Review
Environmental Sciences
Claudia Gundacker, Karine Audouze, Raimund Widhalm, Sebastian Granitzer, Martin Forsthuber, Florence Jornod, Maria Wielsoe, Manhai Long, Thorhallur Ingi Halldorsson, Maria Uhl, Eva Cecilie Bonefeld-Jorgensen
Summary: Prenatal exposure to PFAS may impair fetal growth through oxidative stress and endocrine effects.
Article
Multidisciplinary Sciences
Sverre Wikstroem, Ghada Hussein, Annika Lingroth Karlsson, Christian H. Lindh, Carl-Gustaf Bornehag
Summary: Many first trimester sporadic miscarriages are unexplained, and this study aimed to investigate the association between levels of Perfluoroalkyl substances (PFASs) in early pregnancy with unexplained first trimester miscarriage. The results showed a positive correlation between PFOA exposure and sporadic first trimester miscarriage, while other PFASs showed no significant association with miscarriage. This suggests a potential shared but unknown mechanism between PFOA exposure and miscarriage.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Geraldo Neto, Martin Bobak, Juan P. Gonzalez-Rivas, Jana Klanova
Summary: This study examines the association between PFAS and depression, finding a significant association between PFOA and depression in the overall sample, and significant associations between PFNA and PFDA and depression in the group with normal body fat status. Further research should investigate the role of obesity and possible mechanisms linking PFAS to depression.
Article
Environmental Sciences
Yuang Wei, Haibing He, Tian Han, Bao Wang, Peng Ji, Xiangzheng Wu, Jian Qian, Pengfei Shao
Summary: Through comprehensive bioinformatics analysis, the correlation between five perfluorinated compounds (PFCs) and prostate cancer was discovered, and the promotive role of perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) in the growth of prostate cancer cells was verified. This study provided novel insights into the role of PFCs in prostate cancer and raised attention to the environmental association with cancer risks and progression.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Ola Wasel, Kathryn M. Thompson, Yu Gao, Amy E. Godfrey, Jiejun Gao, Cecon T. Mahapatra, Linda S. Lee, Maria S. Sepulveda, Jennifer L. Freeman
Summary: This study compared the toxicity of four PFAAs in relation to chain length and head group, finding that longer chain length and sulfonate group increase toxicity. Discrepancies with other zebrafish studies were linked to a lack of neutralization of acidic compounds in exposure solutions, emphasizing the importance of reporting pH rigorously in all experiments.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2021)
Article
Environmental Sciences
Wei Zheng, Lei Hu, Zekai Chen, Jun Tang, Yuliang Pan, Wende Yan, Xiaoyong Chen, Yuanying Peng, Lijun Chen
Summary: Perfluorinated compounds (PFCs) are a class of new persistent organic pollutants widely found in the environment. This study examined the effects of two typical PFCs, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), on the composition and diversity of soil microorganisms and the availability of soil macronutrients in urban forest ecosystems. The results showed that PFOA and PFOS application significantly increased soil nitrate and ammonium content, while total phosphorus content remained unchanged. Total potassium content decreased in PFOA treatments but increased in PFOS and PFOA-PFOS combined treatments. The dominant bacterial phylum shifted from Chloroflexi to Acidobacteria with increasing PFCs concentrations. Fungal community composition did not change significantly in response to PFCs treatments. Soil bacterial richness decreased but diversity increased, while fungal richness and diversity generally decreased with increasing PFCs concentrations. Soil fungal community was found to be more sensitive to PFCs pollutants than bacterial communities. Structural equation modeling revealed that PFCs exposure indirectly affected the diversity and richness of soil bacteria and fungi by directly impacting nitrate and ammonium content. The concentration of PFCs pollutants played a primary role in determining the composition, richness, and diversity of forest soil microbial communities.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Sarah Dee Geiger, Ping Yao, Michael G. Vaughn, Zhengmin Qian
Summary: The study investigated the relationship between PFASs and overweight/obesity as well as abdominal obesity in children, revealing an association between elevated PFOA levels and overweight/obesity in children.
