Folate deficiency induced H2A ubiquitination to lead to downregulated expression of genes involved in neural tube defects

Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects

(2018) Qin Zhang et al.   Nature Communications

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

(2016) Magdalena Wienken et al.   MOLECULAR CELL

Folate deficiency facilitates recruitment of upstream binding factor to hot spots of DNA double-strand breaks of rRNA genes and promotes its transcription

(2016) Qiu Xie et al.   NUCLEIC ACIDS RESEARCH

Neural Tube Defects

(2014) Nicholas D.E. Greene et al.   Annual Review of Neuroscience

Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells

(2013) Casey A. Gifford et al.   CELL

Folic acid deficiency inhibits neural rosette formation and neuronal differentiation from rhesus monkey embryonic stem cells

(2012) Yongchang Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

(2012) G. G. Welstead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity

(2012) Mitsuhiro Endoh et al.   PLoS Genetics

Neural tube defects-disorders of neurulation and related embryonic processes

(2012) Andrew J. Copp et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice

(2011) Anna E Beaudin et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The emerging role of epigenetic mechanisms in the etiology of neural tube defects

(2011) Nicholas D.E. Greene et al.   Epigenetics

Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival

(2011) Amber Marean et al.   HUMAN MOLECULAR GENETICS

An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure

(2010) Muriel J. Harris et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Folic Acid Remodels Chromatin onHes1andNeurog2Promoters during Caudal Neural Tube Development

(2010) Shunsuke Ichi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exposure to folic acid antagonists during the first trimester of pregnancy and the risk of major malformations

(2009) Ilan Matok et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Genetics of human neural tube defects

(2009) N. D.E. Greene et al.   HUMAN MOLECULAR GENETICS

One-Carbon Metabolism–Genome Interactions in Folate-Associated Pathologies

(2009) Patrick J. Stover   JOURNAL OF NUTRITION

Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos

(2008) Wenchu Lin et al.   DEVELOPMENTAL DYNAMICS

Histone H2A ubiquitination in transcriptional regulation and DNA damage repair

(2008) Wenlai Zhou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY