Article
Gastroenterology & Hepatology
Cindy E. Ament, Sara Steinmann, Katja Evert, Giovanni M. Pes, Silvia Ribback, Isabella Gigante, Elena Pizzuto, Jesus M. Banales, Pedro M. Rodrigues, Paula Olaizola, Haichuan Wang, Gianluigi Giannelli, Xin Chen, Matthias Evert, Diego F. Calvisi
Summary: This study found that global fucosylation is upregulated in human intrahepatic cholangiocarcinoma (iCCA) tissues, and it is associated with poor prognosis. Fucosylation inhibition can decrease the proliferation and migration of iCCA cells. 6AF treatment can profoundly suppress the growth of iCCA cells.
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Multidisciplinary Sciences
Honami Miyakura, Mei Fukuda, Hiroya Enomoto, Kosuke Ishikawa, Shinya Watanabe, Kentaro Semba
Summary: A new screening system combining BiFC and a transposon gene trap system was established for identifying interacting proteins. This system successfully identified several interactors of the NF-kappa B subunit p65, including PKM, HSP90AB1, ANXA2, HSPA8, and CACYBP, with CACYBP enhancing NF-kappa B reporter activation under TNF alpha stimulation. This screening system provides a valuable method for identifying interacting factors not identified by other methods.
Article
Biochemistry & Molecular Biology
Ewelina Madej, Damian Ryszawy, Anna A. Brozyna, Malgorzata Czyz, Jaroslaw Czyz, Agnieszka Wolnicka-Glubisz
Summary: RIPK4 expression in melanoma is heterogeneous, with higher levels in metastatic melanoma cell lines. Down-regulating RIPK4 reduces invasive potential and pro-invasive protein levels, while PMA treatment leads to RIPK4 degradation and cell migration control via NF-kappa B signaling in a RIPK4-dependent or independent manner depending on cell origin and phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Wenqing Li, Fubo Han, Kaifan Tang, Chengjie Ding, Fen Xiong, Yina Xiao, Chen Li, Qian Liang, Kwang Youl Lee, Ik-Soo Lee, Hongchang Gao
Summary: Demethylzeylasteral exhibits promising potential as a treatment for colon cancer by inhibiting S100A11 expression and directly interacting with it to attenuate cell proliferation. NF-kappa B acts as an upstream transcription factor regulating S100A11 expression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Dai Kusumoto, Tomohisa Seki, Hiromune Sawada, Akira Kunitomi, Toshiomi Katsuki, Mai Kimura, Shogo Ito, Jin Komuro, Hisayuki Hashimoto, Keiichi Fukuda, Shinsuke Yuasa
Summary: The paper presents a morphology-based deep learning system to identify senescent cells and evaluate the effects of anti-senescent reagents. The system uses convolutional neural networks (CNN) to classify cellular senescence and successfully identifies anti-senescent drugs through morphology-based drug screening.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Gourisankar Ghosh, Vivien Ya-Fan Wang
Summary: The NF-kappa B family transcription factors, consisting of five monomers, play a critical role in regulating biological programs through DNA binding and transcriptional activation, despite their sequence and functional similarities, each member of the family displays distinct activities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joong-Seok Woo, Eun-Seon Yoo, Sung-Hyun Kim, Jae-Han Lee, So-Hee Han, Soo-Hyun Jung, Gi-Hwan Jung, Ji-Youn Jung
Summary: OA treatment leads to induction of apoptosis in melanoma cells through increased apoptotic bodies and decreased expression of antiapoptotic proteins such as Bcl-2.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Fisheries
Peng Zhou, Yue Zeng, Zaixiao Rao, Yaqian Li, Huijun Zheng, Rui Luo
Summary: Duck IKK alpha (duIKK alpha) was cloned and characterized in this study, showing high sequence identities with goose IKK alpha. DuIKK alpha was found to be widely expressed in tissues, with relatively high levels in liver and heart. Overexpression of duIKK alpha increased NF-kappa B activity and induced the expression of various cytokines, while knockdown reduced NF-kappa B activation and showed antiviral activity against DTMUV.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Immunology
Zhiyan Zhou, Ranhui Xi, Jiaxin Liu, Xian Peng, Lei Zhao, Xuedong Zhou, Jiyao Li, Xin Zheng, Xin Xu
Summary: The study identified multiple subtypes of taste receptors in human gingival fibroblasts and highlighted TAS2R16's role in inhibiting pro-inflammatory responses by regulating NF-kappa B signaling. This provides a new target and paradigm for the treatment of periodontitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Dianbo Long, Yiyang Xu, Guping Mao, Ruobing Xin, Zengfa Deng, Hongyi Liao, Zhiwen Li, Zhi Yang, Baoxi Yu, Zhijian Yang, Aishan He, Ziji Zhang, Yan Kang
Summary: tRNA-derived fragments (tRFs) have been shown to play important roles in cell metabolism by regulating gene expression. This study investigates the role of tRFs in the cellular metabolism of the anterior cruciate ligament (ACL). The findings reveal that TRF365 regulates ACL cell metabolism by targeting IKBKB.
CELL DEATH DISCOVERY
(2022)
Article
Immunology
Kunihiko Moriya, Tomohiro Nakano, Yoshitaka Honda, Miyuki Tsumura, Masato Ogishi, Motoshi Sonoda, Masahiko Nishitani-Isa, Takashi Uchida, Mohamed Hbibi, Yoko Mizoguchi, Masataka Ishimura, Kazushi Izawa, Takaki Asano, Fumihiko Kakuta, Daiki Abukawa, Darawan Rinchai, Peng Zhang, Naotomo Kambe, Aziz Bousfiha, Takahiro Yasumi, Bertrand Boisson, Anne Puel, Jean-Laurent Casanova, Ryuta Nishikomori, Shouichi Ohga, Satoshi Okada, Yoji Sasahara, Shigeo Kure
Summary: This study reports six patients from five families with RELA mutations, leading to autoinflammatory and autoimmune manifestations. The mutations result in loss of function of RelA protein, leading to excessive IFN expression and autoimmune response. The DN RELA mutations are identified as a novel cause of chronic mucocutaneous ulcerations with autoinflammatory and autoimmune manifestations.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Environmental Sciences
John D. Hansen, Keith A. Loftin, Zachary Laughrey, Ondrej Adamovsky
Summary: Various stressors can have profound impacts on immunity to pathogens, with little research into the effects of cyanobacterial toxins on disease resistance in mammals. Recent studies suggest that freshwater cyanotoxins may alter disease susceptibility parameters for fish, wildlife, and human health through interaction with specific components of innate immunity. However, the results of this study indicate that the tested toxins did not directly interact with key pathogen recognition receptors for innate immunity in humans.