Article
Environmental Sciences
M. L. Brusseau, B. Guo
Summary: This research focused on the relationship between soil porewater concentrations and soil concentrations of PFAS, based on a comprehensive model. The model was validated using measured parameters and literature data, showing accurate predictions of concentration ratios. Numerical simulations demonstrated the importance of air-water interfacial adsorption for the distribution of longer-chain PFAS. It was found that PFAS soil porewater concentrations can vary from ng/L to mg/L depending on soil concentrations and site conditions.
Article
Biochemistry & Molecular Biology
Aurelie Charazac, Charlotte Hinault, Bastien Dolfi, Solene Hautier, Celia Deconde Le Butor, Frederic Bost, Nicolas Chevalier
Summary: Endocrine Disrupting Compounds (EDCs) are compounds found in everyday products that can disrupt hormonal effects and have adverse health effects. This study found that four specific EDCs promoted the proliferation of cancer cell lines from hormone-sensitive organs (prostate and breast), with PFOA and PCB153 showing this effect at very low concentrations (10(-12) M).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
May Yang, Yuna Lee, Liying Gao, Karen Chiu, Daryl D. Meling, Jodi A. Flaws, Genoa R. Warner
Summary: Perfluorooctanoic acid (PFOA), a synthetic fluorosurfactant, is found in imported food packaging, cookware, and textiles. Previous studies have shown developmental toxicity of PFOA, and this study discovered adverse effects of PFOA on adult ovarian function.
TOXICOLOGICAL SCIENCES
(2022)
Article
Engineering, Environmental
Qiaoying Chen, Shujun Yi, Qingqing Ye, Yumin Zhu, Wenjue Zhong, Lingyan Zhu
Summary: This study used a rat model to estimate the dermal penetration efficiency of 15 representative PFASs. The results showed that the penetration and absorption of PFASs were parabolically associated with the perfluorinated carbon chain length. The lipid-rich stratum corneum of the skin barrier suppressed the penetration of less hydrophobic short-chain PFASs, while the water-rich viable epidermis and dermis served as obstacles to hydrophobic long-chain PFAS permeation. Short-chain PFASs were mainly eliminated through urinary excretion, while long-chain PFASs entered the body through dermal penetration. These results highlight the significant contribution of dermal penetration to the body burden of PFASs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Bruno Bezerra de Souza, Shaini Aluthgun Hewage, Jitendra A. Kewalramani, Adri Ct van Duin, Jay N. Meegoda
Summary: This work provides a computational explanation for the destruction of PFAS in water by ultrasound. Simulation results showed that over 98% of PFAS degradation can occur at 5000K in a water vapor phase, replicating the observed micro/nano bubbles implosion and PFAS destruction during ultrasound application.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Alex Robinson, Elma Lahive, Stephen Short, Heather Carter, Darren Sleep, Gloria Pereira, Peter Kille, David Spurgeon
Summary: The study found that there is significant variation in species sensitivity to toxicants, with chemicals targeting specific biological targets showing greater variation compared to those with non-specific narcotic mechanisms. Earthworm toxicity tests revealed different levels of sensitivity among species for chemicals with varying modes of action, indicating potential bias in earthworm ecotoxicology literature. The results highlighted the importance of toxicodynamics and toxicokinetics in explaining species sensitivity variations.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Multidisciplinary
Hua-Qing Yin, Kui Tan, Stephanie Jensen, Simon J. Teat, Saif Ullah, Xiuze Hei, Ever Velasco, Kolade Oyekan, Noah Meyer, Xin-Yao Wang, Timo Thonhauser, Xue-Bo Yin, Jing Li
Summary: The study introduces a luminescent MOF In(tcpp) for the sensitive detection and removal of fluoride ions (F-) and perfluorooctanoic acid (PFOA) in water, showing high selectivity, sensitivity, recyclability, and adsorption efficiency.
