Maresin 1 Improves Cognitive Decline and Ameliorates Inflammation in a Mouse Model of Alzheimer’s Disease

Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1H NMR-Based Metabolomics Analysis

(2019) Yu Hao et al.   MEDIATORS OF INFLAMMATION

Maresin1 regulates neutrophil recruitment and IL-10 expression in Aspergillus fumigatus keratitis

(2019) Qing Tang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

BDNF, TNFα, HSP90, CFH, and IL-10 Serum Levels in Patients with Early or Late Onset Alzheimer's Disease or Mild Cognitive Impairment

(2018) Duygu Gezen-Ak et al.   JOURNAL OF ALZHEIMERS DISEASE

Restoration of Lipoxin A4 Signaling Reduces Alzheimer's Disease-Like Pathology in the 3xTg-AD Mouse Model

(2018) Haley C. Dunn et al.   JOURNAL OF ALZHEIMERS DISEASE

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

(2018) Antonella Tramutola et al.   Translational Neurodegeneration

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

Maresin1 stimulates alveolar fluid clearance through the alveolar epithelial sodium channel Na,K-ATPase via the ALX/PI3K/Nedd4-2 pathway

(2017) Jun-Li Zhang et al.   LABORATORY INVESTIGATION

Gene networks in neurodegenerative disorders

(2017) Daniela Recabarren et al.   LIFE SCIENCES

Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer’s Disease

(2017) Jong Kil Lee et al.   MOLECULES

ω3-polyunsaturated fatty acids induce cell death through apoptosis and autophagy in glioblastoma cells: In vitro and in vivo

(2017) Soyeon Kim et al.   ONCOLOGY REPORTS

Maresin 1 Ameliorates Lung Ischemia/Reperfusion Injury by Suppressing Oxidative Stress via Activation of the Nrf-2-Mediated HO-1 Signaling Pathway

(2017) Quanchao Sun et al.   Oxidative Medicine and Cellular Longevity

Role of Interleukin-10 in Acute Brain Injuries

(2017) Joshua M. Garcia et al.   Frontiers in Neurology

Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer’s disease mice

(2016) Sandro Alves et al.   BRAIN

Regulatory T cells delay disease progression in Alzheimer-like pathology

(2016) Cira Dansokho et al.   BRAIN

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies

(2016) Antonella Tramutola et al.   Expert Review of Neurotherapeutics

The rise and fall of insulin signaling in Alzheimer’s disease

(2016) B. Chami et al.   METABOLIC BRAIN DISEASE

Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats

(2016) YUJIE WANG et al.   Molecular Medicine Reports

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

(2016) Jesmond Dalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

(2016) Gabrielle Fredman et al.   Nature Communications

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies

(2016) Antonella Tramutola et al.   Expert Review of Neurotherapeutics

Resolution of inflammation is altered in Alzheimer's disease

(2015) Xiuzhe Wang et al.   Alzheimers & Dementia

Nicotinic Acetylcholine Receptors Sensitize a MAPK-linked Toxicity Pathway on Prolonged Exposure to β-Amyloid

(2015) Komal Arora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1

(2015) Laura Schnöder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resolvin D1 Reduces Infarct Size Through a Phosphoinositide 3-Kinase/Protein Kinase B Mechanism

(2015) Kim Gilbert et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease

(2015) Yuan Gao et al.   JOURNAL OF IMMUNOLOGY

Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis

(2015) Mingqin Zhu et al.   MOLECULAR NEUROBIOLOGY

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

(2015) Marie-Victoire Guillot-Sestier et al.   NEURON

Anti-inflammatory Signaling in Microglia Exacerbates Alzheimer’s Disease-Related Pathology

(2015) Jean-Philippe Michaud et al.   NEURON

Innate Immunity Fights Alzheimer's Disease

(2015) Marie-Victoire Guillot-Sestier et al.   TRENDS IN NEUROSCIENCES

p38 MAPK: A Potential Target of Chronic Pain

(2014) X. Lin et al.   CURRENT MEDICINAL CHEMISTRY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife

(2014) A. Singh-Manoux et al.   NEUROLOGY

Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages

(2014) Bin Deng et al.   PLoS One

Microglia actions in Alzheimer’s disease

(2013) Stefan Prokop et al.   ACTA NEUROPATHOLOGICA

Aspirin-Triggered Lipoxin A4 Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease–Like Pathology in Mice

(2013) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

(2013) Jesmond Dalli et al.   FASEB JOURNAL

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

7,8-Dihydroxyflavone Suppresses Oxidative Stress-Induced Base Modification in DNA via Induction of the Repair Enzyme 8-Oxoguanine DNA Glycosylase-1

(2013) Ki Cheon Kim et al.   Biomed Research International

Lipid Metabolism and Neuroinflammation in Alzheimer's Disease: A Role for Liver X Receptors

(2012) Jihong Kang et al.   ENDOCRINE REVIEWS

Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways

(2012) Norbert Zilka et al.   Journal of Neuroinflammation

Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline

(2010) Karin Yurko-Mauro et al.   Alzheimers & Dementia

Soluble βamyloid1-42: a critical player in producing behavioural and biochemical changes evoking depressive-related state?

(2010) M Colaianna et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways

(2010) P Prieto et al.   CELL DEATH AND DIFFERENTIATION

The p38 mitogen-activated protein kinase pathway—A potential target for intervention in infarction, hypertrophy, and heart failure

(2010) Michael S. Marber et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

β-Amyloid 1-42 Oligomers Impair Function of Human Embryonic Stem Cell-Derived Forebrain Cholinergic Neurons

(2010) Linn Wicklund et al.   PLoS One

Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis

(2009) Stanley B. Cohen et al.   ARTHRITIS AND RHEUMATISM

Involvement of phosphoinositide 3-kinase γ in the neuro-inflammatory response and cognitive impairments induced by β-amyloid 1–40 peptide in mice

(2009) Giselle F. Passos et al.   BRAIN BEHAVIOR AND IMMUNITY

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

p38 Kinase Is Activated in the Alzheimer's Disease Brain

(2003) Kenneth Hensley et al.   JOURNAL OF NEUROCHEMISTRY