期刊
BIOTECHNOLOGY AND BIOENGINEERING
卷 114, 期 1, 页码 7-20出版社
WILEY
DOI: 10.1002/bit.26059
关键词
amyloid; protein misfolding; toxic oligomers; functional amyloid; amyloid materials
资金
- National Institutes of Health [GM 95808]
- National Science Foundation Graduate Research Fellowship [DGE-1256082]
Amyloids have long been associated with protein dysfunction and neurodegenerative diseases, but recent research has demonstrated that some organisms utilize the unique properties of the amyloid fold to create functional structures with important roles in biological processes. Additionally, new engineering approaches have taken advantage of amyloid structures for implementation in a wide variety of materials and devices. In this review, the role of amyloid in human disease is discussed and compared to the functional amyloids, which serve a largely structural purpose. We then consider the use of amyloid constructs in engineering applications, including their utility as building blocks for synthetic biology and molecular engineering. (C) 2016 Wiley Periodicals, Inc.
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