Article
Engineering, Multidisciplinary
Shuo Wang, Mingkuan Lu, Yong Cao, Zaijin Tao, Zhenyu Sun, Xuanzhe Liu, Jingwen Liu, Shen Liu
Summary: Biodegradability is an important factor in the development of medical biomaterials. However, the post-implantation degradation of polylactide (PLA) can lead to complications such as in-stent restenosis and postoperative adhesion, hindering its clinical application. In this study, we found that PLA degradation promotes excessive M2 polarization in macrophages, resulting in a pro-adhesion microenvironment. This is mediated by phosphorylation of the STAT6 pathway. Our findings provide insights into the regulatory mechanisms underlying PLA degradation and suggest potential strategies for optimizing PLA anti-adhesion membranes.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Wei Peng, Yong Xie, Zixiang Luo, Yudong Liu, Jiaqi Xu, Chengjun Li, Tian Qin, Hongbin Lu, Jianzhong Hu
Summary: Macrophages polarized to the M2 subtype after spinal cord injury (SCI) are beneficial for promoting neurological recovery. The crosstalk between endothelial cells (ECs) and macrophages is crucial for the imbalance between proinflammatory and pro-resolving responses caused by macrophage heterogeneity; however, this crosstalk is strengthened post-SCI, leading to inflammatory cascades and second damage.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Casimiro Luca Gigliotti, Chiara Dianzani, Ian Stoppa, Chiara Monge, Salvatore Sutti, Daniele Sblattero, Chiara Puricelli, Roberta Rolla, Umberto Dianzani, Elena Boggio
Summary: Activated T cells express ICOS, which regulates immune response and tissue repair. The effect of ICOS:ICOSL interaction on human M1 and M2 macrophages was investigated. ICOS-CH3 treatment increased cytokine secretion in M1 and M2 cells. However, the effects differed in LPS-treated M1 cells and LPS + IL4-treated M2 cells. ICOS-CH3 also modulated cell migration and beta-Pix expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Juan Wang, Huiying Gao, Yuan Xie, Peng Wang, Yu Li, Junli Zhao, Chunlin Wang, Xin Ma, Yuwen Wang, Qinwen Mao, Haibin Xia
Summary: The study demonstrated that Lycium barbarum polysaccharide (LBP) can protect against inflammatory bowel disease (IBD) by regulating macrophage polarization. LBP attenuated the symptoms of colitis and regulated the balance between M1 and M2 macrophages in colon tissues, indicating its potential therapeutic effects. Mechanistic studies revealed that LBP inhibited M1-like macrophage phenotype and promoted M2-like phenotype by modulating the STAT1 and STAT6 pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Yan Yang, Na Zhao, Ruobing Wang, Zhuorong Zhan, Shuyu Guo, Haiyang Song, Erik A. C. Wiemer, Jingjing Ben, Junqing Ma
Summary: This study revealed that major vault protein (MVP) plays a crucial role in macrophage polarization during fracture repair. The lack of MVP impairs the inflammatory state transition of macrophages, resulting in impaired fracture repair.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Veterinary Sciences
Yueli Wang, Jing Xi, Jihai Yi, Chuang Meng, Xiaoli Zhao, Zhihua Sun, Huan Zhang, Xiaoyu Deng, Zhongchen Ma, Honghuan Li, Yong Wang, Chuangfu Chen
Summary: Brucella infection can induce macrophage polarization towards M2 type, which is regulated by STAT6 and is closely associated with intracellular survival of Brucella.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Cell Biology
Long Yang, Xuan Zhang, Yan Gu, Yan Shi, Long-Bin Wang, Jia-Xin Shi, Xing-Xing Zhen, Ya-Wei Xin, Wen-Wen Gu, Jian Wang
Summary: The study reveals that SEC5 is involved in regulating the M2 polarization of decidual macrophages (dM phi s) by interacting with STAT6. Decreased SEC5 expression inhibits the M2 polarization of dM phi s, interfering with the physical activities of extravillous trophoblasts (EVTs) and immunotolerance at the maternal-fetal interface, leading to early pregnancy loss.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Chongyang Huang, Jun Wang, Hongbin Liu, Ruo Huang, Xinwen Yan, Mengyao Song, Gao Tan, Fachao Zhi
Summary: This study found that exogenous BHB can promote M2 macrophage polarization, which helps to resolve intestinal inflammation and repair damaged intestinal tissues. This finding suggests that exogenous BHB may be a useful therapeutic approach for IBD treatment.
