Article
Chemistry, Analytical
Jinchun Hu, Zhenguo Zhang, Congcong Zhang, Jiancheng Zhang, Han Zhou, Fansheng Ning, Daijie Wang, Xin Du
Summary: In this study, an electrochemical sensor based on molecularly imprinted polymer and nanomaterial amplification was developed for the detection of rare ginsenoside Rg3 in ginseng. The sensor showed a great linear relation and low detection limit, and was successfully utilized in different real samples.
Article
Materials Science, Composites
Xia Sun, Shaoshuai He, Zhihui Qin, Junjie Li, Fanglian Yao
Summary: This study successfully fabricated a novel fully-physically crosslinked nanocomposite hydrogel with self-healing ability and underwater sensing capacity, showing fast self-healing, high strain sensitivity, and pressure sensitivity, which can be used as strain and pressure sensors to monitor human movements and applied underwater.
COMPOSITES COMMUNICATIONS
(2021)
Article
Engineering, Electrical & Electronic
Fan Ding, Ge Zhang, Chenpu Chen, Shujing Jiang, Hao Tang, Liang Tan, Ming Ma
Summary: A nanocomposite material consisting of MOG-Cu and MWCNTs was prepared and used as a sensor for electrochemical detection of nitrite. The addition of MWCNTs did not affect the formation and structure of the composite material, but increased the electrochemical surface area and facilitated charge transport, leading to enhanced oxidation current of nitrite. The sensor demonstrated high sensitivity, low detection limit, and good reproducibility, making it a valuable tool for monitoring nitrite in food samples.
ACS APPLIED ELECTRONIC MATERIALS
(2021)
Article
Energy & Fuels
S. P. Vinodhini, Joseph Raj Xavier
Summary: This work focuses on synthesizing hybrid nanocomposite electrode materials for supercapacitor applications. The performance of different hybrid electrode materials, such as MoS2/CNTs, TiO2/CNTs, and MoS2/TiO2/CNTs, was enhanced by incorporating carbon nanotubes (CNTs) into MoS2 and TiO2. The synthesized MoS2/TiO2/CNTs exhibited superior electrochemical performance compared to other hybrid electrode materials, with a higher specific capacitance and lower overall impedance. It also displayed good cycling stability and high energy and power densities.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Samuel Veloso Carneiro, Jose Joelson Pires Oliveira, Vivian Stephanie Ferreira Rodrigues, Lillian Maria Uchoa Dutra Fechine, Renato Altobelli Antunes, Manoel Lourenco Alves Neto, Thiago Alves de Moura, Carlos Lenz Cesar, Hernandes Faustino de Carvalho, Alexandre Rocha Paschoal, Rafael Melo Freire, Pierre Basilio Almeida Fechine
Summary: This study proposes a sensor device based on doped-carbon quantum dots for the detection of nitrite in meat products through fluorescence quenching. The device shows high selectivity and linear range adaptation, making it an effective tool for nitrite detection in meat products.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Cristina Craciun, Florin Andrei, Anca Bonciu, Simona Brajnicov, Tatiana Tozar, Mihaela Filipescu, Alexandra Palla-Papavlu, Maria Dinescu
Summary: This work focuses on the application of MAPLE in the development of electrochemical sensors for nitrite detection in water. The modified carbon-based screen-printed electrodes with a composite coating of CNTs, chitosan, and C32H16FeN8 show improved electrochemical response towards nitrite oxidation. The MAPLE modified electrodes have a low detection limit of 0.12 mu M, making them highly useful for nitrite detection.
Article
Biochemistry & Molecular Biology
Wei Wang, Jiahao Wang, Xue Feng, Haichun Gao
Summary: Nitrite and nitric oxide (NO) are commonly used bacteriostatic agents, but they have different mechanisms for inhibiting bacterial growth. This study found that both nitrite and NO inhibit bacterial respiration by compromising cytochrome c biosynthesis, and this is achieved by eliminating the interference of cAMP-Crp.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Gang Xiong, Zhanping Zhang, Yuhong Qi
Summary: Semiconductor photocatalytic materials have potential in antifouling applications due to their antibacterial properties, stability, and nontoxic nature. This study introduces g-C3N4/TNTs/CNTs (CNTC) photocatalytic composite powders into polydimethylsiloxane (PDMS) coatings to enhance their antifouling performance. The results show successful recombination of CNTC, which resulted in decreased recombination rate of photogenerated carriers. The addition of CNTC increased the hydrophobicity and roughness of the coatings while reducing the surface energy. CNTC effectively improved the anti-attachment performance of PDMS coatings to bacteria and benthic diatom.
