary
Camilla Reggio, Jacopo Barberi, Sara Ferraris, Silvia Spriano
Summary: Functionalization of medical devices with biomolecules, such as polyphenols, can enhance implant outcomes by promoting osseointegration and reducing infections and inflammation. The role of calcium ions and surface features in functionalizing medical devices with a red pomace extract was investigated. It was found that polyphenols were adsorbed more effectively in the presence of calcium ions, while a smooth surface exhibited lower adsorption due to the lack of reactive functional groups.
Review
Chemistry, Physical
Francesco Baino, Maziar Montazerian, Enrica Verne
Summary: Improving angiogenesis is crucial for successful regenerative medicine approaches, and cobalt-doped bioactive glasses offer potential by combining traditional bioactivity with pro-angiogenic effects. Concerns about possible toxic effects on cells and tissues have been raised, but important biological improvements have been observed in vitro and in vivo. This review provides an overview of biomedical applications of Co-releasing glasses, including various products and their therapeutic applications in bone repair, wound healing, and cancer treatment, along with existing evidence and future challenges.