Article
Cell Biology
Lu Lu, Taotao Lu, Julian Shen, Xinru Lv, Wei Wei, Hong Wang, Xiehua Xue
Summary: The study showed that Alisol A 24-acetate (AA) protected against BMECs damage and tight junctions loss by inhibiting miR92a-3p expression.
Article
Immunology
Min Yu, Xiaokun Ma, Dudu Jiang, Lijing Wang, Qing Zhan, Jiangmin Zhao
Summary: In an experiment to mimic ischemic stroke conditions, CXCL5 inhibitor was found to alleviate damage in human brain microvascular endothelial cells (BMECs), indicating that CXCL5 may regulate the function of BMECs by mediating the p38 pathway.
MICROBIOLOGY AND IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Marie Piantino, Fiona Louis, Yukari Shigemoto-Mogami, Kimiko Kitamura, Kaoru Sato, Tomoko Yamaguchi, Kenji Kawabata, Syunsuke Yamamoto, Shinji Iwasaki, Hideki Hirabayashi, Michiya Matsusaki
Summary: This study compared HBEC and hiPS-BMEC and found that hiPS-BMEC had higher expressions of transporters and tight junction proteins, resembling the BBB more accurately. Additionally, it confirmed the presence of transferrin receptor in hiPS-BMEC and its functionality in the RMT pathway.
MATERIALS TODAY BIO
(2022)
Article
Medicine, General & Internal
A. Ben-Zvi, S. Liebner
Summary: The blood-brain barrier is crucial for maintaining tissue homeostasis in the central nervous system, achieved by microvascular endothelial cells forming a tight barrier that restricts the entry of water-soluble molecules. The Wnt/beta-catenin pathway plays a significant role in the development of these unique endothelial properties.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Cell Biology
Yeonmi Lee, Minchul Kim, Miju Lee, Seongjun So, Soon-Suk Kang, Jiwan Choi, Deokhoon Kim, Hyohoon Heo, Sung Soo Lee, Hee Ra Park, Jung Jae Ko, Jihwan Song, Eunju Kang
Summary: This study demonstrates that mtDNA mutations in patients with AD could lead to mitochondrial dysfunction and accelerated A beta deposition. Early screening for mtDNA mutations in iPSC lines would be essential for developing autologous cell therapy or drug screening for patients with AD.
CELL PROLIFERATION
(2022)
Article
Critical Care Medicine
Kijana K. George, Benjamin P. Heithoff, Oleksii Shandra, Stefanie Robel
Summary: Mild traumatic brain injury/concussion (mTBI) accounts for 70-90% of all reported TBI cases. Recent clinical studies revealed increased blood-brain barrier (BBB) permeability in mTBI patients, which correlated with secondary damage after mTBI. This study demonstrates that BBB damage causes atypical astrocytes, and even relatively small BBB disturbances are sustained long term.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Multidisciplinary Sciences
Karlijn A. L. Hasaart, Freek Manders, Joske Ubels, Mark Verheul, Markus J. van Roosmalen, Niels M. Groenen, Rurika Oka, Ewart Kuijk, Susana M. Chuva de Sousa Lopes, Ruben van Boxtel
Summary: This study compares the mutation burden between cultured iPSCs and their isogenic embryonic cells, finding that iPSCs maintain genomic integrity during culture at a similar degree as pluripotent cells in vivo.
Review
Neurosciences
Melanie E. M. Stamp, Michael Halwes, David Nisbet, David J. Collins
Summary: The blood-brain barrier is a selectively permeable membrane that protects neural tissue from harmful substances but also limits drug delivery to the brain. Physical approaches such as focused ultrasound have shown promise in disrupting the blood-brain barrier temporarily and locally, allowing drugs to enter specific regions of the brain. However, the safety, efficacy, and practicality of these physical approaches for clinical use are still being researched.
FLUIDS AND BARRIERS OF THE CNS
(2023)
Article
Cell Biology
Rebecca Schmitt, Sana Qayum, Artem Pliss, Andrey N. Kuzmin, Vijaya Prakash Krishnan Muthaiah, Kathiravan Kaliyappan, Paras N. Prasad, Supriya D. Mahajan
Summary: Blood brain barrier (BBB) breakdown is an important factor in traumatic brain injury (TBI), leading to prolonged neurological deficits and increased mortality risk in TBI patients. However, the role of endothelium in BBB breakdown has not been adequately studied. This study investigates TBI-induced changes in brain endothelium at the subcellular level, particularly focusing on mitochondrial dysfunction. The findings suggest that mitochondrial dysfunction in brain endothelial cells is a crucial component of BBB breakdown and TBI progression.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Canling Long, Rui Guo, Ruijuan Han, Kang Li, Yanbing Wan, Jiqing Xu, Xiaoyu Gong, Yanqiu Zhao, Xinhuang Yao, Jia Liu
Summary: The study found that M1- or M2-polarized macrophages play critical roles in the proliferation, cardiac differentiation, and maturation of iPSCs.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell & Tissue Engineering
Chanchan Song, Linli Wang, Qingyang Li, Baoyi Liao, Weihua Qiao, Qiang Li, Nianguo Dong, Liangping Li
Summary: A simple HLA gene-swapping system has been developed to generate iPSCs with specific HLA alleles, allowing for the evasion of transplant rejection by CD8+ T cells and activation of NK cells. These modified iPSCs have been successfully differentiated into functional ECs for use in cellular heart valve engineering.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Veterinary Sciences
Abinaya Chandrasekaran, Barbara Blicher Thomsen, Jorgen Steen Agerholm, Lais Vicari de Figueiredo Pessoa, Naira Caroline Godoy Pieri, Vahideh Sabaghidarmiyan, Katarina Langley, Miriam Kolko, Andre Furugen Cesar de Andrade, Fabiana Fernandes Bressan, Poul Hyttel, Mette Berendt, Kristine Freude
