Article
Oncology
Wing-Lok Chan, Cheuk-Wai Choi, Ian Yu-Hong Wong, Terence Hon-Ting Tsang, Adrian Tin-Chung Lam, Rosa Pui-Ying Tse, K. K. Chan, Claudia Wong, Betty Tze-Ting Law, Emina Edith Cheung, Siu-Yin Chan, Ka-On Lam, Dora Kwong, Simon Law
Summary: This study reviewed the long-term clinical outcomes and safety data of induction chemotherapy followed by surgery or definitive chemoradiotherapy in patients with locally advanced unresectable esophageal cancer. The results showed that patients who received subsequent surgery had significantly longer median overall survival compared to those who had definitive chemoradiotherapy or no definitive treatment. Induction chemotherapy followed by conversion surgery offered a chance of cure with long-term survival benefit and manageable toxicities in these patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Mojtaba Moradi, Nader Goodarzi, Azita Faramarzi, Hadi Cheraghi, Amir Hossein Hashemian, Cyrus Jalili
Summary: Melatonin protects the testes against BEP-induced testicular damage by restoring spermatogenesis, improving testosterone levels, and ameliorating oxidative stress. Furthermore, melatonin therapy suppresses BEP-evoked apoptosis in testes, suggesting its potential as a clinical therapy against BEP-associated gonadotoxicity and male sub/infertility.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Engineering, Environmental
Webber Wei-Po Lai, Chia-Hsun Tien, Zih-Syuan Tang
Summary: In this study, the efficiency of UV/peracetic acid (UV/PAA) treatment for the removal of 5-fluorouracil and cyclophosphamide was investigated. The results showed that UV/PAA could efficiently remove these two drugs within 20 min. The study also examined the influence of various factors on the removal process and proposed possible degradation pathways for the byproducts formed. The UV/PAA treatment demonstrated good applicability in the removal of these compounds from real water samples.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Oncology
Kam Singh, Sarah Gillett, Jane Ireson, Anne Hills, John A. Tidy, Robert E. Coleman, Barry W. Hancock, Matthew C. Winter
Summary: High-risk gestational trophoblastic neoplasia (GTN) is highly chemosensitive and can be effectively treated with M-EA and EMA-CO regimens in the UK. Both regimens have excellent prognosis, but EMA-CO may lead to more toxicities and treatment delays compared to M-EA. Patient-specific factors should be considered when choosing between the two regimens.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Reproductive Biology
Juliana Z. Almeida, L. A. Vieira, C. Maside, A. C. A. Ferreira, N. A. R. Sa, H. H. Correia, V. R. Araujo, R. S. Raposo, J. Smitz, C. C. Campello, J. R. Figueiredo, R. B. Oria
Summary: 5FU does not affect follicular morphology but detrimentally affects follicular growth, estradiol production, and oocyte maturation in isolated ovarian follicles. Concentrations of 5FU greater than 3 mM reduce estradiol levels.
Article
Dentistry, Oral Surgery & Medicine
Marco F. Caminiti, Mohamed El-Rabbany, Justin Jeon, Grace Bradley
Summary: The study suggests that topical application of 5-fluorouracil (5-FU) can effectively reduce the recurrence rates of odontogenic keratocysts (OKCs), showing potential advantages over conventional therapies. Further large-scale case-controlled studies are needed to establish the efficacy of this new technique compared to traditional treatment methods.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Oncology
Samuel A. Funt, Deaglan J. McHugh, Stephanie Tsai, Andrea Knezevic, Devon O'Donnell, Sujata Patil, Deborah Silber, Maria Bromberg, Maryann Carousso, Victor E. Reuter, Brett S. Carver, Joel Sheinfeld, Robert J. Motzer, Dean F. Bajorin, George J. Bosl, Darren R. Feldman
Summary: The study analyzed the outcomes of 944 patients with good-risk germ cell tumors treated with EPx4 between 1982 and 2016. The results showed that EPx4 is highly effective and well tolerated, with a favorable response rate and disease-specific survival of 98%. Full-dose administration of etoposide and cisplatin and complete resection of residual disease lead to optimal outcomes. EPx4 should be recommended for certain patient groups at increased risk for bleomycin pulmonary toxicity and during ongoing transmission of severe acute respiratory syndrome coronavirus 2.
