Review
Biochemistry & Molecular Biology
Juliana Cazarin, Corinne Dupuy, Denise Pires de Carvalho
Summary: Radioiodine therapy is a standard and effective treatment for differentiated thyroid cancers, but some patients develop resistance to this treatment due to cell dedifferentiation leading to NIS repression. Oxidative stress may play a crucial role in thyroid cancer, affecting NIS expression and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Leonard Girnita, Terry J. Smith, Joseph A. M. J. L. Janssen
Summary: This article reviews the generation of autoantibodies in thyroid eye disease (TED) and their direct effects on orbital fibroblast responses through the TSH receptor (TSHR), IGF-I receptor (IGF-IR), or both. Evidence suggests that IGF-IR functions not only as a typical tyrosine kinase receptor, but also as a functional receptor tyrosine kinase/G-protein-coupled receptor hybrid. Teprotumumab, a monoclonal IGF-IR antibody, effectively reduces TED disease activity and its in vitro actions on fibrocytes and orbital fibroblasts. The article proposes four possible IGF-IR activation models underlying the clinical responses to teprotumumab in TED patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Cell Biology
Joseph A. M. J. L. Janssen, Terry J. Smith
Summary: The insulin-like growth factor-I receptor (IGF-IR) plays an important role in the pathogenesis of TAO, and targeting this receptor with specific biologic agents may lead to a paradigm shift in the therapy of TAO.
Article
Surgery
Xiaoyi Liu, Zhengju Fu, Hongmei Xu, Kui Che, Jingwei Chi, Jianxia Hu
Summary: The study investigated the positivity of thyroid antibodies in breast cancer patients, patients with benign breast diseases, and healthy controls. It found that breast cancer patients had a higher rate of TPO-ab positivity compared to the other groups, and those with positive TPO-ab had lower rates of axillary lymph node metastasis. Thyroid peroxidase antibody was identified as a predictor for low axillary lymph node metastasis prevalence in breast cancer patients with luminal A and B subtypes.
INDIAN JOURNAL OF SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Nataliya V. Yaglova, Sergey S. Obernikhin, Ekaterina P. Timokhina, Valentin V. Yaglov, Dibakhan A. Tsomartova, Svetlana V. Nazimova, Elina S. Tsomartova, Marina Y. Ivanova, Elizaveta V. Chereshneva, Tatiana A. Lomanovskaya
Summary: This study aimed to evaluate the impact of deuterium on thyroid hormone synthesis and secretion, as well as the role of Na+/I- symporter (NIS) in altered thyroid function. The results showed that the thyroid gland had a rapid response to shifts in deuterium/protium balance, while the thyroid and pituitary glands had different responses. Furthermore, deuterium blood/tissue and cytosol/organelle gradients may affect the production rate of thyroid hormones independently of the NIS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yi Han, Huaihui Zhang, Tao Huang, Fang Wang, Yuncheng Zhu
Summary: This study revealed that sex influences the hormone secretion by the anterior pituitary in patients with first-episode BD-mania. Increased PRL may be a mechanism underlying the onset in female patients, with a moderate inverse relationship between TSH and PRL. Thyroid hormones and prolactin levels could serve as potential markers for identifying BD-mania.
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreas Lim, Hendra Budiawan, A. Hussein S. Kartamihardja
Summary: This study, involving 14 subjects, revealed that H2-receptor antagonist significantly reduces the 24-hour iodine-131 uptake in the thyroid gland.
NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Neurosciences
Md Sahab Uddin, Md Tanvir Kabir, Maroua Jalouli, Md Ataur Rahman, Philippe Jeandet, Tapan Behl, Athanasios Alexiou, Ghadeer M. Albadrani, Mohamed M. Abdel-Daim, Asma Perveen, Ghulam Md Ashraf
Summary: Alzheimer's disease (AD) is a chronic neurodegenerative disease associated with immunological processes and inflammation. Aggregated and misfolded proteins, as well as external factors such as obesity and systemic inflammation, may contribute to the development and progression of the disease.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Environmental Sciences
Mousa O. Germoush, Maged M. A. Fouda, Mohamed Kamel, Mohamed M. Abdel-Daim
Summary: The study demonstrated the potential therapeutic effect of Spirulina platensis against MC-LR-induced toxic effects in male Wistar rats, by alleviating oxidative damage in liver and kidneys, cardiotoxicity, and neurotoxicity. Spirulina restored normal levels of serum markers and normalized tissue antioxidant biomarkers, mitigating organ toxicities induced by MC-LR.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Fisheries
Hany M. R. Abdel-Latif, Mohamed M. Abdel-Daim, Mustafa Shukry, Joanna Nowosad, Dariusz Kucharczyk
Summary: The article discusses the use of plant protein sources as alternatives to fish meal protein in aquaculture, with a focus on the application of Moringa oleifera and its effects on fish growth and immune function.
Article
Biochemistry & Molecular Biology
Zakiah N. Almohawes, Attalla El-Kott, Kareem Morsy, Ali A. Shati, Ayman E. El-Kenawy, Heba S. Khalifa, Fahmy G. Elsaid, Abd-El-Karim M. Abd-Lateif, Ahmed Abu-Zaiton, Eman R. Ebealy, Mohamed M. Abdel-Daim, Reham A. Ghanem, Eman M. Abd-Ella
Summary: This study evaluated the potential of salidroside to alleviate high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) by downregulating miR-21. The results showed that salidroside improved glucose and insulin tolerance and preserved liver health in rats fed a high-fat diet. Salidroside also reduced serum and hepatic lipid levels and downregulated the expression of genes related to fatty acid synthesis. Furthermore, salidroside activated AMPK and upregulated PPAR-alpha, which may mediate its anti-steatotic effects.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Chemistry, Medicinal
Fouad Damiri, Nagavendra Kommineni, Samuel Ogbeide Ebhodaghe, Raviteja Bulusu, Vaskuri G. S. Sainaga Jyothi, Amany A. Sayed, Aeshah A. Awaji, Mousa O. Germoush, Hamdan S. Al-Malky, Mohammed Z. Nasrullah, Md. Habibur Rahman, Mohamed M. Abdel-Daim, Mohammed Berrada
Summary: This article provides a comprehensive overview of the research progress and future prospects of carbohydrate-based microneedles in drug delivery, indicating that carbohydrate-based microneedles have promising commercialization opportunities in the market.
Article
Nutrition & Dietetics
Ashwani Arya, Deepak Kaushik, Rafa Almeer, Simona G. Bungau, Amany A. Sayed, Mohamed M. Abdel-Daim, Saurabh Bhatia, Vineet Mittal
Summary: By optimizing different factors in microwave and ultrasound-based extraction, the extraction yield and concentration of plant actives in Celastrus paniculatus can be significantly improved. The use of green technologies not only reduces extraction time but also meets the demand for herbal extracts.
FRONTIERS IN NUTRITION
(2022)
Review
Oncology
Asmaa F. Khafaga, Shaker A. Mousa, Lotfi Aleya, Mohamed M. Abdel-Daim
Summary: This review focuses on various established 3D culture models of hepatocellular carcinoma (HCC) and their role in investigating tumor-tumor microenvironment interactions and HCC-related therapeutic resistance.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Partha Biswas, Shabana Bibi, Qudsia Yousafi, Asim Mehmood, Shahzad Saleem, Awais Ihsan, Dipta Dey, M. D. Nazmul Hasan Zilani, M. D. Nazmul Hasan, Rasha Saleem, Aeshah A. Awaji, Usama A. Fahmy, Mohamed M. Abdel-Daim
Summary: An onco-informatics-based evaluation was conducted to assess the expression and predictive significance of the MDM2 gene in brain lower-grade glioma (LGG) cancer. The study analyzed the differential expression of MDM2 and searched for mutations and copy number variations. Several transcriptome servers and bioinformatics tools were used to determine the survival rate and protein interactions related to the MDM2 gene in LGG cancer patients.