Summary: Domestic dogs are considered superior models for translational medicine, particularly in the field of neurodegenerative medicine. The generation of canine induced pluripotent stem cells provides a potential method for developing in vitro models for neurodegenerative diseases. However, challenges and new perspectives must be considered before utilizing the canine model in translational neurological studies, as shown by the differences encountered in neural differentiation potential during this study.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sebastiano Giallongo, Daniela Rehakova, Marco Raffaele, Oriana Lo Re, Irena Koutna, Manlio Vinciguerra
Summary: Induced pluripotent stem cells (iPSCs) have great potential in regenerative medicine and therapy, but concerns arise regarding genomic instability due to high oxidative stress. Future research should focus on the impact of redox balance and epigenetic modifications on iPSCs.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Cell Biology
Chunyu Bai, Qiwei Ren, Haifeng Liu, Xiangchen Li, Weijun Guan, Yuhua Gao
Summary: Pancreatic beta cell transplantation is the ideal method for treating type 1 diabetes, and producing beta cells from induced pluripotent stem cells (iPSCs) shows promise. This study demonstrates a novel approach for beta cell production and advocates for using iPSCs in cell replacement therapy for T1DM.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Sarah Alsobaie, Tamador Alsobaie, Amal Alshammary, Sakis Mantalaris
Summary: This study developed a method to culture lung mature type I pneumocytes from human induced pluripotent stem cells (IPSCs) in only 20 days without using feeder cells. The three-dimensional (3D) bioprocess allowed cell derivation into endoderm, and subsequently into type II alveolar epithelial cells within a very short period. This research provides an individualized model for lung engineering, therapy, and drug testing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Oncology
Nicholas Howard, Marco Clementino, Donghern Kim, Lei Wang, Angela Verma, Xianglin Shi, Zhuo Zhang, Robert S. DiPaola
SEMINARS IN CANCER BIOLOGY
(2019)
Article
Pharmacology & Pharmacy
Angela Verma, Yau-Min Lam, Yun-Chung Leung, Xiaohui Hu, Xin Chen, Edwin Cheung, Kin Yip Tam
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2019)
Review
Pharmacology & Pharmacy
Tanya Chhibber, Sounak Bagchi, Behnaz Lahooti, Angela Verma, Abraham Al-Ahmad, Manash K. Paul, Gurudutt Pendyala, Rahul Dev Jayant
DRUG DISCOVERY TODAY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Sounak Bagchi, Rahul Jayant
Article
Instruments & Instrumentation
Vivek B. Borse, Aditya N. Konwar, Rahul D. Jayant, Pravin O. Patil
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2020)
Article
Engineering, Biomedical
Mugdha Makrand Joglekar, Devlina Ghosh, Dhivyaa Anandan, Puja Yatham, Rahul Dev Jayant, N. Arunai Nambiraj, Amit Kumar Jaiswal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2020)
Review
Immunology
Behnaz Lahooti, Tanya Chhibber, Sounak Bagchi, Sree Pooja Varahachalam, Rahul D. Jayant
Summary: Neuroinflammation characterized by glial cell activation is a hallmark of several neurological and neurodegenerative disorders, with chronic inflammation being a critical contributing factor for disease manifestation in conditions like HIV-1-associated neurocognitive disorders, Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Involvement of inflammasomes, particularly the NLRP complex, has been implicated in the development of these diseases, leading to the development of potential NLRP-targeting small-molecule therapeutics for the treatment of chronic neurological diseases.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Nanoscience & Nanotechnology
Sree Pooja Varahachalam, Behnaz Lahooti, Masoumeh Chamaneh, Sounak Bagchi, Tanya Chhibber, Kevin Morris, Joe F. Bolanos, Nam-Young Kim, Ajeet Kaushik
Summary: COVID-19 pandemic, caused by SARS-CoV-2, severely affects the respiratory system and presents challenges in diagnostics and therapeutics. Nanotechnology offers promising solutions for targeted drug delivery, improving treatment outcomes.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Amarjitsing Rajput, Prashant Pingale, Darshan Telange, Shailesh Chalikwar, Vivek Borse
Summary: The oral route of administration for lipid-based nanocarriers is crucial for improving the bioavailability of drugs with low bioavailability. Through lymphatic transport, these drug delivery systems can enhance oral bioavailability and therapeutic activity. Avoiding first-pass metabolism can lead to significant improvements in oral bioavailability. Further research, including detailed clinical studies, is needed to explore the safety and efficacy of various lipid-based nanocarriers.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Ajeet Kaushik, Jose Rodriguez, Dan Rothen, Vinay Bhardwaj, Rahul Dev Jayant, Pradip Pattany, Beatriz Fuentes, Hitendra Chand, Nagesh Kolishetti, Nazira El-Hage, Kamel Khalili, Norma S. Kenyon, Madhavan Nair
ACS APPLIED BIO MATERIALS
(2019)
Article
Multidisciplinary Sciences
Ajeet Kaushik, Adriana Yndart, Venkata Atluri, Sneham Tiwari, Asahi Tomitaka, Purnima Gupta, Rahul Dev Jayant, David Alvarez-Carbonell, Kamel Khalili, Madhavan Nair
SCIENTIFIC REPORTS
(2019)