Review
Chemistry, Multidisciplinary
Yanan Wang, Thomas Burgi
Summary: Ligand exchange reaction is a versatile post-synthesis modification method that plays an important role in thiolate-protected gold nanoclusters by adjusting the gold-sulfur interface. This process follows a SN2-like mechanism, supported by both experiments and calculations. Ligand exchange reaction can impart different functionalities and properties to gold nanoclusters.
NANOSCALE ADVANCES
(2021)
Article
Multidisciplinary Sciences
Chun-Yu Liu, Shang-Fu Yuan, Song Wang, Zong-Jie Guan, De-en Jiang, Quan-Ming Wang
Summary: This study uncovers the role of the amidinate ligand in yielding two closely related copper hydride clusters with different catalytic hydrogenation activities. The researchers synthetized stable copper hydride clusters using ligand engineering strategy and observed reversible interconversion between the clusters triggered by solvent. Deuteration experiments demonstrated that the type of hydride in the clusters dictates the catalytic activity.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Julia McKay, Michael J. Cowan, Cristian A. Morales-Rivera, Giannis Mpourmpakis
Summary: Thiolate-protected metal nanoclusters (TPNCs) have garnered significant interest for their stability, precise structure, and physicochemical properties. Through computational studies, strong correlation between metal-sulfur and sulfur-ligand bond dissociation energies has been identified, providing a pathway for predicting TPNC ligand removal energetics. Computational results also shed light on the kinetic favorability of breaking S-R over M-S bonds in certain complexes, aiding in the targeted design of TPNC catalysts.
Article
Chemistry, Multidisciplinary
Li Tang, Along Ma, Cheng Zhang, Xuguang Liu, Rongchao Jin, Shuxin Wang
Summary: This study successfully reported the complete structure of a [Au42Cd40(SR)52](2-) core-shell nanocluster, revealing its composition and the way it is protected, and demonstrated the surface effect on catalytic activity and selectivity through catalytic tests and comparative studies with relevant nanoclusters.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Applied
Yahui Guo, Helena T. N. N. Amunyela, Yuliang Cheng, Yunfei Xie, Hang Yu, Weirong Yao, Hung-Wing Li, He Qian
Summary: Metal nanoclusters, especially protein-templated gold nanoclusters, have attracted significant interest for their unique properties and potential applications. Natural proteins serve as ideal templates for the synthesis of these nanoclusters, allowing for exploration of their properties and applications in various fields.
Article
Nanoscience & Nanotechnology
Yuanze Sun, Xueke Yu, Pengye Liu, Wenhua Han, Wen-wu Xu, Yan Su, Jijun Zhao
Summary: Understanding the behavior of isomeric structures of thiolate-protected gold nanoclusters in their excited state is challenging. This study predicts four isomers of Au-24(SR)(16) nanoclusters based on grand unified model and ring model. Calculations using density functional theory show that one of the predicted isomers has an energy 0.1 eV lower than the previously crystallized isomer. Nonradiative relaxation dynamics simulations reveal that most of the low-excited states consist of core states. The results have practical implications for predicting new gold nanoclusters for experimental synthesis and exploring atomic structures for photovoltaic and optoelectronic devices.
Article
Chemistry, Analytical
Tingting Pan, Ting Zhou, Yifeng Tu, Jilin Yan
Summary: A fluorescence method for measuring acid phosphatase (ACP) activity was developed in this study. It was found that in a weakly acidic environment, the generation of ascorbic acid enhanced gold nanocluster fluorescence through the reduction of Ce4+ to Ce3+, allowing for linear measurement of ACP activity. The whole analysis process was completed in 1.5 hours with results in good agreement with a reference method, demonstrating the effectiveness of the method.
Article
Physics, Applied
Yuanze Sun, Xueke Yu, Wenwu Xu, Yan Su, Jijun Zhao
Summary: This study successfully predicted the geometric structure of thiolate-protected gold nanoclusters Au-44(SR)(32) and analyzed its absorption spectra and energy levels. The findings enhance our understanding of these nanoclusters and validate the effectiveness and applicability of the models used in this study.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2023)
Review
Chemistry, Multidisciplinary
Qiaofeng Yao, Zhennan Wu, Zhihe Liu, Yingzheng Lin, Xun Yuan, Jianping Xie
Summary: "Thiolate-protected noble metal nanoclusters exhibit molecule-like properties, behaving as molecular entities and displaying structurally sensitive molecular reactivity to ions, molecules, and other nanoclusters. Their molecular interactions and reactions are crucial for applications in various fields, yet there is a lack of systematic summary in the current literature. Advances in synthesis and characterization techniques allow for the production of noble metal nanoclusters with molecular purity and precise atomic resolution, revealing active sites for molecular interactions and reactions. Understanding and utilizing these interactions and reactions in synthesis, self-assembly, and applications can increase the acceptance of metal nanoclusters in various fields."
Article
Chemistry, Physical
Anna Gonzalez-Rosell, Rweetuparna Guha, Cecilia Cerretani, Vanessa Rueck, Mikkel B. Liisberg, Benjamin B. Katz, Tom Vosch, Stacy M. Copp
Summary: This study reports two different types of silver nanodusters with distinct structural properties, which exhibit different luminescence lifetimes and wavelengths. These are the first DNA-stabilized quasi-spherical superatoms observed, expanding the possibilities for structure-property relations of Ag-N-DNAs.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Physical
Dipankar Bain, Aarti Devi, Sikta Rashi, Sikta Chakraborty, Sarita Kolay, Amitava Patra
Summary: Aggregation-induced emission (AIE) of D-penicillamine-capped Au-14 nanoclusters (NCs) was explored with the introduction of zinc ions. The interaction between the carboxylate groups of penicillamine ligands and zinc ions formed large cross-linked aggregates, leading to significant photoluminescence enhancement. The pH conditions were found to control the photophysical properties of these aggregates. The zinc-induced Au-14 NCs exhibited a 50-fold increase in photoluminescence and were used as a probe for detecting zinc ions.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Xiuxiu Wang, Zong-Chang Han, Wei Wei, Hanshi Hu, Pengfei Li, Peiqing Sun, Xiangzhi Liu, Zhijia Lv, Feng Wang, Yi Cao, Zijian Guo, Jun Li, Jing Zhao
Summary: Metal clusters, such as iron-sulfur clusters, play important roles in sustaining life and metalloprotein functions. In this study, the formation and crystal structure of a planar square tetranuclear silver cluster were reported when silver ions were mixed with human copper chaperone Atox1. Quantum chemical studies revealed that the tetranuclear silver cluster has an aromatic all-metal structure, representing the first observation of such structure in a protein.
Article
Chemistry, Physical
Saniya Gratious, Sayani Mukherjee, Sukhendu Mandal
Summary: Transformation chemistry has made significant advancements in synthesizing and functionalizing nanoclusters. However, the rational synthesis and understanding of structural evolution in nanoclusters are yet to be achieved. Recently, co-reactant-less transformations of nanoclusters have been revealed, triggered by various conditions such as pH, solvent, light, and temperature. In this perspective, the authors discuss how this unique transformation method contributes to the understanding of growth patterns and property evolution in nanoclusters.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Review
Chemistry, Inorganic & Nuclear
Tokuhisa Kawawaki, Yuichi Negishi
Summary: This review summarizes the basic knowledge of metal nanoclusters and their application using electrochemical methods. Metal nanoclusters are a type of material with unique properties, but there is still room for improvement in terms of evaluation and application methods.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Li Tang, Xi Kang, Xiangyu Wang, Xianhui Zhang, Xun Yuan, Shuxin Wang
Summary: This study presents a new method for investigating the interaction between metalloid clusters and homometal thiolates at the atomic level through isotopic exchange. It was found that all Ag atoms in the Ag-44(SR)(30) template are exchangeable, and metal exchange in the Ag-29(BDT)(12)(TPP)(4) metalloid cluster is likely a shell to kernel transfer process. These insights will guide future preparation of metalloid clusters with customized structures and properties.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Analytical
Meng-Meng Liu, Yu Zhong, Yao Chen, Li-Na Wu, Wei Chen, Xin-Hua Lin, Yun Lei, Ai-Lin Liu
Summary: In this study, a facile paper-polylactic (PLA) platform coupled with electrochemical sensor was designed for the construction and intervention of a 3D cell damage model. The results showed the potential of the paper-PLA platform in 3D cell culture and drug evaluation.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Zhongnan Huang, Sunxing Yu, Meili Jian, Zhimin Weng, Haohua Deng, Huaping Peng, Wei Chen
Summary: This study presents an electrochemiluminescence (ECL) platform based on gold nanoclusters for ultrasensitive detection of glutathione (GSH) and adenosine triphosphate (ATP). The platform exhibits high sensitivity, wide dynamic range, and strong anti-interference properties, showing great potential in the detection of GSH-related substances.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Kaiyuan Huang, Quanhui Fang, Weiming Sun, Shaobin He, Qiaofeng Yao, Jianping Xie, Wei Chen, Haohua Deng
Summary: This study demonstrates the crucial role of cucurbit[n]uril host-guest assemblies in modulating the luminescence of AuNCs and their application in luminescence switching, thus offering new avenues for the fabrication and development of optical devices and smart materials.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Biochemical Research Methods
Hamada A. A. Noreldeen, Shao-Bin He, Kai-Yuan Huang, Chen-Ting Zhu, Qing-Lin Zhou, Hua-Ping Peng, Hao-Hua Deng, Wei Chen
Summary: This study used fluorescence spectra data and machine learning to distinguish heavy metal ions, and found that the accuracy of first-order data is higher than second-order data. Linear discriminant analysis performed well in high-dimensional data analysis and could differentiate ions with different concentrations and molar ratios.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Yilun Sheng, Zhongnan Huang, Yaling Chen, Xiaoyun Guo, Lan Chen, Huaping Peng, Wei Chen
Summary: This study proposes a highly sensitive and facile fluorescence-sensing platform based on a high-quantum-yield sulfur quantum dot probe for the detection of nifedipine. The method is simple, sensitive, and can be used for the analysis of pharmaceutical components.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Guolin Hong, Canping Su, Mingchun Lai, Zhongnan Huang, Zhimin Weng, Yaling Chen, Haohua Deng, Wei Chen, Huaping Peng
Summary: In this study, a novel co-reactant-mediated high-performance low-potential Au nano-cluster (AuNC)-based ECL system was successfully developed for the detection of SARS-CoV-2 N protein. The ECL system exhibited higher energy efficiency and quantum yield, with a wide linear range and low detection limit. It showed good reproducibility and stability, making it suitable for the detection of actual serum samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Shao-Bin He, Hui-Jing Yang, Liu Yang, Hamada A. A. Noreldeen, Hua-Ping Peng, Hao-Hua Deng, Wei Chen, Guo-Lin Hong
Summary: Rutin was found to regulate the peroxidase-like activity of Fe-OSiNDs, acting as a coenzyme. Rutin activated the peroxidase-like activity of Fe-OSiNDs at low concentrations, accelerating the oxidation process. The addition of beta-glucuronidase hydrolyzed rutin and suppressed its peroxidase-like activity, allowing the establishment of a colorimetric sensor for beta-glucuronidase.
MICROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Qi Zhang, Sai Cheng, Zhiming Xin, Haohua Deng, Ying Wang, Qiang Li, Gangwei Wu, Wei Chen
Summary: 1,2,3,4,6-O-pentagalloylglucose protects against acute lung injury (ALI) by inhibiting inflammation and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Qile Li, Ke Xu, Haipeng Zhang, Zengguang Huang, Chao Xu, Zhen Zhou, Huaping Peng, Linxing Shi
Summary: In this study, a novel Ru(bpy)(3)(2+)-Au-WS2 nanocomposite ECL probe was developed for the detection of carcinoembryonic antigen (CEA). The probe showed high sensitivity and selectivity due to the synergistic effect and biocompatibility of Au nanoparticles (Au NPs) and WS2 nanosheet. The ECL platform exhibited excellent anodic ECL performance, good reproducibility, stability, and anti-interference performance.
