Article
Materials Science, Multidisciplinary
Guochao Xu, Shuang Song, Muhammad Azhar Hayat Nawaz, Junying Lv, Cong Yu, Xing Jin
Summary: Mesoporous silica nanoparticles with fluorescent and tumor targeting functions were synthesized and loaded with paclitaxel to create smart composite materials for targeted chemotherapy and tumor imaging. Results showed the potential applicability of PTX-YMSN for tumor treatment, combining the advantages of drug delivery nanosystem and organic fluorophore.
Article
Biochemistry & Molecular Biology
Hyung Woo Choi, Jae Hyun Lim, Taewook Kang, Bong Geun Chung
Summary: The study presents a multi-stimuli responsive drug delivery system for cancer treatments. The mesoporous organo-silica nanocomposites, triggered by glutathione, hyaluronidase, and hydrogen peroxide, enable chemo-, photothermal, and photodynamic therapies. The system reduces side effects and enhances cancer therapeutic efficacy.
Article
Chemistry, Multidisciplinary
Hongqian Cao, Yanfei Qi, Xibao Gao, Zi Jin Wei, Jiarui Xia, Lei Wang, Hao Wang, Yang Yang, Junbai Li
Summary: The novel peptide nanodrug, consisting of three functional motifs - bis(pyrene), FFVLK and CREKA, is used as a two-photon excited photosensitizer for precise photodynamic therapy (PDT), showing excellent two-photon imaging ability, tumor target effect and high reactive oxygen species productivity to improve treatment precision and efficiency in PDT.
CHEMICAL COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Elena de las Heras, M. Lluisa Sagrista, Montserrat Agut, Santi Nonell
Summary: This study explores the use of actively-targeted chemo-photo-nanocarriers to improve the localization of chemotherapy drugs in tumor cells. The results show that the attachment of high concentrations of doxorubicin to cetuximab-IRDye700DX-mesoporous silica nanoparticles yields efficient and selective photokilling of EGFR-expressing cells, without any dark toxicity.
Article
Polymer Science
Yuqi Chen, Xuelian Wang, Zhuhang Lu, Cong Chang, Yueli Zhang, Bo Lu
Summary: Surface modification of HMSNs with unique advantages has been successfully achieved for drug delivery and effective cancer treatment. Functionalized nanoparticles were developed for targeted and dual-responsive release of loaded DOX·HCL and ICG. The addition of CS and HDA further enhanced the targeted drug delivery system, which exhibited excellent drug loading capacity and pH/enzyme-responsive drug release properties, effectively inhibiting cancer cells viability.
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
(2023)
Article
Biophysics
Yueli Zhang, Zhilan Ye, Ruixuan He, Yuyang Li, Bei Xiong, Mengqi Yi, Yuqi Chen, Jia Liu, Bo Lu
Summary: This study developed a drug carrier consisting of hollow mesoporous silica nanoparticle (HMSNs) encapsulated with folic acid-modified bovine serum albumin (BSA-FA) for tumor targeting and controlled drug release. The carrier achieved specific intracellular drug delivery through folic acid and released the drug in response to intracellular conditions. The targeted and controlled drug release properties of the carrier make it a promising approach for cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Spectroscopy
Hong-Li Ye, Xi-Wen He, Wen-You Li, Yu-Kui Zhang
Summary: Transferrin-functionalized silicon nanoparticles were successfully prepared and characterized for their structural and optical properties. The results showed that Trf-SiNPs exhibited low toxicity to tumor cells and could be effectively applied for targeted fluorescence imaging.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Nanoscience & Nanotechnology
Pranjyan Dash, Senthilkumar Thirumurugan, Ching-Li Tseng, Yu-Chien Lin, Sung-Lung Chen, Udesh Dhawan, Ren-Jei Chung
Summary: This study developed dumbbell-shaped nanocomposites consisting of titanium dioxide/gold nanorods coated with mesoporous silica shells. Methotrexate was loaded onto the nanocomposites and upconversion nanoparticles were decorated to enhance the therapeutic effects. In vitro and in vivo experiments demonstrated the synergistic photodynamic therapy, photothermal therapy, and chemotherapy effects of the nanocomposites, making them a promising candidate for cancer treatment using near-infrared light.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Yu Chen, Sheng Zhang, Tianjiao Cheng, Wei Lin, Linlin Mao, Zhonghui Chen, Yang Yang, Hanqing Huang, Jinqiu Li, Zhiyong Ke, Zhong-Kai Cui
Summary: Mitochondria are recognized as ideal targets for tumor therapy, and mitochondria-specific photosensitizers play a critical role in inducing cell apoptosis. In this study, a new aggregation-induced emission (AIE) photosensitizer with excellent properties was developed for mitochondrial targeting, exhibiting good biocompatibility, reactive oxygen species (ROS) stimulation ability, anticancer efficacy, and two-photon imaging properties.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tsung-Han Ho, Chien-Hsin Yang, Zheng-En Jiang, Hung-Yin Lin, Yih-Fung Chen, Tzong-Liu Wang
Summary: In this study, a facile and effective method was used to coat mesoporous silica shell on ligand-free upconversion nanoparticles. Two types of mesoporous silica-coated UCNPs with different emissions were successfully synthesized. Photosensitizers were loaded into the mesoporous silica shell, and the UCNP@mSiO(2)/PS nanocarrier system showed enhanced ROS generation and therapeutic efficacy in PDT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Jiahui Lu, Chen Ni, Jie Huang, Yawen Liu, Yingkai Tao, Pengcheng Hu, Yong Wang, Shaohui Zheng, Meilin Shi
Summary: This study successfully designed a novel multifunctional nanocomplex with superior properties in MR imaging, photothermal conversion, and generation of reactive oxygen species. The nanocomplexes exhibited strong inhibition to the growth of MDA-MB-231 tumor in vitro and in vivo under the guidance of MR and fluorescence imaging.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Tanveer A. Tabish, Mian Zahid Hussain, Roland A. Fischer, Angela Casini
Summary: Much progress has been made in subcellular targeted therapy of cancer by attacking disease cell's mitochondria. Mitochondrial dysfunction controls key metabolic changes and is related to tumor invasion, proliferation, tumorigenesis, and metastasis. Supramolecular metal-organic frameworks (MOFs) can be targeted to the tumor's mitochondria selectively and disrupt cancer cells' metabolic processes. Mitochondria-targeted MOFs (mitoMOFs) have the potential to revolutionize targeted therapy and improve therapeutic outcomes with minimal side-effects.
Article
Chemistry, Multidisciplinary
Shihui Ding, Wenbo Wu, Tingting Peng, Wen Pang, Pengfei Jiang, Qiuqiang Zhan, Shuhong Qi, Xunbin Wei, Bobo Gu, Bin Liu
Summary: The study introduced a NIR light excitable UCNP@TBD nanocomposite, which combines TBD with UCNP and exhibits good photostability, biocompatibility, and ROS generation efficiency under NIR light excitation for improved anticancer therapeutic outcomes.
NANOSCALE ADVANCES
(2021)
Article
Optics
Sandro Heuke, Carla Silva Martins, Remi Andre, Loic Legoff, Herve Rigneault
Summary: Two-photon excited fluorescence (2PEF) microscopy is a popular nonlinear imaging method for biomedical samples. It uses multiple detectors and spectral filter sets to discriminate different fluorophores based on their emission behavior. However, 2PEF suffers from the loss of fluorescence photons outside the filter transmission range and may fail to discriminate fluorophores with similar emission profiles. Here, we propose an alternative 2PEF method that discriminates fluorophores based on their excitation spectra.
Review
Chemistry, Multidisciplinary
Blanca Escriche-Navarro, Andrea Escudero, Elena Lucena-Sanchez, Felix Sancenon, Alba Garcia-Fernandez, Ramon Martinez-Manez
Summary: Cancer immunotherapy has shown promise in treating various forms of cancer by stimulating the patient's immune system, but there are limitations to current treatments. The use of nanomaterials, particularly mesoporous silica nanoparticles (MSNs), has emerged as a potential tool to enhance cancer immunotherapy by improving efficacy and reducing side effects. This review explores the role of MSN and other nano/micro-materials in enhancing cancer immunotherapy and summarizes the different immunotherapeutic strategies addressed using MSN to date.
Article
Psychology, Multidisciplinary
Jiali Huang, Xiaohui Li, Jiaqi Zhao, Yuanyuan An
Summary: This study investigates the long-term effect of resilience on academic self-concept in migrant children, and examines the mediating effect of different emotion regulation strategies. The results show that resilience predicts academic self-concept positively, with reappraisal mediating this relationship. The study highlights the importance of promoting resilience and reappraisal ability to enhance academic self-concept in students.
CURRENT PSYCHOLOGY
(2023)
Article
Plant Sciences
Han Wang, Yan Liu, Yi-Kai Jang, Si-Yi Wang, Xiao-Mao Li, Juan Pan, Wei Guan, Adnan Mohammed Algradi, Hai-Xue Kuang, Bing-You Yang
Summary: Two new phenylpropanoids and nine known compounds were isolated from Solanum capsicoides leaves. Their structures were determined using spectroscopic methods and comparing with literature. In addition, the compounds showed inhibitory effects on inflammation.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Agronomy
Huiling Zhang, Liu Yu, Yanan Zhao, Zhonghua Zhang, Zhixin Zhang, Maosong Pei, Botao Song
Summary: Anthocyanins not only have strong antioxidant capacity, but also enhance plant resistance to biological and abiotic stresses. This study identified a new MYB gene, StMYB3, as a potential regulator of anthocyanin synthesis in potatoes. Additionally, the study found a significant correlation between the promoter activity of certain potato structural genes and the activation of StMYB3. These findings provide a theoretical basis for understanding the regulation theory of anthocyanin synthesis and offer a new gene resource for molecular breeding of potatoes with high anthocyanin content.
Article
Peripheral Vascular Disease
Fang Sun, Xiaoli Liu, Hexuan Zhang, Xunmei Zhou, Zhigang Zhao, Hongbo He, Zhencheng Yan, Yingsha Li, Qiang Li, Yaoming Li, Jun Jiang, Zhiming Zhu
Summary: This study examined the efficacy of catheter-based adrenal ablation for aldosterone-producing adenoma (APA) and compared it with adrenalectomy. The results showed that adrenal ablation had a certain improvement in clinical and biochemical outcomes for APA patients, especially in terms of biochemical success rate. Compared with surgery, adrenal ablation has the advantages of shorter operating time and faster recovery of physical activity.
HYPERTENSION RESEARCH
(2023)
Article
Oncology
Shun Lu, Jian Fang, Ziping Wang, Yun Fan, Yunpeng Liu, Jianxing He, Jianying Zhou, Jie Hu, Jinjing Xia, Wenxin Liu, Jane Shi, Jing Yi, Lejie Cao
Summary: The IMpower132 study demonstrated a significant progression-free survival (PFS) benefit with atezolizumab plus pemetrexed and carboplatin or cisplatin (APP) in Chinese patients with non-squamous advanced non-small cell lung cancer. While overall survival (OS) data is still immature, there is a trend favoring APP over pemetrexed plus carboplatin or cisplatin (PP) in terms of OS. Safety profile of the APP regimen was consistent with known risks of individual treatment components.
Article
Chemistry, Multidisciplinary
Yanan Wang, Minju Pu, Jiahui Yan, Jingwen Zhang, Huichao Wei, Liangmin Yu, Xuefeng Yan, Zhiyu He
Summary: Calcium overload is a key factor in the development of acute kidney injury (AKI), but no approved pharmacotherapies for AKI exist. Researchers have developed a drug delivery system that targets the kidneys and responds to reactive oxygen species (ROS). In animal models, this system effectively reduced renal damage and improved kidney function by scavenging excess calcium and inhibiting apoptosis and inflammatory response.
Article
Chemistry, Applied
Hu Tu, Xiaoyan Li, Kang Xie, Jipeng Zhang, Yuncui Liu, Xiaoyu Shao, Xinghuan Lin, Ruquan Zhang, Bo Duan
Summary: A high strength chitosan/edge hydroxylated boron nitride nanosheets dielectric film was fabricated via dual chemically-physically crosslinking and drafting orientation strategy, showing excellent mechanical and dielectric properties. It could be completely degraded in soil within 90 days.
CARBOHYDRATE POLYMERS
(2023)
Article
Pathology
Xiaohang Yang, Jingjing Yin, Yu Fu, Yuanming Shen, Chuyao Zhang, Shuzhong Yao, Congjian Xu, Min Xia, Ge Lou, Jihong Liu, Bei Lin, Jianliu Wang, Weidong Zhao, Jieqing Zhang, Wenjun Cheng, Hongyan Guo, Ruixia Guo, Fengxia Xue, Xipeng Wang, Lili Han, Xiaomao Li, Ping Zhang, Jianguo Zhao, Wenting Li, Yingyu Dou, Zizhuo Wang, Jingbo Liu, Kezhen Li, Gang Chen, Chaoyang Sun, Pengming Sun, Weiguo Lu, Qin Yao
Summary: In this study, the mode of myometrial invasion diagnosis in FIGO stage I non-endometrioid carcinoma was explored and the differences in diagnostic efficiency among intraoperative frozen section (IFS), intraoperative gross examination (IGE), magnetic resonance imaging (MRI), and computed tomography (CT) were evaluated. It was found that IFS is a reliable method that should be routinely performed in clinical practice for accurately assessing myometrial invasion in non-endometrioid endometrial carcinoma patients.
DIAGNOSTIC PATHOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Zhiguo Liu, Ye Yuan, Lili Wang, Xuan Zhao, Lixin Wang, Lihu Wang, Zhihui Zhao, Xin Zhao, Yuetong Chu, Yaning Gao, Fangyuan Yang, Yulu Wang, Qiong Zhang, Jin Zhao, Mengjun Liu
Summary: This study systematically investigated plant adenylate cyclases using Chinese jujube, a plant with high cAMP content. Three novel ACs were identified and their functions were confirmed using in vitro and in vivo methods. Overexpression of these AC genes in Arabidopsis resulted in accelerated seed germination, root growth, and flowering. Transcriptome data suggested that the biological functions of ACs may be mediated through the regulation of key genes involved in the circadian rhythm pathway and hormone signal transduction pathway. This research lays the foundation for further studying plant AC genes and provides strong evidence for cAMP serving as a signaling molecule in plants.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Song- Han, Deborah A. Sarkes, Margaret M. Hurley, Rebecca Renberg, Can Huang, Yuwen Li, Justin P. Jahnke, James J. Sumner, Dimitra N. Stratis-Cullum, Arum Han
Summary: Discovery of microorganisms and their relevant surface peptides that specifically bind to target materials can be achieved through iterative biopanning-based screening. Recently, microfluidics-based biopanning methods have been developed to overcome the limitations of conventional methods. In this work, a magnetophoretic microfluidic biopanning platform was developed to isolate microorganisms that bind to gold, and successful screening of bacterial peptide display library and soil microbes was demonstrated.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Xiaojie Liu, Yong Zhao, Yahui Du, Quanliang Wang, Xin Jing, Liangmin Yu, Mingliang Sun
Summary: Conjugated donor-acceptor (D-A) polymer heterojunctions have been developed as efficient photocatalysts, but maintaining reproducibility and controlling photocatalytic activity are challenging. In this study, ladder-like small molecules BTx were synthesized and used to develop BTx/g-C3N4 heterojunctions for sterilization and contaminant degradation. By introducing an additional acceptor unit into the small molecule, intramolecular and intermolecular charge transfer were enhanced, resulting in improved photocatalytic performance. Specifically, BTORIC2Cl/g-C3N4 exhibited near-infrared absorption and achieved high photocatalytic activity and antibacterial rates. The study proposes a novel approach for fabricating small molecule/g-C3N4 heterojunctions as efficient photocatalysts via molecular engineering.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Applied
Xinqi Wang, Lijiu Cao, Yue Hu, Yufang Chen, Tao Jin, Jian Huang, Xinhe Zhang, Shudong Lin
Summary: In recent years, the application of highly transparent hydrophobic coatings has been a focus in preventing smudging on electronic displays, automotive glass surfaces, and solar cell surfaces. This study developed a novel hydrophobic melamine resin by modifying melamine with stearyl chloride, leading to the fabrication of high-transparency hydrophobic coatings. The incorporation of long-chain alkyl materials and polyethylene glycol improved the surface properties and flexibility of the resin.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Computer Science, Artificial Intelligence
Hangkai Hu, Gao Huang, Xiang Li, Shiji Song
Summary: This article introduces an off-policy meta-RL algorithm that allows meta-learners to adapt their exploration strategy and balance task-agnostic and task-related information through latent context reorganization.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Chemistry, Physical
Xiaojie Liu, Yahui Du, Yong Zhao, Ziwei Huang, Xin Jing, Dongxue Wang, Liangmin Yu, Mingliang Sun
Summary: Heterojunctions based on two-dimensional benzodithiophene (BDT) and thieno[2,3-f]benzofuran (TBF) conjugated polymers/g-C3N4 were fabricated using a symmetry-breaking strategy. PD3 with a fluorinated benzotriazole electron acceptor unit exhibited higher charge mobility and more compact π-π stacking. PD5 with asymmetric side chains in the donor unit BDT demonstrated efficient charge transfer and comparable light utilization rate in the corresponding PD5/g-C3N4 heterojunction. PD5/g-C3N4 showed superior photocatalytic sterilization performance with high degradation rates for S. aureus, E. coli, and Rhodamine B. This study provides insights into the structure-property correlation of asymmetric conjugated polymers/g-C3N4 for potential photocatalysis applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Physiology
Menglin Pang, Lin Chen, Na Jiang, Mengmeng Jiang, Baofeng Wang, Lili Wang, Xiao-yan Jia
Summary: This study found that serum 25(OH)D level is negatively associated with fatigue in elderly maintenance hemodialysis patients.
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
