期刊
BIOSENSORS & BIOELECTRONICS
卷 86, 期 -, 页码 879-884出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2016.07.086
关键词
6-Mercaptopurine; 6-Thioguanine; Dasatinib; Sensor; Pt/MWCNTs; Ionic liquid
类别
资金
- University of Guilan, Rasht, Iran
- Graduate University of Advanced Technology, Kerman, Iran
6-Mercaptopurine, 6-thioguanine and dasatinib are three important anticancer drugs with high adverse effects in human body. In this study, a Pt/MWCNTs-1-butyl-3-methylimidazolium hexafluoro phosphate modified carbon paste electrode was developed for the simultaneously determination of 6-mercaptopurine, 6-thioguanine and dasatinib for the first time. The Pt/MWCNTs synthesized by polyol method and have been characterized by transmission electron microscopy and X-ray diffraction methods. The obtained data revealed that the electro-oxidation of 6-mercaptopurine, 6-thioguanine and dasatinib is facilitated as a novel voltammetric sensor. After optimization of electrochemical parameters employing this sensor at pH 8.0, the oxidation peak currents for 6-mercaptopurine, 6-thioguanine and dasatinib were found to vary linearly with their concentrations in the range of 0.05-550 mu M; 0.1-500 mu M and 5.0-500 mu M with detection limits of 0.009 mu M, 0.05 mu M and 1.0 mu M respectively using square wave voltammetric method. The modified electrode has been applied for the selective and precise analysis of 6-mercaptopurine, 6-thioguanine and dasatinib in pharmaceutical formulations and urine samples. (C) 2016 Elsevier B.V. All rights reserved.
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