Article
Environmental Sciences
Andrea B. Kirk, Kelsey Marie Plasse, Karli C. Kirk, Clyde F. Martin, Gamze Ozsoy
Summary: PFASs have been commonly found in serum samples from US adults collected over the past two decades, as well as in other data sets from around the world. However, there is limited knowledge about infant PFAS exposures, mainly due to the scarcity of infant serum samples. This paper provides a statistical and probabilistic analysis of data from the 2007-2008 NHANES, which includes a rare subset of infant data, to examine infant PFAS exposures in the US. The findings reveal that US infants are widely exposed to PFASs, with relatively constant serum concentrations despite their growth and high caloric and fluid intake.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Meeting Abstract
Pharmacology & Pharmacy
Kim Henderson, John Ross, Brandon Borders, Seth Gibbs, Peter Hong, Brandon Wood, Tom Vinci, Brian Roche, Jeremy Smith
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2016)
Article
Pharmacology & Pharmacy
Suramya Waidyanatha, Heather Toy, Natalie South, Seth Gibbs, Esra Mutlu, Brian Burback, Barry S. McIntyre, Natasha Catlin
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
S. Peter Hong, Seth T. Gibbs, Dean J. Kobs, Michael A. Hawk, Claire R. Croutch, Merrill R. Osheroff, Jerry D. Johnson, Brian L. Burback
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2013)
Article
Pharmacology & Pharmacy
S. Peter Hong, Seth T. Gibbs, Dean J. Kobs, Merrill R. Osheroff, Jerry D. Johnson, Brian L. Burback
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2013)
Article
Pharmacology & Pharmacy
Kim A. Henderson, R. Brandon Borders, John B. Ross, Amir Abdulalil, Seth Gibbs, Anthony J. Skowronek, Katherine Knostman, Jay Bailey, Jeremy Smith, Tom Vinci, Brandon Wood, Michael V. Knopp, Brian M. Roche
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2018)
Article
Toxicology
Michael J. Hackett, Kelsy D. Kinderknecht, Nancy A. Niemuth, John A. Taylor, Seth T. Gibbs, Joseph Novak, Sam J. Harbo
TOXICOLOGICAL SCIENCES
(2019)
Article
Food Science & Technology
Suramya Waidyanath, Esra Mutlu, Seth Gibbs, Billie Stiffler, Jon Andre, Brian Burback, Cynthia Rider
FOOD AND CHEMICAL TOXICOLOGY
(2019)
Article
Medicine, Legal
Vijay Pralhad Kale, Seth Gibbs, John A. Taylor, Amy Zmarowski, Joseph Novak, Kristin Patton, Barney Sparrow, Jenni Gorospe, Satheesh Anand, Resat Cinar, George Kunos, Robert J. Chorvat, Pramod S. Terse
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Esra Mutlu, Seth T. Gibbs, Natalie South, Jessica Pierfelice, Brian Burback, Dori Germolec, Suramya Waidyanatha
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2020)
Article
Medicine, Legal
Vijay Pralhad Kale, Jeffery Wallery, Joseph Novak, Seth Gibbs, Mohammed Bourdi, Minh-Ha T. Do, John C. McKew, Pramod S. Terse
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Suramya Waidyanatha, Esra Mutlu, Seth Gibbs, Jessica Pierfelice, Jeremy P. Smith, Brian Burback, Chad T. Blystone
Summary: The study found that phenolic benzotriazoles have low oral absorption, which decreases with increasing doses. Substituted compounds may be less metabolized compared to the unsubstituted.
Article
Toxicology
Suramya Waidyanatha, Seth Gibbs, Natalie South, Jeremy P. Smith, Esra Mutlu, Brian Burback, Yu Cao, Cynthia V. Rider
TOXICOLOGY REPORTS
(2020)
Article
Toxicology
M. C. Huang, A. L. Dzierlenga, V. G. Robinson, S. Waidyanatha, M. J. DeVito, M. A. Eifrid, C. A. Granville, S. T. Gibbs, C. R. Blystone
TOXICOLOGY REPORTS
(2019)
Article
Toxicology
M. C. Huang, V. G. Robinson, S. Waidyanatha, A. L. Dzierlenga, M. J. DeVito, M. A. Eifrid, S. T. Gibbs, C. R. Blystone
TOXICOLOGY REPORTS
(2019)