Article
Engineering, Environmental
Hao Luo, Jiaxin Yan, Yiwei Shan, Jianwen Zhou, Jun Yu, Bruno Boury, Hui Wu, He Xiao, Liulian Huang, Zhanhui Yuan, Lihui Chen
Summary: Dual covalent decoration of graphitic carbon nitride (CN) with covalent organic frameworks (COF) and carboxylated carbon nanotubes (CNT) can enhance the efficiency of photocatalytic ammonia (NH3) production under visible light. The introduction of COF helps regulate the band gap and increase the specific surface area and N-2 adsorption ability. The introduction of CNT enhances optical light harvesting and accelerates the transfer of photo-excited electrons, maintaining efficient separation of photo-generated carriers.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Engineering, Environmental
Leema Rose Viannie, N. R. Banapurmath, Manzoore Elahi M. Soudagar, Anilkumar Nandi, Nazia Hossain, Ashwini Shellikeri, Vinita Kaulgud, Ma Mujtaba, Sher Afghan Khan, Mohammad Asif
Summary: In this study, highly flexible polymer nanocomposite sheets were successfully developed using MWCNT in a PDMS matrix via solution processing technique, showing superior electrical conductivity and stability. An optimal filler concentration of 5.58 wt% exhibited high stiffness, tensile strength, and elongation, making it suitable for fabricating flexible strain sensors.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Keerthi Prabhu, Shweta J. J. Malode, Raviraj M. M. Kulkarni, Nagaraj P. P. Shetti
Summary: The electrochemical degradation of 1-naphthaleneacetic acid (1-NAA) using MWNTs and Ca-ZnO nanoparticles embedded in CPEs was studied. The impact of various factors on 1-NAA was investigated by analyzing samples of water, fruits, soil, and vegetables using SWV technique. The sensor displayed exceptional catalytic properties in a pH 3.0 0.2 M PB solution.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Physical
Hongyuan Zhao, Huina Ma, Xiaoguang Li, Binbin Liu, Runqiang Liu, Sridhar Komarneni
Summary: The electrode sensor prepared with halloysite/multi-walled carbon nanotubes nanocomposite showed excellent performance in detecting methyl parathion, with a low detection limit and good detection effect.
APPLIED CLAY SCIENCE
(2021)
Article
Chemistry, Analytical
Fudan Zhu, Huilan Shi, Cunli Wang, Xian Zhou, Xin Zhang, Fengchun Yang
Summary: A disposable electrochemical sensor based on a bismuth selenide/carboxylic multiwalled carbon nanotube (Bi2Se3@MWNTs-COOH) nanocomposite has been designed for nitrite detection, showing excellent performance with fast electron transfer rate and high electrochemically active surface area. The sensor has a wide detection range of 0.01 mu M - 7.0 mM and a low detection limit of 0.002 mu M, making it an effective analytical tool for monitoring nitrite. This work provides new insights into nitrite detection and encourages exploration of rapid and cost-effective detection methods using nanocomposites and disposable systems.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Yan Chen, Li Tan, Hui Zhang, Xue Zhang, Qiyuan Chen, Haojie Jiang, Fengjuan Ge, Shuai Wei, Xinhua Gao, Peng Wang
Summary: A metal-free photocatalyst consisting of CNT and mpg-C3N4 was synthesized with improved photodegradation rate and stability, potentially enhanced by increased electron transfer and oxygen adsorption. This study offers a promising method for utilizing a stable, metal-free semiconductor driven by visible light for environmental remediation.