Article
Engineering, Biomedical
Jeong-Ki Kim, Seong-Beom Han, Serk In Park, In-San Kim, Dong-Hwee Kim
Summary: Alternatively activated or M2 macrophages play a vital role in anti-inflammation, wound healing, and tissue repair. This study demonstrates that M2 activation requires mechanical cues from the extracellular microenvironment, and matrix rigidity-dependent macrophage spreading is mediated by F-actin formation. The study also identifies a new mechanosensing function of STAT6 in M2 activation.
Article
Cell Biology
Jiaqi Fang, Qian Ou, Boheng Wu, Sisi Li, Mian Wu, Jialing Qiu, Nuo Cen, Kaixin Hu, Yangfei Che, Yuan Ma, Jianping Pan
Summary: This study investigated the influence of TcpC, a virulence factor of Uropathogenic Escherichia coli (UPEC), on the polarization of macrophages into M1 and M2 subsets and the potential mechanisms involved. The results showed that TcpC inhibits M1 macrophage polarization through down-regulation of p38, ERK/NF-κB signaling pathways, while promoting M2 macrophage polarization through up-regulation of the Akt/STAT6 signaling pathway. These findings not only shed light on the regulatory effects of TcpC on macrophage polarization and signaling pathways, but also provide a novel mechanism for TcpC-mediated evasion of macrophage-mediated innate immunity.
Article
Biochemistry & Molecular Biology
Naga Lakshmi Challa, Ankita Sarkar, Satyamoorthy Kapettu, Prakash Babu Phanithi, Partha Chakrabarti, Kishore V. L. Parsa, Parimal Misra
Summary: Macrophage-driven chronic low-grade inflammatory response is closely associated with insulin resistance and type 2 diabetes. The TGS1 gene plays a role in regulating macrophage activation and polarization, and affects the development of insulin resistance in skeletal muscle cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Hua-Yu Hsu, Hsin-Ying Clair Chiou, Mei-Lan Tsai, Huey-Ling You, Yu-Chih Lin, Wei-Ting Liao, Yi-Ching Lin
Summary: Arsenic can promote macrophage polarization to M2 type, resulting in the epithelial-mesenchymal transition of lung epithelial cells. This study found that arsenic induces repolarization of M1 macrophages to M2 macrophages through the autophagy/mitophagy pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Siyuan Zhou, Ting Zhao, Xuqiong Chen, Wuwen Zhang, Xiaoyi Zou, Yi Yang, Qinshi Wang, Ping Zhang, Tong Zhou, Tongbao Feng
Summary: Our study shows that Runx1 promotes IL-4/IL-13-induced M2 macrophage polarization and may enhance STAT6 phosphorylation to achieve this effect. RNA-Seq analysis identified a number of differentially expressed genes highly expressed in M2 macrophages, further supporting this finding.
Article
Oncology
Qiao Yi Chen, Beibei Gao, Dongdong Tong, Chen Huang
Summary: In addition to hijacking key genes to drive tumor progression, cancer cells can dynamically interact with the host microenvironment and manipulate the surrounding stroma, known as the tumor microenvironment (TME), to create optimal conditions for tumor cells to thrive. This process involves complex cellular communication and molecular signaling, with emerging pathways involving extracellular vesicles (EVs) gaining attention.
Article
Cell & Tissue Engineering
Zhi-Hui Li, Jun-Feng Chen, Jing Zhang, Zi-Ying Lei, Li-Li Wu, Shi-Bo Meng, Jia-Lei Wang, Jing Xiong, Deng-Na Lin, Jun-Yi Wang, Zhi-Liang Gao, Bing-Liang Lin
Summary: This study found that mesenchymal stem cell (MSC) treatment can improve the condition of acute-on-chronic liver failure (ACLF) by promoting M2 macrophage polarization and increasing the expression of Mertk in macrophages to alleviate inflammatory injury.