Article
Biochemistry & Molecular Biology
Muhammad Zahid Khan, Abul Kalam Azad, Saleem Jan, Muhammad Safdar, Shabana Bibi, Amin Malik Shah Abdul Majid, Ghadeer M. Albadrani, Nehal Ahmed Talaat Nouh, Jawaher A. Abdulhakim, Mohamed M. Abdel-Daim
Summary: The essential oil of Urtica dioica L. whole plant was evaluated for its antioxidant, phytotoxic, and antibacterial activities using GC-MS technique. The analysis identified various constituents and demonstrated potential antioxidant effects and antibacterial activity against selected pathogens. Protein-ligand docking study further correlated docking results with experimental analysis and provided insight for further investigation.
Article
Environmental Sciences
Ali B. Jebur, Raghda A. El-Sayed, Mohamed M. Abdel-Daim, Fatma M. El-Demerdash
Summary: The study aimed to investigate the protective effects of pomegranate peel extract (PGPE) against testicular toxicity and oxidative stress induced by fenpropathrin (FNP). The results showed that PGPE exerted significant protective effects against oxidative stress and toxicity in the testes of rats, indicating its potential antioxidant activity.
Review
Multidisciplinary Sciences
Hesham R. El-Seedi, Noha S. Said, Nermeen Yosri, Hamada B. Hawash, Dina M. El-Sherif, Mohamed Abouzid, Mohamed M. Abdel-Daim, Mohammed Yaseen, Hany Omar, Qiyang Shou, Nour F. Attia, Xiaobo Zou, Zhiming Guo, Shaden A. M. Khalifa
Summary: The use of gelatin and gelatin-blend polymers for the synthesis of electrospun nanofibers has brought about a revolution in the biomedical field. Gelatin, despite variations in processing technology, is a versatile biopolymer. Electrospinning is an efficient and cost-effective technique for manufacturing gelatin electrospun nanofibers (GNFs), which have high porosity, large surface area, and biocompatibility. However, some limitations, such as rapid degradation and poor mechanical strength, can be overcome through cross-linking, leading to improved biological properties and various biomedical applications of GNFs.
Editorial Material
Multidisciplinary Sciences
Nikita Maruti Gaikwad, Pravin Digambar Chaudhari, Karimunnisa Sameer Shaikh, Somdatta Yashwant Chaudhari, Rasha Mohammed Saleem, Mohammad Algahtani, Ahmed E. Altyar, Ghadeer M. Albadrani, Mohamed Kamel, Mohamed M. Abdel-Daim
Summary: Drug repurposing is the process of discovering new activity for existing drugs. This study investigates the interaction of Albendazole, a well-known antihelmintic drug, with the tyrosine kinase protein receptor VEGFR-2. The findings suggest that Albendazole has potential as a potent angiogenesis inhibitor and could aid in the development of anticancer therapies.
Correction
Biology
Yasmina K. Mahmoud, Ahmed A. Ali, Heba M. A. Abdelrazek, Tahany Saleh Aldayel, Mohamed M. Abdel-Daim, Menna Allah I. El-Menyawy
Article
Multidisciplinary Sciences
Ahmed E. Altyar, Osama A. Kensara, Amany A. Sayed, Lotfi Aleya, Mikhlid H. Almutairi, Mohamed Sayed Zaazouee, Alaa Ahmed Elshanbary, Fatma M. El-Demerdash, Mohamed M. Abdel-Daim
Summary: The study evaluated the potential protective effects of morin against acute AFB1-induced hepatic and cardiac toxicity. The results showed that morin significantly decreased the levels of certain serum markers and exerted protective effects on hepatic and cardiac parameters.
Correction
Environmental Sciences
Eman A. Alwaleed, Mostafa El-Sheekh, Mohamed M. Abdel-Daim, Hani Saber
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
