Article
Cardiac & Cardiovascular Systems
Shye-Jao Wu, Ya-Fen Fan, Yu-Chu Tsai, Shen Sun, Chen-Yen Chien, Jiun-Yi Li
Summary: This study investigates the surgical outcomes of non-prompt aortic surgery for acute type A aortic dissection (ATAAD) patients. The results show that urgent but non-prompt aortic surgery could provide acceptable surgical results for ATAAD patients without preoperative shock and malperfusion who did not seek medical attention or who could not make their minds to undergo surgery immediately after symptom onset, as long as they are hospitalized with intensive care.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Daniela Crousillat, Joan Briller, Niti Aggarwal, Leslie Cho, Thais Coutinho, Colleen Harrington, Eric Isselbacher, Kathryn Lindley, Maral Ouzounian, Ourania Preventza, Jyoti Sharma, Ranya Sweis, Melissa Russo, Nandita Scott, Nupoor Narula
Summary: Despite being more common in men, women with thoracic aortic aneurysm and dissection (TAAD) receive lower rates of treatment and surgical intervention, leading to worse outcomes. Additionally, an increasing number of women with TAAD desire pregnancy, which poses an increased risk of aortic complications. Understanding the sex-specific differences in TAAD holds the potential to enhance care delivery, reduce treatment disparities, and optimize outcomes for women with TAAD.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Nerea Lopez Perez, Philippe Reymond, Mustafa Cikirikcioglu, Mathieu van Steenberghe, Tornike Sologashvili, Nicolas Murith, Thomas Perneger, Christoph Huber
Summary: This study examines the ratio between ascending and descending aorta diameters as a potential surrogate marker for decision making in cases of ascending aortic dilatation. A retrospective observational cohort study was conducted on 50 patients who underwent surgery for acute type A aorta dissection. The results suggest that the ratio between descending and ascending aorta diameters may be a useful tool for stratifying the risk of dissection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Zhenfeng Li, Tao Luo, Shuo Wang, Heyue Jia, Qi Gong, Xiaoping Liu, Michael P. F. Sutcliffe, Haijing Zhu, Qian Liu, Duanduan Chen, Jiang Xiong, Zhongzhao Teng
Summary: This study investigated the association between the macroscopic mechanical response of aortic dissection (AoD) flap, its fibre features, and patient physiological features and clinical presentations. The study found that fibre dispersion and waviness in the aortic dissection flap changed with patient age and clinical presentations. The elastin and collagen area percentages were positively correlated with material constants, while the elastin and collagen waviness were negatively correlated with material constants. The study also found that D2 was an effective parameter to differentiate patient groups with different age and clinical presentations.
ACTA BIOMATERIALIA
(2022)
Article
Hematology
Henrik Gune, Marten Larsson, Shahab Nozohoor, Erik Herou, Cecilia Luts, Sigurdur Ragnarsson, Maria Samuelsson, Johan Sjogren, Peter J. Svensson, Igor Zindovic
Summary: The study did not demonstrate a significant association between blood group and bleeding after surgery for acute type A aortic dissection, with patients with blood type O receiving significantly more fibrinogen concentrate post-operatively.
BLOOD COAGULATION & FIBRINOLYSIS
(2021)
Article
Biochemistry & Molecular Biology
Juan Manuel Chao de la Barca, Alexis Richard, Pauline Robert, Maroua Eid, Olivier Fouquet, Lydie Tessier, Celine Wetterwald, Justine Faure, Celine Fassot, Daniel Henrion, Pascal Reynier, Laurent Loufrani
Summary: Aortic aneurysm is the second-most common disease affecting the aorta worldwide, and there has been no report on deep metabolomic phenotyping in experimental animal models of aortic aneurysm. In this study, targeted metabolomics analysis was performed on the blood and aortas of an experimental mice model of aortic aneurysm. The results revealed profound alterations in the metabolic profile of the aortas and blood, mainly centered on changes in NO, lipid, and energetic metabolisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Juan J. Velasco, Yupeng Li, Bulat A. Ziganshin, Mohammad A. Zafar, John A. Rizzo, Deqiong Ma, Hui Zang, Asanish Kalyanasundaram, John A. Elefteriades
Summary: The KIF6 gene's 719Arg variant is strongly associated with an increased risk of aortic dissection in patients with thoracic aortic aneurysms. These findings have potential implications for predicting and managing aortic dissection, providing a valuable non-size criterion in surgical decision making.
