期刊
REGENERATIVE MEDICINE
卷 14, 期 10, 页码 969-979出版社
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2018-0079
关键词
electrical stimulation; inflammation; magnetic stimulation; nerve injury; stimulation paradigm
资金
- National Natural Science Foundation of China [81830076, 81672146, 81571261]
- National Science Foundation of Shanghai, China [17401901000]
- SUMHS Seed Foundation Project [HMSF-16-21-010]
- Science and Technology Development Foundation of Pudong New District, Shanghai, China [PKJ2016-Y55, PWZxq2017-03]
- Translational Medicine Program of Shanghai Jiao Tong University [ZH2018QNA56]
- Interdisciplinary Program of Shanghai Jiao Tong University [YG2017MS22, YG2017MS64, YG2017QN56]
- Program of Shanghai Sixth People's Hospital East Campus Foundation [2019YY001]
- Program of Shanghai Sixth People's Hospital Foundation [LY2Y0272]
Central and peripheral nerve injuries pose a great threat to people. Complications such as inflammation, muscle atrophy, traumatic neuromas and delayed reinnervation can bring huge challenges to clinical practices and barriers to complete nerve regrowth. Physical interventions such as electrical and magnetic stimulation show satisfactory results with varying parameters for acute and chronic nerve damages. The biological basis of electrical and magnetic stimulation mainly relies on protein synthesis, ion channel regulation and growth factor secretion. This review focuses on the various paradigms used in different models of electrical and magnetic stimulation and their regenerative potentials and underlying mechanisms in nerve injuries. The combination of physical stimulation and conductive biomaterial scaffolds displays an infinite potentiality in translational application in nerve regeneration.
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