Article
Acoustics
Sofie Snipstad, Yrr Morch, Einar Sulheim, Andreas Aslund, Andre Pedersen, Catharina de Lange Davies, Rune Hansen, Sigrid Berg
Summary: Combining microbubbles with ultrasound improves drug delivery to tumors, reducing tumor growth and extending survival in experimental models. Enhanced nanoparticle uptake following ultrasound treatment underscores the need for further understanding of tumor biology and ultrasound-mediated treatment mechanisms.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Martynas Maciulevicius, Diana Navickaite, Sonam Chopra, Baltramiejus Jakstys, Saulius Satkauskas
Summary: Research has shown that different calcium concentrations affect cell membrane permeability and cell viability during sonoporation, with ultrasound-microbubble cavitation playing a significant role. The study also indicates that inertial cavitation activities are directly involved in calcium delivery via sonoporation, leading to rapid cell death.
Article
Pharmacology & Pharmacy
Martynas Maciulevicius, Renaldas Raisutis, Baltramiejus Jakstys, Linas Svilainis, Andrius Chaziachmetovas, Saulius Satkauskas
Summary: Microbubble and ultrasound facilitated intracellular Ca2+ delivery, known as sonoporation, offers a promising alternative to conventional chemotherapy due to its spatio-temporally controllable and side-effect-free nature. This study demonstrates that a 5 mM concentration of Ca2+ in combination with ultrasound or ultrasound and Sonovue microbubbles can be used as an alternative to the anticancer drug bleomycin. Ca2+ delivery via sonoporation induces cell death in Chinese hamster ovary cells, similar to the combination of bleomycin and sonoporation, without causing systemic toxicity. Furthermore, Ca2+ delivery via sonoporation alters vital characteristics of viable cells and elicits sudden cell death within a short period of time.
Article
Pharmacology & Pharmacy
Martynas Maciulevicius, Mindaugas Tamosiunas, Diana Navickaite, Saulius Satkauskas, Mindaugas S. Venslauskas
Summary: In this study, the efficiency of delivering the anticancer drug doxorubicin into cells using cell sonoporation was investigated. The results showed that inertial cavitation is an efficient technique for the release and intracellular transfer of doxorubicin. Cell death caused by doxorubicin was related to intranuclear and extranuclear mechanisms as revealed by cell confocal imaging. The rate of forward scattering was found to have a high and significant correlation with doxorubicin delivery efficiency and cell viability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Environmental
Hyejoo Park, Hyojeon Kim, Ga-Yeong Kim, Mi-Young Lee, Young Kim, Seoktae Kang
Summary: The study showed that using Pseudomonas aeruginosa-encapsulated alginate/gellan gum microbeads for diesel biodegradation was more effective than using suspended bacteria. The microbial activity in PAGMs was well maintained, while suspended bacteria showed decreased activity after direct contact with toxic hydrocarbons.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Chemical
Martin P. Walsh, Rohan Tikekar, Nitin Nitin, Steven Wrenn
Summary: This study investigates the effectiveness of high-frequency ultrasound-induced microbubble cavitation on bacterial inactivation using liposomal bilayers as a model for bacterial cell membranes. The addition of a positive charge on micmbubbles increased their proximity to liposomes, but dampened microbubble's oscillation. Microstreaming from stable cavitation at 3.3 MHz led to approximately 19% mixing of phospholipids, while inertial cavitation at 1.0 MHz increased this mixing to 50%.
JOURNAL OF FOOD ENGINEERING
(2021)
Review
Pharmacology & Pharmacy
Rachel Chapla, Katherine T. Huynh, Carolyn E. Schutt
Summary: Targeted delivery of therapeutics is crucial for reducing systemic toxicity and optimizing therapeutic efficacy. Ultrasound-controlled targeting is an externally-stimulated drug delivery strategy, using ultrasound waves to stimulate gas-filled microbubbles and deliver attached cargo to surrounding cells. The attachment of nanocarrier particles to microbubbles greatly enhances drug delivery capabilities.
Article
Physics, Applied
Luc Biasiori-Poulanges, Guillaume T. Bokman, Enea Baumann, Outi Supponen
Summary: This study proposes shock waves as an instant release mechanism for gas-encapsulated droplets, and explores the key factors involved in the release process through numerical and theoretical investigations. Analytical models are derived to predict the water hammer pressure, sheet jet velocity, and droplet drift.