Article
Biophysics
Quan-Quan Zhuang, Jia-Lin Yang, Hui-Na Qiu, Kai-Yuan Huang, Yu Yang, Hua-Ping Peng, Hao-Hua Deng, Hui-Qiong Jiang, Wei Chen
Summary: This study presented a novel class of luminogen called 6-Aza-2-thiothymine-decorated gold nanoclusters (ATT-AuNCs) with aggregation-induced emission property, which demonstrated potent antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA). By generating reactive oxygen species (ROS) and altering the expression of multiple target proteins in MRSA cells, ATT-AuNCs effectively eliminated MRSA. Additionally, ATT-AuNCs could serve as a wound-healing agent. Therefore, ATT-AuNCs are considered robust antimicrobial aggregation-induced emission luminogens (AIEgens) capable of targeting multiple pathways to eliminate drug-resistant bacteria.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Spectroscopy
Chen -Ting Zhu, Kai -Yuan Huang, Qing-Lin Zhou, Xiang -Ping Zhang, Gang-Wei Wu, Hua-Ping Peng, Hao-Hua Deng, Wei Chen, Hamada A. A. Noreldeen
Summary: Sulfonamides are widely used but their accumulation in the human body can cause serious diseases. Therefore, a convenient, effective, and sensitive method to detect them is needed. In this study, a sensor array using BSA-AuNCs was constructed to detect five Sulfonamides, and the changes in fluorescence intensity at different excitation wavelengths were used for identification. This method shows great potential in the fields of food and drug monitoring.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Huaping Peng, Mingchun Lai, Huijing Wang, Zhimin Weng, Yu Yang, Zhongnan Huang, Weiming Sun, Juewen Liu, Wei Chen
Summary: In this study, an energy level engineering strategy was proposed to regulate the electrochemiluminescence (ECL) performance using ligand-protected gold nanoclusters (AuNCs) as luminophores and N,N-diisopropylethylamine (DIPEA) as a coreactant. The energy level matching between the AuNCs and DIPEA effectively promoted electron transfer reactions, improving excitation efficiency and reducing trigger potential. The narrow bandgap of the AuNCs further enhanced emission efficiency. The developed theory was successfully applied to design a highly stable near-infrared ECL system with low trigger potential.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Zhongnan Huang, Zhenglian Li, Zhimin Weng, Paramasivam Balasubramanian, Mingchun Lai, Wei Chen, Juewen Liu, Huaping Peng
Summary: In this study, a model system was developed to evaluate the effect of electrocatalysis (EC) on electrochemiluminescence (ECL) through kinetic analysis of electrocatalytic reactions. The results demonstrated a dual EC-mediated ECL enhancement and identified the catalytically active sites. With a better understanding of the EC mechanism, the researchers successfully used EC to regulate ECL and developed a biosensor with a record low limit of detection.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Ruiting Chen, Hejing Chen, Huaping Peng, Yanjie Zheng, Zhen Lin, Xinhua Lin
Summary: A DNA biosensor based on a multi-walled carbon nanotube array modified electrode was developed for the detection of the MDR1 gene, which is crucial in cancer clinical therapy.
Article
Chemistry, Multidisciplinary
Yu Yang, Chaoguo Wei, Wenjun Wang, Hamada A. A. Noreldeen, Zhongnan Huang, Haohua Deng, Huaping Peng, Xinghua Xia, Wei Chen
Summary: Research has shown that using 6-aza-2-thio-thymine-AuNCs (ATT-AuNCs) as a photoactive material can achieve high performance in photoelectrochemical properties, with characteristics such as higher cathodic photocurrent density and carrier density compared to other AuNCs.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