Article
Chemistry, Multidisciplinary
Michal Macko, Jan Antos, Frantisek Bozek, Jiri Konecny, Jiri Huzlik, Jitka Hegrova, Ivo Kuritka
Summary: This paper aims to enhance the EPA health risk assessment by incorporating two new variables that consider the size of nanoparticles: the toxicity multiplier and the size multiplier. A case study was performed to observe the impact of the new variables on the assessed cadmium concentration. The proposed method with adjustments resulted in a significantly higher risk value compared to the current state-of-the-art method, with nanoparticles contributing to 88% of the total risk value.
Article
Oncology
Amy de Haar-Holleman, Lisa M. C. van Hoogstraten, Maarten C. C. M. Hulshof, Metin Tascilar, Katharin Bruck, Richard P. Meijer, J. Alfred Witjes, Lambertus A. Kiemeney, Katja K. H. Aben
Summary: This study compared the toxicity, overall survival (OS), and disease-free survival (DFS) between oral capecitabine and intravenous 5-fluorouracil (5-FU) in chemoradiotherapy for muscle-invasive bladder cancer (MIBC) patients. There was no significant difference in adverse events, 2-year OS, and 2-year DFS between the two regimens. Capecitabine-based CRT may be considered as an alternative to a 5-FU-based regimen.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Hiroo Imai, Ken Saijo, Yoshifumi Kawamura, Shuto Kodera, Keigo Komine, Tomoyuki Iwasaki, Noriko Takenaga, Yuki Kasahara, Kota Ouchi, Hidekazu Shirota, Masanobu Takahashi, Chikashi Ishioka
Summary: The efficacy of carboplatin and etoposide combination therapy (CE) and cisplatin and etoposide combination therapy (PE) is comparable in patients with neuroendocrine carcinoma (NEC). However, the incidence of renal dysfunction is significantly higher in the PE group than in the CE group.
Article
Oncology
Chalirmporn Atasilp, Rinradee Lenavat, Natchaya Vanwong, Phichai Chansriwong, Ekaphop Sirachainan, Thanyanan Reungwetwattana, Pimonpan Jinda, Somthawin Aiempradit, Suwannee Sirilerttrakul, Monpat Chamnanphon, Apichaya Puangpetch, Nipaporn Sankuntaw, Patompong Satapornpong, Chonlaphat Sukasem
Summary: This study investigated the effects of MTHFR polymorphisms on hematological toxicity and treatment efficacy of 5-FU therapy in colorectal cancer patients. The results showed that the 677G>A polymorphism was significantly associated with leukopenia, neutropenia, and thrombocytopenia, while the 1298A>C polymorphism had no significant association with hematological toxicity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Vivian Cristina Noronha Novaes, Edilson Ervolino, Giovani Lopes Fernandes, Clara Possarle Cunha, Leticia Helena Theodoro, Valdir Gouveia Garcia, Juliano Milanezi de Almeida
Summary: Chemotherapy with antineoplastic agents 5-FU and CIS increased the intensity and duration of inflammation and compromised tissue repair by reducing cellular and vascular turnover. The more severe periodontal breakdown was caused by 5-FU.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Biochemistry & Molecular Biology
Gerile Naren, Jiaojiao Guo, Qiujuan Bai, Na Fan, Buhe Nashun
Summary: Chemotherapeutic agent 5-fluorouracil has adverse effects on reproduction, causing developmental block, malformation, and ovarian damage in females. However, studies suggest that the toxicity is reversible and certain drugs used in combination can protect the reproductive system from damage.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Article
Oncology
Jia-Di Wu, Zhi-Qiang Wang, Qiao-Qiao Li, Zhi-Chao Li, Chao Ren, De-Shen Wang, Ji-Yang Chen, Qiong Tan, Yu-Hong Li, Hong Yang
Summary: This study provides updated long-term follow-up data confirming the feasibility and promising survival outcomes of TPF chemotherapy followed by surgery for patients with borderline resectable esophageal squamous cell carcinoma (BR-ESCC).