Article
Hematology
John DePaolo, Michael G. Levin, Catherine Tcheandjieu, James R. Priest, Dipender Gill, Stephen Burgess, Scott M. Damrauer, Julio A. Chirinos
Summary: Observational studies have shown that high blood pressure is a significant risk factor for thoracic aortic dilation, and reducing blood pressure is recommended for preventing the progression of aortic aneurysms. However, the causal relationship between blood pressure and aortic size has not been conclusively established.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Pratik Rai, Lucy Robinson, Hannah A. Davies, Riaz Akhtar, Mark Field, Jillian Madine
Summary: This review investigates the presence, distribution, and role of PGs and GAGs in the aorta and their association with TAAD. Despite contradictory findings on changes in GAGs with aging, it is apparent that PGs and GAGs play an important role in maintaining the extracellular matrix of the aortic wall and show differences in association with TAAD. Further investigation is needed to establish a cause-effect relationship and understand the underlying mechanisms. The increased presence of PGs in serum associated with aortic disease suggests the potential use of these biomarkers for diagnosis or prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Changshun He, Bo Jiang, Mo Wang, Pengwei Ren, Sae-Il Murtada, Alexander W. Caulk, Guangxin Li, Lingfeng Qin, Roland Assi, Constantinos J. Lovoulos, Martin A. Schwartz, Jay D. Humphrey, George Tellides
Summary: This study investigates the role of mTOR signaling in aortic disease. The activation of mTOR in vascular wall cells determines whether aortic tears progress to dissection or rupture. Inhibition of mTOR signaling prevents aortic rupture but promotes dissection. Thus, caution should be exercised when exploring mTOR inhibition for aortic disease.
Article
Engineering, Biomedical
Piotr Reorowicz, Zbigniew Tyfa, Damian Obidowski, Karol Wisniewski, Ludomir Stefanczyk, Krzysztof Jozwik, Michael Lee Levy
Summary: The Flow Diverter is a treatment method for fusiform aneurysms, commonly used for cerebral vascular anomalies but not for aortic aneurysms. Numerical simulation in a patient-specific model of abdominal aortic aneurysms allowed investigation and visualization of blood hemodynamics before and after stent implantation. The Flow Diverter stent significantly changed the flow pattern in the aneurysm region but did not affect blood flow to the renal arteries.
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Alice Le Huu, Ourania Preventza
Summary: Approximately one-third of patients with acute Stanford type B or DeBakey type III aortic dissection will develop complications necessitating endovascular intervention to stabilize the condition. The immediate goal of endovascular therapy is to restore flow to the true lumen and stabilize the aneurysm, while the long-term goal is to remodel the descending thoracic aorta and prevent further surgeries.
ANNALS OF CARDIOTHORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Mario Lescan, Migdat Mustafi, Viktoria Wilhelm, Marius Keller, Christian Schlensak, Peter Rosenberger, Harry Magunia
Summary: This study found a correlation between preoperative dissection flap motility and aortic remodeling after TEVAR/FET, with acute and subacute dissection patients showing better aortic expansion and flap motility.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Surgery
Diletta Loschi, Annarita Santoro, Enrico Rinaldi, Claudia Anselmi, Camilla Grignani, Roberto Chiesa, Germano Melissano
Summary: This study investigates the types and outcomes of thoracic endovascular aneurysm repair and Candy Plug (CP) implantation for type B aortic dissection. The CP technique is found to be safe and effective, but there is a significant rate of aortic-related reintervention and high rate of major complications in open repair.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Biophysics
Marta Kozun, Maciej Kaczorowski, Agnieszka Halon
Summary: The mechanical properties of dissected wall of the ascending aortic aneurysm were analyzed. The results showed that the adventitia in healthy tissue and dissected ascending aorta aneurysm have the same mechanical function of protecting the vessel. Dissection affects the mechanical properties of the ascending aorta wall layers.