RESEARCH ON CHEMICAL INTERMEDIATES
(2021)
Article
Environmental Sciences
Yasamin Khoshnavaz, Erknaz Ecehan Erk, Guangli Li, Mohammad Mehmandoust, Nevin Erk
Summary: In this study, a stable and green Au@g-C3N4 nanocomposite was introduced as a selective electrochemical sensor for VOR determination. The electrochemical behavior of VOR on the developed electrode was investigated, and the Au@g-C3N4 nanocomposite showed higher electrochemical activity for VOR detection. The as-fabricated sensor exhibited ultrahigh selectivity for recognizing VOR with a detection limit of 3.2 nM, and it was successfully applied to determine VOR in pharmaceutical and biological samples.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Physical
Jamal-Deen Musah, A. M. Ilyas, Andrei Novitskii, Illia Serhiienko, Kingsley O. Egbo, Gopalan Saianand, Vladimir Khovaylo, Samuel Kwofie, Kin Man Yu, Vellaisamy A. L. Roy
Summary: This study demonstrates that substitution of erbium within bismuth selenide can enhance both the Seebeck coefficient and electrical conductivity, while reducing thermal conductivity. The optimal composition of Bi1.85Er0.15Se3 shows that minimal substitution is required for optimizing thermoelectric performance.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Chemistry, Multidisciplinary
Stella Vargheese, Muthu Dinesh, K. V. Kavya, Dhanaprabhu Pattappan, Ramasamy Thangavelu Rajendra Kumar, Yuvaraj Haldorai
Summary: The synthesis of nitrogen-doped porous carbon (N-PC) via carbonization of a triazine-based covalent organic framework (COF) synthesized by Friedel-Crafts reaction was described in this report. The N-PC exhibited high surface area, porosity, uniform pore size, and excellent electrochemical performance. These results suggest that COF materials are promising for future research on energy storage devices.
Article
Environmental Sciences
Dharman Ranjith Kumar, Kugalur Shanmugam Ranjith, Yuvaraj Haldorai, Asokan Kandasami, Ramasamy Thangavelu Rajendra Kumar
Summary: In this study, it was demonstrated that the visible photocatalytic activities of ZnO nanorod arrays can be enhanced by C ion implantation. The results showed that C ion-implanted ZnO NRAs exhibit increased degradation efficiency under ambient visible light irradiation, indicating an improvement in visible light-driven photocatalytic performance.
Article
Environmental Sciences
Dhanaprabhu Pattappan, Stella Vargheese, K. Kavya, R. T. Rajendra Kumar, Yuvaraj Haldorai
Summary: Metal-organic frameworks (MOFs) have shown potential as effective visible light photocatalysts for degrading dyes. Among nickel, iron, and titanium-based MOFs, Fe-MOF exhibited the highest dye degradation efficiency and stability under solar light irradiation, attributed to its ability to suppress photoinduced charge recombination. Furthermore, the photodegradation of dye using Fe-MOF followed first-order kinetics and was mainly driven by superoxide anion radicals.
Article
Environmental Sciences
Dhanaprabhu Pattappan, K. Kavya, Stella Vargheese, R. T. Rajendra Kumar, Yuvaraj Haldorai
Summary: The g-C3N4/NH2-MIL-101(Fe) composite prepared by a solvothermal method is an efficient photocatalyst for the degradation of acetaminophen and reduction of Cr(VI) under sunlight illumination. The composite showed different catalytic performance under different pH conditions, with reduction efficiency increasing as pH decreased.
Article
Materials Science, Multidisciplinary
K. V. Kavya, Dinesh Muthu, Dhanaprabhu Pattappan, Stella Vargheese, N. Gokila, M. S. Sivaramkumar, Ramasamy Thangavelu Rajendra Kumar, Yuvaraj Haldorai
Summary: In this study, a Pd@Ni-MOF nanocomposite sensor was prepared for the detection of dopamine, showing good detection performance and stability. The sensor exhibited acceptable recovery in determining dopamine levels in urine samples.
Article
Chemistry, Inorganic & Nuclear
Sabarish Kumaravel, Mathankumar Manoharan, Yuvaraj Haldorai, R. T. Rajendra Kumar
Summary: In this study, graphitic carbon nitride and porous graphitic carbon nitride were successfully prepared by reducing melamine using a pyrolysis method. The enhanced photocatalytic degradation efficiency of porous graphitic carbon nitride was attributed to an increase in surface area, leading to a higher number of active sites for dye degradation. Reactive oxygen species experiments revealed that the generation of (.)OH radicals was responsible for the degradation of dyes.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2022)
Article
Chemistry, Physical
N. Gokila, K. Muthumalai, Yuvaraj Haldorai, Ramasamy Thangavelu Rajendra Kumar
Summary: Cobalt metal organic framework (Co-H2ABDC MOF) was successfully synthesized using a solvothermal method and used to fabricate an electrochemical non-enzymatic sensor. The properties and stability of the synthesized material were confirmed using various characterization techniques.