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Gabriela G. F. van der Schoot, Harm L. Ormel, Nico-Derk L. Westerink, Johan B. Wempe, Joop D. Lefrandt, Anne M. May, Aline H. Vrieling, Coby Meijer, Jourik A. Gietema, Annemiek M. E. Walenkamp
Summary: Examining the effects of physical exercise on pulmonary and vascular endothelial toxicity in patients with testicular cancer during or after BEP chemotherapy, this post hoc analysis of a randomized clinical trial found that exercising during chemotherapy helps preserve lung function and minimize vascular damage.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Toxicology
Chiara Russo, Franziska Ferk, Miroslav Misik, Nathalie Ropek, Armen Nersesyan, Doris Mejri, Klaus Holzmann, Margherita Lavorgna, Marina Isidori, Siegfried Knasmueller
ARCHIVES OF TOXICOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Margherita Lavorgna, Rosa Iacovino, Chiara Russo, Cristina Di Donato, Concetta Piscitelli, Marina Isidori
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Plant Sciences
Margherita Lavorgna, Elena Orlo, Roberta Nugnes, Concetta Piscitelli, Chiara Russo, Marina Isidori
PLANT FOODS FOR HUMAN NUTRITION
(2019)
Article
Multidisciplinary Sciences
Ghania Bouguellid, Chiara Russo, Margherita Lavorgna, Concetta Piscitelli, Karima Ayouni, Erica Wilson, Hye Kyonn Kim, Rob Verpoorte, Young Hae Choi, Dina Kilani-Atmani, Djebbar Atmani, Marina Isidori
Article
Multidisciplinary Sciences
Concetta Piscitelli, Margherita Lavorgna, Rocco De Prisco, Elio Coppola, Eleonora Grilli, Chiara Russo, Marina Isidori
Article
Food Science & Technology
Margherita Lavorgna, Severina Pacifico, Roberta Nugnes, Chiara Russo, Elena Orlo, Simona Piccolella, Marina Isidori
Summary: This study investigated the biological properties and chemical composition of two samples of Criollo var. cocoa raw beans from Indonesia and Peru. Results showed that the Indonesian bean hydroalcoholic extracts had better antioxidant activity and exhibited antimutagenic and antigenotoxic effects, with inhibitory effects on breast and hepatic cancer cells. Different environmental conditions in the geographical areas affected the composition of fatty acids and (epi)catechins in the beans.
Article
Food Science & Technology
Elena Orlo, Chiara Russo, Roberta Nugnes, Margherita Lavorgna, Marina Isidori
Summary: The study compared the antimicrobial and antioxidant activities of three methoxyphenol phytometabolites, eugenol, capsaicin, and vanillin, revealing that eugenol and capsaicin were the most active against pathogens and spoilage bacteria. These findings enhance the potential use of these compounds as food additives to combat pathogens and improve the shelf life of preserved food.
Article
Multidisciplinary Sciences
Chiara Russo, Margherita Lavorgna, Roberta Nugnes, Elena Orlo, Marina Isidori
Summary: The study compared the cytotoxic, antiradical, and antibacterial activities of cannabidiol and cannabidivarin, two phytocannabinoids derived from Cannabis. Both cannabinoids exhibited medium levels of cytotoxicity in cancer and normal cells, with no significant antioxidant capacity demonstrated. The antimicrobial activity showed no notable differences between the two cannabinoids except for cannabidiol being more effective against Staphylococcus aureus.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Ghania Bouguellid, Nadjet Debbache-Benaida, Dina Atmani-Kilani, Chiara Russo, Margherita Lavorgna, Concetta Piscitelli, Karima Ayouni, Meriem Berboucha-Rahmani, Marina Isidori, Djebbar Atmani
Summary: The extracts of Pistacia lentiscus L. fruits showed potential antigenotoxic and antimutagenic properties in in vitro and in vivo assays. They provided protection against common mutagenic and genotoxic agents and enhanced antioxidant enzyme activity in animal models.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2022)
Article
Environmental Sciences
Roberta Nugnes, Margherita Lavorgna, Elena Orlo, Chiara Russo, Marina Isidori
Summary: The ongoing COVID-19 pandemic has led to increased production of plastics worldwide, which poses a significant threat to ecosystems. This study investigated the acute, chronic, and subchronic effects of microplastic polystyrene beads on freshwater species, revealing varying impacts on different organisms and the potential for genetic damage and harmful substance production.
Article
Multidisciplinary Sciences
Chiara Russo, Daniela Barone, Margherita Lavorgna, Concetta Piscitelli, Marcella Macaluso, Severina Pacifico, Simona Piccolella, Antonio Giordano, Marina Isidori
Summary: This study evaluated the cytotoxic activity and chemical composition of tomato extracts from different varieties grown in contaminated soil. The extracts showed varying levels of cytotoxicity towards cancer cells, with extracts from uncontaminated soil exhibiting the highest activity.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Roberta Nugnes, Chiara Russo, Margherita Lavorgna, Elena Orlo, Michael Kundi, Marina Isidori
Summary: Freshwater ecosystems are significant sources of plastic contamination for the marine environment. Microplastic particles pose direct threats to freshwater organisms and indirectly affect the aquatic ecosystem as carriers of other pollutants. This study investigated chronic and sub-chronic effects of polystyrene microplastic particles (PS-MPs) in combination with pharmaceuticals and pesticides on freshwater organisms. The results revealed great environmental concern.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Roberta Nugnes, Chiara Russo, Elena Orlo, Margherita Lavorgna, Marina Isidori
Summary: This study aimed to determine the acute, sub-chronic, and chronic toxicity of imidacloprid in freshwater producers and primary consumers, as well as its potential eco-genotoxic effects on non-target organisms. The results showed that the genotoxicological risk quotient values of imidacloprid were higher than the threshold value in all continents, while chronic toxicity risk quotient values were generally below the threshold value.
ENVIRONMENTAL POLLUTION
(2023)
Article
Polymer Science
Elena Orlo, Mariamelia Stanzione, Margherita Lavorgna, Marina Isidori, Aldo Ruffolo, Ciro Sinagra, Giovanna G. Buonocore, Marino Lavorgna
Summary: Active packaging systems, such as a vinyl resin-based coating containing eugenol loaded in silica nanoparticles, can effectively delay food quality decay and extend the shelf-life. The coating shows good loading capacity of eugenol and higher hydrophobicity. It also exhibits antimicrobial activity against foodborne pathogens and food spoilage bacteria, achieving a high microbial growth reduction.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Environmental Sciences
Chiara Russo, Margherita Lavorgna, Concetta Piscitelli, Marina Isidori
FATE AND EFFECTS OF ANTICANCER DRUGS IN THE ENVIRONMENT
(2020)
Article
Engineering, Environmental
Rong-Gui Zhu, Chang-Gui Pan, Feng-Jiao Peng, Chao-Yang Zhou, Jun-Jie Hu, Kefu Yu
Summary: This comprehensive survey investigated the occurrence, bioaccumulation, and trophic magnification of parabens and their metabolite 4-HB in a marine food web. Results showed that parabens were the predominant pollutants in marine organisms, with significant bioaccumulation from sediments. The estimated trophic magnification factor indicated biomagnification for MeP and trophic dilution for 4-HB. Overall, the risks for humans consuming marine organisms were found to be low.