Article
Immunology
Qingchen Zhu, Tao Yu, Shucheng Gan, Yan Wang, Yifei Pei, Qifan Zhao, Siyu Pei, Shumeng Hao, Jia Yuan, Jing Xu, Fajian Hou, Xuefeng Wu, Chao Peng, Ping Wu, Jun Qin, Yichuan Xiao
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Leiming Wang, Chiang-Min Cheng, Jun Qin, Mafei Xu, Chung-Yang Kao, Jingjing Shi, Erli You, Wanchun Gong, Laura Pedro Rosa, Peter Chase, Louis Scampavia, Franck Madoux, Timothy Spicer, Peter Hodder, H. Eric Xu, Sophia Y. Tsai, Ming-Jer Tsai
Article
Oncology
Huairui Yuan, Ying Han, Xuege Wang, Ni Li, Qiuli Liu, Yuye Yin, Hanling Wang, Lulu Pan, Li Li, Kun Song, Tong Qiu, Qiang Pan, Qilong Chen, Guoying Zhang, Yi Zang, Minjia Tan, Jian Zhang, Qintong Li, Xiaoming Wang, Jun Jiang, Jun Qin
Article
Immunology
Xinyi Qi, Jinxin Qiu, Jiali Chang, Yan Ji, Qi Yang, Guoliang Cui, Liming Sun, Qian Chai, Jun Qin, Ju Qiu
Summary: Brg1 plays a critical role in the differentiation of NKp46(+) ILC3s by promoting T-bet expression in NKp46(-) ILC3s, facilitating the conversion of NKp46(-) ILC3s into NKp46(+) ILC3s, and ultimately restraining intestinal inflammation. Our study demonstrates that Brg1 enhances T-bet and inhibits GM-CSF expression in ILC3s through a cell-intrinsic manner, highlighting its essential role in regulating intestinal immunity.
MUCOSAL IMMUNOLOGY
(2021)
Article
Oncology
Qiuli Liu, Jian Pang, Lin-ang Wang, Zhuowei Huang, Jing Xu, Xingxia Yang, Qiubo Xie, Yiqiang Huang, Tang Tang, Dali Tong, Gaolei Liu, Luofu Wang, Dianzheng Zhang, Qiang Ma, Hualiang Xiao, Weihua Lan, Jun Qin, Jun Jiang
Summary: The study demonstrates that PHF8 is essential for the development of NEPC by transcriptionally upregulating the FOXA2 gene, which regulates the expression of genes involved in NEPC development. Both PHF8 and FOXA2 could potentially serve as biomarkers for NEPC and targeting them may be a therapeutic strategy for NEPC treatment.
JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jing Xu, Tao Yu, Enrica Caterina Pietronigro, Jia Yuan, Jessica Arioli, Yifei Pei, Xuan Luo, Jialin Ye, Gabriela Constantin, Chaoming Mao, Yichuan Xiao
Article
Immunology
Xinfang Huang, Shumeng Hao, Junli Liu, Yuanyuan Huang, Manman Liu, Chunyuan Xiao, Yan Wang, Siyu Pei, Tao Yu, Jing Xu, Haikun Wang, Dongfang Dai, Xiao Su, Yichuan Xiao
Summary: Peli1 is identified as a critical negative regulator of Tfh cell differentiation, promoting autoimmune diseases while protecting against H1N1 influenza virus infection. Targeting Peli1 may have therapeutic benefits for Tfh-related autoimmune or infectious diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Yan Wang, Zunyun Fu, Xutong Li, Yinming Liang, Siyu Pei, Shumeng Hao, Qingchen Zhu, Tao Yu, Yifei Pei, Jia Yuan, Jialin Ye, Jiemeng Fu, Jing Xu, Jin Hong, Ruirui Yang, Hui Hou, Xinfang Huang, Chao Peng, Mingyue Zheng, Yichuan Xiao
Summary: The study reveals that the KU complex is abundantly expressed in CD4(+) T cells and enhances cell activation and proliferation in aged mice with EAE pathology by facilitating DNA-PKcs recruitment and phosphorylation of the kinase ZAK. A specific ZAK inhibitor can alleviate EAE pathology in aged mice.
Article
Immunology
Siyu Pei, Mingzhu Huang, Jia Huang, Xiaodong Zhu, Hui Wang, Simona Romano, Xiuyu Deng, Yan Wang, Yixiao Luo, Shumeng Hao, Jing Xu, Tao Yu, Qingchen Zhu, Jia Yuan, Kunwei Shen, Zhiqiang Liu, Guohong Hu, Chao Peng, Qingquan Luo, Zhenzhen Wen, Dongfang Dai, Yichuan Xiao
Summary: The study reveals that down-regulation of BFAR induced by TGFβ is a key mechanism affecting Th9 induction, which in turn impacts Th9-mediated cancer immunotherapy by regulating the activation of TGFβ signaling pathway.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Qiang Pan, Shanshan Zhong, Hanling Wang, Xuege Wang, Ni Li, Yaqi Li, Guoying Zhang, Huairui Yuan, Yannan Lian, Qilong Chen, Ying Han, Jiacheng Guo, Qiuli Liu, Tong Qiu, Jun Jiang, Qintong Li, Minjia Tan, Huiyong Yin, Junjie Peng, Yichuan Xiao, Jun Qin
Summary: Cholesterol metabolism is closely related to colorectal cancer, but the clinical benefit of statins in inhibiting the mevalonate pathway is uncertain. This study reveals that ZMYND8 plays a crucial role in enhancing de novo cholesterol biosynthesis and promoting the growth of intestinal tumors with high YAP expression.