CHEMICAL PHYSICS LETTERS
(2022)
Review
Pharmacology & Pharmacy
Faisal Aziz, Imran Khan, Shruti Shukla, Debasish Kumar Dey, Qiu Yan, Abhijit Chakraborty, Hisae Yoshitomi, Seung-Kyu Hwang, Sonam Sonwal, Hoomin Lee, Yuvaraj Haldorai, Jianbo Xiao, Yun Suk Huh, Vivek K. Bajpai, Young-Kyu Han
Summary: Helicobacter pylori and its cytotoxin associated antigen A play significant roles in the development of gastric cancer. Glycosylation alterations and overexpression of Lewis Y may serve as potential biomarkers for the prognosis of gastric cancer.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Gopalan Saianand, Anantha-Iyengar Gopalan, Liang Wanga, K. Venkatramanan, Vellaisamy A. L. Roy, Prashant Sonar, Dong-Eun Lee, Ravi Naidu
Summary: Conducting polymers (CPs) have been proven to play an important role in enhancing photocatalytic efficacy due to their unique physicochemical properties and energy levels. Novel inorganic-organic heterojunction design materials, including hybrid/composite semiconducting photocatalysts (SCPs) comprising CPs and titanium dioxide (TiO2), have received significant attention for their potential in enhancing photocatalytic activity and visible light activation. This topical review aims to highlight the recent advancements (2016-2021) in the visible light photocatalytic performance of CP-TiO2 functional composites, and the role of CPs in improving both visible light activation and photocatalytic performances.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2022)
Article
Biophysics
K. V. Kavya, Stella Vargheese, Shruti Shukla, Imran Khan, Debasish Kumar Dey, Vivek K. Bajpai, Kavitha Thangavelu, Raju Vivek, R. T. Rajendra Kumar, Young-Kyu Han, Yun Suk Huh, Yuvaraj Haldorai
Summary: This study explores the ability of a drug-loaded polymer to inhibit cervical cancer cells. The results show that the polymer treatment activates cell death mechanisms and disrupts the cell membrane. Further experiments demonstrate that the polymer treatment effectively suppresses a protein and simulates a cellular pathway. This combination therapy approach has the potential to enhance treatment efficacy and overcome chemosensitivity issues.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Vaskuri C. S. Theja, Vaithinathan Karthikeyan, Dani S. Assi, Saianand Gopalan, Vellaisamy A. L. Roy
Summary: This article investigates the effect of multiwalled carbon nanotube (MWCNT) inclusions on the thermoelectric performance of Cu3SbS4. The results demonstrate that adding an optimal amount of MWCNT inclusions significantly improves the Seebeck coefficient and reduces the thermal conductivity of Cu3SbS4. The optimized composite sample achieves a maximum figure of merit (ZT) of 0.43 at 623 K, which is 70% higher than pristine Cu3SbS4. In addition, the addition of nanoinclusions also enhances the mechanical stability of the samples.
Review
Chemistry, Multidisciplinary
Liang Wang, Ying Cheng, Saianand Gopalan, Fang Luo, Khairunnisa Amreen, Ritesh Kumar Singh, Sanket Goel, Zhenyu Lin, Ravi Naidu
Summary: Currently, various advanced methods are being used in gas sensing and monitoring, including detecting hazardous gas leaks and monitoring ambient air. Commonly used technologies include photoionization detectors, electrochemical sensors, and optical infrared sensors. However, these sensors, which are nonselective or semiselective, can be affected by unwanted analytes. To address this issue, gas separation and discrimination technologies such as gas permeable membranes, metal-organic frameworks, microfluidics, and IR bandpass filters have been developed. Although these technologies have not been extensively utilized in the field for vapor intrusion monitoring, they show promise for further development and application. This review provides an overview and summary of the existing gas separation and discrimination technologies for popular gas sensors used in environmental applications.
Article
Chemistry, Multidisciplinary
Radhakrishnan Padmanaban, Ahobilam Gayathri, Aanantha Iyengar Gopalan, Dong-Eun Lee, Kannan Venkatramanan
Summary: This study compares the deviations in experimental viscosity, density, and ultrasonic velocity of two new ethanol-based binary liquid mixtures by applying various theoretical models. The results are expected to be useful in predicting the suitable molecular proportions for industrial application.
APPLIED SCIENCES-BASEL
(2023)
Review
Green & Sustainable Science & Technology
Suvankar Sen, Saianand Gopalan, Raja Sellappan, Andrews Nirmala Grace, Prashant Sonar
Summary: Perovskite solar cells (PSCs) have great potential in renewable energy and optoelectronic applications, but the presence of lead (Pb) in most perovskites raises concerns about toxicity and instability. To address these issues, researchers are exploring tin (Sn) as a potential alternative to lead, aiming to improve the performance and environmental friendliness of PSCs.
ADVANCED ENERGY AND SUSTAINABILITY RESEARCH
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