Article
Engineering, Environmental
Andres F. Torres-Franco, Deborah Leroy-Freitas, Cristina Martinez-Fraile, Elisa Rodriguez, Pedro A. Garcia-Encina, Raul Munoz
Summary: Anaerobic and microalgae-based technologies have emerged as sustainable alternatives for municipal wastewater treatment. However, the presence of viruses in the treated wastewater is a major concern for reuse applications. This study assessed the ability of these technologies to reduce viruses during secondary wastewater treatment. The results showed that all technologies were effective in reducing the concentration of viruses, with microalgae-based treatment exhibiting the highest potential for reducing the disinfection requirements of treated wastewater.
Article
Engineering, Environmental
Young Gwang Kim, Sae Yun Kwon, Spencer J. Washburn, Scott C. Brooks, Ji Won Yoon, Lucien Besnard
Summary: The study uses Hg isotope ratios to identify the sources and exposure pathways of mercury in bivalves, finding that dissolved Hg phases in the water column are the primary source and exposure pathway to bivalves. This provides new insights into using bivalves as bioindicators for sediment quality monitoring.
Article
Engineering, Environmental
Hui Geng, Ying Xu, Rui Liu, Dianhai Yang, Xiaohu Dai
Summary: This study investigates the effect of cation exchange resin (CER) on the sequential recovery of hydrogen and methane from anaerobic digestion (AD) and the corresponding mechanisms. The results show that CER can simultaneously enhance the production of hydrogen and methane by promoting the solubilisation, hydrolysis, and acidification of organic matter. Additionally, CER facilitates effective contact between bacteria and organic particulates and reduces the energy barrier for mass transfer during methane production. The study also reveals changes in the microbial community structure and metagenomics during the AD process.
Article
Engineering, Environmental
Xiaojing Lin, Zhan Jin, Shunfeng Jiang, Zhiquan Wang, Suqing Wu, Ke Bei, Min Zhao, Xiangyong Zheng
Summary: Dehumidification combined with addition of absorbent resin supplement (ARS) was used to achieve rapid evaporation of non-pretreated urine, resulting in high water evaporation efficiency and nutrient recovery.
Article
Engineering, Environmental
Yangli Che, Chaoran Lin, Shen Li, Jiao Liu, Longhai Zhu, Shilei Yu, Nan Wang, Haoshuai Li, Mutai Bao, Yang Zhou, Tonghao Si, Rui Bao
Summary: Hydrodynamic processes play a crucial role in the transmission of sediments, microbial assembly, and organic carbon redistribution in the ocean. Through experiments and analysis, we found that hydrodynamics shape the assembly of microbial communities and control the redistribution of different sourced organic carbon, thereby influencing microbial-mediated biogeochemical transformation.
Article
Engineering, Environmental
Chao Chen, Yu Yang, Nigel J. D. Graham, Zhenyu Li, Xingtao Yang, Zhining Wang, Nadia Farhat, Johannes S. Vrouwenvelder, Li -an Hou
Summary: The fouling of seawater reverse osmosis membranes is a persistent challenge in desalination. This study monitored the operational performance of a desalination plant for 7 years and the fouling development in different areas of membrane modules. The findings showed that operational performance declined over time and fouling mainly occurred at the feed side of the modules, with the highest microbial diversity. Keystone species like Chloroflexi and Planctomycetes played an important role in maintaining community structure and biofilm maturation. Polysaccharides, soluble microbial products, marine humic acid-like substances, and inorganic substances contributed to fouling. Overall, biofouling had a significant impact on membrane fouling after 7 years of operation.
Article
Engineering, Environmental
Dan Li, Jieyi Sun, Yibo Fu, Wentao Hong, Heli Wang, Qian Yang, Junhong Wu, Sen Yang, Jianhui Xu, Yunfei Zhang, Yirong Deng, Yin Zhong, Ping'an Peng
Summary: Sulfidation-oxidation treatment of magnetite (Fe3O4) enhances the production of dark center dot OH, which can efficiently degrade dissolved organic matter (DOM) and accelerate carbon cycling.
