Article
Multidisciplinary Sciences
Stephane Bugeon, Joshua Duffield, Mario Dipoppa, Anne Ritoux, Isabelle Prankerd, Dimitris Nicoloutsopoulos, David Orme, Maxwell Shinn, Han Peng, Hamish Forrest, Aiste Viduolyte, Charu Bai Reddy, Yoh Isogai, Matteo Carandini, Kenneth D. Harris
Summary: This study reveals that inhibitory subtypes in the primary visual cortex exhibit diverse correlates with brain state. These subtypes' activity patterns are organized by the main axis of transcriptomic variation. Different subtypes show significant differences in response to visual stimuli, as well as modulation by brain state. These findings highlight the importance of inhibitory neurons in cortical processing.
Article
Substance Abuse
Jerome C. Foo, Marcus W. Meinhardt, Ivan Skorodumov, Rainer Spanagel
Summary: By studying alcohol-addicted rats, this research has found associations between compulsive-like drinking behavior and individual drinking patterns and solution preference. These findings provide a theoretical basis for the prevention and treatment of drinking problems.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Psychology, Clinical
Andrew W. Hertel, Scott A. Baldwin, Kirsten P. Peterson, Kristen P. Lindgren
Summary: Endorsing and frequently thinking about having a drinking identity are positively associated with alcohol consumption and risk for hazardous drinking. Greater identification with drinking predicts subsequent increases in alcohol consumption and risk for hazardous drinking, although drinking behavior variables do not predict changes in identification with drinking.
ADDICTIVE BEHAVIORS
(2021)
Article
Neurosciences
E. K. Erickson, A. J. DaCosta, S. C. Mason, Y. A. Blednov, R. D. Mayfield, R. A. Harris
Summary: Astrocytes play a crucial role in the behavioral effects of ethanol through GPCR-mediated calcium signaling. Activation of G(q)-DREADD in astrocytes increases ethanol intake, while reducing calcium signaling decreases sensitivity to ethanol. Astrocyte calcium signaling also alters the stimulatory and sedative-hypnotic effects of ethanol.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Lindsay A. Sobotka, Khalid Mumtaz, Alice Hinton, Lanla F. Conteh
Summary: Liver transplant recipients are more likely to experience pregnancy-related complications such as miscarriage, intrauterine growth restriction, and hypertension, leading to higher costs and longer hospital stays. However, they have zero inpatient mortalities compared with the general population, indicating no increased risk of mortality during pregnancy.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Psychology, Multidisciplinary
Samantha Johnstone, Kesia Courtenay, Todd A. A. Girard
Summary: This study investigates the associations between binge and problematic drinking patterns with a negative emotional memory bias (NMB), and finds that these associations are indirectly related through coping motivations and depressive symptoms. It also suggests that this model primarily holds for females, yet may also apply to males at higher levels of problematic alcohol use.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Developmental
C. Benjet, P. Mortier, G. Kiekens, D. D. Ebert, R. P. Auerbach, R. C. Kessler, P. Cuijpers, J. G. Green, M. K. Nock, K. Demyttenaere, Y. Albor, R. Bruffaerts
Summary: The first year of college carries a high risk for the development of alcohol use disorders. Male gender, romantic break-up, hazardous drinking, and alcohol use characteristics at baseline were identified as key predictors. Screening incoming college students can help identify those at risk and provide targeted preventive interventions.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Public, Environmental & Occupational Health
Jirada Prasartpornsirichoke, Rasmon Kalayasiri, Polathep Vichitkunakorn, Woraphat Ratta-apha, Wanlop Atsariyasing, Natwarat Anekwit, Warot Lamyai, Chanchai Thongpanich, Surinporn Likhitsathian, Teerayuth Rungnirundorn, Wanida Rattanasumawong, Nawapat Chuatai, Sakol Srisuklorm, Athip Tanaree, Roengrudee Patanavanich
Summary: Parental supply of alcohol is associated with alcohol-related harms and severity of alcohol use disorder in Thai middle school students. Supply of alcohol from peers and siblings plays an important role in both outcomes. An increasing number of sources of alcohol supply increases the risk of alcohol-related harm and severity of alcohol use disorder.
Article
Clinical Neurology
Xin Liu, Chilman Bae, Benjamin B. Gelman, Jin Mo Chung, Shao-Jun Tang
Summary: This article investigates the pathogenesis of HIV-associated pain and reveals the crucial role of astrogliosis in pain development. The authors demonstrate that astrogliosis is controlled by a neuron-to-astrocyte Wnt5a signal, and its disruption blocks mechanical hyperalgesia and neural circuit polarization induced by the HIV protein gp120. They also uncover that the astrogliosis promotes hyperalgesia and neuropathic circuit polarization through IL-1beta regulated by the Wnt5a-ROR2-MMP2 axis.
Article
Biochemistry & Molecular Biology
Refat Aboghazleh, Ellen Parker, Lynn T. Yang, Daniela Kaufer, Jens P. Dreier, Alon Friedman, Gerben van Hameren
Summary: Traumatic brain injury is a major health concern that can lead to long-lasting complications, with immediate electrophysiological events including cortical spreading depolarization and increased oxidative stress. Severe TBI may result in immediate death, but not all animals exhibit this outcome, with some showing non-spreading depression followed by terminal spreading depression in both cortex and brainstem.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Aitor Hernandez-Hernandez, David Oliver, Miguel Angel Martinez-Gonzalez, Miguel Ruiz-Canela, Sonia Eguaras, Estefania Toledo, Pedro Antonio de la Rosa, Maira Bes-Rastrollo, Alfredo Gea
Summary: Alcohol drinking patterns, especially adherence to the Mediterranean alcohol-drinking pattern, can affect the risk of hypertension. Low adherence to the Mediterranean alcohol-drinking pattern is associated with a higher incidence of hypertension, while high adherence is associated with a lower incidence.
Review
Substance Abuse
Fiona R. Beyer, Ryan P. W. Kenny, Eugenie Johnson, Deborah M. Caldwell, Claire Garnett, Stephen Rice, Julija Simpson, Colin Angus, Dawn Craig, Matt Hickman, Susan Michie, Eileen F. S. Kaner
Summary: This study compares the effectiveness of practitioner versus digitally delivered interventions for reducing hazardous and harmful alcohol consumption. The findings suggest that practitioner delivered interventions are more effective in reducing consumption up to 6 months, but there is no evidence of a difference at 12 months.
Review
Cardiac & Cardiovascular Systems
Malgorzata Chudzinska, Lukasz Wolowiec, Joanna Banach, Daniel Rogowicz, Grzegorz Grzesk
Summary: Excessive alcohol consumption is a social problem that significantly increases the morbidity and mortality rates of societies. Alcohol consumption is correlated with increased mortality from various diseases. While low to moderate alcohol consumption may have some beneficial effects on cardiovascular diseases, it is not recommended as a preventive measure due to other health hazards.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Substance Abuse
Kasey G. Creswell, Yvonne M. Terry-McElrath, Megan E. Patrick
Summary: Solitary alcohol use in adolescence and young adulthood is associated with increased risk of adult AUD symptoms, especially among females.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Substance Abuse
Gabriel Caluzzi, Michael Livingston, John Holmes, Sarah MacLean, Dan Lubman, Paul Dietze, Rakhi Vashishtha, Rachel Herring, Amy Pennay
Summary: The decline of adolescent drinking in Western countries is attributed to the denormalisation of drinking and normalisation of non-drinking. Normalisation theory serves as a useful tool in understanding this trend.
Article
Green & Sustainable Science & Technology
Chia-Jung Chang, Bryan Cheng-Yu Hsu, Mei-Yen Chen
Summary: The outbreak of COVID-19 in 2020 has brought challenges to the sporting industry, leading to changes in fan behavior. This study used a technology acceptance model (TAM) to explore the impact of social presence (SP) in online viewing of professional sports. The results confirmed a positive relationship between SP and perceived ease of use and perceived usefulness. The study suggests that technology developers should consider the effects of SP and emphasize practical functions to increase fan usage intention, and professional sporting leagues should prioritize the use of virtual fan technology to enhance the viewing experience.
Article
Critical Care Medicine
Phillip Joseph, Rosa Pari, Sarah Miller, Arabella Warren, Mary Catherine Stovall, Johanna Squires, Chia-Jung Chang, Wenzhong Xiao, Aaron B. Waxman, David M. Systrom
Summary: The study found that neurovascular dysregulation may contribute to exercise intolerance in ME/CFS, and pharmacologic cholinergic stimulation can improve exercise capacity in these patients.
Review
Immunology
Cheng Len Sy, Pao-Yu Chen, Chun-Wen Cheng, Ling-Ju Huang, Ching-Hsun Wang, Tu-Hsuan Chang, Yi-Chin Chang, Chia-Jung Chang, Ing-Moi Hii, Yu-Lung Hsu, Ya-Li Hu, Pi-Lien Hung, Chen-Yen Kuo, Pei-Chin Lin, Po-Yen Liu, Ching-Lung Lo, Shih-Hao Lo, Pei-Ju Ting, Chien-Fang Tseng, Hsiao-Wei Wang, Ching-Hsiang Yang, Susan Shin-Jung Lee, Yao-Shen Chen, Yung-Ching Liu, Fu-Der Wang
Summary: Antimicrobial drug resistance is a major threat to global health, leading to difficulties in treating common infections and increased medical costs. The Taiwan Society of Microbiology has published the Guidelines Recommendations for Evidence-based Antimicrobial agents use in Taiwan (GREAT) to assist clinicians in managing infections caused by multidrug-resistant organisms (MDRO). The guidelines take into account local epidemiology and include antimicrobial agents that may not yet be available in Taiwan.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Biology
Chia-Jung Chang, Chi-Hsuan Lu, Xing Gao, Hsin-Yueh Fang, Yin-Kai Chao
Summary: This study assessed the safety and efficacy of cone-beam computed tomography (CBCT)-guided localization using near-infrared (NIR) marking. The results indicate that needle localization with indocyanine green (ICG) injection is a safe and feasible technique for preoperative localization of solitary pulmonary nodules (SPNs).
Article
Biotechnology & Applied Microbiology
Min J. Jang, Gerard M. Coughlin, Cameron R. Jackson, Xinhong Chen, Miguel R. Chuapoco, Julia L. Vendemiatti, Alexander Z. Wang, Viviana Gradinaru
Summary: In this study, a ultrasensitive, sequential fluorescence in situ hybridization (USeqFISH) method was developed for spatial transcriptomic profiling of endogenous and viral RNA. The method allows investigation of the transduction and cell subtype biases of different AAV variants, as well as profiling of pooled regulatory cargos in AAV genomes. USeqFISH also shows potential applications in in situ AAV profiling and multimodal single-cell analysis in non-human primates.
NATURE BIOTECHNOLOGY
(2023)
Article
Behavioral Sciences
Jennifer Mejaes, Dhruvi Desai, Cody A. Siciliano, David J. Barker
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Neurosciences
Chris A. Leppla, Laurel R. Keyes, Gordon Glober, Gillian A. Matthews, Kanha Batra, Maya Jay, Yu Feng, Hannah S. Chen, Fergil Mills, Jeremy Delahanty, Jacob M. Olson, Edward H. Nieh, Praneeth Namburi, Craig Wildes, Romy Wichmann, Anna Beyeler, Eyal Y. Kimchi, Kay M. Tye
Summary: This study investigates the role of the medial geniculate nucleus (MGN) within the thalamoamygdala circuit in associative learning. The results show that the MGN encodes arousal but not valence, unlike the basolateral amygdala (BLA) which encodes both. The MGN and the BLA also exhibit different responses to expected and unexpected outcomes, with the BLA biased towards reward prediction error and the MGN focused on anticipated punishment.
PSYCHOPHARMACOLOGY
(2023)
Article
Management
Chia-Jung Chang, Shih-Chieh Yang, Eva Wolzok
Summary: This study examines users' behavioral intention to use fitness apps and investigates the effects of technology readiness (TR) and task-technology fit (TTF) using the technology readiness acceptance model (TRAM). The data analysis was conducted using structural equation modeling (SEM) with a sample of 328 consumers from six civil sports centers in Taiwan. The findings suggest that TR has a significant positive relationship with perceived usefulness (PU) and perceived ease of use (PEOU), while TTF only has a significant relationship with PU. The validated model contributes to the existing knowledge on sports technologies.
MANAGING SPORT AND LEISURE
(2023)
Article
Biochemistry & Molecular Biology
Alex R. Brown, Hannah E. Branthwaite, Zahra Z. Farahbakhsh, Snigdha Mukerjee, Patrick R. Melugin, Keaton Song, Habiba Noamany, Cody A. Siciliano
Summary: There is tension between methodologies in model species research and preclinical to clinical translation in alcohol research. To address this, researchers establish a modular alcohol reinforcement paradigm and combine it with existing preclinical alcohol models to determine longitudinal phenotype dynamics and potential neuro-biomarkers of alcohol vulnerability.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Zahra Z. Farahbakhsh, Keaton Song, Hannah E. Branthwaite, Kirsty R. Erickson, Snigdha Mukerjee, Suzanne O. Nolan, Cody A. Siciliano
Summary: Blocking kappa opioid receptors (KORs) has therapeutic potential for substance use disorders and depression, but it does not work through the negative valence system. Instead, it may exert its effects by increasing exploration of novel stimuli and enhancing their rewarding properties.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Xinhong Chen, Damien A. Wolfe, Dhanesh Sivadasan Bindu, Mengying Zhang, Naz Taskin, David Goertsen, Timothy F. Shay, Erin E. Sullivan, Sheng-Fu Huang, Sripriya Ravindra Kumar, Cynthia M. Arokiaraj, Viktor M. Plattner, Lillian J. Campos, John K. Mich, Deja Monet, Victoria Ngo, Xiaozhe Ding, Victoria Omstead, Natalie Weed, Yeme Bishaw, Bryan B. Gore, Ed S. Lein, Athena Akrami, Cory Miller, Boaz P. Levi, Annika Keller, Jonathan T. Ting, Andrew S. Fox, Cagla Eroglu, Viviana Gradinaru
Summary: Efficiently and specifically delivering genes across the brain vasculature remains a challenge for addressing neurological diseases. Researchers have modified adeno-associated virus (AAV9) capsids to transduce brain endothelial cells effectively in mice and rats. These modified AAVs also show superior transduction in non-human primates and ex vivo human brain slices, although the endothelial tropism is not conserved across species. The modified capsids can be used for serotype switching for sequential AAV administration in mice and genetically engineering the blood-brain barrier.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Timothy F. Shay, Erin E. Sullivan, Xiaozhe Ding, Xinhong Chen, Sripriya Ravindra Kumar, David Goertsen, David Brown, Anaya Crosby, Jost Vielmetter, Damien A. Wolfe, Annie W. Lam, Viviana Gradinaru
Summary: The blood-brain barrier (BBB) is a challenge for delivering large molecules to the central nervous system. To overcome this, adeno-associated viruses (AAVs) were used to identify two novel targets for improved BBB crossing: murine-restricted LY6C1 and widely conserved carbonic anhydrase IV (CA-IV). Computational modeling helped generate capsid-receptor binding models and design enhanced LY6C1-binding vector, AAV-PHP.eC. The discovery of primate-conserved CA-IV enables the design of more specific and potent brain-penetrant chemicals and biologicals.
Editorial Material
Multidisciplinary Sciences
Zahra Z. Farahbakhsh, Cody A. Siciliano
Article
Nanoscience & Nanotechnology
Miguel R. Chuapoco, Nicholas C. Flytzanis, Nick Goeden, J. Christopher Octeau, Kristina M. Roxas, Ken Y. Chan, Jon Scherrer, Janet Winchester, Roy J. Blackburn, Lillian J. Campos, Kwun Nok Mimi Man, Junqing Sun, Xinhong Chen, Arthur Lefevre, Vikram Pal Singh, Cynthia M. Arokiaraj, Timothy F. Shay, Julia Vendemiatti, Min J. Jang, John K. Mich, Yemeserach Bishaw, Bryan B. Gore, Victoria Omstead, Naz Taskin, Natalie Weed, Boaz P. Levi, Jonathan T. Ting, Cory T. Miller, Benjamin E. Deverman, James Pickel, Lin Tian, Andrew S. Fox, Viviana Gradinaru
Summary: Crossing the blood-brain barrier in primates is a major challenge for gene delivery. Researchers have identified an engineered variant, AAV.CAP-Mac, which efficiently delivers genes to the brains of multiple non-human primate species, potentially enabling non-invasive systemic gene transfer.
NATURE NANOTECHNOLOGY
(2023)
