期刊
JOURNAL OF FUNCTIONAL FOODS
卷 64, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2019.103659
关键词
Chitosan; Obesity; Gut microbiota; Inflammation
资金
- Natural Science of Shandong Province [ZR2017MH026, 2018GSF118231]
- National Natural Science Foundation of China [81630072-2]
- Program of Qilu young scholars of Shandong University
Chitosan has been applied as a food additive due to its prebiotic functions, while the relationship between changes in the intestinal microbiota caused by chitosan and weight loss remains unclear. This study confirmed the weight control effect of chitosan in the context of high-fat diet consumption. Interestingly, chitosan increased the serum leptin level in the high-fat diet groups and increased the oral glucose tolerance in the low-fat diet groups. Chitosan reduced the chronic inflammation caused by high-fat diet consumption. Moreover, the intestinal microbiome was influenced by the chitosan intervention as the feeding time increased. Chitosan supplementation increased the anti-obesity-related species, such as Coprobacillus cateniformis and Clostridium leptum, and significantly decreased Clostridium lactatifermentans and Clostridium cocleatum. Spearman correlation analysis showed that Coprobacillus cateniformis and Clostridium leptum were positively correlated with serum leptin. This study suggests that the prebiotic effect of chitosan is closely related to the modification of the gut microbiota.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据