ACTA OF BIOENGINEERING AND BIOMECHANICS
(2022)
Article
Cardiac & Cardiovascular Systems
Jens Johansson Ramgren, Shahab Nozohoor, Igor Zindovic, Ronny Gustafsson, Nina Hakacova, Johan Sjogren
Summary: After repair of complete atrioventricular septal defect, there was no difference in 30-day mortality between young and older infants, with an overall 20-year survival rate of 95.1% and 92.6% freedom from left atrioventricular valve-related reoperation. Risk factors for poor survival included additional ventricular septal defect, previous coarctation of the aorta, persistent left superior vena cava, and genetic syndromes other than Trisomy 21.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Johan Noven, Martin Stagmo, Per Wierup, Shahab Nozohoor, Henrik Bjursten, Johan Sjogren, Igor Zindovic, Sigurdur Ragnarsson
Summary: Long-term survival following septal myectomy is excellent, with low left ventricular outflow tract gradients and good hemodynamics demonstrated by exercise echocardiography.
THORACIC AND CARDIOVASCULAR SURGEON
(2022)
Article
Cardiac & Cardiovascular Systems
Henrik Bjursten, Daniel Oudin Astrom, Shahab Nozohoor, Khalil Ahmad, Mariann Tang, Markus Bjurbom, Emma C. Hansson, Anders Jeppsson, Christian Joost Holdflod Moller, Miko Jormalainen, Tatu Juvonen, Ari Mennander, Peter S. Olsen, Christian Olsson, Anders Ahlsson, Anna Oudin, Emily Pan, Peter Raivio, Anders Wickbom, Johan Sjogren, Arnar Geirsson, Tomas Gudbjartsson, Igor Zindovic
Summary: The study found an overrepresentation of surgery for ATAAD during the full moon phase, possibly related to sleep deprivation during the full moon leading to a temporary increase in blood pressure triggering rupture of the aortic wall.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Maxime Vignac, Stelia Ntika, Christian Olsson, Anders Franco-Cereceda, Hanna M. Bjorck
Summary: This study found no association between Metformin treatment and prevalence of AscAA, but revealed an inverse association between diabetes and AscAA prevalence.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Emily Pan, Susanne J. Nielsen, Ari Mennander, Erik Bjorklund, Andreas Martinsson, Martin Lindgren, Emma C. Hansson, Aldina Pivodic, Anders Jeppsson
Summary: This study aimed to evaluate the association between statin use after coronary artery bypass grafting (CABG) and long-term adverse events. The results showed that ongoing statin use was significantly associated with a reduced incidence of adverse events and mortality, regardless of the statin dose.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Carl Granath, Salah A. Mohamed, Christian Olsson, Michael Grattan, Luc Mertens, Anders Franco-Cereceda, Hanna M. Bjorck
Summary: There are significant sex differences in clinical associations of BAV phenotypes, with differences in prevalence of aortic valve insufficiency and aortic dimensions between men and women. These differences suggest that sex should be considered in individualized patient management studies on BAV phenotypes.
Article
Anesthesiology
Anna Holmen, Anna Corderfeldt, Lukas Lannemyr, Goran Dellgren, Emma C. Hansson
Summary: The use of a cytokine hemoadsorber during valvular surgery for endocarditis could potentially reduce the need for vasopressors and transfusion, although the difference was not statistically significant.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Cardiac & Cardiovascular Systems
Carl Granath, David Freiholtz, Fredrik Bredin, Christian Olsson, Anders Franco-Cereceda, Hanna M. Bjorck
Summary: This study found a potential association between ASA therapy and a lower prevalence of ascending aortic aneurysm, particularly in patients with tricuspid aortic valves. Additionally, the study suggests that ASA may attenuate aortic aneurysmal growth through inhibition of cyclooxygenase-2 in the ascending aortic wall.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Markus Bjurbom, Christian Olsson, Arnar Geirsson, Tomas Gudbjartsson, Jarmo Gunn, Emma C. Hansson, Vibeke Hjortdal, Anders Jeppsson, Ari Mennander, Jacob Ede, Igor Zindovic, Anders Ahlsson, Anders Wickbom, Magnus Dalen
Summary: This study aimed to evaluate the association between previous cardiac surgery and outcomes after surgery for acute type A aortic dissection. The results showed that major adverse events were more frequent in patients with previous cardiac surgery, but previous cardiac surgery itself was not an independent predictor for adverse events.
ANNALS OF THORACIC SURGERY
(2023)
Article
Public, Environmental & Occupational Health
Daniel Oudin Astrom, Henrik Bjursten, Anna Oudin, Shahab Nozohoor, Khalil Ahmad, Mariann Tang, Markus Bjurbom, Emma C. Hansson, Anders Jeppsson, Christian Joost Holdflod Moller, Miko Jormalainen, Tatu Juvonen, Ari Mennander, Peter S. Olsen, Christian Olsson, Anders Ahlsson, Emily Pan, Peter Raivio, Anders Wickbom, Johan Sjogren, Arnar Geirsson, Tomas Gudbjartsson, Igor Zindovic
Summary: This study aimed to investigate the association between daily mean temperature and the risk of surgery for acute type A aortic dissection (ATAAD). The results showed an increased risk of ATAAD surgery at cold and hot temperatures, but the associations were not statistically significant, providing weak evidence of an association.
GLOBAL HEALTH ACTION
(2022)
Article
Multidisciplinary Sciences
Anna Oudin, Henrik Bjursten, Daniel Oudin Astroem, Shahab Nozohoor, Khalil Ahmad, Mariann Tang, Markus Bjurbom, Emma C. Hansson, Anders Jeppsson, Christian H. Moeller, Mikko Jormalainen, Tatu Juvonen, Ari Mennander, Peter S. Olsen, Christian Olsson, Anders Ahlsson, Emily Pan, Peter Raivio, Anders Wickbom, Johan Sjogren, Arnar Geirsson, Tomas Gudbjartsson, Igor Zindovic
Summary: A study conducted in 10 Nordic cities found that national holidays and weekends have a negative impact on the incidence of surgery for acute type A aortic dissection (ATAAD), leading to a decrease in the number of surgical repairs.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Markus Bjurbom, Magnus Dalen, Anders Franco-Cereceda, Christian Olsson
Summary: It remains equivocal if acute type A aortic dissection (ATAAD) surgical outcomes are improving. We analyzed recent outcome trends and found that the 30-day mortality and neurological insult rate decreased significantly. However, major complications remained unchanged. The number of surgeons performing ATAAD procedures decreased, and several predictors of mortality were identified. Overall, early outcomes after ATAAD improved, but major complications still require attention.
SCANDINAVIAN CARDIOVASCULAR JOURNAL
(2023)
Article
Anesthesiology
Anna Holmen, Anna Corderfeldt, Lukas Lannemyr, Goran Dellgren, Emma C. Hansson
Summary: This study investigated the impact of using a cytokine hemoadsorber on hemodynamic stability in patients undergoing valve surgery for endocarditis. The results showed that the intervention group had a lower norepinephrine dose and significantly reduced need for red blood cell transfusions postoperatively compared to the control group.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
