Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition

High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition.

(2019) Maxim S. Svetlov et al.   RNA

Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides

(2019) Nelli F. Khabibullina et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibiotic export: transporters involved in the final step of natural product production

(2019) Emmanuele Severi et al.   MICROBIOLOGY-SGM

Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome

(2018) Andrey G. Tereshchenkov et al.   JOURNAL OF MOLECULAR BIOLOGY

Biosynthesis of Translation Inhibitor Klebsazolicin Proceeds through Heterocyclization and N-Terminal Amidine Formation Catalyzed by a Single YcaO Enzyme

(2018) Dmitrii Y. Travin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site

(2018) Lucile Pantel et al.   MOLECULAR CELL

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Focus: The interface between data collection and data processing in cryo-EM

(2017) Nikhil Biyani et al.   JOURNAL OF STRUCTURAL BIOLOGY

Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel

(2017) Mikhail Metelev et al.   Nature Chemical Biology

Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins

(2017) Mashal M. Almutairi et al.   NUCLEIC ACIDS RESEARCH

Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state

(2017) Ilya A. Osterman et al.   NUCLEIC ACIDS RESEARCH

Experimental charge density from electron microscopic maps

(2017) Jimin Wang   PROTEIN SCIENCE

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining

(2016) Michael A. Skinnider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest

(2016) Stefan Arenz et al.   Nature Communications

Plantazolicin Is an Ultranarrow-Spectrum Antibiotic That Targets the Bacillus anthracis Membrane

(2016) Katie J. Molohon et al.   ACS Infectious Diseases

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A

(2015) Yury S. Polikanov et al.   MOLECULAR CELL

High-resolution structure of the Escherichia coli ribosome

(2015) Jonas Noeske et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

High-resolution structure of the Escherichia coli ribosome

(2015) Jonas Noeske et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria

(2014) Anne-Catrin Letzel et al.   BMC GENOMICS

Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome

(2014) Yury S. Polikanov et al.   MOLECULAR CELL

Tools for Characterizing Bacterial Protein Synthesis Inhibitors

(2013) Cédric Orelle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure of Microcin B-Like Compounds Produced by Pseudomonas syringae and Species Specificity of Their Antibacterial Action

(2013) M. Metelev et al.   JOURNAL OF BACTERIOLOGY

Discovery and Characterization of an Isopeptidase That Linearizes Lasso Peptides

(2013) Mikhail O. Maksimov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition

(2013) Cédric Orelle et al.   NUCLEIC ACIDS RESEARCH

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

(2012) Marcus D Hanwell et al.   Journal of Cheminformatics

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family

(2010) Daniel H Haft et al.   BMC BIOLOGY

The Mechanism of Microcin C Resistance Provided by the MccF Peptidase

(2010) Anton Tikhonov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Broad-Host-Range Expression Vectors with Tightly Regulated Promoters and Their Use To Examine the Influence of TraR and TraM Expression on Ti Plasmid Quorum Sensing

(2008) S. R. Khan et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY