Article
Infectious Diseases
Kim C. Fournier, Valerie E. Paquet, Sabrina A. Attere, Judith Farley, Helene Marquis, Hubert Gantelet, Christian Ravaille, Antony T. Vincent, Steve J. Charette
Summary: New variants of the pRAS3 plasmid were discovered, along with a genetic element similar to one found in a swine pathogen. Despite differences between plasmids, no specific trend in tetracycline resistance was observed. Furthermore, Blast analysis revealed the widespread distribution of pRAS3 plasmids in other bacterial species.
Article
Infectious Diseases
Pierre-Etienne Marcoux, Sabrina A. Attere, Valerie E. Paquet, Maude F. Paquet, Sarah B. Girard, Judith Farley, Michel Frenette, Antony T. Vincent, Steve J. Charette
Summary: We discovered a plasmid in Aeromonas salmonicida subsp. salmonicida, called pAsa-2939, which carries antibiotic resistance genes. This 67 kb plasmid displays unique features and contains a transposon with an unusual organization. The transposon carries a catB3 gene that has not been found in this bacterial species before. The plasmid can be transferred into Aeromonas hydrophila, but not into Escherichia coli.
Review
Multidisciplinary Sciences
Antony T. Vincent, Nava Hosseini, Steve J. Charette
Summary: This literature review provides an overview of the plasmidome of Aeromonas salmonicida, focusing on antibiotic resistance genes, virulence factors, and cryptic plasmids with unknown biological functions.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Microbiology
Pierre-Etienne Marcoux, Sarah B. Girard, Kim C. Fournier, Catherine A. Tardif, Ariane Gosselin, Steve J. Charette
Summary: This study reveals the fusion process between the pAsa5 plasmid and the complete version of the pAsa8 plasmid. The insertion of the pAsa8 transposon into pAsa5 in a certain strain appears to be an abnormal event compared to the fusion of the two full-length plasmids. The fusion is mediated by a 22-nucleotide sequence present in both plasmids. Furthermore, the study shows that pAsa8 can be introduced into new strains through conjugation and fusion with pAsa5 can be detected.
Article
Microbiology
Dongjuan Dai, Connor Brown, Helmut Burgmann, D. G. Joakim Larsson, Indumathi Nambi, Tong Zhang, Carl-Fredrik Flach, Amy Pruden, Peter J. Vikesland
Summary: By using long-read sequencing, this study reveals that the activated sludge treatment in wastewater treatment plants acts as a barrier against the proliferation of most antibiotic resistance genes (ARGs), although some genes still persist or increase and require further attention.
Article
Fisheries
Asmaa K. Al-Mokaddem, Dalia A. Abdel-moneam, Reham A. Ibrahim, Mona Saleh, Mohamed Shaalan
Summary: Aeromonas salmonicida was isolated for the first time from Mugil carinatus fish in Suez Gulf, Egypt. The bacteriological, molecular and histopathological methods were used to identify the fish samples. The isolated A. salmonicida strains were confirmed through biochemical identification, molecular identification and histopathological analysis. The study also revealed the pathological lesions caused by A. salmonicida infection.
AQUACULTURE REPORTS
(2022)
Article
Multidisciplinary Sciences
Xun Qian, Santosh Gunturu, Wei Sun, James R. Cole, Bo Norby, Jie Gu, James M. Tiedje
Summary: The environmental resistome is global, diverse, and influenced by human activities. By utilizing long-read sequencing, researchers were able to analyze antibiotic resistance genes (ARGs) in a ceftiofur-treated cow, revealing that multidrug-resistance genes comprise a significant portion of the resistome abundance, with some located on plasmids, and Enterobacteriaceae being dominant hosts of antibiotic-resistant plasmids.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Limiao Hu, Xi Zeng, Qi Ai, Caijuan Liu, Xiaotuan Zhang, Yajun Chen, Logen Liu, Guo-Qing Li
Summary: In this study, the authors investigated the antibiotic resistance pattern of H. pylori in a Chinese medical center. The results showed high rates of resistance to clarithromycin, metronidazole, and levofloxacin. The study also compared short-read- and long-read-based whole-genome sequencing methods for identifying genotypes and found that both methods were effective in predicting antibiotic resistance. Furthermore, the study discovered the heterozygous status of the 23S rRNA gene in H. pylori strains, which is important for clarithromycin resistance. Overall, the study provides important evidence for empirical treatment of H. pylori and demonstrates the potential of Nanopore sequencing in predicting clarithromycin resistance.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemical Research Methods
Francesco E. Emiliani, Ian Hsu, Aaron McKenna
Summary: Recombinant DNA is a crucial tool in biotechnology and medicine, and validation of plasmid sequences is a critical and time-consuming step. In this study, a high-throughput plasmid sequencing approach using DNA transposition and Oxford Nanopore sequencing was developed, resulting in robust and accurate plasmid assemblies.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Biochemical Research Methods
Francesco E. Emiliani, Ian Hsu, Aaron McKenna
Summary: Circuit-seq is a high-throughput plasmid sequencing method using DNA transposition and Oxford Nanopore sequencing. It can rapidly and accurately generate complete plasmid assemblies, analyze plasmid size and complexity, and estimate plasmid contamination levels.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Genetics & Heredity
Linda van der Graaf-van Bloois, Jaap A. Wagenaar, Aldert L. Zomer
Summary: Researchers have developed a new prediction tool RFPlasmid, which uses a combination of multiple features to predict whether the likely source of a contig is plasmid or chromosomal. The tool supports models for 17 different bacterial taxa and has a taxon agnostic model for metagenomic assemblies or unsupported organisms. RFPlasmid is available both as a standalone tool and via a web interface.
MICROBIAL GENOMICS
(2021)
Review
Biochemical Research Methods
Sosie Yorki, Terrance Shea, Christina A. Cuomo, Bruce J. Walker, Regina C. LaRocque, Abigail L. Manson, Ashlee M. Earl, Colin J. Worby
Summary: Recent advances in technology and computation have made metagenomic assembly a viable method for studying complex microbial communities. Previous benchmarking has shown that short-read (SR) assemblers are more accurate, long-read (LR) assemblers provide more contiguous sequences, and hybrid (HY) assemblers balance accuracy and length. However, there has been no specific assessment of these assemblers on low-abundance species, including clinically relevant organisms in the gut. Our study examined the performance of different assemblers on low-abundance species, specifically looking at the assembly of Escherichia coli contigs and antibiotic resistance genes (ARGs). We found that each assembler type has its own strengths and trade-offs, and the optimal approach depends on the specific goal of the study.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Virology
Nava Hosseini, Valerie E. Paquet, Mahdi Chehreghani, Sylvain Moineau, Steve J. Charette
Summary: Aquaculture is facing antibiotic resistance issues in fighting pathogenic bacteria, with phage therapy being a potential alternative. A specific combination of four phages has shown effectiveness against A. salmonicida subsp. salmonicida, but strains with Prophage 3 exhibit reduced sensitivity. This highlights the impact of prophage content on the efficacy of phage therapy.
Article
Microbiology
Wenxuan Zhao, Wei Zeng, Bo Pang, Ming Luo, Yao Peng, Jialiang Xu, Biao Kan, Zhenpeng Li, Xin Lu
Summary: This study describes a novel ONT sequencing method that can assemble genomes of multidrug-resistant strains and plasmids using long-read sequencing data only, without the need for short-read sequencing. This method greatly improves base-calling accuracy, saving both time and money, and supporting the application of ONT data in genome-based epidemiological analyses.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Engineering, Environmental
Ziqi Wu, You Che, Chenyuan Dang, Miao Zhang, Xuyang Zhang, Yuhong Sun, Xiang Li, Tong Zhang, Yu Xia
Summary: This study used nanopore long reads and a bioinformatic framework to identify antibiotic resistance genes (ARGs) and resistant bacteria in the receiving water body of a wastewater treatment plant (WWTP). The researchers found that the concentration of WWTP-borne resistant bacteria in the receiving water was 10 times higher than in clean water, with some of them being animal/human pathogens. Plasmids and class 1 integrons were identified as major vehicles for the persistence and dissemination of ARGs. The study highlights the importance of extensive carrier identification in understanding the driving force behind the accumulation of resistance genes in complex environmental conditions, and paves the way for effective mitigation strategies.