Article
Engineering, Environmental
Cheng Yu, Kaijun Wang, Kaiyuan Zhang, Ruiyang Liu, Pingping Zheng
Summary: This study implemented a microaerobic-aerobic configuration in a full-scale municipal wastewater treatment facility and investigated the effects on sludge characteristics, pollutant removal, microbial community, and granulation mechanisms. The results showed successful transition from flocculent-activated sludge to well-defined AGS after two months of operation. The primary pathways for pollutant removal were simultaneous nitrification, denitrification, and phosphorus removal. Moreover, the incorporation of internal separators induced shifts in the flow pattern, which promoted granulation.
Article
Engineering, Environmental
Zhe Zhang, Shaoyang Hu, Guangrong Sun, Wei Wang
Summary: Halogenated aromatic disinfection byproducts (DBPs), such as halogenated phenols, have garnered widespread attention due to their high toxicity and prevalence. This study reports on the analysis, occurrence, and cytotoxicity of a group of emerging halogenated aromatic DBPs, known as halogenated polyhydroxyphenols (HPPs), in drinking water.
Article
Engineering, Environmental
Shengyue Chen, Jinliang Huang, Peng Wang, Xi Tang, Zhenyu Zhang
Summary: Accurate prediction of river water quality is crucial for sustainable water management. This study introduces wavelet analysis and transfer learning techniques to assist LSTM modeling, proposing a newly coupled modeling approach that improves short-term prediction of river water quality.
Article
Engineering, Environmental
Bang Du, Xinmin Zhan, Piet N. L. Lens, Yifeng Zhang, Guangxue Wu
Summary: Efficient anaerobic digestion relies on the cooperation of different microorganisms with different metabolic pathways. This study investigated the effects of different operational modes and the addition of powdered activated carbon (PAC) on ethanol metabolic pathways. The results showed that the SBR mode and the presence of CO2 facilitated ethanol metabolism towards propionate production, while the CFR mode with extended solids retention time enriched Geobacter. Adjusting operational modes and PAC addition can modulate anaerobic ethanol metabolism and enrich Geobacter.
Article
Engineering, Environmental
Wanfa Wang, Si-Liang Li, Jun Zhong, Yuanbi Yi, Fujun Yue, Zenglei Han, Qixin Wu, Ding He, Cong-Qiang Liu
Summary: This study compares the carbon biogeochemical processes in karst and non-karst regions within large thermal stratified river-reservoir systems. The results demonstrate that karst reservoirs have a reduced potential for carbon emissions and highlight the importance of considering geologic settings to improve accuracy in regional and global CO2 emission estimates.
Article
Engineering, Environmental
Chunxia Jiang, Zelong Zhao, Dong Zhu, Xiong Pan, Yuyi Yang
Summary: This study analyzed the occurrence and distribution of antibiotic resistance genes (ARGs) in different environmental media of the Yangtze River using metagenomics. Core resistome dominated by multidrug resistance genes was found in all samples, while rare resistome dominated by various resistance genes was more prevalent in plasmids. Specific bacteria were identified as hosts for both core and rare resistomes, with high clinical concern ARGs found in the rare resistome. Particle-associated environment provided the most ideal conditions for resistome hosts. This study provided insights into the genetic locations of ARGs and the community assembly mechanisms of ARG hosts in freshwater environments.
Article
Engineering, Environmental
Yu Zhang, Yongtao He, Linchun Jia, Lei Xu, Zheng Wang, Yueling He, Ling Xiong, Xumeng Lin, Hong Chen, Gang Xue
Summary: By synergizing organic carbon source, thiosulfate, and zero-valent iron, efficient mixotrophic denitrification of oligotrophic secondary effluent can be achieved. Thiosulfate plays a vital role in promoting TN removal efficiency, while corrosion of Fe0 releases OH- to neutralize H+ from thiosulfate-driven denitrification, creating a suitable environment for denitrification. The coordination of thiosulfate and Fe0 maintains the dominance of Thiobacillus for denitrification.