APPLIED PHYSICS LETTERS
(2022)
Review
Pharmacology & Pharmacy
Arvin Honari, Shashank R. Sirsi
Summary: Despite recent advancements in ultrasound-mediated drug delivery, no platform utilizing ultrasound contrast agents has received FDA approval. The sonoporation effect has promising applications in clinical settings, but there are safety concerns. Clinical trials are being conducted to evaluate sonoporation's efficacy in treating tumors.
Article
Biophysics
Md Danish Eqbal, Farha Naaz, Kajal Sharma, Venkat Gundabala
Summary: The development of a 3D glass-PDMS hybrid device allows for complete on-chip generation of cell-laden alginate beads in the presence of electric fields, with active control of droplet size. This approach successfully encapsulated E. coli cells into alginate microbeads and demonstrated promising technology for cell encapsulation with applications in various fields.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Engineering, Biomedical
Vismaya S. Bachu, Jayanidhi Kedda, Ian Suk, Jordan J. Green, Betty Tyler
Summary: HIFU is an emerging and increasingly useful modality in the treatment of cancer and other diseases, using high-energy ultrasound pulses to target specific areas while minimizing damage to surrounding tissues. Its wide applications across various tumor types and organ systems, along with its potential future pathways, highlight the growing importance of this technology in biomedical fields.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Pharmacology & Pharmacy
Payton Martinez, Nick Bottenus, Mark Borden
Summary: This study aimed to explore the acoustic response of different microbubble sizes and concentrations. The results showed that the onset of harmonic cavitation and broadband cavitation dose depended on the mechanical index, microbubble size, and microbubble concentration. Furthermore, when microbubble size and concentration were combined into gas volume fraction, all different microbubble size distributions aligned to similar onset and peak.
Article
Microbiology
Ikram Ullah Khan, Mehwish Shoukat, Muhammad Asif, Syed Haroon Khalid, Sajid Asghar, Muhammad Usman Munir, Muhammad Irfan, Akhtar Rasul, Sameer H. Qari, Alaa T. Qumsani, Mohamed M. Hassan, Maryam A. Alahdal, Muhammad Usman, Zulqurnain Khan
Summary: This study developed alginate-based floating microbeads to enhance the eradication of Helicobacter pylori infections. The developed microbeads showed significant antibacterial activity against Staphylococcus aureus and Escherichia coli, and had the potential to overcome the narrow therapeutic index and low bioavailability of clarithromycin.
Review
Chemistry, Multidisciplinary
Zihao Wen, Chen Liu, Zihao Teng, Quanyi Jin, Zhihuan Liao, Xuan Zhu, Shuaidong Huo
Summary: Ultrasound has been used to enhance drug delivery efficiency by improving cell membrane permeability. The cavitation effect generated by ultrasound can facilitate the delivery of various cargoes, especially nanocarriers. Understanding the biophysical mechanism of ultrasound-cell membrane interaction is significant for the scientific community in drug delivery and nanomedicine.
Article
Multidisciplinary Sciences
Ziga Lokar, Rok Petkovsek, Matevz Dular
Summary: Understanding and controlling the interaction of cavitation bubbles with nearby materials is crucial for optimizing various processes. Significant differences in bubble behavior were observed depending on the properties of the surrounding fluids, while the influence of membrane properties was less pronounced. This study highlights the importance of focusing on liquid properties rather than membrane mechanics in the optimization process.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Woo Young Kim, Seong Young Ko
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2019)
Article
Automation & Control Systems
Muhammad Umar Farooq, Seong Young Ko
INTERNATIONAL JOURNAL OF CONTROL AUTOMATION AND SYSTEMS
(2020)
Article
Materials Science, Multidisciplinary
Shaohui Zheng, Zhen Jin, Cuiping Han, Jingjing Li, Hang Xu, Sukho Park, Jong-Oh Park, Eunpyo Choi, Kai Xu
JOURNAL OF MATERIALS SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Zhen Jin, Kim Tien Nguyen, Gwangjun Go, Bungjeon Kang, Hyun-Ki Min, Seok-Jae Kim, Yun Kim, Hao Li, Chang-Sei Kim, Seonmin Lee, Sukho Park, Kyu-Pyo Kim, Kang Moo Huh, Jihwan Song, Jong-Oh Park, Eunpyo Choi
Article
Robotics
Gwangjun Go, Sin-Gu Jeong, Ami Yoo, Jiwon Han, Byungjeon Kang, Seokjae Kim, Tien Kim Nguyen, Zhen Jin, Chang-Sei Kim, Yu Ri Seo, Ju Yeon Kang, Ju Yong Na, Eun Kyoo Song, Yongyeon Jeong, Jong Keun Seon, Jong-Oh Park, Eunpyo Choi
Article
