期刊
BIOTECHNOLOGY LETTERS
卷 39, 期 4, 页码 613-622出版社
SPRINGER
DOI: 10.1007/s10529-016-2272-3
关键词
Cell therapy; Colitis; Dextran sulfate sodium; Mesenchymal stem cell; Oxidative stress
资金
- Fundo de Incentivo a Pesquisa e Eventos (FIPE) of Hospital de Clinicas de Porto Alegre
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Objective To investigate the effects of oxidative stress injury in dextran sulfate sodium (DSS)-induced colitis in mice treated with mesenchymal stem cells (MSC). Results Mice exposed to oral administration of 2% DSS over 7 days presented a high disease activity index and an intense colonic inflammation. Systemic infusion of MSC protected from severe colitis, reducing weight loss and diarrhea while lowering the infiltration of inflammatory cells. Moreover, toxic colitis injury increased oxidative stress. Administration of DSS decreased reduced glutathione (GSH) and superoxide dismutase (SOD) activity, and increased thiobarbituric acid-reactive substances levels in the colon. No alteration was found in catalase (CAT) and glutathione peroxidase (GPx) activity. Otherwise, MSC transplantation was able to prevent the decrease of GSH levels and SOD activity suggestive of an antioxidant property of MSC. Conclusion The oxidative stress is a pathomechanism underlying the pathophysiology of colitis and MSC play an important role in preventing the impairment of antioxidants defenses in inflamed colon.
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