Review
Multidisciplinary Sciences
Antony T. Vincent, Nava Hosseini, Steve J. Charette
Summary: This literature review provides an overview of the plasmidome of Aeromonas salmonicida, focusing on antibiotic resistance genes, virulence factors, and cryptic plasmids with unknown biological functions.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Virology
Gabrielle R. Leduc, Valerie E. Paquet, Antony T. Vincent, Steve J. Charette
Summary: Aeromonas salmonicida strains cause bacterial infections in aquaculture, and study shows that a phage, T7-Ah, can infect various strains of this bacterium, potentially offering a treatment option for these infections.
ARCHIVES OF VIROLOGY
(2021)
Article
Microbiology
Pierre-Etienne Marcoux, Antony T. Vincent, Marie-Ange Massicotte, Valerie E. Paquet, Emilie J. Doucet, Nava Hosseini, Melanie V. Trudel, Gabriel Byatt, Mathilde Laurent, Michel Frenette, Steve J. Charette
Summary: European strains of Aeromonas salmonicida subsp. salmonicida are more prone to losing the TTSS locus compared to Canadian strains. A cluster of genes encoding putative proteins with DNA binding capacity and phage proteins was found to be almost perfectly correlated with the susceptibility of different strains to lose the locus. This discovery opens up new opportunities for studying the thermosensitivity of pAsa5.
Article
Fisheries
Sarah B. Girard, Valerie E. Paquet, Steve J. Charette
Summary: Aeromonas salmonicida subspecies salmonicida, a fish pathogen, expresses various virulence factors such as an A-layer, lipases and proteases during infection. This study optimized protocols for liquid tests to quickly and accurately determine the presence of these virulence factors. The new protocols provide opportunities for quicker characterization and more precise results for A. salmonicida subsp. salmonicida strains.
JOURNAL OF FISH DISEASES
(2022)
Article
Mechanics
Jesse Greener, William Y. Harvey, Cynthia Gagne-Thivierge, Sepideh Fakhari, Seyed Mohammad Taghavi, Jean Barbeau, Steve J. Charette
Summary: A microfluidic approach was used to study the effect of shear stress on biofilms from a dental unit waterline (DUWL)-isolated P. aeruginosa strain, PPF-1. The response of the PPF-1 biofilm to shear stress was compared to a clinical P. aeruginosa strain, PAO1, and the effects of additional Mg2+ ions were investigated. It was found that PPF-1 biofilms showed weaker attachment and more frequent slough/regrowth cycles under low ionic conditions, suggesting increased downstream colonization. However, introducing Mg2+ into the culture increased their mechanical stability and elevated their tolerances to shear stresses.
Article
Microbiology
Ignacio Vasquez, Ahmed Hossain, Hajarooba Gnanagobal, Katherinne Valderrama, Briony Campbell, Michael Ness, Steve J. Charette, Anthony K. Gamperl, Rocco Cipriano, Cristopher Segovia, Javier Santander
Summary: In this study, the complete closed genomes of four Aeromonas salmonicida strains were sequenced and compared to elucidate their molecular diversity and pathogenic evolution. The genomic differences between typical and atypical strains were found to be mainly related to insertion sequences (ISs) activity. The relationship between phenotype and A. salmonicida subspecies' taxonomy was not evident.
Article
Microbiology
Antony T. Vincent, Steve J. Charette
Summary: Aeromonas salmonicida, a bacterial species known as a feared pathogen in fish farming, is not exclusively aquatic. It includes psychrophilic and mesophilic strains, and the study of its dual lifestyle is becoming increasingly important and relevant for speciation research.
Article
Microbiology
Valerie E. Paquet, Alicia F. Durocher, Steve J. Charette
Summary: This study highlights the phenotypic differences between psychrophilic and mesophilic strains of Aeromonas salmonicida during predation by the protozoan Tetrahymena pyriformis. The psychrophilic strains are fully digested by the ciliate, while the mesophilic strains display mechanisms to resist phagocytosis and/or digestion, allowing them to survive predation. In some cases, the mesophilic strains are packaged inside fecal pellets after passage through the phagocytic pathway. This study sheds light on the phenotypic diversity and mechanisms used by A. salmonicida to confront predators.