Automation & Control Systems
Binxiang Xu, Seong Young Ko
Article
Biotechnology & Applied Microbiology
Zhen Jin, Jinlong Chang, Peipei Dou, Shang Jin, Min Jiao, Heyun Tang, Wenshuai Jiang, Wu Ren, Shaohui Zheng
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Engineering, Biomedical
Kim Tien Nguyen, Gwangjun Go, Zhen Jin, Bobby Aditya Darmawan, Ami Yoo, Seokjae Kim, Minghui Nan, Sang Bong Lee, Byungjeon Kang, Chang-Sei Kim, Hao Li, Doyeon Bang, Jong-Oh Park, Eunpyo Choi
Summary: This study proposes a novel method utilizing a magnetically guided self-rolled microrobot for targeted drug delivery, combined with real-time X-ray imaging and microrobot retrieval. The microrobot features precise localization and rapid drug release, showing potential for use in precise localized drug delivery systems.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biophysics
Zhen Jin, Yanbing Dun, Linyan Xie, Wenshuai Jiang, Xuming Sun, Pengcheng Hu, Shaohui Zheng, Yi Yu
Summary: The study developed a multifunctional PION@PDA-PEG nanocomposite combining MR imaging, photothermal therapy, and chemotherapy for anti-cancer drug delivery. The nanocomposite showed excellent biocompatibility, MRI contrast agent capability, and a drug loading capacity of over 24.1 wt%. In vitro cell experiments demonstrated enhanced anti-tumor effects through synergistic photothermal-chemotherapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Binxiang Xu, Liming An, Seong Young Ko
Summary: The study introduces a novel device for fracture reduction surgery, which has been evaluated through experiments to be simple, cost-effective, and accurate, meeting the practical needs in clinical settings.
APPLIED SCIENCES-BASEL
(2021)
Review
Robotics
Muhammad Umar Farooq, Seong Young Ko
Summary: Magnetic resonance imaging (MRI) provides better visualization for diagnosis, interventional radiology, and surgery without X-ray exposure. The symbiosis of MRI and robotics can improve patient outcomes and surgical convenience. Technological advancements have led to the development of MRI-compatible robots. This article reviews the literature on robotic systems developed for the MRI environment between 2009 and 2021, discussing surgical robots, sensing solutions, research emphasis, limitations, and prospects.
IEEE TRANSACTIONS ON ROBOTICS
(2023)
Article
Automation & Control Systems
Rongrong Liu, Farrukh Anique, Rongwan Chen, Sung Suk Oh, Jung Ki Jo, Seong Young Ko
Summary: This paper presents an automatic biopsy device that can be used in the MRI environment and works with a MR conditional robotic prostate biopsy system. The device, based on a compact cam design, can perform all actions required for prostate biopsy using a single actuator. Experimental evaluation showed that the device can easily and completely perform tissue sampling, with comparable performance to existing manual biopsy guns. MRI compatibility testing demonstrated a 18.7% reduction in signal-to-noise ratio during device operation.
Article
Automation & Control Systems
Muhammad Umar Farooq, Seong Young Ko, Sungmin Seung, Chaewon Kim, Kyoungrae Cha, Sung Suk Oh, Heon You
Summary: This study proposes the first MRI-compatible robotic system for pituitary tumor removal via trans-sphenoidal/endonasal access. The presented robot follows the gold standard procedure of pituitary tumor resection and integrates with a commercial MR scanner, providing wide applicability. It has procedure-, anatomy-, and geometry-specific design, with 6-degree-of-freedom actuated by a bed-type actuation platform in the MRI room. The robot's accuracy and repeatability are within a desirable range, and in vivo experiments on live porcine under MRI validate the proposed solution.
Article
Computer Science, Information Systems
Farrukh Anique, Rongrong Liu, Muhammad Umar Farooq, Sung Suk Oh, Jung Ki Jo, Seong Young Ko
Summary: Biopsies are a common method for diagnosing and prognosing prostate cancer, and advancements in MRI technology have allowed for real-time guidance during the biopsy process. A proposed device aims to collect and temporarily store tissue samples taken during an MRI-guided prostate biopsy, potentially enabling a teleoperated and uninterrupted procedure. The device, made of a double layer of paper, has been tested and optimized for tissue collection performance, as well as MRI compatibility. It shows potential for integration with an MRI-safe or conditional robotic manipulator for real-time MRI-guided prostate biopsy.
Article
Computer Science, Information Systems
Muhammad Umar Farooq, Hyunwoo Baek, Sungmin Seung, Kyoungrae Cha, Heon You, Dong-Soo Kwon, Seong Young Ko