Article
Biochemistry & Molecular Biology
Jinxi Li, James D. Glover, Haiguo Zhang, Meifang Peng, Jingze Tan, Chandana Basu Mallick, Dan Hou, Yajun Yang, Sijie Wu, Yu Liu, Qianqian Peng, Shijie C. Zheng, Edie Crosse, Alexander Medvinsky, Richard A. Anderson, Helen Brown, Ziyu Yuan, Shen Zhou, Yanqing Xu, John P. Kemp, Yvonne Y. W. Ho, Danuta Z. Loesch, Lizhong Wang, Yingxiang Li, Senwei Tang, Xiaoli Wu, Robin G. Walters, Kuang Lin, Ruogu Meng, Jun Lv, Jonathan M. Chernus, Katherine Neiswanger, Eleanor Feingold, David M. Evans, Sarah E. Medland, Nicholas G. Martin, Seth M. Weinberg, Mary L. Marazita, Gang Chen, Zhengming Chen, Yong Zhou, Michael Cheeseman, Lan Wang, Li Jin, Denis J. Headon, Sijia Wang
Summary: This study conducted genome-wide scans in Han Chinese cohorts and identified 18 loci associated with fingerprint type, as well as a genetic basis for the recognized pattern-block correlations. Additionally, a variant near EVI1 was found to alter regulatory activity and play a role in dermatoglyph patterning. Trans-ethnic meta-analysis identified 43 fingerprint-associated loci and revealed a genetic correlation between fingerprint patterns and hand proportions. These findings highlight the importance of limb development genes in shaping fingerprint patterning.
Article
Multidisciplinary Sciences
Miao Wang, Yugang Zhang, Garrison P. Komaniecki, Xuan Lu, Ji Cao, Mingming Zhang, Tao Yu, Dan Hou, Nicole A. Spiegelman, Ming Yang, Ian R. Price, Hening Lin
Summary: This study reveals the role of protein deacetylase SIRT2 in Golgi stress induced by bacterial infection. Shigella secrete effector protein IcsB, which transfers fatty acyl groups to modify host proteins to evade immune surveillance. Upregulated SIRT2 counteracts this function by removing the fatty acyl groups and enhancing the killing of Shigella.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Cheng-Long Hu, Bing-Yi Chen, Zijuan Li, Tianbiao Yang, Chun-Hui Xu, Ruirui Yang, Peng-Cheng Yu, Jingyao Zhao, Ting Liu, Na Liu, Bin Shan, Qunling Zhang, Junhong Song, Ming-Yue Fei, Li-Juan Zong, Jia-Ying Zhang, Ji-Chuan Wu, Shu-Bei Chen, Yong Wang, Binhe Chang, Dan Hou, Ping Liu, Yilun Jiang, Xiya Li, Xinchi Chen, Chu-Han Deng, Yi-Yi Ren, Roujia Wang, Jiacheng Jin, Kai Xue, Ying Zhang, Meirong Du, Jun Shi, Ling-Yun Wu, Chun-Kang Chang, Shuhong Shen, Zhu Chen, Sai-Juan Chen, Xiaolong Liu, Xiao-Jian Sun, Mingyue Zheng, Lan Wang
Summary: Aberrant expression of UHRF1, an epigenetic regulator, in acute myeloid leukemia (AML) is associated with poor prognosis. UHRF1 is crucial for the self-renewal of leukemia initiation cells (LICs) and its interaction with SAP30 represses gene expression. Inhibition of UHRF1 or SAP30 leads to derepression of MXD4, an MYC antagonist, and suppresses leukemogenesis. Furthermore, a UHRF1 inhibitor, UF146, shows promising therapeutic efficacy in a myeloid leukemia model.