期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-019-12187-5
关键词
-
资金
- Garron Family Cancer Center fellowship
- Worldwide Cancer Research
- Gertrud-Hagmann-Stiftung
- RESTRACOMP of the Hospital for Sick Children
- Canadian Institute of Health Research (CIHR) CGS-M scholarship
- Ontario Graduate Scholarship (OGS)
- Canadian Cancer Society [702296]
- Canadian Institutes of Health Research [159805]
- Kids' Brain Tumor Cure Foundation
- aka The PLGA foundation
- Genome Canada through Genome Quebec
- Ontario Genomics
Infant gliomas have paradoxical clinical behavior compared to those in children and adults: low-grade tumors have a higher mortality rate, while high-grade tumors have a better outcome. However, we have little understanding of their biology and therefore cannot explain this behavior nor what constitutes optimal clinical management. Here we report a comprehensive genetic analysis of an international cohort of clinically annotated infant gliomas, revealing 3 clinical subgroups. Group 1 tumors arise in the cerebral hemispheres and harbor alterations in the receptor tyrosine kinases ALK, ROS1, NTRK and MET. These are typically single-events and confer an intermediate outcome. Groups 2 and 3 gliomas harbor RAS/MAPK pathway mutations and arise in the hemispheres and midline, respectively. Group 2 tumors have excellent long-term survival, while group 3 tumors progress rapidly and do not respond well to chemoradiation. We conclude that infant gliomas comprise 3 subgroups, justifying the need for specialized therapeutic strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据