FEMS MICROBIOLOGY LETTERS
(2022)
Article
Infectious Diseases
Paul B. L. George, Florent Rossi, Magali-Wen St-Germain, Pierre Amato, Thierry Badard, Michel G. Bergeron, Maurice Boissinot, Steve J. Charette, Brenda L. Coleman, Jacques Corbeil, Alexander Culley, Marie-Lou Gaucher, Matthieu Girard, Stephane Godbout, Shelley P. Kirychuk, Andre Marette, Allison McGeer, Patrick T. O'Shaughnessy, E. Jane Parmley, Serge Simard, Richard J. Reid-Smith, Edward Topp, Luc Trudel, Maosheng Yao, Patrick Brassard, Anne-Marie Delort, Araceli D. Larios, Valerie Letourneau, Valerie E. Paquet, Marie-Helene Pedneau, Emilie Pic, Brooke Thompson, Marc Veillette, Mary Thaler, Ilaria Scapino, Maria Lebeuf, Mahsa Baghdadi, Alejandra Castillo Toro, Amelia Belanger Cayouette, Marie-Julie Dubois, Alicia F. Durocher, Sarah B. Girard, Andrea Katherin Carranza Diaz, Asmaa Khalloufi, Samantha Leclerc, Joanie Lemieux, Manuel Perez Maldonado, Genevieve Pilon, Colleen P. Murphy, Charly A. Notling, Daniel Ofori-Darko, Juliette Provencher, Annabelle Richer-Fortin, Nathalie Turgeon, Caroline Duchaine
Summary: Antimicrobial resistance (AMR) is a growing global problem that affects public health, agriculture, and the environment. The mechanism of aerial transport of antimicrobial-resistant bacteria via bioaerosols is not well understood. This ongoing project in Canada aims to assess the presence and fate of AMR in bioaerosols, including the emissions of antibiotic resistance genes, their long-distance transport, and dissemination models. A multidisciplinary approach is necessary to understand the role of bioaerosols in the spread of AMR.
Article
Biology
Marie-Stephanie Fradette, Steve J. Charette
Summary: This study aimed to compare different methods for enhancing the recovery of Cryptosporidium spp. and Giardia spp. parasites from water samples. The results showed that the elution of Method 1623.1 combined with microfiltration method resulted in lower costs and less laboratory work time, without compromising the recovery of the parasites.
BMC RESEARCH NOTES
(2022)
Article
Infectious Diseases
Lucie Galiot, Xavier C. Monger, Antony T. Vincent
Summary: Antibiotic resistance is a widespread issue that challenges the study and control of bacterial communities due to the mobility of resistance genes. This study investigates the relationship between insertion sequences and antibiotic resistance genes in microbiomes using two datasets. Statistically significant correlations were found in both datasets, but further research is needed to fully understand the contribution of insertion sequences to gene mobility.
Editorial Material
Microbiology
Steve J. Charette
Article
Microbiology
Antony T. Vincent, Laurent Intertaglia, Victor Loyer, Valerie E. Paquet, Emilie Adouane, Patrick Martin, Celine Berard, Raphael Lami, Steve J. Charette
Summary: The study identified a new genomic island, AsaGEJ2d, in sick salmon isolates from France, which is distinct from known AsaGEI variants. This suggests diversity of AsaGEIs and their distribution in different regions.
FEMS MICROBIOLOGY LETTERS
(2021)
Article
Microbiology
Eve Bernet, Marthe Lebughe, Antony T. Vincent, Mohammad Mehdi Haghdoost, Golara Golbaghi, Steven Laplante, Annie Castonguay, Frederic J. Veyrier
Summary: The study suggests that a boron-based salt, sodium tetraphenylborate (NaBPh4), displays high bactericidal activity against Neisseria meningitidis and Neisseria gonorrhoeae, with limited impact on closely related commensal species. The drug candidate's target(s) are likely located intracellularly or within the cell envelope, and mutants with decreased susceptibility show reduced virulence. This narrow selectivity of NaBPh4 is observed to have potential therapeutic importance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
